1982 …2025

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2020

Base Editor Correction of COL7A1 in Recessive Dystrophic Epidermolysis Bullosa Patient-Derived Fibroblasts and iPSCs

Osborn, M. J., Newby, G. A., McElroy, A. N., Knipping, F., Nielsen, S. C., Riddle, M. J., Xia, L., Chen, W., Eide, C. R., Webber, B. R., Wandall, H. H., Dabelsteen, S., Blazar, B. R., Liu, D. R. & Tolar, J., Feb 2020, In : Journal of Investigative Dermatology. 140, 2, p. 338-347.e5

Research output: Contribution to journalArticle

4 Scopus citations

Effective Multi-lineage Engraftment in a Mouse Model of Fanconi Anemia Using Non-genotoxic Antibody-Based Conditioning

Srikanthan, M. A., Humbert, O., Haworth, K. G., Ironside, C., Rajawat, Y. S., Blazar, B. R., Palchaudhuri, R., Boitano, A. E., Cooke, M. P., Scadden, D. T. & Kiem, H. P., Jun 12 2020, In : Molecular Therapy - Methods and Clinical Development. 17, p. 455-464 10 p.

Research output: Contribution to journalArticle

Open Access
Open Access

Follistatin and Soluble Endoglin Predict 1-Year Nonrelapse Mortality after Allogeneic Hematopoietic Cell Transplantation

Newell, L. F., DeFor, T. E., Cutler, C., Verneris, M. R., Blazar, B. R., Miller, J. S., Antin, J. H., Howard, A., Wu, J., MacMillan, M. L., Panoskaltsis-Mortari, A., Weisdorf, D. J. & Holtan, S. G., Mar 2020, In : Biology of Blood and Marrow Transplantation. 26, 3, p. 606-611 6 p.

Research output: Contribution to journalArticle

GCNT1-mediated O-glycosylation of the sialomucin CD43 is a sensitive indicator of notch signaling in activated T cells

Perkey, E., De Sousa, D. M., Carrington, L., Chung, J., Dils, A., Granadier, D., Koch, U., Radtke, F., Ludewig, B., Blazar, B. R., Siebel, C. W., Brennan, T. V., Nolz, J., Labrecque, N. & Maillard, I., Mar 15 2020, In : Journal of Immunology. 204, 6, p. 1674-1688 15 p.

Research output: Contribution to journalArticle

Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia

Mathew, N. R., Vinnakota, J. M., Apostolova, P., Erny, D., Hamarsheh, S., Andrieux, G., Kim, J. S., Hanke, K., Goldmann, T., Chappell-Maor, L., El-Khawanky, N., Ihorst, G., Schmidt, D., Duyster, J., Finke, J., Blank, T., Boerries, M., Blazar, B. R., Jung, S., Prinz, M. & 1 others, Zeiser, R., Mar 2 2020, In : Journal of Clinical Investigation. 130, 3, p. 1315-1329 15 p.

Research output: Contribution to journalArticle

Open Access

IL-2 enhances ex vivo-expanded regulatory T-cell persistence after adoptive transfer

Furlan, S. N., Singh, K., Lopez, C., Tkachev, V., Hunt, D. J., Hibbard, J., Betz, K. M., Blazar, B. R., Trapnell, C. & Kean, L. S., Apr 28 2020, In : Blood Advances. 4, 8, p. 1594-1605 12 p.

Research output: Contribution to journalArticle

Open Access

Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease

Thangavelu, G., Du, J., Paz, K. G., Loschi, M., Zaiken, M. C., Flynn, R., Taylor, P. A., Kirchmeier, A. K., Panoskaltsis-Mortari, A., Luznik, L., MacDonald, K. P., Hill, G. R., Maillard, I., Munn, D. H., Serody, J. S., Murphy, W. J., Miklos, D., Cutler, C. S., Koreth, J., Antin, J. H. & 5 others, Soiffer, R. J., Ritz, J., Dahlberg, C., Miller, A. T. & Blazar, B. R., Jan 1 2020, In : Blood. 135, 1, p. 28-40 13 p.

Research output: Contribution to journalArticle

Interleukin-27 Enforces Regulatory T Cell Functions to Prevent Graft-versus-Host Disease

Le, H. T., Keslar, K., Nguyen, Q. T., Blazar, B. R., Hamilton, B. K. & Min, B., Feb 12 2020, In : Frontiers in immunology. 11, 181.

Research output: Contribution to journalArticle

Open Access

Mesenchymal stromal cells shape the MDS microenvironment by inducing suppressive monocytes that dampen NK cell function

Sarhan, D., Wang, J., Arvindam, U. S., Hallstrom, C., Verneris, M. R., Grzywacz, B., Warlick, E., Blazar, B. R. & Miller, J. S., Mar 12 2020, In : JCI Insight. 5, 5, e130155.

Research output: Contribution to journalArticle

Open Access

Metabolic reprogramming augments potency of human pSTAT3-inhibited iTregs to suppress alloreactivity

Walton, K., Fernandez, M. R., Sagatys, E. M., Reff, J., Kim, J., Lee, M. C., Kiluk, J. V., Hui, J. Y. C., McKenna, D., Hupp, M., Forster, C., Linden, M. A., Lawrence, N. J., Lawrence, H. R., Pidala, J., Pavletic, S. Z., Blazar, B. R., Sebti, S. M., Cleveland, J. L., Anasetti, C. & 1 others, Betts, B. C., May 7 2020, In : JCI Insight. 5, 9

Research output: Contribution to journalArticle

Open Access

Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function

Field, C. S., Baixauli, F., Kyle, R. L., Puleston, D. J., Cameron, A. M., Sanin, D. E., Hippen, K. L., Loschi, M., Thangavelu, G., Corrado, M., Edwards-Hicks, J., Grzes, K. M., Pearce, E. J., Blazar, B. R. & Pearce, E. L., Feb 4 2020, In : Cell Metabolism. 31, 2, p. 422-437.e5

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation

Hamarsheh, S., Osswald, L., Saller, B. S., Unger, S., De Feo, D., Vinnakota, J. M., Konantz, M., Uhl, F. M., Becker, H., Lübbert, M., Shoumariyeh, K., Schürch, C., Andrieux, G., Venhoff, N., Schmitt-Graeff, A., Duquesne, S., Pfeifer, D., Cooper, M. A., Lengerke, C., Boerries, M. & 8 others, Duyster, J., Niemeyer, C. M., Erlacher, M., Blazar, B. R., Becher, B., Groß, O., Brummer, T. & Zeiser, R., Dec 1 2020, In : Nature communications. 11, 1, 1659.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration

Piao, W., Xiong, Y., Li, L., Saxena, V., Smith, K. D., Hippen, K. L., Paluskievicz, C., Willsonshirkey, M., Blazar, B. R., Abdi, R. & Bromberg, J. S., Jan 28 2020, In : Cell reports. 30, 4, p. 1052-1062.e5

Research output: Contribution to journalArticle

Open Access

Salmonella-mediated therapy targeting indoleamine 2, 3-dioxygenase 1 (IDO) activates innate immunity and mitigates colorectal cancer growth

Phan, T., Nguyen, V. H., D’Alincourt, M. S., Manuel, E. R., Kaltcheva, T., Tsai, W., Blazar, B. R., Diamond, D. J. & Melstrom, L. G., Apr 1 2020, In : Cancer gene therapy. 27, 3-4, p. 235-245 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The lymph node stromal laminin α5 shapes alloimmunity

Li, L., Shirkey, M. W., Zhang, T., Xiong, Y., Piao, W., Saxena, V., Paluskievicz, C., Lee, Y., Toney, N., Cerel, B. M., Li, Q., Simon, T., Smith, K. D., Hippen, K. L., Blazar, B. R., Abdi, R. & Bromberg, J. S., May 1 2020, In : Journal of Clinical Investigation. 130, 5, p. 2602-2619 18 p.

Research output: Contribution to journalArticle

Open Access

Validation of Minnesota acute graft-versus-host disease Risk Score

MacMillan, M. L., DeFor, T. E., Holtan, S. G., Rashidi, A., Blazar, B. R. & Weisdorf, D. J., Jan 31 2020, In : Haematologica. 105, 2, p. 519-524 6 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance

ElTanbouly, M. A., Zhao, Y., Nowak, E., Li, J., Schaafsma, E., Le Mercier, I., Ceeraz, S., Lines, J. L., Peng, C., Carriere, C., Huang, X., Day, M., Koehn, B., Lee, S. W., Morales, M. S., Hogquist, K. A., Jameson, S. C., Mueller, D., Rothstein, J., Blazar, B. R. & 2 others, Cheng, C. & Noelle, R. J., Jan 17 2020, In : Science. 367, 6475, eaay0524.

Research output: Contribution to journalArticle

3 Scopus citations
2019

A confirmation of chronic graft-versus-host disease prediction using allogeneic HY antibodies following sex-mismatched hematopoietic cell transplantation

Paul, J., Nakasone, H., Sahaf, B., Wu, F., Wang, K., Ho, V., Wu, J., Kim, H., Blazar, B., Ritz, J., Howard, A., Cutler, C. & Miklos, D., Jun 30 2019, In : Haematologica. 104, 7, p. e314-e317

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells

Sinha, R. K., Flynn, R., Zaiken, M., Paz, K., Gavin, A. L., Nemazee, D., Fernández, J. A., Xu, X., Griffin, J. H. & Blazar, B. R., Aug 29 2019, In : Blood. 134, 9, p. 776-781 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Adaptive NK cell reconstitution is associated with better clinical outcomes

Cichocki, F., Taras, E., Chiuppesi, F., Wagner, J. E., Blazar, B. R., Brunstein, C., Luo, X., Diamond, D. J., Cooley, S., Weisdorf, D. J. & Miller, J. S., Jan 24 2019, In : JCI Insight. 4, 2, Y.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
1 Scopus citations

Analysis of BMT CTN-0201 and -0901 samples did not reproduce the reported association between recipient REG3A rs7588571 and chronic GVHD

Rashidi, A., Shanley, R., Anasetti, C., Waller, E. K., Scott, B. L., Blazar, B. R. & Weisdorf, D. J., Mar 1 2019, In : Bone marrow transplantation. 54, 3, p. 490-493 4 p.

Research output: Contribution to journalArticle

CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration

Xiong, Y., Piao, W., Colin Brinkman, C., Li, L., Kulinski, J. M., Olivera, A., Cartier, A., Hla, T., Hippen, K. L., Blazar, B. R., Schwab, S. R. & Bromberg, J. S., Mar 15 2019, In : Science Immunology. 4, 33, eaav1263.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Chimeric antigen receptor costimulation domains modulate human regulatory T cell function

Boroughs, A. C., Larson, R. C., Choi, B. D., Bouffard, A. A., Riley, L. S., Schiferle, E., Kulkarni, A. S., Cetrulo, C. L., Ting, D., Blazar, B. R., Demehri, S. & Maus, M. V., Jan 1 2019, In : JCI Insight. 4, 8, e126194.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Chronic stimulation drives human NK cell dysfunction and epigenetic reprograming

Merino, A., Zhang, B., Dougherty, P., Luo, X., Wang, J., Blazar, B. R., Miller, J. S. & Cichocki, F., Sep 3 2019, In : Journal of Clinical Investigation. 129, 9, p. 3770-3785 16 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol

MacDonald, K. N., Ivison, S., Hippen, K. L., Hoeppli, R. E., Hall, M., Zheng, G., Dijke, I. E., Aklabi, M. A., Freed, D. H., Rebeyka, I., Gandhi, S., West, L. J., Piret, J. M., Blazar, B. R. & Levings, M. K., Dec 2019, In : Cytotherapy. 21, 12, p. 1216-1233 18 p.

Research output: Contribution to journalArticle

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD

Koehn, B. H., Saha, A., McDonald-Hyman, C., Loschi, M., Thangavelu, G., Ma, L., Zaiken, M., Dysthe, J., Krepps, W., Panthera, J., Hippen, K., Jameson, S. C., Miller, J. S., Cooper, M. A., Farady, C. J., Iwawaki, T., Ting, J. P. Y., Serody, J. S., Murphy, W. J., Hill, G. R. & 5 others, Murray, P. J., Bronte, V., Munn, D. H., Zeiser, R. & Blazar, B. R., Nov 7 2019, In : Blood. 134, 19, p. 1670-1682 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality

Thangavelu, G., Lee, Y. C., Loschi, M., Melanie Schaechter, K., Feser, C. J., Koehn, B., Nowak, E. C., Zeiser, R., Serody, J. S., Murphy, W. J., Munn, D. H., Chambon, P., Noelle, R. J. & Blazar, B. R., May 1 2019, In : Journal of Immunology. 202, 9, p. 2795-2805 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets

Tanimine, N., Germana, S. K., Fan, M., Hippen, K., Blazar, B. R., Markmann, J. F., Turka, L. A. & Priyadharshini, B., Jun 2019, In : PloS one. 14, 6, e0217761.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node

Simon, T., Li, L., Wagner, C., Zhang, T., Saxena, V., Brinkman, C. C., Tostanoski, L. H., Ostrand-Rosenberg, S., Jewell, C., Shea-Donohue, T., Hippen, K., Blazar, B., Abdi, R. & Bromberg, J. S., Oct 1 2019, In : Transplantation. 103, 10, p. 2075-2089 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality

Saha, A., Taylor, P. A., Lees, C. J., Panoskaltsis-Mortari, A., Osborn, M. J., Feser, C. J., Thangavelu, G., Melchinger, W., Refaeli, Y., Hill, G. R., Munn, D. H., Murphy, W. J., Serody, J. S., Maillard, I., Kreymborg, K., van den Brink, M., Dong, C., Huang, S., Zang, X., Allison, J. P. & 2 others, Zeiser, R. & Blazar, B. R., Jan 1 2019, In : JCI Insight. 4, 19, e127716.

Research output: Contribution to journalArticle

Open Access

Dose-escalated interleukin-2 therapy for refractory chronic graft-versus-host disease in adults and children

Whangbo, J. S., Kim, H. T., Mirkovic, N., Leonard, L., Poryanda, S., Silverstein, S., Kim, S., Reynolds, C. G., Rai, S. C., Verrill, K., Lee, M. A., Margossian, S., Duncan, C., Lehmann, L., Huang, J., Nikiforow, S., Alyea, E. P., Armand, P., Cutler, C. S., Ho, V. T. & 5 others, Blazar, B. R., Antin, J. H., Soiffer, R. J., Ritz, J. & Koreth, J., Sep 10 2019, In : Blood Advances. 3, 17, p. 2550-2561 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
1 Scopus citations

Early E. Casseliflavus gut colonization and outcomes of allogeneic hematopoietic cell transplantation

Rashidi, A., Ebadi, M., Shields-Cutler, R. R., Kruziki, K., Manias, D. A., Barnes, A. M. T., DeFor, T. E., Ferrieri, P., Young, J. A. H., Knights, D., Blazar, B. R., Weisdorf, D. J. & Dunny, G. M., Jan 1 2019, In : PloS one. 14, 8, e0220850.

Research output: Contribution to journalArticle

Open Access

Early notch signals induce a pathogenic molecular signature during priming of alloantigen-specific conventional CD4+ T cells in graft-versus-host disease

Chung, J., Radojcic, V., Perkey, E., Parnell, T. J., Niknafs, Y., Jin, X., Friedman, A., Labrecque, N., Blazar, B. R., Brennan, T. V., Siebel, C. W. & Maillard, I., Jan 1 2019, In : Journal of Immunology. 203, 2, p. 557-568 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Efficacy and immunologic effects of extracorporeal photopheresis plus interleukin-2 in chronic graft-versus-host disease

Belizaire, R., Kim, H. T., Poryanda, S. J., Mirkovic, N. V., Hipolito, E., Savage, W. J., Reynolds, C. G., Fields, M. J., Whangbo, J., Kubo, T., Nikiforow, S., Alyea, E. P., Armand, P., Cutler, C. S., Ho, V. T., Blazar, B. R., Antin, J. H., Ritz, J., Soiffer, R. J. & Koreth, J., Apr 9 2019, In : Blood Advances. 3, 7, p. 969-979 11 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

First-in-human trial of rhIL-15 and haploidentical natural killer cell therapy for advanced acute myeloid leukemia

Cooley, S., He, F., Bachanova, V., Vercellotti, G. M., DeFor, T. E., Curtsinger, J. M., Robertson, P., Grzywacz, B., Conlon, K. C., Waldmann, T. A., McKenna, D. H., Blazar, B. R., Weisdorf, D. J. & Miller, J. S., Jan 1 2019, In : Blood Advances. 3, 13, p. 1970-1980 11 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

Clement, R. L., Daccache, J., Mohammed, M. T., Diallo, A., Blazar, B. R., Kuchroo, V. K., Lovitch, S. B., Sharpe, A. H. & Sage, P. T., Oct 1 2019, In : Nature immunology. 20, 10, p. 1360-1371 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program

Hou, S., Clement, R. L., Diallo, A., Blazar, B. R., Rudensky, A. Y., Sharpe, A. H. & Sage, P. T., Mar 1 2019, In : Journal of Experimental Medicine. 216, 3, p. 605-620 16 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Generation and function of progenitor t cells from stemregenin-1-expanded CD34+ human hematopoietic progenitor cells

Singh, J., Chen, E. L. Y., Xing, Y., Stefanski, H. E., Blazar, B. R. & Zúñiga-Pflücker, J. C., Jan 1 2019, In : Blood Advances. 3, 20, p. 2934-2948 15 p.

Research output: Contribution to journalArticle

Open Access

MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota

Koyama, M., Mukhopadhyay, P., Schuster, I. S., Henden, A. S., Hülsdünker, J., Varelias, A., Vetizou, M., Kuns, R. D., Robb, R. J., Zhang, P., Blazar, B. R., Thomas, R., Begun, J., Waddell, N., Trinchieri, G., Zeiser, R., Clouston, A. D., Degli-Esposti, M. A. & Hill, G. R., Nov 19 2019, In : Immunity. 51, 5, p. 885-898.e7

Research output: Contribution to journalArticle

6 Scopus citations
3 Scopus citations
5 Scopus citations

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Wang, Z., Aguilar, E. G., Luna, J. I., Dunai, C., Khuat, L. T., Le, C. T., Mirsoian, A., Minnar, C. M., Stoffel, K. M., Sturgill, I. R., Grossenbacher, S. K., Withers, S. S., Rebhun, R. B., Hartigan-O’Connor, D. J., Méndez-Lagares, G., Tarantal, A. F., Isseroff, R. R., Griffith, T. S., Schalper, K. A., Merleev, A. & 13 others, Saha, A., Maverakis, E., Kelly, K., Aljumaily, R., Ibrahimi, S., Mukherjee, S., Machiorlatti, M., Vesely, S. K., Longo, D. L., Blazar, B. R., Canter, R. J., Murphy, W. J. & Monjazeb, A. M., Jan 1 2019, In : Nature Medicine. 25, 1, p. 141-151 11 p.

Research output: Contribution to journalArticle

Open Access
66 Scopus citations

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

Puleston, D. J., Buck, M. D., Klein Geltink, R. I., Kyle, R. L., Caputa, G., O'Sullivan, D., Cameron, A. M., Castoldi, A., Musa, Y., Kabat, A. M., Zhang, Y., Flachsmann, L. J., Field, C. S., Patterson, A. E., Scherer, S., Alfei, F., Baixauli, F., Austin, S. K., Kelly, B., Matsushita, M. & 17 others, Curtis, J. D., Grzes, K. M., Villa, M., Corrado, M., Sanin, D. E., Qiu, J., Pällman, N., Paz, K., Maccari, M. E., Blazar, B. R., Mittler, G., Buescher, J. M., Zehn, D., Rospert, S., Pearce, E. J., Balabanov, S. & Pearce, E. L., Aug 6 2019, In : Cell Metabolism. 30, 2, p. 352-363.e8

Research output: Contribution to journalArticle

Open Access
15 Scopus citations
Open Access
2 Scopus citations

Reduction in murine acute GVHD severity by human gingival tissue-derived mesenchymal stem cells via the CD39 pathways

Ni, X., Xia, Y., Zhou, S., Peng, H., Wu, X., Lu, H., Wang, H., Liu, R., Blazar, B. R., Gu, J. & Lu, L., Jan 1 2019, In : Cell Death and Disease. 10, 1, 13.

Research output: Contribution to journalArticle

Open Access

Rorc restrains the potency of ST2+ regulatory T cells in ameliorating intestinal graft-versus-host disease

Yang, J., Ramadan, A., Reichenbach, D. K., Loschi, M., Zhang, J., Griesenauer, B., Liu, H., Hippen, K. L., Blazar, B. R. & Paczesny, S., Mar 7 2019, In : JCI Insight. 4, 5

Research output: Contribution to journalArticle

Open Access
2 Scopus citations