1982 …2020

Research output per year

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Research Output

2011

Physiologic control of IDO competence in splenic dendritic cells

Baban, B., Chandler, P. R., Johnson, B. A., Huang, L., Li, M., Sharpe, M. L., Francisco, L. M., Sharpe, A. H., Blazar, B. R., Munn, D. H. & Mellor, A. L., Sep 1 2011, In : Journal of Immunology. 187, 5, p. 2329-2335 7 p.

Research output: Contribution to journalArticle

58 Scopus citations

PKC-θ function at the immunological synapse: Prospects for therapeutic targeting

Zanin-Zhorov, A., Dustin, M. L. & Blazar, B. R., Aug 1 2011, In : Trends in Immunology. 32, 8, p. 358-363 6 p.

Research output: Contribution to journalReview article

49 Scopus citations
27 Scopus citations

Regulatory T cells in acute myelogenous leukemia: Is it time for immunomodulation?

Ustun, C., Miller, J. S., Munn, D. H., Weisdorf, D. J. & Blazar, B. R., Nov 10 2011, In : Blood. 118, 19, p. 5084-5095 12 p.

Research output: Contribution to journalReview article

105 Scopus citations

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

Beyer, M., Thabet, Y., Müller, R. U., Sadlon, T., Classen, S., Lahl, K., Basu, S., Zhou, X., Bailey-Bucktrout, S. L., Krebs, W., Schönfeld, E. A., Böttcher, J., Golovina, T., Mayer, C. T., Hofmann, A., Sommer, D., Debey-Pascher, S., Endl, E., Limmer, A., Hippen, K. L. & 15 others, Blazar, B. R., Balderas, R., Quast, T., Waha, A., Mayer, G., Famulok, M., Knolle, P. A., Wickenhauser, C., Kolanus, W., Schermer, B., Bluestone, J. A., Barry, S. C., Sparwasser, T., Riley, J. L. & Schultze, J. L., Sep 1 2011, In : Nature immunology. 12, 9, p. 898-907 10 p.

Research output: Contribution to journalArticle

121 Scopus citations

Resurrecting the recalcitrant T-cell

Wagner, J. E. & Blazar, B. R., Oct 20 2011, In : Blood. 118, 16, p. 4302-4303 2 p.

Research output: Contribution to journalComment/debate

Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human t regulatory cells

Golovina, T. N., Mikheeva, T., Brusko, T. M., Blazar, B. R., Bluestone, J. A. & Riley, J. L., Feb 1 2011, In : PloS one. 6, 1, e15868.

Research output: Contribution to journalArticle

90 Scopus citations

Roles of CD28, CTLA4, and inducible costimulator in acute graft-versus-host disease in mice

Li, J., Semple, K., Suh, W. K., Liu, C., Chen, F., Blazar, B. R. & Yu, X. Z., Jul 1 2011, In : Biology of Blood and Marrow Transplantation. 17, 7, p. 962-969 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Sleeping Beauty-mediated correction of Fanconi anemia type C

Hyland, K. A., Olson, E. R., Clark, K. J., Aronovich, E. L., Hackett, P. B., Blazar, B. R., Tolar, J. & Scott Mcivor, R., Sep 1 2011, In : Journal of Gene Medicine. 13, 9, p. 462-469 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Stem cell gene therapy for fanconi anemia: Report from the 1st international fanconi anemia gene therapy working group meeting

Tolar, J., Adair, J. E., Antoniou, M., Bartholomae, C. C., Becker, P. S., Blazar, B. R., Bueren, J., Carroll, T., Cavazzana-Calvo, M., Clapp, D. W., Dalgleish, R., Galy, A., Gaspar, H. B., Hanenberg, H., Von Kalle, C., Kiem, H. P., Lindeman, D., Naldini, L., Navarro, S., Renella, R. & 7 others, Rio, P., Sevilla, J., Schmidt, M., Verhoeyen, E., Wagner, J. E., Williams, D. A. & Thrasher, A. J., Jul 2011, In : Molecular Therapy. 19, 7, p. 1193-1198 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Stromal cell-derived factor-1 and hematopoietic cell homing in an adult zebrafish model of hematopoietic cell transplantation

Glass, T. J., Lund, T. C., Patrinostro, X., Tolar, J., Bowman, T. V., Zon, L. I. & Blazar, B. R., Jul 21 2011, In : Blood. 118, 3, p. 766-774 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Synthetic zinc finger nuclease design and rapid assembly

Osborn, M. J., Defeo, A. P., Blazar, B. R. & Tolar, J., Sep 1 2011, In : Human gene therapy. 22, 9, p. 1155-1165 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

Sakuishi, K., Apetoh, L., Sullivan, J. M., Blazar, B. R., Kuchroo, V. K. & Anderson, A. C., Jun 1 2011, In : Journal of Experimental Medicine. 208, 6, 1 p.

Research output: Contribution to journalComment/debate

6 Scopus citations

The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo

Yang, J., Riella, L. V., Chock, S., Liu, T., Zhao, X., Yuan, X., Paterson, A. M., Watanabe, T., Vanguri, V., Yagita, H., Azuma, M., Blazar, B. R., Freeman, G. J., Rodig, S. J., Sharpe, A. H., Chandraker, A. & Sayegh, M. H., Aug 1 2011, In : Journal of Immunology. 187, 3, p. 1113-1119 7 p.

Research output: Contribution to journalArticle

80 Scopus citations

The programmed Death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo

Paterson, A. M., Brown, K. E., Keir, M. E., Vanguri, V. K., Riella, L. V., Chandraker, A., Sayegh, M. H., Blazar, B. R., Freeman, G. J. & Sharpe, A. H., Aug 1 2011, In : Journal of Immunology. 187, 3, p. 1097-1105 9 p.

Research output: Contribution to journalArticle

93 Scopus citations

Thymic T-cell development in allogeneic stem cell transplantation

Krenger, W., Blazar, B. R. & Holländer, G. A., Jun 23 2011, In : Blood. 117, 25, p. 6768-6776 9 p.

Research output: Contribution to journalReview article

104 Scopus citations

Vstm3 is a member of the CD28 family and an important modulator of T-cell function

Levin, S. D., Taft, D. W., Brandt, C. S., Bucher, C., Howard, E. D., Chadwick, E. M., Johnston, J., Hammond, A., Bontadelli, K., Ardourel, D., Hebb, L., Wolf, A., Bukowski, T. R., Rixon, M. W., Kuijper, J. L., Ostrander, C. D., West, J. W., Bilsborough, J., Fox, B., Gao, Z. & 4 others, Xu, W., Ramsdell, F., Blazar, B. R. & Lewis, K. E., Apr 1 2011, In : European Journal of Immunology. 41, 4, p. 902-915 14 p.

Research output: Contribution to journalArticle

132 Scopus citations

Zinc fingers hit off target.

Cheng, L., Blazar, B., High, K. & Porteus, M., Oct 1 2011, In : Nature Medicine. 17, 10, p. 1192-1193 2 p.

Research output: Contribution to journalArticle

5 Scopus citations
2010

4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood t cells against b-cell malignancies

Tammana, S., Huang, X., Wong, M., Milone, M. C., Ma, L., Levine, B. L., June, C. H., Wagner, J. E., Blazar, B. R. & Zhou, X., Jan 1 2010, In : Human gene therapy. 21, 1, p. 75-86 12 p.

Research output: Contribution to journalArticle

97 Scopus citations
2 Scopus citations

Adenosine receptor A2a deficiency in leukocytes increases arterial neointima formation in apolipoprotein E-deficient mice

Wang, H., Zhang, W., Tang, R., Zhu, C., Bucher, C., Blazar, B. R., Geng, J. G., Zhang, C., Linden, J., Wu, C. & Huo, Y., May 1 2010, In : Arteriosclerosis, thrombosis, and vascular biology. 30, 5, p. 915-922 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13

Highfill, S. L., Rodriguez, P. C., Zhou, Q., Goetz, C. A., Koehn, B. H., Veenstra, R., Taylor, P. A., Panoskaltsis-Mortari, A., Serody, J. S., Munn, D. H., Tolar, J., Ochoa, A. C. & Blazar, B. R., Dec 16 2010, In : Blood. 116, 25, p. 5738-5747 10 p.

Research output: Contribution to journalArticle

281 Scopus citations

Bone marrow transplantation for recessive dystrophic epidermolysis bullosa

Wagner, J. E., Ishida-Yamamoto, A., McGrath, J. A., Hordinsky, M., Keene, D. R., Riddle, M. J., Osborn, M. J., Lund, T., Dolan, M., Blazar, B. R. & Tolar, J., Aug 12 2010, In : New England Journal of Medicine. 363, 7, p. 629-639 11 p.

Research output: Contribution to journalArticle

213 Scopus citations

Chemotherapy rescues tumor-driven aberrant CD4+ T-cell differentiation and restores an activated polyfunctional helper phenotype

Ding, Z. C., Blazar, B. R., Mellor, A. L., Munn, D. H. & Zhou, G., Mar 25 2010, In : Blood. 115, 12, p. 2397-2406 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Concise review: Hitting the right spot with mesenchymal stromal cells

Tolar, J., Le Blanc, K., Keating, A. & Blazar, B. R., Aug 1 2010, In : STEM CELLS. 28, 8, p. 1446-1455 10 p.

Research output: Contribution to journalArticle

274 Scopus citations

Constitutively active Stat5b in CD4+ T cells inhibits graft-versus-host disease lethality associated with increased regulatory T-cell potency and decreased T effector cell responses

Vogtenhuber, C., Bucher, C., Highfill, S. L., Koch, L. K., Goren, E., Panoskaltsis-Mortari, A., Taylor, P. A., Farrar, M. A. & Blazar, B. R., Jul 22 2010, In : Blood. 116, 3, p. 466-474 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Development of a decellularized lung bioreactor system for bioengineering the lung: The matrix reloaded

Price, A. P., England, K. A., Matson, A. M., Blazar, B. R. & Panoskaltsis-Mortari, A., Aug 1 2010, In : Tissue Engineering - Part A. 16, 8, p. 2581-2591 11 p.

Research output: Contribution to journalArticle

231 Scopus citations

Emerging strategies to boost thymic function

Holländer, G. A., Krenger, W. & Blazar, B. R., Aug 1 2010, In : Current Opinion in Pharmacology. 10, 4, p. 443-453 11 p.

Research output: Contribution to journalReview article

48 Scopus citations

GVHD after haploidentical transplantation: A novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression

Miller, W. P., Srinivasan, S., Panoskaltsis-Mortari, A., Singh, K., Sen, S., Hamby, K., Deane, T., Stempora, L., Beus, J., Turner, A., Wheeler, C., Anderson, D. C., Sharma, P., Garcia, A., Strobert, E., Elder, E., Crocker, I., Crenshaw, T., Penedo, M. C. T., Ward, T. & 5 others, Song, M., Horan, J., Larsen, C. P., Blazar, B. R. & Kean, L. S., Dec 9 2010, In : Blood. 116, 24, p. 5403-5417 15 p.

Research output: Contribution to journalArticle

33 Scopus citations

Hematopoietic progenitor cell regulation by CD4+CD25+ T cells

Urbieta, M., Barao, I., Jones, M., Jurecic, R., Panoskaltsis-Mortari, A., Blazar, B. R., Murphy, W. J. & Levy, R. B., Jun 10 2010, In : Blood. 115, 23, p. 4934-4943 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

L-selectin is dispensable for T regulatory cell function postallogeneic bone marrow transplantation

Carlson, M. J., Fulton, L. M., Coghill, J. M., West, M. L., Burgents, J. E., Wan, Y., Panoskaltsis-Mortari, A., Tedder, T. F., Blazar, B. R. & Serody, J. S., Dec 1 2010, In : American Journal of Transplantation. 10, 12, p. 2596-2603 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
16 Scopus citations

NCI First International Workshop on The Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Biology Underlying Recurrence of Malignant Disease following Allogeneic HSCT: Graft-versus-Tumor/Leukemia Reaction

Miller, J. S., Warren, E. H., van den Brink, M. R. M., Ritz, J., Shlomchik, W. D., Murphy, W. J., Barrett, A. J., Kolb, H. J., Giralt, S., Bishop, M. R., Blazar, B. R. & Falkenburg, J. H. F., May 1 2010, In : Biology of Blood and Marrow Transplantation. 16, 5, p. 565-586 22 p.

Research output: Contribution to journalReview article

82 Scopus citations

Pre-transplant risk factors affecting outcome in Hurler syndrome

Orchard, P. J., Milla, C., Braunlin, E., Defor, T., Bjoraker, K., Blazar, B. R., Peters, C., Wagner, J. & Tolar, J., Jul 1 2010, In : Bone marrow transplantation. 45, 7, p. 1239-1246 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia

Zhou, Q., Munger, M. E., Highfill, S. L., Tolar, J., Weigel, B. J., Riddle, M., Sharpe, A. H., Vallera, D. A., Azuma, M., Levine, B. L., June, C. H., Murphy, W. J., Munn, D. H. & Blazar, B. R., Oct 7 2010, In : Blood. 116, 14, p. 2484-2493 10 p.

Research output: Contribution to journalArticle

169 Scopus citations

Protein kinase C-θ mediates negative feedback on regulatory T cell function

Zanin-Zhorov, A., Ding, Y., Kumari, S., Attur, M., Hippen, K. L., Brown, M., Blazar, B. R., Abramson, S. B., Lafaille, J. J. & Dustin, M. L., Apr 16 2010, In : Science. 328, 5976, p. 372-376 5 p.

Research output: Contribution to journalArticle

204 Scopus citations

Reprogrammed Foxp3+ Regulatory T Cells Provide Essential Help to Support Cross-presentation and CD8+ T Cell Priming in Naive Mice

Sharma, M. D., Hou, D. Y., Baban, B., Koni, P. A., He, Y., Chandler, P. R., Blazar, B. R., Mellor, A. L. & Munn, D. H., Dec 14 2010, In : Immunity. 33, 6, p. 942-954 13 p.

Research output: Contribution to journalArticle

135 Scopus citations

Robert Truitt tribute.

Johnson, B., Drobyski, W., Blazar, B. & Korngold, R., Jan 1 2010, In : Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 16, 1, p. 143-144 2 p.

Research output: Contribution to journalArticle

Separation of graft-versus-host disease from graft-versus-leukemia responses by targeting CC-chemokine receptor 7 on donor T cells

Coghill, J. M., Carlson, M. J., Panoskaltsis-Mortari, A., West, M. L., Burgents, J. E., Blazar, B. R. & Serody, J. S., Jun 10 2010, In : Blood. 115, 23, p. 4914-4922 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation

Kelly, R. M., Goren, E. M., Taylor, P. A., Mueller, S. N., Stefanski, H. E., Osborn, M. J., Scott, H. S., Komarova, E. A., Gudkov, A. V., Holländer, G. A. & Blazar, B. R., Feb 4 2010, In : Blood. 115, 5, p. 1088-1097 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

STAT3 signaling in CD4+ T cells is critical for the pathogenesis of chronic sclerodermatous graft-versus-host disease in a murine model

Radojcic, V., Pletneva, M. A., Yen, H. R., Ivcevic, S., Panoskaltsis-Mortari, A., Gilliam, A. C., Drake, C. G., Blazar, B. R. & Luznik, L., Jan 15 2010, In : Journal of Immunology. 184, 2, p. 764-774 11 p.

Research output: Contribution to journalArticle

57 Scopus citations

Superior efficacy of tumor cell vaccines grown in physiologic oxygen

Olin, M. R., Andersen, B. M., Zellmer, D. M., Grogan, P. T., Popescu, F. E., Xiong, Z., Forster, C. L., Seiler, C., SantaCruz, K. S., Chen, W., Blazar, B. R. & Ohlfest, J. R., Oct 1 2010, In : Clinical Cancer Research. 16, 19, p. 4800-4808 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

Sakuishi, K., Apetoh, L., Sullivan, J. M., Blazar, B. R., Kuchroo, V. K. & Anderson, A. C., Sep 27 2010, In : Journal of Experimental Medicine. 207, 10, p. 2187-2194 8 p.

Research output: Contribution to journalArticle

935 Scopus citations

Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells

Liang, X., Moseman, E. A., Farrar, M. A., Bachanova, V., Weisdorf, D. J., Blazar, B. R. & Chen, W., Jun 17 2010, In : Blood. 115, 24, p. 5041-5052 12 p.

Research output: Contribution to journalArticle

77 Scopus citations
2009

Acute graft-versus-host disease: From the bench to the bedside

Socié, G. & Blazar, B. R., Nov 12 2009, In : Blood. 114, 20, p. 4327-4336 10 p.

Research output: Contribution to journalArticle

195 Scopus citations
147 Scopus citations

Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease

Sarantopoulos, S., Stevenson, K. E., Kim, H. T., Cutler, C. S., Bhuiya, N. S., Schowalter, M., Ho, V. T., Alyea, E. P., Koreth, J., Blazar, B. R., Soiffer, R. J., Antin, J. H. & Ritz, J., Nov 17 2009, In : Blood. 113, 16, p. 3865-3874 10 p.

Research output: Contribution to journalArticle

200 Scopus citations

Amelioration of epidermolysis bullosa by transfer of wild-type bone marrow cells

Tolar, J., Akemi, I. Y., Riddle, M., McElmurry, R. T., Osborn, M., Xia, L., Lund, T., Slattery, C., Uitto, J., Christiano, A. M., Wagner, J. E. & Blazar, B. R., Jan 29 2009, In : Blood. 113, 5, p. 1167-1174 8 p.

Research output: Contribution to journalArticle

122 Scopus citations

Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia

Zhou, Q., Bucher, C., Munger, M. E., Highfill, S. L., Tolar, J., Munn, D. H., Levine, B. L., Riddle, M., June, C. H., Vallera, D. A., Weigel, B. J. & Blazar, B. R., Oct 29 2009, In : Blood. 114, 18, p. 3793-3802 10 p.

Research output: Contribution to journalArticle

81 Scopus citations

Donor T cells primed on leukemia lysate-pulsed recipient APCs mediate strong graft-versus-leukemia effects across MHC barriers in full chimeras

Ghosh, A., Koestner, W., Hapke, M., Schlaphoff, V., Länger, F., Baumann, R., Koenecke, C., Cornberg, M., Welte, K., Blazar, B. R. & Sauer, M. G., Nov 17 2009, In : Blood. 113, 18, p. 4440-4448 9 p.

Research output: Contribution to journalArticle

14 Scopus citations