1982 …2020

Research output per year

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Research Output

2014

Donor CD4+Foxp3+regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice

Ganguly, S., Ross, D. B., Panoskaltsis-Mortari, A., Kanakry, C. G., Blazar, B. R., Levy, R. B. & Luznik, L., Sep 25 2014, In : Blood. 124, 13, p. 2131-2141 11 p.

Research output: Contribution to journalArticle

75 Scopus citations
32 Scopus citations

Functional NK cell repertoires are maintained through IL-2Rα and fas ligand

Felices, M., Lenvik, T. R., Ankarlo, D. E. M., Foley, B., Curtsinger, J., Luo, X., Blazar, B. R., Anderson, S. K. & Miller, J. S., Apr 15 2014, In : Journal of Immunology. 192, 8, p. 3889-3897 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Higher therapeutic CsA levels early post transplantation reduce risk of acute GVHD and improves survival

Rogosheske, J. R., Fargen, A. D., Defor, T. E., Warlick, E., Arora, M., Blazar, B. R., Weisdorf, D. J. & Brunstein, C. G., Jan 1 2014, In : Bone marrow transplantation. 49, 1, p. 122-125 4 p.

Research output: Contribution to journalArticle

22 Scopus citations

Ibrutinib treatment ameliorates murine chronic graft-versus-host disease

Dubovsky, J. A., Flynn, R., Du, J., Harrington, B. K., Zhong, Y., Kaffenberger, B., Yang, C., Towns, W. H., Lehman, A., Johnson, A. J., Muthusamy, N., Devine, S. M., Jaglowski, S., Serody, J. S., Murphy, W. J., Munn, D. H., Luznik, L., Hill, G. R., Wong, H. K., MacDonald, K. K. P. & 10 others, Maillard, I., Koreth, J., Elias, L., Cutler, C., Soiffer, R. J., Antin, J. H., Ritz, J., Panoskaltsis-Mortari, A., Byrd, J. C. & Blazar, B. R., Nov 3 2014, In : Journal of Clinical Investigation. 124, 11, p. 4867-4876 10 p.

Research output: Contribution to journalArticle

90 Scopus citations

IL-33 is an unconventional alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells

Matta, B. M., Lott, J. M., Mathews, L. R., Liu, Q., Rosborough, B. R., Blazar, B. R. & Turnquist, H. R., Oct 15 2014, In : Journal of Immunology. 193, 8, p. 4010-4020 11 p.

Research output: Contribution to journalArticle

109 Scopus citations

Immunosuppressive myeloid cells induced by chemotherapy attenuate antitumor cd4 t-cell responses through the PD-1-PD-L1 axis

Ding, Z. C., Lu, X., Yu, M., Lemos, H., Huang, L., Chandler, P., Liu, K., Walters, M., Krasinski, A., Mack, M., Blazar, B. R., Mellor, A. L., Munn, D. H. & Zhou, G., Jul 1 2014, In : Cancer Research. 74, 13, p. 3441-3453 13 p.

Research output: Contribution to journalArticle

66 Scopus citations

Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation

Murase, K., Kim, H. T., Gregory Bascug, O. R., Kawano, Y., Ryan, J., Matsuoka, K. I., Davids, M. S., Koreth, J., Ho, V. T., Cutler, C., Armand, P., Alyea, E. P., Blazar, B. R., Antin, J. H., Soiffer, R. J., Letai, A. & Ritz, J., Sep 1 2014, In : Haematologica. 99, 9, p. 1499-1508 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

Flynn, R., Du, J., Veenstra, R. G., Reichenbach, D. K., Panoskaltsis-Mortari, A., Taylor, P. A., Freeman, G. J., Serody, J. S., Murphy, W. J., Munn, D. H., Sarantopoulos, S., Luznik, L., Maillard, I., Koreth, J., Cutler, C., Soiffer, R. J., Antin, J. H., Ritz, J., Dubovsky, J. A., Byrd, J. C. & 3 others, MacDonald, K. P., Hill, G. R. & Blazar, B. R., Jun 19 2014, In : Blood. 123, 25, p. 3988-3998 11 p.

Research output: Contribution to journalArticle

98 Scopus citations

Influenza infection results in local expansion of memory CD8+ T cells with antigen non-specific phenotype and function

Sckisel, G. D., Tietze, J. K., Zamora, A. E., Hsiao, H. H., Priest, S. O., Wilkins, D. E. C., Lanier, L. L., Blazar, B. R., Baumgarth, N. & Murphy, W. J., Jan 1 2014, In : Clinical and Experimental Immunology. 175, 1, p. 79-91 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Intravital imaging of donor allogeneic effector and regulatory T cells with host dendritic cells during GVHD

Lin, K. L., Fulton, L. M., Berginski, M., West, M. L., Taylor, N. A., Moran, T. P., Coghill, J. M., Blazar, B. R., Bear, J. E. & Serody, J. S., Mar 6 2014, In : Blood. 123, 10, p. 1604-1614 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Modification of T cell responses by stem cell mobilization requires direct signaling of the T cell by G-CSF and IL-10

MacDonald, K. P. A., Le Texier, L., Zhang, P., Morris, H., Kuns, R. D., Lineburg, K. E., Leveque, L., Don, A. L., Markey, K. A., Vuckovic, S., Bagger, F. O., Boyle, G. M., Blazar, B. R. & Hill, G. R., Apr 1 2014, In : Journal of Immunology. 192, 7, p. 3180-3189 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis

May, S. L., Zhou, Q., Lewellen, M., Carter, C. M., Coffey, D., Highfill, S. L., Bucher, C. M., Matise, I., Morse, H. C., O'Sullivan, M. G., Schutten, M., Johnson, C., Bellgrau, D., Blazar, B. R. & Modiano, J. F., Jun 19 2014, In : PloS one. 9, 6, e100629.

Research output: Contribution to journalArticle

3 Scopus citations
15 Scopus citations
50 Scopus citations

Post-Transplantation B Cell Activating Factor and B Cell Recovery before Onset of Chronic Graft-versus-Host Disease

Jacobson, C. A., Sun, L., Kim, H. T., McDonough, S. M., Reynolds, C. G., Schowalter, M., Koreth, J., Cutler, C. S., Ho, V. T., Alyea, E. P., Armand, P., Blazar, B. R., Soiffer, R. J., Antin, J. H., Ritz, J. & Sarantopoulos, S., May 2014, In : Biology of Blood and Marrow Transplantation. 20, 5, p. 668-675 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Prevention of graft-versus-host disease by adoptive T regulatory therapy is associated with active repression of peripheral blood toll-like receptor 5 mRNA expression

Sawitzki, B., Brunstein, C., Meisel, C., Schumann, J., Vogt, K., Appelt, C., Curtsinger, J. M., Verneris, M. R., Miller, J. S., Wagner, J. E. & Blazar, B. R., Feb 1 2014, In : Biology of Blood and Marrow Transplantation. 20, 2, p. 173-182 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Sdf1 expression reveals a source of perivascular-derived mesenchymal stem cells in zebrafish

Lund, T. C., Patrinostro, X., Kramer, A. C., Stadem, P., Ann Higgins, L., Markowski, T. W., Wroblewski, M. S., Lidke, D. S., Tolar, J. & Blazar, B. R., Jan 1 2014, In : STEM CELLS. 32, 10, p. 2767-2779 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism

Zanin-Zhorov, A., Weiss, J. M., Nyuydzefe, M. S., Chen, W., Scher, J. U., Mo, R., Depoil, D., Rao, N., Liu, B., Wei, J., Lucas, S., Koslow, M., Roche, M., Schueller, O., Weiss, S., Poyurovsky, M. V., Tonra, J., Hippen, K. L., Dustin, M. L., Blazar, B. R. & 2 others, Liu, C. J. & Waksal, S. D., Nov 25 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 47, p. 16814-16819 6 p.

Research output: Contribution to journalArticle

78 Scopus citations

Superiority of rapamycin over tacrolimus in preserving nonhuman primate treg half-life and phenotype after adoptive transfer

Singh, K., Stempora, L., Harvey, R. D., Kirk, A. D., Larsen, C. P., Blazar, B. R. & Kean, L. S., Dec 1 2014, In : American Journal of Transplantation. 14, 12, p. 2691-2703 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Therapeutic benefit of bortezomib on acute graft-versus-host disease is tissue specific and is associated with interleukin-6 levels

Pai, C. C. S., Hsiao, H. H., Sun, K., Chen, M., Hagino, T., Tellez, J., Mall, C., Blazar, B. R., Monjazeb, A., Abedi, M. & Murphy, W. J., Dec 1 2014, In : Biology of Blood and Marrow Transplantation. 20, 12, p. 1899-1904 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Treatment of chronic graft-versus-host disease with bortezomib

Pai, C. C. S., Chen, M., Mirsoian, A., Grossenbacher, S. K., Tellez, J., Ames, E., Sun, K., Jagdeo, J., Blazar, B. R., Murphy, W. J. & Abedi, M., Jan 1 2014, In : Blood. 124, 10, p. 1677-1688 12 p.

Research output: Contribution to journalArticle

43 Scopus citations
24 Scopus citations
2013
54 Scopus citations

Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy

Bouchlaka, M. N., Sckisel, G. D., Chen, M., Mirsoian, A., Zamora, A. E., Maverakis, E., Wilkins, D. E. C., Alderson, K. L., Hsiao, H. H., Weiss, J. M., Monjazeb, A. M., Hesdorffer, C., Ferrucci, L., Longo, D. L., Blazar, B. R., Wiltrout, R. H., Redelman, D., Taub, D. D. & Murphy, W. J., Oct 1 2013, In : Journal of Experimental Medicine. 210, 11, p. 2223-2237 15 p.

Research output: Contribution to journalArticle

67 Scopus citations

An Inherently Bifunctional Subset of Foxp3+ T Helper Cells Is Controlled by the Transcription Factor Eos

Sharma, M., Huang, L., Choi, J. H., Lee, E. J., Wilson, J., Lemos, H., Pan, F., Blazar, B. R., Pardoll, D., Mellor, A., Shi, H. & Munn, D., May 23 2013, In : Immunity. 38, 5, p. 998-1012 15 p.

Research output: Contribution to journalArticle

105 Scopus citations

A Randomized Trial of One versus Two Doses of Influenza Vaccine after Allogeneic Transplantation

Karras, N. A., Weeres, M., Sessions, W., Xu, X., DeFor, T., Young, J. A. H., Stefanski, H., Brunstein, C., Cooley, S., Miller, J. S., Blazar, B. R., Wagner, J. E. & Verneris, M. R., Jan 1 2013, In : Biology of Blood and Marrow Transplantation. 19, 1, p. 109-116 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Bone Marrow Stromal and Vascular Smooth Muscle Cells Have Chemosensory Capacity via Bitter Taste Receptor Expression

Lund, T. C., Kobs, A. J., Kramer, A., Nyquist, M., Kuroki, M. T., Osborn, J., Lidke, D. S., Low-Nam, S. T., Blazar, B. R. & Tolar, J., Mar 8 2013, In : PloS one. 8, 3, e58945.

Research output: Contribution to journalArticle

32 Scopus citations

CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease

Coghill, J. M., Fowler, K. A., West, M. L., Fulton, L. M., van Deventer, H., McKinnon, K. P., Vincent, B. G., Lin, K., Panoskaltsis-Mortari, A., Cook, D. N., Blazar, B. R. & Serody, J. S., Aug 1 2013, In : Blood. 122, 5, p. 825-836 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

DNA methylation of Runx1 regulatory regions correlates with transition from primitive to definitive hematopoietic potential in vitro and in vivo

Webber, B. R., Iacovino, M., Choi, S. H., Tolar, J., Kyba, M. & Blazar, B. R., Jan 1 2013, In : Blood. 122, 17, p. 2978-2986 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Effect of Radiation Dose-Rate on Hematopoietic Cell Engraftment in Adult Zebrafish

Glass, T. J., Hui, S. K., Blazar, B. R. & Lund, T. C., Sep 18 2013, In : PloS one. 8, 9, e73745.

Research output: Contribution to journalArticle

8 Scopus citations

Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality

Saha, A., Aoyama, K., Taylor, P. A., Koehn, B. H., Veenstra, R. G., Panoskaltsis-Mortari, A., Munn, D. H., Murphy, W. J., Azuma, M., Yagita, H., Fife, B. T., Sayegh, M. H., Najafian, N., Socie, G., Ahmed, R., Freeman, G. J., Sharpe, A. H. & Blazar, B. R., Jan 1 2013, In : Blood. 122, 17, p. 3062-3073 12 p.

Research output: Contribution to journalArticle

100 Scopus citations

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation

Socie, G. & Blazar, B. R., Jan 1 2013, Elsevier Inc.

Research output: Book/ReportBook

1 Scopus citations
12 Scopus citations

Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration

Aoyama, K., Saha, A., Tolar, J., Riddle, M. J., Veenstra, R. G., Taylor, P. A., Blomhoff, R., Panoskaltsis-Mortari, A., Klebanoff, C. A., Socié, G., Munn, D. H., Murphy, W. J., Serody, J. S., Fulton, L. M., Teshima, T., Chandraratna, R. A., Dmitrovsky, E., Guo, Y., Noelle, R. J. & Blazar, B. R., Jan 1 2013, In : Blood. 122, 12, p. 2125-2134 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
26 Scopus citations
31 Scopus citations

Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease

Matsuoka, K. I., Koreth, J., Kim, H. T., Bascug, G., McDonough, S., Kawano, Y., Murase, K., Cutler, C., Ho, V. T., Alyea, E. P., Armand, P., Blazar, B. R., Antin, J. H., Soiffer, R. J. & Ritz, J., Apr 3 2013, In : Science Translational Medicine. 5, 179, 179ra43.

Research output: Contribution to journalArticle

242 Scopus citations

Minicircle DNA is superior to plasmid DNA in eliciting antigen-specific CD8 + T-cell responses

Dietz, W. M., Skinner, N. E. B., Hamilton, S. E., Jund, M. D., Heitfeld, S. M., Litterman, A. J., Hwu, P., Chen, Z. Y., Salazar, A. M., Ohlfest, J. R., Blazar, B. R., Pennell, C. A. & Osborn, M. J., Aug 2013, In : Molecular Therapy. 21, 8, p. 1526-1535 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

MSCs for graft-versus-host disease

Tolar, J., Le Blanc, K. & Blazar, B. R., Jan 1 2013, Mesenchymal Stromal Cells: Biology and Clinical Applications. Springer New York, p. 455-465 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Overview of the Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation

Socié, G. A. & Blazar, B. R., Aug 27 2013, Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation. Elsevier Inc., p. 1-17 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Pharmacologic inhibition of PKCa & PKCu prevents GVHD while preserving GVL activity in mice

Haarberg, K. M. K., Li, J., Heinrichs, J., Wang, D., Liu, C., Bronk, C. C., Kaosaard, K., Owyang, A. M., Holland, S., Masuda, E., Tso, K., Blazar, B. R., Anasetti, C., Beg, A. A. & Yu, X. Z., Jan 1 2013, In : Blood. 122, 14, p. 2500-2511 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Phase i study of alemtuzumab for therapy of steroid-refractory chronic graft-versus-host disease

Nikiforow, S., Kim, H. T., Bindra, B., McDonough, S., Glotzbecker, B., Armand, P., Koreth, J., Ho, V. T., Alyea, E. P., Blazar, B. R., Ritz, J., Soiffer, R. J., Antin, J. H. & Cutler, C. S., May 1 2013, In : Biology of Blood and Marrow Transplantation. 19, 5, p. 804-811 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Rituximab prophylaxis prevents corticosteroid-requiring chronic GVHD after allogeneic peripheral blood stem cell transplantation: Results of a phase 2 trial

Cutler, C., Kim, H. T., Bindra, B., Sarantopoulos, S., Ho, V. T., Chen, Y. B., Rosenblatt, J., McDonough, S., Watanaboonyongcharoen, P., Armand, P., Koreth, J., Glotzbecker, B., Alyea, E., Blazar, B. R., Soiffer, R. J., Ritz, J. & Antin, J. H., Aug 22 2013, In : Blood. 122, 8, p. 1510-1517 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

TALEN-based gene correction for epidermolysis bullosa

Osborn, M. J., Starker, C. G., McElroy, A. N., Webber, B. R., Riddle, M. J., Xia, L., Defeo, A. P., Gabriel, R., Schmidt, M., Von Kalle, C., Carlson, D. F., Maeder, M. L., Joung, J. K., Wagner, J. E., Voytas, D. F., Blazar, B. R. & Tolar, J., Jun 2013, In : Molecular Therapy. 21, 6, p. 1151-1159 9 p.

Research output: Contribution to journalArticle

170 Scopus citations

Tumor growth control with IDO-silencing Salmonellareply

Manuel, E. R., Blazar, B. R. & Diamond, D. J., Jul 15 2013, In : Cancer Research. 73, 14, p. 4592-4593 2 p.

Research output: Contribution to journalLetter

2 Scopus citations
2012

Advances in graft-versus-host disease biology and therapy

Blazar, B. R., Murphy, W. J. & Abedi, M., Jun 1 2012, In : Nature Reviews Immunology. 12, 6, p. 443-458 16 p.

Research output: Contribution to journalReview article

484 Scopus citations

A preclinical evaluation of minnelide as a therapeutic agent against pancreatic cancer

Chugh, R., Sangwan, V., Patil, S. P., Dudeja, V., Dawra, R. K., Banerjee, S., Schumacher, R. J., Blazar, B. R., Georg, G. I., Vickers, S. M. & Saluja, A. K., Oct 17 2012, In : Science Translational Medicine. 4, 156, 156ra139.

Research output: Contribution to journalArticle

160 Scopus citations

Attenuation of acute graft-versus-host disease in the absence of the transcription factor RORγt

Fulton, L. M., Carlson, M. J., Coghill, J. M., Ott, L. E., West, M. L., Panoskaltsis-Mortari, A., Littman, D. R., Blazar, B. R. & Serody, J. S., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1765-1772 8 p.

Research output: Contribution to journalArticle

31 Scopus citations