1982 …2020

Research output per year

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Research Output

2016

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

Flynn, R., Paz, K., Du, J., Reichenbach, D. K., Taylor, P. A., Panoskaltsis-Mortari, A., Vulic, A., Luznik, L., MacDonald, K. K. P., Hill, G. R., Nyuydzefe, M. S., Weiss, J. M., Chen, W., Trzeciak, A., Serody, J. S., Aguilar, E. G., Murphy, W. J., Maillard, I., Munn, D., Koreth, J. & 6 others, Cutler, C. S., Antin, J. H., Ritz, J., Waksal, S. D., Zanin-Zhorov, A. & Blazar, B. R., Apr 28 2016, In : Blood. 127, 17, p. 2144-2154 11 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations
Open Access
17 Scopus citations

Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner

McDonald-Hyman, C., Flynn, R., Panoskaltsis-Mortari, A., Peterson, N., MacDonald, K. P. A., Hill, G. R., Luznik, L., Serody, J. S., Murphy, W. J., Maillard, I., Munn, D. H., Turka, L. A., Koreth, J., Cutler, C. S., Soiffer, R. J., Antin, J. H., Ritz, J. & Blazar, B. R., Aug 18 2016, In : Blood. 128, 7, p. 1013-1017 5 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration

Brinkman, C. C., Iwami, D., Hritzo, M. K., Xiong, Y., Ahmad, S., Simon, T., Hippen, K. L., Blazar, B. R. & Bromberg, J. S., Jun 21 2016, In : Nature communications. 7, 12021.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Umbilical cord blood-derived T regulatory cells to prevent GVHD: Kinetics, toxicity profile, and clinical effect

Brunstein, C. G., Miller, J. S., McKenna, D. H., Hippen, K. L., DeFor, T. E., Sumstad, D., Curtsinger, J., Verneris, M. R., MacMillan, M. L., Levine, B. L., Riley, J. L., June, C. H., Le, C., Weisdorf, D. J., McGlave, P. B., Blazar, B. R. & Wagner, J. E., Feb 25 2016, In : Blood. 127, 8, p. 1044-1051 8 p.

Research output: Contribution to journalArticle

Open Access
157 Scopus citations

Understanding Luminal Microorganisms and Their Potential Effectiveness in Treating Intestinal Inflammation

Ince, M. N., Blazar, B. R., Edmond, M. B., Tricot, G. & Wannemuehler, M. J., Jan 1 2016, In : Inflammatory bowel diseases. 22, 1, p. 194-201 8 p.

Research output: Contribution to journalReview article

Open Access
7 Scopus citations
2015

A Bortezomib-Based Regimen Offers Promising Survival and Graft-versus-Host Disease Prophylaxis in Myeloablative HLA-Mismatched and Unrelated Donor Transplantation: A Phase II Trial

Koreth, J., Kim, H. T., Lange, P. B., Bindra, B., Reynolds, C. G., Chammas, M. J., Armand, P., Cutler, C. S., Ho, V. T., Glotzbecker, B., Nikiforow, S., Ritz, J., Blazar, B. R., Soiffer, R. J., Antin, J. H. & Alyea, E. P., Nov 2015, In : Biology of Blood and Marrow Transplantation. 21, 11, p. 1907-1913 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
32 Scopus citations

Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

McDonald-Hyman, C., Turka, L. A. & Blazar, B. R., Mar 25 2015, In : Science Translational Medicine. 7, 280, 280rv2.

Research output: Contribution to journalReview article

54 Scopus citations
55 Scopus citations

A refined risk score for acute graft-versus-host disease that predicts response to initial therapy, survival, and transplant-related mortality

MacMillan, M. L., Robin, M., Harris, A. C., DeFor, T. E., Martin, P. J., Alousi, A., Ho, V. T., Bolaños-Meade, J., Ferrara, J. L. M., Jones, R., Arora, M., Blazar, B. R., Holtan, S. G., Jacobsohn, D., Pasquini, M., Socie, G., Antin, J. H., Levine, J. E. & Weisdorf, D. J., Apr 1 2015, In : Biology of Blood and Marrow Transplantation. 21, 4, p. 761-767 7 p.

Research output: Contribution to journalArticle

85 Scopus citations

B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality

Veenstra, R. G., Flynn, R., Kreymborg, K., McDonald-Hyman, C., Saha, A., Taylor, P. A., Osborn, M. J., Panoskaltsis-Mortari, A., Schmitt-Graeff, A., Lieberknect, E., Murphy, W. J., Serody, J. S., Munn, D. H., Freeman, G. J., Allison, J. P., Mak, T. W., van den Brink, M., Zeiser, R. & Blazar, B. R., Jan 1 2015, In : Blood. 125, 21, p. 3335-3346 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

B Cells in Chronic Graft-versus-Host Disease

Sarantopoulos, S., Blazar, B. R., Cutler, C. & Ritz, J., Jan 1 2015, In : Biology of Blood and Marrow Transplantation. 21, 1, p. 16-23 8 p.

Research output: Contribution to journalReview article

50 Scopus citations
39 Scopus citations

CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire

Suessmuth, Y., Mukherjee, R., Watkins, B., Koura, D. T., Finstermeier, K., Desmarais, C., Stempora, L., Horan, J. T., Langston, A., Qayed, M., Khoury, H. J., Grizzle, A., Cheeseman, J. A., Conger, J. A., Robertson, J., Garrett, A., Kirk, A. D., Waller, E. K., Blazar, B. R., Mehta, A. K. & 2 others, Robins, H. S. & Kean, L. S., Jun 18 2015, In : Blood. 125, 25, p. 3835-3850 16 p.

Research output: Contribution to journalArticle

75 Scopus citations
207 Scopus citations

Cutting edge: Identification of autoreactive CD4+ and CD8+ T cell subsets resistant to PD-1 pathway blockade

Pauken, K. E., Nelson, C. E., Martinov, T., Spanier, J. A., Heffernan, J. R., Sahli, N. L., Quarnstrom, C. F., Osum, K. C., Schenkel, J. M., Jenkins, M. K., Blazar, B. R., Vezys, V. & Fife, B. T., Apr 15 2015, In : Journal of Immunology. 194, 8, p. 3551-3555 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Ex vivo fucosylation of third-party human regulatory T cells enhances anti-graft-versus-host disease potency in vivo

Parmar, S., Liu, X., Najjar, A., Shah, N., Yang, H., Yvon, E., Rezvani, K., McNiece, I., Zweidler-McKay, P., Miller, L., Wolpe, S., Blazar, B. R. & Shpall, E. J., Jan 1 2015, In : Blood. 125, 9, p. 1502-1506 5 p.

Research output: Contribution to journalArticle

34 Scopus citations

Fanconi anemia gene editing by the CRISPR/Cas9 system

Osborn, M. J., Gabriel, R., Webber, B. R., Defeo, A. P., McElroy, A. N., Jarjour, J., Starker, C. G., Wagner, J. E., Joung, J. K., Voytas, D. F., Von Kalle, C., Schmidt, M., Blazar, B. R. & Tolar, J., Feb 1 2015, In : Human gene therapy. 26, 2, p. 114-126 13 p.

Research output: Contribution to journalArticle

73 Scopus citations

GVHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells

Koehn, B. H., Apostolova, P., Haverkamp, J. M., Miller, J. S., McCullar, V., Tolar, J., Munn, D. H., Murphy, W. J., Brickey, W. J., Serody, J. S., Gabrilovich, D. I., Bronte, V., Murray, P. J., Ting, J. P. Y., Zeiser, R. & Blazar, B. R., Sep 24 2015, In : Blood. 126, 13, p. 1621-1628 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Human group 3 innate lymphoid cells express DR3 and respond to TL1A with enhanced IL-22 production and IL-2-dependent proliferation

Ahn, Y. O., Weeres, M. A., Neulen, M. L., Choi, J., Kang, S. H., Heo, D. S., Bergerson, R., Blazar, B. R., Miller, J. S. & Verneris, M. R., Aug 1 2015, In : European Journal of Immunology. 45, 8, p. 2335-2342 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Inducible T-cell receptor expression in precursor T cells for leukemia control

Hoseini, S. S., Hapke, M., Herbst, J., Wedekind, D., Baumann, R., Heinz, N., Schiedlmeier, B., Vignali, D. A. A., Van Den Brink, M. R. M., Schambach, A., Blazar, B. R. & Sauer, M. G., Jul 13 2015, In : Leukemia. 29, 7, p. 1530-1542 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inflammasome effects in GvHD

Koehn, B., Zeiser, R. & Blazar, B. R., Jan 1 2015, In : Oncotarget. 6, 36, p. 38444-38445 2 p.

Research output: Contribution to journalEditorial

4 Scopus citations

Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versus-tumor effect in mice

Li, Y., Chen, H. L., Bannick, N., Henry, M., Holm, A. N., Metwali, A., Urban, J. F., Rothman, P. B., Weiner, G. J., Blazar, B. R., Elliott, D. E. & Ince, M. N., Feb 1 2015, In : Journal of Immunology. 194, 3, p. 1011-1020 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

In vitro T-cell generation from adult, embryonic, and induced pluripotent stem cells: Many roads to one destination

Smith, M. J., Webber, B. R., Mohtashami, M., Stefanski, H. E., Zúñiga-Pflücker, J. C. & Blazar, B. R., Nov 2015, In : Stem Cells. 33, 11, p. 3174-3180 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Late administration of murine CTLA-4 blockade prolongs CD8-mediated anti-tumor effects following stimulatory cancer immunotherapy

Sckisel, G. D., Mirsoian, A., Bouchlaka, M. N., Tietze, J. K., Chen, M., Blazar, B. R. & Murphy, W. J., Dec 1 2015, In : Cancer Immunology, Immunotherapy. 64, 12, p. 1541-1552 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation

Varelias, A., Gartlan, K. H., Kreijveld, E., Olver, S. D., Lor, M., Kuns, R. D., Lineburg, K. E., Teal, B. E., Raffelt, N. C., Cheong, M., Alexander, K. A., Koyama, M., Markey, K. A., Sturgeon, E., Leach, J., Reddy, P., Kennedy, G. A., Yanik, G. A., Blazar, B. R., Tey, S. K. & 4 others, Clouston, A. D., MacDonald, K. P. A., Cooke, K. R. & Hill, G. R., Apr 9 2015, In : Blood. 125, 15, p. 2435-2444 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Out-of-Sequence Signal 3 Paralyzes Primary CD4+ T-Cell-Dependent Immunity

Sckisel, G. D., Bouchlaka, M. N., Monjazeb, A. M., Crittenden, M., Curti, B. D., Wilkins, D. E. C., Alderson, K. A., Sungur, C. M., Ames, E., Mirsoian, A., Reddy, A., Alexander, W., Soulika, A., Blazar, B. R., Longo, D. L., Wiltrout, R. H. & Murphy, W. J., Aug 18 2015, In : Immunity. 43, 2, p. 240-250 11 p., 3145.

Research output: Contribution to journalArticle

26 Scopus citations

Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts

Patil, S., Lis, L. G., Schumacher, R. J., Norris, B. J., Morgan, M. L., Cuellar, R. A. D., Blazar, B. R., Suryanarayanan, R., Gurvich, V. J. & Georg, G. I., Dec 10 2015, In : Journal of medicinal chemistry. 58, 23, p. 9334-9344 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Reprint of: B Cells in Chronic Graft-versus-Host Disease

Sarantopoulos, S., Blazar, B. R., Cutler, C. & Ritz, J., Feb 1 2015, In : Biology of Blood and Marrow Transplantation. 21, 2, p. S11-S18

Research output: Contribution to journalReview article

4 Scopus citations

Role of transgene regulation in ex vivo lentiviral correction of artemis deficiency

Multhaup, M. M., Podetz-Pedersen, K. M., Karlen, A. D., Olson, E. R., Gunther, R., Somia, N. V., Blazar, B. R., Cowan, M. J. & McIvor, R. S., Apr 1 2015, In : Human gene therapy. 26, 4, p. 232-243 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: A multicenter survey

Zeiser, R., Burchert, A., Lengerke, C., Verbeek, M., Maas-Bauer, K., Metzelder, S. K., Spoerl, S., Ditschkowski, M., Ecsedi, M., Sockel, K., Ayuk, F., Ajib, S., De Fontbrune, F. S., Na, I. K., Penter, L., Holtick, U., Wolf, D., Schuler, E., Meyer, E., Apostolova, P. & 33 others, Bertz, H., Marks, R., Lübbert, M., Wäsch, R., Scheid, C., Stölzel, F., Ordemann, R., Bug, G., Kobbe, G., Negrin, R., Brune, M., Spyridonidis, A., Schmitt-Gräff, A., Van Der Velden, W., Huls, G., Mielke, S., Grigoleit, G. U., Kuball, J., Flynn, R., Ihorst, G., Du, J., Blazar, B. R., Arnold, R., Kröger, N., Passweg, J., Halter, J., Socié, G., Beelen, D., Peschel, C., Neubauer, A., Finke, J., Duyster, J. & Von Bubnoff, N., Oct 1 2015, In : Leukemia. 29, 10, p. 2062-2068 7 p.

Research output: Contribution to journalArticle

219 Scopus citations

ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease

Zhang, J., Ramadan, A. M., Griesenauer, B., Li, W., Turner, M. J., Liu, C., Kapur, R., Hanenberg, H., Blazar, B. R., Tawara, I. & Paczesny, S., Oct 7 2015, In : Science Translational Medicine. 7, 308, 308ra160.

Research output: Contribution to journalArticle

69 Scopus citations

Strategies to inhibit alloantibody production in alloprimed murine recipients of hematopoietic stem cell grafts

Blazar, B. R., Flynn, R., Lee, R., Marcucci, G., Caliguiri, M. A. & Heeger, P. S., Apr 1 2015, In : American Journal of Transplantation. 15, 4, p. 931-941 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease

Flynn, R., Allen, J. L., Luznik, L., MacDonald, K. P., Paz, K., Alexander, K. A., Vulic, A., Du, J., Panoskaltsis-Mortari, A., Taylor, P. A., Poe, J. C., Serody, J. S., Murphy, W. J., Hill, G. R., Maillard, I., Koreth, J., Cutler, C. S., Soiffer, R. J., Antin, J. H., Ritz, J. & 4 others, Chao, N. J., Clynes, R. A., Sarantopoulos, S. & Blazar, B. R., Jun 25 2015, In : Blood. 125, 26, p. 4085-4094 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

The IL-33/ST2 axis augments effector T-cell responses during acute GVHD

Reichenbach, D. K., Schwarze, V., Matta, B. M., Tkachev, V., Lieberknecht, E., Liu, Q., Koehn, B. H., Pfeifer, D., Taylor, P. A., Prinz, G., Dierbach, H., Stickel, N., Beck, Y., Warncke, M., Junt, T., Schmitt-Graeff, A., Nakae, S., Follo, M., Wertheimer, T., Schwab, L. & 7 others, Devlin, J., Watkins, S. C., Duyster, J., Ferrara, J. L. M., Turnquist, H. R., Zeiser, R. & Blazar, B. R., Jan 1 2015, In : Blood. 125, 20, p. 3183-3192 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells

Sharma, M., Shinde, R., McGaha, T., Huang, L., Holmgaard, R., Wolchok, J., Mautino, M., Celis, E., Sharpe, A., Francisco, L., Powell, J., Yagita, H., Mellor, A., Blazar, B. & Munn, D., Jan 1 2015, In : Journal for ImmunoTherapy of Cancer. 3, O19.

Research output: Contribution to journalArticle

The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment

Sharma, M. D., Shinde, R., McGaha, T. L., Huang, L., Holmgaard, R. B., Wolchok, J. D., Mautino, M. R., Celis, E., Sharpe, A. H., Francisco, L. M., Powell, J. D., Yagita, H., Mellor, A. L., Blazar, B. R. & Munn, D. H., Nov 2015, In : Science Advances. 1, 10, 1500845.

Research output: Contribution to journalArticle

62 Scopus citations

Therapeutic activity of multiple common γ-chain cytokine inhibition in acute and chronic GVHD

Hechinger, A. K., Smith, B. A. H., Flynn, R., Hanke, K., McDonald-Hyman, C., Taylor, P. A., Pfeifer, D., Hackanson, B., Leonhardt, F., Prinz, G., Dierbach, H., Schmitt-Graeff, A., Kovarik, J., Blazar, B. R. & Zeiser, R., Jan 15 2015, In : Blood. 125, 3, p. 570-580 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Transcriptome analysis of GVHD reveals aurora kinase a as a targetable pathway for disease prevention

Furlan, S. N., Watkins, B., Tkachev, V., Flynn, R., Cooley, S., Ramakrishnan, S., Singh, K., Giver, C., Hamby, K., Stempora, L., Garrett, A., Chen, J., Betz, K. M., Ziegler, C. G. K., Tharp, G. K., Bosinger, S. E., Promislow, D. E. L., Miller, J. S., Waller, E. K., Blazar, B. R. & 1 others, Kean, L. S., Nov 25 2015, In : Science Translational Medicine. 7, 315, 3231.

Research output: Contribution to journalArticle

27 Scopus citations
2014

Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice

Mirsoian, A., Bouchlaka, M. N., Sckisel, G. D., Chen, M., Pai, C. C. S., Maverakis, E., Spencer, R. G., Fishbein, K. W., Siddiqui, S., Monjazeb, A. M., Martin, B., Maudsley, S., Hesdorffer, C., Ferrucci, L., Longo, D. L., Blazar, B. R., Wiltrout, R. H., Taub, D. D. & Murphy, W. J., Jan 1 2014, In : Journal of Experimental Medicine. 211, 12, p. 2373-2383 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

A Phase II Study of Bortezomib Plus Prednisone for Initial Therapy of Chronic Graft-versus-Host Disease

Herrera, A. F., Kim, H. T., Bindra, B., Jones, K. T., Alyea, E. P., Armand, P., Cutler, C. S., Ho, V. T., Nikiforow, S., Blazar, B. R., Ritz, J., Antin, J. H., Soiffer, R. J. & Koreth, J., Nov 1 2014, In : Biology of Blood and Marrow Transplantation. 20, 11, p. 1737-1743 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Bystander activation and anti-tumor effects of CD8+ T cells following interleukin-2 based immunotherapy is independent of CD4+ T cell help

Monjazeb, A. M., Tietze, J. K., Grossenbacher, S. K., Hsiao, H. H., Zamora, A. E., Mirsoian, A., Koehn, B., Blazar, B. R., Weiss, J. M., Wiltrout, R. H., Sckisel, G. D. & Murphy, W. J., Aug 13 2014, In : PloS one. 9, 8, e102709.

Research output: Contribution to journalArticle

13 Scopus citations

CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells against primary MDS and MDSC CD33+ targets

Gleason, M. K., Ross, J. A., Warlick, E. D., Lund, T. C., Verneris, M. R., Wiernik, A., Spellman, S., Haagenson, M. D., Lenvik, A. J., Litzow, M. R., Epling-Burnette, P. K., Blazar, B. R., Weiner, L. M., Weisdorf, D. J., Vallera, D. A. & Miller, J. S., May 8 2014, In : Blood. 123, 19, p. 3016-3026 11 p.

Research output: Contribution to journalArticle

113 Scopus citations

CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis

Kaliyaperumal, S., Watkins, B., Sharma, P., Furlan, S., Ramakrishnan, S., Giver, C., Garcia, A., Courtney, C., Knight, H., Strobert, E., Elder, E., Crenshaw, T., Blazar, B. R., Waller, E. K., Westmoreland, S. & Kean, L. S., Mar 20 2014, In : Blood. 123, 12, p. 1967-1969 3 p.

Research output: Contribution to journalLetter

15 Scopus citations

Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice

Zhang, S. L., Wang, X., Manna, S., Zlotoff, D. A., Bryson, J. L., Blazar, B. R. & Bhandoola, A., Jul 10 2014, In : Blood. 124, 2, p. 296-304 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
193 Scopus citations

CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease

Alexander, K. A., Flynn, R., Lineburg, K. E., Kuns, R. D., Teal, B. E., Olver, S. D., Lor, M., Raffelt, N. C., Koyama, M., Leveque, L., Le Texier, L., Melino, M., Markey, K. A., Varelias, A., Engwerda, C., Serody, J. S., Janela, B., Ginhoux, F., Clouston, A. D., Blazar, B. R. & 2 others, Hill, G. R. & MacDonald, K. P. A., Oct 1 2014, In : Journal of Clinical Investigation. 124, 10, p. 4266-4280 15 p.

Research output: Contribution to journalArticle

73 Scopus citations

Donor CD4+Foxp3+regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice

Ganguly, S., Ross, D. B., Panoskaltsis-Mortari, A., Kanakry, C. G., Blazar, B. R., Levy, R. B. & Luznik, L., Sep 25 2014, In : Blood. 124, 13, p. 2131-2141 11 p.

Research output: Contribution to journalArticle

75 Scopus citations