1982 …2020

Research output per year

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Research Output

Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging

Min, D., Panoskaltsis-Mortari, A., Kuro-o, M., Holländer, G. A., Blazar, B. R. & Weinberg, K. I., Mar 15 2007, In : Blood. 109, 6, p. 2529-2537 9 p.

Research output: Contribution to journalArticle

148 Scopus citations

Synergistic anti-tumor responses after administration of agonistic antibodies to CD40 and IL-2: Coordination of dendritic and CD8+ cell responses

Murphy, W. J., Welniak, L., Back, T., Hixon, J., Subleski, J., Seki, N., Wigginton, J. M., Wilson, S. E., Blazar, B. R., Malyguine, A. M., Sayers, T. J. & Wiltrout, R. H., Mar 1 2003, In : Journal of Immunology. 170, 5, p. 2727-2733 7 p.

Research output: Contribution to journalArticle

80 Scopus citations

Synthetic unmethylated cytosine-phosphate-guanosine oligodeoxynucleotides are potent stimulators of antileukemia responses in naive and bone marrow transplant recipients

Blazar, B. R., Krieg, A. M. & Taylor, P. A., Aug 15 2001, In : Blood. 98, 4, p. 1217-1225 9 p.

Research output: Contribution to journalArticle

75 Scopus citations

Synthetic zinc finger nuclease design and rapid assembly

Osborn, M. J., Defeo, A. P., Blazar, B. R. & Tolar, J., Sep 1 2011, In : Human gene therapy. 22, 9, p. 1155-1165 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Systemic delivery of Salmonella typhimurium transformed with IDO shRNA enhances intratumoral vector colonization and suppresses tumor growth

Blache, C. A., Manuel, E. R., Kaltcheva, T. I., Wong, A. N., Ellenhorn, J. D. I., Blazar, B. R. & Diamond, D. J., Dec 15 2012, In : Cancer Research. 72, 24, p. 6447-6456 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells

Furlan, S. N., Watkins, B., Tkachev, V., Cooley, S., Panoskaltsis-Mortari, A., Betz, K., Brown, M., Hunt, D. J., Schell, J. B., Zeleski, K., Yu, A., Giver, C. R., Waller, E. K., Miller, J. S., Blazar, B. R. & Kean, L. S., Nov 24 2016, In : Blood. 128, 21, p. 2568-2579 12 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

TALEN-based gene correction for epidermolysis bullosa

Osborn, M. J., Starker, C. G., McElroy, A. N., Webber, B. R., Riddle, M. J., Xia, L., Defeo, A. P., Gabriel, R., Schmidt, M., Von Kalle, C., Carlson, D. F., Maeder, M. L., Joung, J. K., Wagner, J. E., Voytas, D. F., Blazar, B. R. & Tolar, J., Jun 2013, In : Molecular Therapy. 21, 6, p. 1151-1159 9 p.

Research output: Contribution to journalArticle

170 Scopus citations

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

Flynn, R., Paz, K., Du, J., Reichenbach, D. K., Taylor, P. A., Panoskaltsis-Mortari, A., Vulic, A., Luznik, L., MacDonald, K. K. P., Hill, G. R., Nyuydzefe, M. S., Weiss, J. M., Chen, W., Trzeciak, A., Serody, J. S., Aguilar, E. G., Murphy, W. J., Maillard, I., Munn, D., Koreth, J. & 6 others, Cutler, C. S., Antin, J. H., Ritz, J., Waksal, S. D., Zanin-Zhorov, A. & Blazar, B. R., Apr 28 2016, In : Blood. 127, 17, p. 2144-2154 11 p.

Research output: Contribution to journalArticle

Open Access
46 Scopus citations

Targeting myeloid leukemia with a DT390-mIL-3 fusion immunotoxin: Ex vivo and in vivo studies in mice

Vallera, D. A., Seo, S. Y., Panoskaltsis-Mortari, A., Griffin, J. D. & Blazar, B. R., Oct 19 1999, In : Protein Engineering. 12, 9, p. 779-785 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM)

Taylor, P. A., Panoskaltsis-Mortari, A., Freeman, G. J., Sharpe, A. H., Noelle, R. J., Rudensky, A. Y., Mak, T. W., Serody, J. S. & Blazar, B. R., Apr 15 2005, In : Blood. 105, 8, p. 3372-3380 9 p.

Research output: Contribution to journalArticle

87 Scopus citations

Targeting of the CNS in MPS-IH using a nonviral transferrin-α-L-iduronidase fusion gene product

Osborn, M. J., McElmurry, R. T., Peacock, B., Tolar, J. & Blazar, B. R., Aug 1 2008, In : Molecular Therapy. 16, 8, p. 1459-1466 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease

Paz, K., Flynn, R., Du, J., Tannheimer, S., Johnson, A. J., Dong, S., Stark, A. K., Okkenhaug, K., Panoskaltsis-Mortari, A., Sage, P. T., Sharpe, A. H., Luznik, L., Ritz, J., Soiffer, R. J., Cutler, C. S., Koreth, J., Antin, J. H., Miklos, D. B., MacDonald, K. P., Hill, G. R. & 10 others, Maillard, I., Serody, J. S., Murphy, W. J., Munn, D. H., Feser, C. J., Zaiken, M., Vanhaesebroeck, B., Turka, L. A., Byrd, J. C. & Blazar, B. R., Jun 2019, In : American Journal of Transplantation. 19, 6, p. 1820-1830 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease

Flynn, R., Allen, J. L., Luznik, L., MacDonald, K. P., Paz, K., Alexander, K. A., Vulic, A., Du, J., Panoskaltsis-Mortari, A., Taylor, P. A., Poe, J. C., Serody, J. S., Murphy, W. J., Hill, G. R., Maillard, I., Koreth, J., Cutler, C. S., Soiffer, R. J., Antin, J. H., Ritz, J. & 4 others, Chao, N. J., Clynes, R. A., Sarantopoulos, S. & Blazar, B. R., Jun 25 2015, In : Blood. 125, 26, p. 4085-4094 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

Sakuishi, K., Apetoh, L., Sullivan, J. M., Blazar, B. R., Kuchroo, V. K. & Anderson, A. C., Sep 27 2010, In : Journal of Experimental Medicine. 207, 10, p. 2187-2194 8 p.

Research output: Contribution to journalArticle

971 Scopus citations

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

Sakuishi, K., Apetoh, L., Sullivan, J. M., Blazar, B. R., Kuchroo, V. K. & Anderson, A. C., Jun 2011, In : Journal of Experimental Medicine. 208, 6, p. 1331 1 p.

Research output: Contribution to journalComment/debate

6 Scopus citations
96 Scopus citations

T cell depletion with anti-cd5 immunotoxin in histocompatible bone marrow transplantation: The correlation between residual CD5 negative T cells and subsequent graft-versus-host disease

Filipovich, A. H., Vallera, D., McGlave, P., Polich, D., Gajl-Peczalska, K., Haake, R., Lasky, L., Blazar, B., Ramsay, N. K. C., Kersey, J. & Weisdorf, D., Sep 1990, In : Transplantation. 50, 3, p. 410-415 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

T-cell expression of AhR inhibits the maintenance of pTreg cells in the gastrointestinal tract in acute GVHD

Dant, T. A., Lin, K. L., Bruce, D. W., Montgomery, S. A., Kolupaev, O. V., Bommiasamy, H., Bixby, L. M., Woosley, J. T., McKinnon, K. P., Gonzalez, F. J., Blazar, B. R., Vincent, B. G., Coghill, J. M. & Serody, J. S., Jul 20 2017, In : Blood. 130, 3, p. 348-359 12 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

T cell lysis of murine renal cancer: Multiple signaling pathways for cell death via Fas

Sayers, T. J., Brooks, A. D., Seki, N., Smyth, M. J., Yagita, H., Blazar, B. R. & Malyguine, A. M., Sep 19 2000, In : Journal of Leukocyte Biology. 68, 1, p. 81-86 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction

Smith, M. J., Reichenbach, D. K., Parker, S. L., Riddle, M. J., Mitchell, J., Osum, K. C., Mohtashami, M., Stefanski, H. E., Fife, B. T., Bhandoola, A., Hogquist, K. A., Holländer, G. A., Zúñiga-Pflücker, J. C., Tolar, J. & Blazar, B. R., May 18 2017, In : JCI Insight. 2, 10

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

TCR affinity and specificity requirements for human regulatory T-cell function

Plesa, G., Zheng, L., Medvec, A., Wilson, C. B., Robles-Oteiza, C., Liddy, N., Bennett, A. D., Gavarret, J., Vuidepot, A., Zhao, Y., Blazar, B. R., Jakobsen, B. K. & Riley, J. L., Apr 12 2012, In : Blood. 119, 15, p. 3420-3430 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

The adjuvant effects of Mycobacterium tuberculosis heat shock protein 70 result from the rapid and prolonged activation of antigen-specific CD8+ T cells in vivo

Harmala, L. A. E., Ingulli, E. G., Curtsinger, J. M., Lucido, M. M., Schmidt, C. S., Weigel, B. J., Blazar, B. R., Mescher, M. F. & Pennell, C. A., Nov 15 2002, In : Journal of Immunology. 169, 10, p. 5622-5629 8 p.

Research output: Contribution to journalArticle

54 Scopus citations

The balance between donor T cell anergy and suppression versus lethal graft-versus-host disease is determined by host conditioning

Gonzalez, M., Quezada, S. A., Blazar, B. R., Panoskaltsis-Mortari, A., Rudensky, A. Y. & Noelle, R. J., Nov 15 2002, In : Journal of Immunology. 169, 10, p. 5581-5589 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease

Cooke, K. R., Luznik, L., Sarantopoulos, S., Hakim, F. T., Jagasia, M., Fowler, D. H., van den Brink, M. R. M., Hansen, J. A., Parkman, R., Miklos, D. B., Martin, P. J., Paczesny, S., Vogelsang, G., Pavletic, S., Ritz, J., Schultz, K. R. & Blazar, B. R., Feb 1 2017, In : Biology of Blood and Marrow Transplantation. 23, 2, p. 211-234 24 p.

Research output: Contribution to journalReview article

Open Access
102 Scopus citations
96 Scopus citations

The E. Donnall Thomas lecture: Manipulating and visualizing T-cell alloresponses

Blazar, B. R., Sep 2005, In : Biology of Blood and Marrow Transplantation. 11, 9, p. 651-656 6 p.

Research output: Contribution to journalReview article

1 Scopus citations
18 Scopus citations

The host immune response is essential for the beneficial effect of adult stem cells after myocardial ischemia

Tolar, J., Wang, X., Braunlin, E., McElmurry, R. T., Nakamura, Y., Bell, S., Xia, L., Zhang, J., Hu, Q., Panoskaltsis-Mortari, A., Zhang, J. & Blazar, B. R., Apr 1 2007, In : Experimental Hematology. 35, 4, p. 682-690 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

The IL-33/ST2 axis augments effector T-cell responses during acute GVHD

Reichenbach, D. K., Schwarze, V., Matta, B. M., Tkachev, V., Lieberknecht, E., Liu, Q., Koehn, B. H., Pfeifer, D., Taylor, P. A., Prinz, G., Dierbach, H., Stickel, N., Beck, Y., Warncke, M., Junt, T., Schmitt-Graeff, A., Nakae, S., Follo, M., Wertheimer, T., Schwab, L. & 7 others, Devlin, J., Watkins, S. C., Duyster, J., Ferrara, J. L. M., Turnquist, H. R., Zeiser, R. & Blazar, B. R., 2015, In : Blood. 125, 20, p. 3183-3192 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation

Chen, W., Liang, X., Peterson, A. J., Munn, D. H. & Blazar, B. R., Jan 1 2008, In : Journal of Immunology. 181, 8, p. 5396-5404 9 p.

Research output: Contribution to journalArticle

302 Scopus citations

The infusion of ex vivo activated and expanded CD4 +CD25 + immune regulatory cells inhibits graft-versus-host disease lethality

Taylor, P. A., Lees, C. J. & Blazar, B. R., May 15 2002, In : Blood. 99, 10, p. 3493-3499 7 p.

Research output: Contribution to journalArticle

828 Scopus citations

The Knife’s Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques

Zheng, H. B., Watkins, B., Tkachev, V., Yu, S., Tran, D., Furlan, S., Zeleski, K., Singh, K., Hamby, K., Hotchkiss, C., Lane, J., Gumber, S., Adams, A. B., Cendales, L., Kirk, A. D., Kaur, A., Blazar, B. R., Larsen, C. P. & Kean, L. S., Mar 1 2017, In : American Journal of Transplantation. 17, 3, p. 657-670 14 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation

Liu, B., Salgado, O. C., Singh, S., Hippen, K. L., Maynard, J. C., Burlingame, A. L., Ball, L. E., Blazar, B. R., Farrar, M. A., Hogquist, K. A. & Ruan, H. B., Dec 1 2019, In : Nature communications. 10, 1, 354.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

The lymph node stromal laminin α5 shapes alloimmunity

Li, L., Shirkey, M. W., Zhang, T., Xiong, Y., Piao, W., Saxena, V., Paluskievicz, C., Lee, Y., Toney, N., Cerel, B. M., Li, Q., Simon, T., Smith, K. D., Hippen, K. L., Blazar, B. R., Abdi, R. & Bromberg, J. S., May 1 2020, In : Journal of Clinical Investigation. 130, 5, p. 2602-2619 18 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo

Yang, J., Riella, L. V., Chock, S., Liu, T., Zhao, X., Yuan, X., Paterson, A. M., Watanabe, T., Vanguri, V., Yagita, H., Azuma, M., Blazar, B. R., Freeman, G. J., Rodig, S. J., Sharpe, A. H., Chandraker, A. & Sayegh, M. H., Aug 1 2011, In : Journal of Immunology. 187, 3, p. 1113-1119 7 p.

Research output: Contribution to journalArticle

83 Scopus citations
Open Access
18 Scopus citations

The programmed Death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo

Paterson, A. M., Brown, K. E., Keir, M. E., Vanguri, V. K., Riella, L. V., Chandraker, A., Sayegh, M. H., Blazar, B. R., Freeman, G. J. & Sharpe, A. H., Aug 1 2011, In : Journal of Immunology. 187, 3, p. 1097-1105 9 p.

Research output: Contribution to journalArticle

99 Scopus citations

The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP

Sayers, T. J., Brooks, A. D., Koh, C. Y., Ma, W., Seki, N., Raziuddin, A., Blazar, B. R., Zhang, X., Elliott, P. J. & Murphy, W. J., Jul 1 2003, In : Blood. 102, 1, p. 303-310 8 p.

Research output: Contribution to journalArticle

205 Scopus citations

The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells

Sharma, M., Shinde, R., McGaha, T., Huang, L., Holmgaard, R., Wolchok, J., Mautino, M., Celis, E., Sharpe, A., Francisco, L., Powell, J., Yagita, H., Mellor, A., Blazar, B. & Munn, D., Jan 1 2015, In : Journal for ImmunoTherapy of Cancer. 3, O19.

Research output: Contribution to journalArticle

The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment

Sharma, M. D., Shinde, R., McGaha, T. L., Huang, L., Holmgaard, R. B., Wolchok, J. D., Mautino, M. R., Celis, E., Sharpe, A. H., Francisco, L. M., Powell, J. D., Yagita, H., Mellor, A. L., Blazar, B. R. & Munn, D. H., Nov 2015, In : Science Advances. 1, 10, 1500845.

Research output: Contribution to journalArticle

69 Scopus citations

The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8 + T cells

Borges Da Silva, H., Beura, L. K., Wang, H., Hanse, E. A., Gore, R., Scott, M. C., Walsh, D. A., Block, K. E., Fonseca, R., Yan, Y., Hippen, K. L., Blazar, B. R., Masopust, D., Kelekar, A., Vulchanova, L., Hogquist, K. A. & Jameson, S. C., Jul 12 2018, In : Nature. 559, 7713, p. 264-268 5 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations

The puzzling world of murine T regulatory cells

Battaglia, M., Blazar, B. R. & Roncarolo, M. G., Apr 25 2002, In : Microbes and Infection. 4, 5, p. 559-566 8 p.

Research output: Contribution to journalReview article

30 Scopus citations

Therapeutic activity of multiple common γ-chain cytokine inhibition in acute and chronic GVHD

Hechinger, A. K., Smith, B. A. H., Flynn, R., Hanke, K., McDonald-Hyman, C., Taylor, P. A., Pfeifer, D., Hackanson, B., Leonhardt, F., Prinz, G., Dierbach, H., Schmitt-Graeff, A., Kovarik, J., Blazar, B. R. & Zeiser, R., Jan 15 2015, In : Blood. 125, 3, p. 570-580 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Therapeutic benefit of bortezomib on acute graft-versus-host disease is tissue specific and is associated with interleukin-6 levels

Pai, C. C. S., Hsiao, H. H., Sun, K., Chen, M., Hagino, T., Tellez, J., Mall, C., Blazar, B. R., Monjazeb, A., Abedi, M. & Murphy, W. J., Dec 1 2014, In : Biology of Blood and Marrow Transplantation. 20, 12, p. 1899-1904 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner

McDonald-Hyman, C., Flynn, R., Panoskaltsis-Mortari, A., Peterson, N., MacDonald, K. P. A., Hill, G. R., Luznik, L., Serody, J. S., Murphy, W. J., Maillard, I., Munn, D. H., Turka, L. A., Koreth, J., Cutler, C. S., Soiffer, R. J., Antin, J. H., Ritz, J. & Blazar, B. R., Aug 18 2016, In : Blood. 128, 7, p. 1013-1017 5 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations
Open Access
14 Scopus citations

The role of B7 costimulation by murine acute myeloid leukemia in the generation and function of a CD8+T-cell line with potent in vivo graft-versus-leukemia properties

Boyer, M. W., Vallera, D. A., Taylor, P. A., Gray, G. S., Katsanis, E., Gorden, K., Orchard, P. J. & Blazar, B. R., Dec 1 1997, In : Blood. 89, 9, p. 3477-3485 9 p.

Research output: Contribution to journalArticle

47 Scopus citations
39 Scopus citations

The tissue expression of cytokines in human acute cutaneous graft-versus-host disease

Roy, J., Blazar, B. R., Ochs, L. & Weisdorf, D. J., Aug 27 1995, In : Transplantation. 60, 4, p. 343-348 6 p.

Research output: Contribution to journalArticle

31 Scopus citations