1982 …2020

Research output per year

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Research Output

2012

Advances in graft-versus-host disease biology and therapy

Blazar, B. R., Murphy, W. J. & Abedi, M., Jun 2012, In : Nature Reviews Immunology. 12, 6, p. 443-458 16 p.

Research output: Contribution to journalReview article

498 Scopus citations

A preclinical evaluation of minnelide as a therapeutic agent against pancreatic cancer

Chugh, R., Sangwan, V., Patil, S. P., Dudeja, V., Dawra, R. K., Banerjee, S., Schumacher, R. J., Blazar, B. R., Georg, G. I., Vickers, S. M. & Saluja, A. K., Oct 17 2012, In : Science Translational Medicine. 4, 156, 156ra139.

Research output: Contribution to journalArticle

165 Scopus citations

Attenuation of acute graft-versus-host disease in the absence of the transcription factor RORγt

Fulton, L. M., Carlson, M. J., Coghill, J. M., Ott, L. E., West, M. L., Panoskaltsis-Mortari, A., Littman, D. R., Blazar, B. R. & Serody, J. S., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1765-1772 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes

Hippen, K. L., Bucher, C., Schirm, D. K., Bearl, A. M., Brender, T., Mink, K. A., Waggie, K. S., De Latour, R. P., Janin, A., Curtsinger, J. M., Dillon, S. R., Miller, J. S., Socie, G. & Blazar, B. R., Jan 12 2012, In : Blood. 119, 2, p. 619-628 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

Bortezomib-based graft-versus-host disease prophylaxis in HLA-mismatched unrelated donor transplantation

Koreth, J., Stevenson, K. E., Kim, H. T., McDonough, S. M., Bindra, B., Armand, P., Ho, V. T., Cutler, C., Blazar, B. R., Antin, J. H., Soiffer, R. J., Ritz, J. & Alyea, E. P., Sep 10 2012, In : Journal of Clinical Oncology. 30, 26, p. 3202-3208 7 p.

Research output: Contribution to journalArticle

102 Scopus citations

Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells

Veenstra, R. G., Taylor, P. A., Zhou, Q., Panoskaltsis-Mortari, A., Hirashima, M., Flynn, R., Liu, D., Anderson, A. C., Strom, T. B., Kuchroo, V. K. & Blazar, B. R., Jul 19 2012, In : Blood. 120, 3, p. 682-690 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Control of acute myeloid leukemia relapse - Dance between KIRs and HLA

Miller, J. S. & Blazar, B. R., Aug 30 2012, In : New England Journal of Medicine. 367, 9, p. 866-868 3 p.

Research output: Contribution to journalEditorial

7 Scopus citations

Cooking up tolerance: Has a new recipe been created?

Kean, L. S. & Blazar, B. R., Jul 2012, In : American Journal of Transplantation. 12, 7, p. 1667-1669 3 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Delineation of antigen-specific and antigen-nonspecific CD8+ memory T-cell responses after cytokine-based cancer immunotherapy

Tietze, J. K., Wilkins, D. E. C., Sckisel, G. D., Bouchlaka, M. N., Alderson, K. L., Weiss, J. M., Ames, E., Bruhn, K. W., Craft, N., Wiltrout, R. H., Longo, D. L., Lanier, L. L., Blazar, B. R., Redelman, D. & Murphy, W. J., Mar 29 2012, In : Blood. 119, 13, p. 3073-3083 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans

Srinivasan, M., Flynn, R., Price, A., Ranger, A., Browning, J. L., Taylor, P. A., Ritz, J., Antin, J. H., Murphy, W. J., Luznik, L., Shlomchik, M. J., Panoskaltsis-Mortari, A. & Blazar, B. R., Feb 9 2012, In : Blood. 119, 6, p. 1570-1580 11 p.

Research output: Contribution to journalArticle

129 Scopus citations
48 Scopus citations
11 Scopus citations

IDO in Human Gut Graft-versus-Host Disease

Ratajczak, P., Janin, A., Peffault de Larour, R., Koch, L., Roche, B., Munn, D., Blazar, B. R. & Socié, G., Jan 2012, In : Biology of Blood and Marrow Transplantation. 18, 1, p. 150-155 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

IFN-γ receptor-deficient donor T cells mediate protection from graft-versus-host disease and preserve graft-versus-tumor responses after allogeneic bone marrow transplantation

Sun, K., Hsiao, H. H., Li, M., Ames, E., Bouchlaka, M., Welniak, L. A., Hagino, T., Jagdeo, J., Pai, C. C., Chen, M., Blazar, B. R., Abedi, M. & Murphy, W. J., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 2033-2042 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease

Hanash, A. M., Dudakov, J. A., Hua, G., O'Connor, M. H., Young, L. F., Singer, N. V., West, M. L., Jenq, R. R., Holland, A. M., Kappel, L. W., Ghosh, A., Tsai, J. J., Rao, U. K., Yim, N. L., Smith, O. M., Velardi, E., Hawryluk, E. B., Murphy, G. F., Liu, C., Fouser, L. A. & 3 others, Kolesnick, R., Blazar, B. R. & van den Brink, M. R. M., Aug 24 2012, In : Immunity. 37, 2, p. 339-350 12 p.

Research output: Contribution to journalArticle

313 Scopus citations

MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection

Zuklys, S., Mayer, C. E., Zhanybekova, S., Stefanski, H. E., Nusspaumer, G., Gill, J., Barthlott, T., Chappaz, S., Nitta, T., Dooley, J., Nogales-Cadenas, R., Takahama, Y., Finke, D., Liston, A., Blazar, B. R., Pascual-Montano, A. & Hollände, G. A., Oct 15 2012, In : Journal of Immunology. 189, 8, p. 3894-3904 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Nonhuman primate transplant models finally evolve: Detailed immunogenetic analysis creates new models and strengthens the old

Kean, L. S., Singh, K., Blazar, B. R. & Larsen, C. P., Apr 2012, In : American Journal of Transplantation. 12, 4, p. 812-819 8 p.

Research output: Contribution to journalShort survey

19 Scopus citations

Polyfunctional CD4+ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy

Ding, Z. C., Huang, L., Blazar, B. R., Yagita, H., Mellor, A. L., Munn, D. H. & Zhou, G., Sep 13 2012, In : Blood. 120, 11, p. 2229-2239 11 p.

Research output: Contribution to journalArticle

43 Scopus citations
13 Scopus citations
30 Scopus citations

Regulation of acute graft-versus-host disease by microRNA-155

Ranganathan, P., Heaphy, C. E. A., Costinean, S., Stauffer, N., Na, C., Hamadani, M., Santhanam, R., Mao, C., Taylor, P. A., Sandhu, S., He, G., Shana'ah, A., Nuovo, G. J., Lagana, A., Cascione, L., Obad, S., Broom, O., Kauppinen, S., Byrd, J. C., Caligiuri, M. & 7 others, Perrotti, D., Hadley, G. A., Marcucci, G., Devine, S. M., Blazar, B. R., Croce, C. M. & Garzon, R., May 17 2012, In : Blood. 119, 20, p. 4786-4797 12 p.

Research output: Contribution to journalArticle

97 Scopus citations

Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation

Jenq, R. R., Ubeda, C., Taur, Y., Menezes, C. C., Khanin, R., Dudakov, J. A., Liu, C., West, M. L., Singer, N. V., Equinda, M. J., Gobourne, A., Lipuma, L., Young, L. F., Smith, O. M., Ghosh, A., Hanash, A. M., Goldberg, J. D., Aoyama, K., Blazar, B. R., Pamer, E. G. & 1 others, van den Brink, M. R. M., May 7 2012, In : Journal of Experimental Medicine. 209, 5, p. 903-911 9 p.

Research output: Contribution to journalArticle

331 Scopus citations

Regulatory T cells exhibit decreased proliferation but enhanced suppression after pulsing with sirolimus

Singh, K., Kozyr, N., Stempora, L., Kirk, A. D., Larsen, C. P., Blazar, B. R. & Kean, L. S., Jun 2012, In : American Journal of Transplantation. 12, 6, p. 1441-1457 17 p.

Research output: Contribution to journalArticle

37 Scopus citations

Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function

Zanin-Zhorov, A., Lin, J., Scher, J., Kumari, S., Blair, D., Hippen, K. L., Blazar, B. R., Abramson, S. B., Lafaille, J. J. & Dustin, M. L., Jan 31 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 5, p. 1625-1630 6 p.

Research output: Contribution to journalArticle

34 Scopus citations
17 Scopus citations
30 Scopus citations

Systemic delivery of Salmonella typhimurium transformed with IDO shRNA enhances intratumoral vector colonization and suppresses tumor growth

Blache, C. A., Manuel, E. R., Kaltcheva, T. I., Wong, A. N., Ellenhorn, J. D. I., Blazar, B. R. & Diamond, D. J., Dec 15 2012, In : Cancer Research. 72, 24, p. 6447-6456 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

TCR affinity and specificity requirements for human regulatory T-cell function

Plesa, G., Zheng, L., Medvec, A., Wilson, C. B., Robles-Oteiza, C., Liddy, N., Bennett, A. D., Gavarret, J., Vuidepot, A., Zhao, Y., Blazar, B. R., Jakobsen, B. K. & Riley, J. L., Apr 12 2012, In : Blood. 119, 15, p. 3420-3430 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9

Gleason, M. K., Lenvik, T. R., McCullar, V., Felices, M., O'Brien, M. S., Cooley, S. A., Verneris, M. R., Cichocki, F., Holman, C. J., Panoskaltsis-Mortari, A., Niki, T., Hirashima, M., Blazar, B. R. & Miller, J. S., Mar 29 2012, In : Blood. 119, 13, p. 3064-3072 9 p.

Research output: Contribution to journalArticle

166 Scopus citations

Understanding Chronic GVHD from Different Angles

Blazar, B., White, E. S. & Couriel, D., Jan 1 2012, In : Biology of Blood and Marrow Transplantation. 18, 1 SUPPL., p. S184-S188

Research output: Contribution to journalArticle

9 Scopus citations

Zebrafish stromal cells have endothelial properties and support hematopoietic cells

Lund, T. C., Glass, T. J., Somani, A., Nair, S., Tolar, J., Nyquist, M., Patrinostro, X. & Blazar, B. R., Jan 2012, In : Experimental Hematology. 40, 1, p. 61-70.e1

Research output: Contribution to journalArticle

4 Scopus citations
2011

A low frequency of pancreatic islet insulin-expressing cells derived from cord blood stem cell allografts in humans

Huang, C. J., Butler, A. E., Moran, A., Rao, P. N., Wagner, J. E., Blazar, B. R., Rizza, R. A., Manivel, J. C. & Butler, P. C., May 2011, In : Diabetologia. 54, 5, p. 1066-1074 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
4 Scopus citations

Clinical perspectives for regulatory T cells in transplantation tolerance

Hippen, K. L., Riley, J. L., June, C. H. & Blazar, B. R., Dec 1 2011, In : Seminars in Immunology. 23, 6, p. 462-468 7 p.

Research output: Contribution to journalReview article

90 Scopus citations

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

Zhou, Q., Munger, M. E., Veenstra, R. G., Weigel, B. J., Hirashima, M., Munn, D. H., Murphy, W. J., Azuma, M., Anderson, A. C., Kuchroo, V. K. & Blazar, B. R., Apr 28 2011, In : Blood. 117, 17, p. 4501-4510 10 p.

Research output: Contribution to journalArticle

358 Scopus citations
24 Scopus citations
31 Scopus citations

Effector CD4+ T cells, the cytokines they generate, and GVHD: Something old and something new

Coghill, J. M., Sarantopoulos, S., Moran, T. P., Murphy, W. J., Blazar, B. R. & Serody, J. S., Mar 24 2011, In : Blood. 117, 12, p. 3268-3276 9 p.

Research output: Contribution to journalReview article

108 Scopus citations

Evidence for early fibrosis and increased airway resistance in bone marrow transplant recipient mice deficient in MMP12

England, K. A., Price, A. P., Tram, K. V., Shapiro, S. D., Blazar, B. R. & Panoskaltsis-Mortari, A., Oct 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 4, p. L519-L526

Research output: Contribution to journalArticle

14 Scopus citations

Ex Vivo Expanded Treg Therapy Promotes Long-Term Islet Allograft Survival in a Non-Human Primate Model

Bansal-Pakala, P., Pahuja, A., Hennessey, E., Graham, M., Hering, B. J. & Blazar, B. R., 2011, In : American Journal of Transplantation. 11, p. 209 1 p.

Research output: Contribution to journalArticle

Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease

Hippen, K. L., Merkel, S. C., Schirm, D. K., Nelson, C., Tennis, N. C., Riley, J. L., June, C. H., Miller, J. S., Wagner, J. E. & Blazar, B. R., Jun 2011, In : American Journal of Transplantation. 11, 6, p. 1148-1157 10 p.

Research output: Contribution to journalArticle

151 Scopus citations
65 Scopus citations
112 Scopus citations

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics

Brunstein, C. G., Miller, J. S., Cao, Q., McKenna, D. H., Hippen, K. L., Curtsinger, J., DeFor, T., Levine, B. L., June, C. H., Rubinstein, P., McGlave, P. B., Blazar, B. R. & Wagner, J. E., Jan 20 2011, In : Blood. 117, 3, p. 1061-1070 10 p.

Research output: Contribution to journalArticle

681 Scopus citations

Lipid composition of whole brain and cerebellum in hurler syndrome (MPS IH) mice

Heinecke, K. A., Peacock, B. N., Blazar, B. R., Tolar, J. & Seyfried, T. N., Sep 1 2011, In : Neurochemical Research. 36, 9, p. 1669-1676 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
4 Scopus citations

Massive ex vivo expansion of human natural regulatory T cells (T regs) with minimal loss of in vivo functional activity

Hippen, K. L., Merkel, S. C., Schirm, D. K., Sieben, C. M., Sumstad, D., Kadidlo, D. M., McKenna, D. H., Bromberg, J. S., Levine, B. L., Riley, J. L., June, C. H., Scheinberg, P., Douek, D. C., Miller, J. S., Wagner, J. E. & Blazar, B. R., May 18 2011, In : Science Translational Medicine. 3, 83, 83ra41.

Research output: Contribution to journalArticle

228 Scopus citations
71 Scopus citations

miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27 kip1, KPC1, and SOCS-1

Lu, C., Huang, X., Zhang, X., Roensch, K., Cao, Q., Nakayama, K. I., Blazar, B. R., Zeng, Y. & Zhou, X., Apr 21 2011, In : Blood. 117, 16, p. 4293-4303 11 p.

Research output: Contribution to journalArticle

201 Scopus citations

Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC

Barao, I., Alvarez, M., Ames, E., Orr, M. T., Stefanski, H. E., Blazar, B. R., Lanier, L. L., Anderson, S. K., Redelman, D. & Murphy, W. J., Jun 30 2011, In : Blood. 117, 26, p. 7032-7041 10 p.

Research output: Contribution to journalArticle

33 Scopus citations