1982 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2004

Tumor regression by anti-CD40 and interleukin-2: Role of CD40 in hematopoietic cells and organ-specific effects

Welniak, L. A., Shorts, L., Subleski, J., Blazar, B. R., Wiltrout, R. H. & Murphy, W. J., Aug 1 2004, In : Biology of Blood and Marrow Transplantation. 10, 8, p. 534-539 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
2003

Acceleration of idiopathic pneumonia syndrome (IPS) in the absence of donor MIP-1α (CCL3) after allogeneic BMT in mice

Panoskaltsis-Mortari, A., Hermanson, J. R., Taras, E., Wangensteen, O. D., Serody, J. S. & Blazar, B. R., May 1 2003, In : Blood. 101, 9, p. 3714-3721 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

A substantial level of donor hematopoietic chimerism is required to protect donor-specific islet grafts in diabetic NOD mice

Guo, Z., Wu, T., Sozen, H., Pan, Y., Heuss, N. D., Kalscheuer, H., Sutherland, D. E. R., Blazar, B. R. & Hering, B. J., Apr 15 2003, In : Transplantation. 75, 7, p. 909-915 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-γ-dependent mechanism

Blazar, B. R., Carreno, B. M., Panoskaltsis-Mortari, A., Carter, L., Iwai, Y., Yagita, H., Nishimura, H. & Taylor, P. A., Aug 1 2003, In : Journal of Immunology. 171, 3, p. 1272-1277 6 p.

Research output: Contribution to journalArticle

Open Access
226 Scopus citations

Blockade of the CD40/CD154 pathway enhances T-cell-depleted allogeneic bone marrow engraftment under nonmyeloablative and irradiation-free conditioning therapy

Pan, Y., Luo, B., Sozen, H., Kalscheuer, H., Blazar, B. R., Sutherland, D. E. R., Hering, B. J. & Guo, Z., Jul 15 2003, In : Transplantation. 76, 1, p. 216-224 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

CD154 on the surface of CD4+CD25+ regulatory T cells contributes to skin transplant tolerance

Jarvinen, L. Z., Blazar, B. R., Adeyi, O. A., Strom, T. B. & Noelle, R. J., Nov 15 2003, In : Transplantation. 76, 9, p. 1375-1379 5 p.

Research output: Contribution to journalArticle

57 Scopus citations

CpG oligodeoxynucleotides potentiate the antitumor effects of chemotherapy or tumor resection in an orthotopic murine model of rhabdomyosarcoma

Weigel, B. J., Rodeberg, D. A., Krieg, A. M. & Blazar, B. R., Aug 1 2003, In : Clinical Cancer Research. 9, 8, p. 3105-3114 10 p.

Research output: Contribution to journalArticle

122 Scopus citations

IL-10 and TGF-β induce alloreactive CD4+CD25- T cells to acquire regulatory cell function

Chen, Z. M., O'Shaughnessy, M. J., Gramaglia, I., Panoskaltsis-Mortari, A., Murphy, W. J., Narula, S., Roncarolo, M. G. & Blazar, B. R., Jun 15 2003, In : Blood. 101, 12, p. 5076-5083 8 p.

Research output: Contribution to journalArticle

152 Scopus citations

IL-2-based immunotherapy after authologous transplantation for lymphoma and breast cancer induces immune activation and cytokine release: A phase I/II trial

Burns, L. J., Weisdorf, D. J., DeFor, T. E., Vesole, D. H., Repka, T. L., Blazar, B. R., Burger, S. R., Panoskaltsis-Mortari, A., Keever-Taylor, C. A., Zhang, M. J. & Miller, J. S., Jul 2003, In : Bone marrow transplantation. 32, 2, p. 177-186 10 p.

Research output: Contribution to journalArticle

158 Scopus citations

In vivo survival and homeostatic proliferation of natural killer cells

Prlic, M., Blazar, B. R., Farrar, M. A. & Jameson, S. C., Apr 21 2003, In : Journal of Experimental Medicine. 197, 8, p. 967-976 10 p.

Research output: Contribution to journalArticle

179 Scopus citations

Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients

Blazar, B. R., Sharpe, A. H., Chen, A. I., Panoskaltsis-Mortari, A., Lees, C., Akiba, H., Yagita, H., Killeen, N. & Taylor, P. A., May 1 2003, In : Blood. 101, 9, p. 3741-3748 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

Mechanisms of donor-specific transfusion tolerance: Preemptive induction of clonal T-cell exhaustion via indirect presentation

Quezada, S. A., Fuller, B., Jarvinen, L. Z., Gonzalez, M., Blazar, B. R., Rudensky, A. Y., Strom, T. B. & Noelle, R. J., Sep 1 2003, In : Blood. 102, 5, p. 1920-1926 7 p.

Research output: Contribution to journalArticle

86 Scopus citations

NK-cell purging of leukemia: Superior antitumor effects of NK cells H2 allogeneic to the tumor and augmentation with inhibitory receptor blockade

Koh, C. Y., Ortaldo, J. R., Blazar, B. R., Bennett, M. & Murphy, W. J., Dec 1 2003, In : Blood. 102, 12, p. 4067-4075 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Plasma pharmacokinetics of high-dose oral busulfan in children and adults undergoing bone marrow transplantation

Bostrom, B., Enockson, K., Johnson, A., Bruns, A. & Blazar, B. R., 2003, In : Pediatric transplantation. 7, SUPPL. 3, p. 12-18 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
355 Scopus citations

Surfactant protein A is a required mediator of keratinocyte growth factor after experimental marrow transplantation

Haddad, I. Y., Milla, C., Yang, S., Panoskaltsis-Mortari, A., Hawgood, S., Lacey, D. L. & Blazar, B. R., Sep 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 285, 3 29-3, p. L602-L610

Research output: Contribution to journalArticle

13 Scopus citations

Synergistic anti-tumor responses after administration of agonistic antibodies to CD40 and IL-2: Coordination of dendritic and CD8+ cell responses

Murphy, W. J., Welniak, L., Back, T., Hixon, J., Subleski, J., Seki, N., Wigginton, J. M., Wilson, S. E., Blazar, B. R., Malyguine, A. M., Sayers, T. J. & Wiltrout, R. H., Mar 1 2003, In : Journal of Immunology. 170, 5, p. 2727-2733 7 p.

Research output: Contribution to journalArticle

80 Scopus citations

The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP

Sayers, T. J., Brooks, A. D., Koh, C. Y., Ma, W., Seki, N., Raziuddin, A., Blazar, B. R., Zhang, X., Elliott, P. J. & Murphy, W. J., Jul 1 2003, In : Blood. 102, 1, p. 303-310 8 p.

Research output: Contribution to journalArticle

205 Scopus citations
2002

Abnormal T cell-dependent B-cell responses in SCID mice receiving allogeneic bone marrow in utero

Waldschmidt, T. J., Panoskaltsis-Mortari, A., Mc Elmurry, R. T., Tygrett, L. T., Taylor, P. A. & Blazar, B. R., Dec 15 2002, In : Blood. 100, 13, p. 4557-4564 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Administration of either anti-CD40 or interleukin-12 following lethal total body irradiation induces acute lethal toxicity affecting the gut

Hixon, J. A., Anver, M. R., Blazar, B. R., Panoskaltsis-Mortari, A., Wiltrout, R. H. & Murphy, W. J., Jan 1 2002, In : Biology of Blood and Marrow Transplantation. 8, 6, p. 316-325 10 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations
49 Scopus citations

Blockade of LIGHT/LTβ and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease

Tamada, K., Tamura, H., Flies, D., Fu, Y. X., Celis, E., Pease, L. R., Blazar, B. R. & Chen, L., 2002, In : Journal of Clinical Investigation. 109, 4, p. 549-557 9 p.

Research output: Contribution to journalArticle

76 Scopus citations
34 Scopus citations

Combined effects of calcineurin inhibitors or sirolimus with anti-CD40L mAb on alloengraftment under nonmyeloablative conditions

Taylor, P. A., Lees, C. J., Wilson, J. M., Ehrhardt, M. J., Campbell, M. T., Noelle, R. J. & Blazar, B. R., Nov 1 2002, In : Blood. 100, 9, p. 3400-3407 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Comparative analysis of murine marrow-derived dendritic cells generated by Flt3L or GM-CSF/IL-4 and matured with immune stimulatory agents on the in vivo induction of antileukemia responses

Weigel, B. J., Nath, N., Taylor, P. A., Panoskaltsis-Mortari, A., Chen, W., Krieg, A. M., Brasel, K. & Blazar, B. R., Dec 1 2002, In : Blood. 100, 12, p. 4169-4176 8 p.

Research output: Contribution to journalArticle

64 Scopus citations
107 Scopus citations

Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants

Davies, S. M., Ruggieri, L., DeFor, T., Wagner, J. E., Weisdorf, D. J., Miller, J. S., Velardi, A. & Blazar, B. R., Nov 15 2002, In : Blood. 100, 10, p. 3825-3827 3 p.

Research output: Contribution to journalArticle

309 Scopus citations

Exuberant inflammation in nicotinamide adenine dinucleotide phosphate-oxidase-deficient mice after allogeneic marrow transplantation

Yang, S., Panoskaltsis-Mortari, A., Shukla, M., Blazar, B. R. & Haddad, I. Y., Jun 1 2002, In : Journal of Immunology. 168, 11, p. 5840-5847 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Gene therapy of murine solid tumors with T cells transduced with a retroviral vascular endothelial growth factor-immunotoxin target gene

Jin, N., Chen, W., Blazar, B. R., Ramakrishnan, S. & Vallera, D. A., 2002, In : Human gene therapy. 13, 4, p. 497-508 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Interleukin-1 blockade does not prevent acute graft-versus-host disease: Results of a randomized, double-blind, placebo-controlled trial of interleukin-1 receptor antagonist in allogeneic bone marrow transplantation

Antin, J. H., Weisdorf, D., Neuberg, D., Nicklow, R., Clouthier, S., Lee, S. J., Alyea, E., McGarigle, C., Blazar, B. R., Sonis, S., Soiffer, R. J. & Ferrara, J. L. M., Nov 15 2002, In : Blood. 100, 10, p. 3479-3483 5 p.

Research output: Contribution to journalArticle

119 Scopus citations

Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease

Rossi, S., Blazar, B. R., Farrell, C. L., Danilenko, D. M., Lacey, D. L., Weinberg, K. I., Krenger, W. & Holländer, G. A., Jul 15 2002, In : Blood. 100, 2, p. 682-691 10 p.

Research output: Contribution to journalArticle

160 Scopus citations

Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1 +, but not B7-2 +, murine myelogenous leukemia

LaBelle, J. L., Hanke, C. A., Blazar, B. R. & Truitt, R. L., Mar 15 2002, In : Blood. 99, 6, p. 2146-2153 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

NK inhibitory-receptor blockade for purging of leukemia: Effects on hematopoietic reconstitution

Koh, C. Y., Raziuddin, A., Welniak, L. A., Blazar, B. R., Bennett, M. & Murphy, W. J., Jan 1 2002, In : Biology of Blood and Marrow Transplantation. 8, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Protection from thymic epithelial cell injury by keratinocyte growth factor: A new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation

Min, D., Taylor, P. A., Panoskaltsis-Mortari, A., Chung, B., Danilenko, D. M., Farrell, C., Lacey, D. L., Blazar, B. R. & Weinberg, K. I., Jun 15 2002, In : Blood. 99, 12, p. 4592-4600 9 p.

Research output: Contribution to journalArticle

213 Scopus citations
269 Scopus citations

Surfactant protein A decreases lung injury and mortality after murine marrow transplantation

Yang, S., Milla, C., Panoskaltsis-Mortari, A., Hawgood, S., Blazar, B. R. & Haddad, I. Y., Sep 2002, In : American journal of respiratory cell and molecular biology. 27, 3, p. 297-305 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

The adjuvant effects of Mycobacterium tuberculosis heat shock protein 70 result from the rapid and prolonged activation of antigen-specific CD8+ T cells in vivo

Harmala, L. A. E., Ingulli, E. G., Curtsinger, J. M., Lucido, M. M., Schmidt, C. S., Weigel, B. J., Blazar, B. R., Mescher, M. F. & Pennell, C. A., Nov 15 2002, In : Journal of Immunology. 169, 10, p. 5622-5629 8 p.

Research output: Contribution to journalArticle

54 Scopus citations

The balance between donor T cell anergy and suppression versus lethal graft-versus-host disease is determined by host conditioning

Gonzalez, M., Quezada, S. A., Blazar, B. R., Panoskaltsis-Mortari, A., Rudensky, A. Y. & Noelle, R. J., Nov 15 2002, In : Journal of Immunology. 169, 10, p. 5581-5589 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

The infusion of ex vivo activated and expanded CD4 +CD25 + immune regulatory cells inhibits graft-versus-host disease lethality

Taylor, P. A., Lees, C. J. & Blazar, B. R., May 15 2002, In : Blood. 99, 10, p. 3493-3499 7 p.

Research output: Contribution to journalArticle

828 Scopus citations

The puzzling world of murine T regulatory cells

Battaglia, M., Blazar, B. R. & Roncarolo, M. G., Apr 25 2002, In : Microbes and Infection. 4, 5, p. 559-566 8 p.

Research output: Contribution to journalReview article

30 Scopus citations

Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell

Taylor, P. A., Friedman, T. M., Korngold, R., Noelle, R. J. & Blazar, B. R., Jun 15 2002, In : Blood. 99, 12, p. 4601-4609 9 p.

Research output: Contribution to journalArticle

118 Scopus citations

Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: Influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival

Wagner, J. E., Barker, J. N., De For, T. E., Scott Baker, K., Blazar, B. R., Eide, C., Goldman, A., Kersey, J., Krivit, W., MacMillan, M. L., Orchard, P. J., Peters, C., Weisdorf, D. J., Ramsay, N. K. C. & Davies, S. M., Sep 1 2002, In : Blood. 100, 5, p. 1611-1618 8 p.

Research output: Contribution to journalArticle

839 Scopus citations
2001

Altered T-cell receptor + CD28-mediated signaling and blocked cell cycle progression in interleukin 10 and transforming growth factor-β-treated alloreactive T cells that do not induce graft-versus-host disease

Boussiotis, V. A., Chen, Z. M., Zeller, J. C., Murphy, W. J., Berezovskaya, A., Narula, S., Roncarolo, M. G. & Blazar, B. R., Jan 15 2001, In : Blood. 97, 2, p. 565-571 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Antibodies to CD40 induce a lethal cytokine cascade after syngeneic bone marrow transplantation

Hixon, J. A., Blazar, B. R., Anver, M. R., Wiltrout, R. H. & Murphy, W. J., Jan 1 2001, In : Biology of Blood and Marrow Transplantation. 7, 3, p. 136-143 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

A phase I clinical, pharmacological, and biological trial of interleukin 6 plus granulocyte-colony stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent/refractory solid tumors: Enhanced hematological responses but a high incidence of grade III/IV constitutional toxicities

Bracho, F., Krailo, M. D., Shen, V., Bergeron, S., Davenport, V., Liu-Mares, W., Blazar, B. R., Panoskaltsis-Mortari, A., Van De Ven, C., Secola, R., Ames, M. M., Reid, J. M., Reaman, G. H. & Cairo, M. S., Jan 2001, In : Clinical Cancer Research. 7, 1, p. 58-67 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo

Koh, C. Y., Blazar, B. R., George, T., Welniak, L. A., Capitini, C. M., Raziuddin, A., Murphy, W. J. & Bennett, M., May 15 2001, In : Blood. 97, 10, p. 3132-3137 6 p.

Research output: Contribution to journalArticle

123 Scopus citations

Bone marrow transplantation without myeloablation for sickle cell disease

Krishnamurti, L., Blazar, B. R. & Wagner, J. E., Jan 4 2001, In : New England Journal of Medicine. 344, 1, 1 p.

Research output: Contribution to journalLetter

60 Scopus citations

CD4+CD25+ immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade

Taylor, P. A., Noelle, R. J. & Blazar, B. R., Jun 4 2001, In : Journal of Experimental Medicine. 193, 11, p. 1311-1317 7 p.

Research output: Contribution to journalArticle

467 Scopus citations

CD47 (Integrin-associated Protein) engagement of dendritic cell and macrophage counterreceptors is required to prevent the clearance of donor lymphohematopoietic cells

Blazar, B. R., Lindberg, F. P., Ingulli, E., Panoskaltsis-Mortari, A., Oldenborg, P. A., Iizuka, K., Yokoyama, W. M. & Taylor, P. A., Aug 20 2001, In : Journal of Experimental Medicine. 194, 4, p. 541-549 9 p.

Research output: Contribution to journalArticle

135 Scopus citations