1982 …2020

Research output per year

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Research Output

2019

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

Clement, R. L., Daccache, J., Mohammed, M. T., Diallo, A., Blazar, B. R., Kuchroo, V. K., Lovitch, S. B., Sharpe, A. H. & Sage, P. T., Oct 1 2019, In : Nature immunology. 20, 10, p. 1360-1371 12 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program

Hou, S., Clement, R. L., Diallo, A., Blazar, B. R., Rudensky, A. Y., Sharpe, A. H. & Sage, P. T., Mar 1 2019, In : Journal of Experimental Medicine. 216, 3, p. 605-620 16 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Generation and function of progenitor t cells from stemregenin-1-expanded CD34+ human hematopoietic progenitor cells

Singh, J., Chen, E. L. Y., Xing, Y., Stefanski, H. E., Blazar, B. R. & Zúñiga-Pflücker, J. C., 2019, In : Blood Advances. 3, 20, p. 2934-2948 15 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Immune Regulatory Cell Biology and Clinical Applications to Prevent or Treat Acute Graft-Versus-Host Disease

Blazar, B. R., Feb 2019, In : Engineering. 5, 1, p. 98-105 8 p.

Research output: Contribution to journalReview article

Open Access

MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota

Koyama, M., Mukhopadhyay, P., Schuster, I. S., Henden, A. S., Hülsdünker, J., Varelias, A., Vetizou, M., Kuns, R. D., Robb, R. J., Zhang, P., Blazar, B. R., Thomas, R., Begun, J., Waddell, N., Trinchieri, G., Zeiser, R., Clouston, A. D., Degli-Esposti, M. A. & Hill, G. R., Nov 19 2019, In : Immunity. 51, 5, p. 885-898.e7

Research output: Contribution to journalArticle

10 Scopus citations
4 Scopus citations
7 Scopus citations

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Wang, Z., Aguilar, E. G., Luna, J. I., Dunai, C., Khuat, L. T., Le, C. T., Mirsoian, A., Minnar, C. M., Stoffel, K. M., Sturgill, I. R., Grossenbacher, S. K., Withers, S. S., Rebhun, R. B., Hartigan-O’Connor, D. J., Méndez-Lagares, G., Tarantal, A. F., Isseroff, R. R., Griffith, T. S., Schalper, K. A., Merleev, A. & 13 others, Saha, A., Maverakis, E., Kelly, K., Aljumaily, R., Ibrahimi, S., Mukherjee, S., Machiorlatti, M., Vesely, S. K., Longo, D. L., Blazar, B. R., Canter, R. J., Murphy, W. J. & Monjazeb, A. M., Jan 1 2019, In : Nature Medicine. 25, 1, p. 141-151 11 p.

Research output: Contribution to journalArticle

Open Access
88 Scopus citations

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

Puleston, D. J., Buck, M. D., Klein Geltink, R. I., Kyle, R. L., Caputa, G., O'Sullivan, D., Cameron, A. M., Castoldi, A., Musa, Y., Kabat, A. M., Zhang, Y., Flachsmann, L. J., Field, C. S., Patterson, A. E., Scherer, S., Alfei, F., Baixauli, F., Austin, S. K., Kelly, B., Matsushita, M. & 17 others, Curtis, J. D., Grzes, K. M., Villa, M., Corrado, M., Sanin, D. E., Qiu, J., Pällman, N., Paz, K., Maccari, M. E., Blazar, B. R., Mittler, G., Buescher, J. M., Zehn, D., Rospert, S., Pearce, E. J., Balabanov, S. & Pearce, E. L., Aug 6 2019, In : Cell Metabolism. 30, 2, p. 352-363.e8

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Publisher Correction: Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion (Nature, (2019), 10.1038/s41586-019-1410-1)

Paczulla, A. M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., Nievergall, E., Dörfel, D., Hanns, P., Passweg, J. R., Lutz, C., Schwaller, J., Zeiser, R., Blazar, B. R., Caligiuri, M. A., Dirnhofer, S. & 7 others, Lundberg, P., Kanz, L., Quintanilla-Martinez, L., Steinle, A., Trumpp, A., Salih, H. R. & Lengerke, C., Jan 1 2019, In : Nature. 572, 7770, p. E19

Research output: Contribution to journalComment/debate

Open Access
Open Access
2 Scopus citations

Reduction in murine acute GVHD severity by human gingival tissue-derived mesenchymal stem cells via the CD39 pathways

Ni, X., Xia, Y., Zhou, S., Peng, H., Wu, X., Lu, H., Wang, H., Liu, R., Blazar, B. R., Gu, J. & Lu, L., Jan 1 2019, In : Cell Death and Disease. 10, 1, 13.

Research output: Contribution to journalArticle

Open Access

Rorc restrains the potency of ST2+ regulatory T cells in ameliorating intestinal graft-versus-host disease

Yang, J., Ramadan, A., Reichenbach, D. K., Loschi, M., Zhang, J., Griesenauer, B., Liu, H., Hippen, K. L., Blazar, B. R. & Paczesny, S., Mar 7 2019, In : JCI Insight. 4, 5

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization

Leung, W. H., Gay, J., Martin, U., Garrett, T. E., Horton, H. M., Certo, M. T., Blazar, B. R., Morgan, R. A., Gregory, P. D., Jarjour, J. & Astrakhan, A., Jun 6 2019, In : JCI insight. 4, 11, e124430.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease

Paz, K., Flynn, R., Du, J., Qi, J., Luznik, L., Maillard, I., MacDonald, K. P., Hill, G. R., Serody, J. S., Murphy, W. J., Sage, P. T., Sharpe, A. H., Miklos, D., Cutler, C. S., Koreth, J., Antin, J. H., Soiffer, R. J., Ritz, J., Bradner, J. E., Melnick, A. M. & 1 others, Blazar, B. R., Jan 3 2019, In : Blood. 133, 1, p. 94-99 6 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
Open Access
2 Scopus citations

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease

Paz, K., Flynn, R., Du, J., Tannheimer, S., Johnson, A. J., Dong, S., Stark, A. K., Okkenhaug, K., Panoskaltsis-Mortari, A., Sage, P. T., Sharpe, A. H., Luznik, L., Ritz, J., Soiffer, R. J., Cutler, C. S., Koreth, J., Antin, J. H., Miklos, D. B., MacDonald, K. P., Hill, G. R. & 10 others, Maillard, I., Serody, J. S., Murphy, W. J., Munn, D. H., Feser, C. J., Zaiken, M., Vanhaesebroeck, B., Turka, L. A., Byrd, J. C. & Blazar, B. R., Jun 2019, In : American Journal of Transplantation. 19, 6, p. 1820-1830 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation

Liu, B., Salgado, O. C., Singh, S., Hippen, K. L., Maynard, J. C., Burlingame, A. L., Ball, L. E., Blazar, B. R., Farrar, M. A., Hogquist, K. A. & Ruan, H. B., Dec 1 2019, In : Nature communications. 10, 1, 354.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

TRAF6 directs FOXP3 localization and facilitates regulatory T-cell function through K63-linked ubiquitination

Ni, X., Kou, W., Gu, J., Wei, P., Wu, X., Peng, H., Tao, J., Yan, W., Yang, X., Lebid, A., Park, B. V., Chen, Z., Tian, Y., Fu, J., Newman, S., Wang, X., Shen, H., Li, B., Blazar, B. R., Wang, X. & 3 others, Barbi, J., Pan, F. & Lu, L., May 2 2019, In : EMBO Journal. 38, 9, e99766.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

Rosato, P. C., Wijeyesinghe, S., Stolley, J. M., Nelson, C. E., Davis, R. L., Manlove, L. S., Pennell, C. A., Blazar, B. R., Chen, C. C., Geller, M. A., Vezys, V. & Masopust, D., Dec 1 2019, In : Nature communications. 10, 1, 567.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations
2018

161533 TriKE stimulates NK-cell function to overcome myeloid-derived suppressor cells in MDS

Sarhan, D., Brandt, L., Felices, M., Guldevall, K., Lenvik, T., Hinderlie, P., Curtsinger, J., Warlick, E., Spellman, S. R., Blazar, B. R., Weisdorf, D. J., Cooley, S., Vallera, D. A., Onfelt, B. & Miller, J. S., Jun 26 2018, In : Blood Advances. 2, 12, p. 1459-1469 11 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

A critical role for donor-derived IL-22 in cutaneous chronic GVHD

Gartlan, K. H., Bommiasamy, H., Paz, K., Wilkinson, A. N., Owen, M., Reichenbach, D. K., Banovic, T., Wehner, K., Buchanan, F., Varelias, A., Kuns, R. D., Chang, K., Fedoriw, Y., Shea, T., Coghill, J., Zaiken, M., Plank, M. W., Foster, P. S., Clouston, A. D., Blazar, B. R. & 2 others, Serody, J. S. & Hill, G. R., Apr 2018, In : American Journal of Transplantation. 18, 4, p. 810-820 11 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

Sharma, M. D., Rodriguez, P. C., Koehn, B. H., Baban, B., Cui, Y., Guo, G., Shimoda, M., Pacholczyk, R., Shi, H., Lee, E. J., Xu, H., Johnson, T. S., He, Y., Mergoub, T., Venable, C., Bronte, V., Wolchok, J. D., Blazar, B. R. & Munn, D. H., Jan 16 2018, In : Immunity. 48, 1, p. 91-106.e6

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Acute Graft-versus-Host Disease

Zeiser, R. & Blazar, B. R., Feb 8 2018, In : The New England journal of medicine. 378, 6, 1 p.

Research output: Contribution to journalLetter

5 Scopus citations

Adaptive NK cells resist regulatory T-cell suppression driven by IL37

Sarhan, D., Hippen, K. L., Lemire, A., Hying, S., Luo, X., Lenvik, T., Curtsinger, J., Davis, Z., Zhang, B., Cooley, S., Cichocki, F., Blazar, B. R. & Miller, J. S., Jul 2018, In : Cancer Immunology Research. 6, 7, p. 766-775 10 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

Habtetsion, T., Ding, Z. C., Pi, W., Li, T., Lu, C., Chen, T., Xi, C., Spartz, H., Liu, K., Hao, Z., Mivechi, N., Huo, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Aug 7 2018, In : Cell Metabolism. 28, 2, p. 228-242.e6

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Amphiregulin modifies the Minnesota acute graft-versus-host disease risk score: Results from BMT CTN 0302/0802

Holtan, S. G., DeFor, T. E., Panoskaltsis-Mortari, A., Khera, N., Levine, J. E., Flowers, M. E. D., Lee, S. J., Inamoto, Y., Chen, G. L., Mayer, S., Arora, M., Palmer, J., Cutler, C. S., Arai, S., Lazaryan, A., Newell, L. F., Jagasia, M. H., Pusic, I., Wood, W. A., Renteria, A. S. & 17 others, Yanik, G., Hogan, W. J., Hexner, E., Ayuk, F., Holler, E., Bunworasate, U., Efebera, Y. A., Ferrara, J. L. M., Pidala, J., Howard, A., Wu, J., Bolaños-Meade, J., Ho, V., Alousi, A., Blazar, B. R., Weisdorf, D. J. & MacMillan, M. L., Aug 14 2018, In : Blood Advances. 2, 15, p. 1882-1888 7 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

A novel approach to improve immune effector responses post transplant by restoration of CCL21 expression

Stefanski, H. E., Jonart, L., Goren, E., Mulé, J. J. & Blazar, B. R., Apr 2018, In : PloS one. 13, 4, e0193461.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

ARID5B regulates metabolic programming in human adaptive NK cells

Cichocki, F. M., Wu, C-Y., Zhang, B., Felices, M., Tesi, B., Tuininga, K., Dougherty, P., Taras, E., Hinderlie, P., Blazar, B. R., Bryceson, Y. T. & Miller, J. S., 2018, In : Journal of Experimental Medicine. 215, 9, p. 2379-2395 17 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Association between recipient TNF rs361525 and acute GVHD: results from analysis of BMT CTN-0201 samples

Rashidi, A., Shanley, R., Yohe, S. L., Thyagarajan, B., Curtsinger, J., Anasetti, C., Waller, E. K., Miller, J. S., Blazar, B. R. & Weisdorf, D. J., Aug 1 2018, In : Bone marrow transplantation. 53, 8, p. 1069-1071 3 p.

Research output: Contribution to journalLetter

Open Access
1 Scopus citations

B-cell targeting in chronic graft-versus-host disease

Zeiser, R., Sarantopoulos, S. & Blazar, B. R., Mar 29 2018, In : Blood. 131, 13, p. 1399-1405 7 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Bortezomib-based immunosuppression after reduced-intensity conditioning hematopoietic stem cell transplantation: Randomized phase II results

Koreth, J., Kim, H. T., Lange, P. B., Poryanda, S. J., Reynolds, C. G., Chamling Rai, S., Armand, P., Cutler, C. S., Ho, V. T., Glotzbecker, B., Yusuf, R., Nikiforow, S., Chen, Y. B., Dey, B., McMasters, M., Ritz, J., Blazar, B. R., Soiffer, R. J., Antin, J. H. & Alyea, E. P., Feb 28 2018, In : Haematologica. 103, 3, p. 522-530 9 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans

Verghese, D. A., Chun, N., Paz, K., Fribourg, M., Woodruff, T. M., Flynn, R., Hu, Y., Xiong, H., Zhang, W., Yi, Z., Du, J., Blazar, B. R. & Heeger, P. S., Dec 20 2018, In : JCI Insight. 3, 24

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates

Watkins, B. K., Tkachev, V., Furlan, S. N., Hunt, D. J., Betz, K., Yu, A., Brown, M., Poirier, N., Zheng, H. B., Taraseviciute, A., Colonna, L., Mary, C., Blancho, G., Soulillou, J. P., Panoskaltsis-Mortari, A., Sharma, P., Garcia, A., Strobert, E., Hamby, K., Garrett, A. & 4 others, Deane, T., Blazar, B. R., Vanhove, B. & Kean, L. S., Aug 31 2018, In : Journal of Clinical Investigation. 128, 9, p. 3991-4007 17 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Chimeric antigen receptor T cell–mediated neurotoxicity in nonhuman primates

Taraseviciute, A., Tkachev, V., Ponce, R., Turtle, C. J., Snyder, J. M., Liggitt, H. D., Myerson, D., Gonzalez-Cuyar, L., Baldessari, A., English, C., Yu, A., Zheng, H., Furlan, S. N., Hunt, D. J., Hoglund, V., Finney, O., Brakke, H., Blazar, B. R., Berger, C., Riddell, S. R. & 3 others, Gardner, R., Kean, L. S. & Jensen, M. C., Jun 2018, In : Cancer discovery. 8, 6, p. 750-763 14 p.

Research output: Contribution to journalArticle

Open Access
73 Scopus citations
Open Access
35 Scopus citations

Corrections: B cells drive autoimmunity in mice with CD28-deficient regulatory T cells (Journal of Immunology (2017) 199 (3972-3980) DOI: 10.4049/jimmunol.1700409)

Zhang, R., Sage, P. T., Finn, K., Huynh, A., Blazar, B. R., Marangoni, F., Mempel, T. R., Sharpe, A. H. & Turka, L. A., Apr 1 2018, In : Journal of Immunology. 200, 7, p. 2505-2506 2 p.

Research output: Contribution to journalComment/debate

Open Access

Crispr/cas9-based cellular engineering for targeted gene overexpression

Osborn, M. J., Lees, C. J., McElroy, A. N., Merkel, S. C., Eide, C. R., Mathews, W., Feser, C. J., Tschann, M., McElmury, R. T., Webber, B. R., Kim, C. J., Blazar, B. R. & Tolar, J., Apr 2018, In : International journal of molecular sciences. 19, 4, 946.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets

Priyadharshini, B., Loschi, M., Newton, R. H., Zhang, J. W., Finn, K. K., Gerriets, V. A., Huynh, A., Rathmell, J. C., Blazar, B. R. & Turka, L. A., Oct 15 2018, In : Journal of Immunology. 201, 8, p. 2215-2219 5 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Delayed immune reconstitution after allogeneic transplantation increases the risks of mortality and chronic GVHD

Bejanyan, N., Brunstein, C. G., Cao, Q., Lazaryan, A., Luo, X., Curtsinger, J. M., Mehta, R. S., Warlick, E. D., Cooley, S. A., Blazar, B. R., Miller, J. S., Weisdorf, D., Wagner, J. E. & Verneris, M. R., Apr 24 2018, In : Blood Advances. 2, 8, p. 909-922 14 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development

Stefanski, H. E., Xing, Y., Taylor, P. A., Maio, S., Henao-Meija, J., Williams, A., Flavell, R. A., Hollander, G. A. & Blazar, B. R., Jun 2018, In : PloS one. 13, 6, e0198871.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

Johnson, M. O., Wolf, M. M., Madden, M. Z., Andrejeva, G., Sugiura, A., Contreras, D. C., Maseda, D., Liberti, M. V., Paz, K., Kishton, R. J., Johnson, M. E., de Cubas, A. A., Wu, P., Li, G., Zhang, Y., Newcomb, D. C., Wells, A. D., Restifo, N. P., Rathmell, W. K., Locasale, J. W. & 3 others, Davila, M. L., Blazar, B. R. & Rathmell, J. C., Dec 13 2018, In : Cell. 175, 7, p. 1780-1795.e19

Research output: Contribution to journalArticle

Open Access
85 Scopus citations
Open Access
5 Scopus citations

Effects of MicroRNA on regulatory T Cells and implications for adoptive cellular therapy to ameliorate graft-versus-host disease

Hippen, K. L., Loschi, M., Nicholls, J., MacDonald, K. P. A. & Blazar, B. R., Jan 31 2018, In : Frontiers in immunology. 9, JAN, 57.

Research output: Contribution to journalShort survey

Open Access
14 Scopus citations

First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation

Romee, R., Cooley, S., Berrien-Elliott, M. M., Westervelt, P., Verneris, M. R., Wagner, J. E., Weisdorf, D. J., Blazar, B. R., Ustun, C., DeFor, T. E., Vivek, S., Peck, L., DiPersio, J. F., Cashen, A. F., Kyllo, R., Musiek, A., Schaffer, A., Anadkat, M. J., Rosman, I., Miller, D. & 6 others, Egan, J. O., Jeng, E. K., Rock, A., Wong, H. C., Fehniger, T. A. & Miller, J. S., Jun 7 2018, In : Blood. 131, 23, p. 2515-2527 13 p.

Research output: Contribution to journalArticle

Open Access
94 Scopus citations
Open Access
18 Scopus citations

Helminth-Induced Production of TGF-b and Suppression of Graft-versus-Host Disease Is Dependent on IL-4 Production by Host Cells

Li, Y., Guan, X., Liu, W., Chen, H. L., Beyatli, S., Metwali, A., Weiner, G. J., Zavazava, N., Blumberg, R. S., Urban, J. F., Blazar, B. R., Elliott, D. E. & Ince, M. N., Nov 15 2018, In : Journal of Immunology. 201, 10, p. 2910-2922 13 p.

Research output: Contribution to journalArticle

Open Access

How ibrutinib, a B-cell malignancy drug, became an FDA-approved second-line therapy for steroid-resistant chronic GVHD

Jaglowski, S. M. & Blazar, B. R., Aug 14 2018, In : Blood Advances. 2, 15, p. 2012-2019 8 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Human CD19-Targeted Mouse T Cells Induce B Cell Aplasia and Toxicity in Human CD19 Transgenic Mice

Pennell, C. A., Barnum, J. L., McDonald-Hyman, C. S., Panoskaltsis-Mortari, A., Riddle, M. J., Xiong, Z., Loschi, M., Thangavelu, G., Campbell, H. M., Storlie, M. D., Refaeli, Y., Furlan, S. N., Jensen, M. C., Kean, L. S., Miller, J. S., Tolar, J., Osborn, M. J. & Blazar, B. R., Jun 6 2018, In : Molecular Therapy. 26, 6, p. 1423-1434 12 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Identification of cellular sources of IL-2 needed for regulatory T cell development and homeostasis

Owen, D. L., Mahmud, S. A., Vang, K. B., Kelly, R. M., Blazar, B. R., Smith, K. A. & Farrar, M. A., Jun 15 2018, In : Journal of Immunology. 200, 12, p. 3926-3933 8 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations