1982 …2020

Research output per year

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Research Output

2020

An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease

Rashidi, A., Herman, A., Gomes, A. L. C., Peled, J. U., Jenq, R. R., Brereton, D. G., Staley, C., Blazar, B. R. & Weisdorf, D. J., Jun 1 2020, In : British journal of haematology. 189, 5, p. 926-930 5 p.

Research output: Contribution to journalArticle

Open Access

Base Editor Correction of COL7A1 in Recessive Dystrophic Epidermolysis Bullosa Patient-Derived Fibroblasts and iPSCs

Osborn, M. J., Newby, G. A., McElroy, A. N., Knipping, F., Nielsen, S. C., Riddle, M. J., Xia, L., Chen, W., Eide, C. R., Webber, B. R., Wandall, H. H., Dabelsteen, S., Blazar, B. R., Liu, D. R. & Tolar, J., Feb 2020, In : Journal of Investigative Dermatology. 140, 2, p. 338-347.e5

Research output: Contribution to journalArticle

4 Scopus citations

Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD

Blazar, B. R., Hill, G. R. & Murphy, W. J., Aug 1 2020, In : Nature Reviews Clinical Oncology. 17, 8, p. 475-492 18 p.

Research output: Contribution to journalReview article

1 Scopus citations

Distinct Regulatory and Effector T Cell Metabolic Demands during Graft-Versus-Host Disease

Hippen, K. L., Aguilar, E. G., Rhee, S. Y., Bolivar-Wagers, S. & Blazar, B. R., Jan 2020, In : Trends in Immunology. 41, 1, p. 77-91 15 p.

Research output: Contribution to journalReview article

Open Access

Effective Multi-lineage Engraftment in a Mouse Model of Fanconi Anemia Using Non-genotoxic Antibody-Based Conditioning

Srikanthan, M. A., Humbert, O., Haworth, K. G., Ironside, C., Rajawat, Y. S., Blazar, B. R., Palchaudhuri, R., Boitano, A. E., Cooke, M. P., Scadden, D. T. & Kiem, H. P., Jun 12 2020, In : Molecular Therapy - Methods and Clinical Development. 17, p. 455-464 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access

GCNT1-mediated O-glycosylation of the sialomucin CD43 is a sensitive indicator of notch signaling in activated T cells

Perkey, E., De Sousa, D. M., Carrington, L., Chung, J., Dils, A., Granadier, D., Koch, U., Radtke, F., Ludewig, B., Blazar, B. R., Siebel, C. W., Brennan, T. V., Nolz, J., Labrecque, N. & Maillard, I., Mar 15 2020, In : Journal of Immunology. 204, 6, p. 1674-1688 15 p.

Research output: Contribution to journalArticle

Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia

Mathew, N. R., Vinnakota, J. M., Apostolova, P., Erny, D., Hamarsheh, S., Andrieux, G., Kim, J. S., Hanke, K., Goldmann, T., Chappell-Maor, L., El-Khawanky, N., Ihorst, G., Schmidt, D., Duyster, J., Finke, J., Blank, T., Boerries, M., Blazar, B. R., Jung, S., Prinz, M. & 1 others, Zeiser, R., Mar 2 2020, In : Journal of Clinical Investigation. 130, 3, p. 1315-1329 15 p.

Research output: Contribution to journalArticle

Open Access

IL-2 enhances ex vivo-expanded regulatory T-cell persistence after adoptive transfer

Furlan, S. N., Singh, K., Lopez, C., Tkachev, V., Hunt, D. J., Hibbard, J., Betz, K. M., Blazar, B. R., Trapnell, C. & Kean, L. S., Apr 28 2020, In : Blood Advances. 4, 8, p. 1594-1605 12 p.

Research output: Contribution to journalArticle

Open Access

Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease

Thangavelu, G., Du, J., Paz, K. G., Loschi, M., Zaiken, M. C., Flynn, R., Taylor, P. A., Kirchmeier, A. K., Panoskaltsis-Mortari, A., Luznik, L., MacDonald, K. P., Hill, G. R., Maillard, I., Munn, D. H., Serody, J. S., Murphy, W. J., Miklos, D., Cutler, C. S., Koreth, J., Antin, J. H. & 5 others, Soiffer, R. J., Ritz, J., Dahlberg, C., Miller, A. T. & Blazar, B. R., Jan 1 2020, In : Blood. 135, 1, p. 28-40 13 p.

Research output: Contribution to journalArticle

Interleukin-27 Enforces Regulatory T Cell Functions to Prevent Graft-versus-Host Disease

Le, H. T., Keslar, K., Nguyen, Q. T., Blazar, B. R., Hamilton, B. K. & Min, B., Feb 12 2020, In : Frontiers in immunology. 11, 181.

Research output: Contribution to journalArticle

Open Access

Mesenchymal stromal cells shape the MDS microenvironment by inducing suppressive monocytes that dampen NK cell function

Sarhan, D., Wang, J., Arvindam, U. S., Hallstrom, C., Verneris, M. R., Grzywacz, B., Warlick, E., Blazar, B. R. & Miller, J. S., Mar 12 2020, In : JCI Insight. 5, 5, e130155.

Research output: Contribution to journalArticle

Open Access

Metabolic reprogramming augments potency of human pSTAT3-inhibited iTregs to suppress alloreactivity

Walton, K., Fernandez, M. R., Sagatys, E. M., Reff, J., Kim, J., Lee, M. C., Kiluk, J. V., Hui, J. Y. C., McKenna, D., Hupp, M., Forster, C., Linden, M. A., Lawrence, N. J., Lawrence, H. R., Pidala, J., Pavletic, S. Z., Blazar, B. R., Sebti, S. M., Cleveland, J. L., Anasetti, C. & 1 others, Betts, B. C., May 7 2020, In : JCI Insight. 5, 9, e136437.

Research output: Contribution to journalArticle

Open Access

Minimal PD-1 expression in mouse and human NK cells under diverse conditions

Judge, S. J., Dunai, C., Aguilar, E. G., Vick, S. C., Sturgill, I. R., Khuat, L. T., Stoffel, K. M., Van Dyke, J., Longo, D. L., Darrow, M. A., Anderson, S. K., Blazar, B. R., Monjazeb, A. M., Serody, J. S., Canter, R. J. & Murphy, W. J., Jun 1 2020, In : Journal of Clinical Investigation. 130, 6, p. 3051-3068 18 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function

Field, C. S., Baixauli, F., Kyle, R. L., Puleston, D. J., Cameron, A. M., Sanin, D. E., Hippen, K. L., Loschi, M., Thangavelu, G., Corrado, M., Edwards-Hicks, J., Grzes, K. M., Pearce, E. J., Blazar, B. R. & Pearce, E. L., Feb 4 2020, In : Cell Metabolism. 31, 2, p. 422-437.e5

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation

Hamarsheh, S., Osswald, L., Saller, B. S., Unger, S., De Feo, D., Vinnakota, J. M., Konantz, M., Uhl, F. M., Becker, H., Lübbert, M., Shoumariyeh, K., Schürch, C., Andrieux, G., Venhoff, N., Schmitt-Graeff, A., Duquesne, S., Pfeifer, D., Cooper, M. A., Lengerke, C., Boerries, M. & 8 others, Duyster, J., Niemeyer, C. M., Erlacher, M., Blazar, B. R., Becher, B., Groß, O., Brummer, T. & Zeiser, R., Dec 1 2020, In : Nature communications. 11, 1, 1659.

Research output: Contribution to journalArticle

Open Access
Open Access
4 Scopus citations

Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration

Piao, W., Xiong, Y., Li, L., Saxena, V., Smith, K. D., Hippen, K. L., Paluskievicz, C., Willsonshirkey, M., Blazar, B. R., Abdi, R. & Bromberg, J. S., Jan 28 2020, In : Cell reports. 30, 4, p. 1052-1062.e5

Research output: Contribution to journalArticle

Open Access

Reopening Schools Safely: The Case for Collaboration, Constructive Disruption of Pre-Coronavirus 2019 Expectations, and Creative Solutions

Cooper, D. M., Guay-Woodford, L., Blazar, B. R., Bowman, S., Byington, C. L., Dome, J., Forthal, D., Konstan, M. W., Kuppermann, N., Liem, R. I., Ochoa, E. R., Pollock, B. H., Price, O. A., Ramsey, B. W., Ross, L. F., Sokol, R. J. & Wright, R. J., Aug 2020, In : Journal of Pediatrics. 223, p. 183-185 3 p.

Research output: Contribution to journalComment/debate

Open Access

Salmonella-mediated therapy targeting indoleamine 2, 3-dioxygenase 1 (IDO) activates innate immunity and mitigates colorectal cancer growth

Phan, T., Nguyen, V. H., D’Alincourt, M. S., Manuel, E. R., Kaltcheva, T., Tsai, W., Blazar, B. R., Diamond, D. J. & Melstrom, L. G., Apr 1 2020, In : Cancer gene therapy. 27, 3-4, p. 235-245 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

STING differentially regulates experimental GVHD mediated by CD8 versus CD4 T cell subsets

Bader, C. S., Barreras, H., Lightbourn, C. O., Copsel, S. N., Wolf, D., Meng, J., Ahn, J., Komanduri, K. V., Blazar, B. R., Jin, L., Barber, G. N., Roy, S. & Levy, R. B., Jul 15 2020, In : Science Translational Medicine. 12, 552

Research output: Contribution to journalArticle

The lymph node stromal laminin α5 shapes alloimmunity

Li, L., Shirkey, M. W., Zhang, T., Xiong, Y., Piao, W., Saxena, V., Paluskievicz, C., Lee, Y., Toney, N., Cerel, B. M., Li, Q., Simon, T., Smith, K. D., Hippen, K. L., Blazar, B. R., Abdi, R. & Bromberg, J. S., May 1 2020, In : Journal of Clinical Investigation. 130, 5, p. 2602-2619 18 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Tissue mast cell counts may be associated with decreased severity of gastrointestinal acute GVHD and nonrelapse mortality

Ustun, C., DeFor, T. E., Karadag, F. K., Yun, H. D., Nathan, S., Brunstein, C. G., Blazar, B. R., Weisdorf, D. J., Holtan, S. G. & Amin, K., May 26 2020, In : Blood Advances. 4, 10, p. 2317-2324 8 p.

Research output: Contribution to journalArticle

Open Access

Validation of Minnesota acute graft-versus-host disease Risk Score

MacMillan, M. L., DeFor, T. E., Holtan, S. G., Rashidi, A., Blazar, B. R. & Weisdorf, D. J., Jan 31 2020, In : Haematologica. 105, 2, p. 519-524 6 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance

ElTanbouly, M. A., Zhao, Y., Nowak, E., Li, J., Schaafsma, E., Le Mercier, I., Ceeraz, S., Lines, J. L., Peng, C., Carriere, C., Huang, X., Day, M., Koehn, B., Lee, S. W., Morales, M. S., Hogquist, K. A., Jameson, S. C., Mueller, D., Rothstein, J., Blazar, B. R. & 2 others, Cheng, C. & Noelle, R. J., Jan 17 2020, In : Science. 367, 6475, eaay0524.

Research output: Contribution to journalArticle

6 Scopus citations

β2-Adrenergic receptor activation on donor cells ameliorates acute GvHD

Mohammadpour, H., Sarow, J. L., MacDonald, C. R., Chen, G. L., Qiu, J., Sharma, U. C., Cao, X., Herr, M. M., Hahn, T. E., Blazar, B. R., Repasky, E. A. & McCarthy, P. L., Jun 18 2020, In : JCI Insight. 5, 12

Research output: Contribution to journalArticle

Open Access
2019

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Paczulla, A. M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., Nievergall, E., Dörfel, D., Hanns, P., Passweg, J. R., Lutz, C., Schwaller, J., Zeiser, R., Blazar, B. R., Caligiuri, M. A., Dirnhofer, S. & 7 others, Lundberg, P., Kanz, L., Quintanilla-Martinez, L., Steinle, A., Trumpp, A., Salih, H. R. & Lengerke, C., Aug 8 2019, In : Nature. 572, 7768, p. 254-259 6 p.

Research output: Contribution to journalLetter

Open Access
24 Scopus citations

Achievement of tolerance induction to prevent acute graft-vs.-host disease

Thangavelu, G. & Blazar, B. R., Jan 1 2019, In : Frontiers in immunology. 10, MAR, 309.

Research output: Contribution to journalReview article

Open Access
6 Scopus citations

A confirmation of chronic graft-versus-host disease prediction using allogeneic HY antibodies following sex-mismatched hematopoietic cell transplantation

Paul, J., Nakasone, H., Sahaf, B., Wu, F., Wang, K., Ho, V., Wu, J., Kim, H., Blazar, B., Ritz, J., Howard, A., Cutler, C. & Miklos, D., Jun 30 2019, In : Haematologica. 104, 7, p. e314-e317

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells

Sinha, R. K., Flynn, R., Zaiken, M., Paz, K., Gavin, A. L., Nemazee, D., Fernández, J. A., Xu, X., Griffin, J. H. & Blazar, B. R., Aug 29 2019, In : Blood. 134, 9, p. 776-781 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Adaptive NK cell reconstitution is associated with better clinical outcomes

Cichocki, F., Taras, E., Chiuppesi, F., Wagner, J. E., Blazar, B. R., Brunstein, C., Luo, X., Diamond, D. J., Cooley, S., Weisdorf, D. J. & Miller, J. S., Jan 24 2019, In : JCI Insight. 4, 2, Y.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
1 Scopus citations

Analysis of BMT CTN-0201 and -0901 samples did not reproduce the reported association between recipient REG3A rs7588571 and chronic GVHD

Rashidi, A., Shanley, R., Anasetti, C., Waller, E. K., Scott, B. L., Blazar, B. R. & Weisdorf, D. J., Mar 1 2019, In : Bone marrow transplantation. 54, 3, p. 490-493 4 p.

Research output: Contribution to journalArticle

Open Access

CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration

Xiong, Y., Piao, W., Colin Brinkman, C., Li, L., Kulinski, J. M., Olivera, A., Cartier, A., Hla, T., Hippen, K. L., Blazar, B. R., Schwab, S. R. & Bromberg, J. S., Mar 15 2019, In : Science Immunology. 4, 33, eaav1263.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Chimeric antigen receptor costimulation domains modulate human regulatory T cell function

Boroughs, A. C., Larson, R. C., Choi, B. D., Bouffard, A. A., Riley, L. S., Schiferle, E., Kulkarni, A. S., Cetrulo, C. L., Ting, D., Blazar, B. R., Demehri, S. & Maus, M. V., 2019, In : JCI Insight. 4, 8, e126194.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Chronic stimulation drives human NK cell dysfunction and epigenetic reprograming

Merino, A., Zhang, B., Dougherty, P., Luo, X., Wang, J., Blazar, B. R., Miller, J. S. & Cichocki, F., Sep 3 2019, In : Journal of Clinical Investigation. 129, 9, p. 3770-3785 16 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol

MacDonald, K. N., Ivison, S., Hippen, K. L., Hoeppli, R. E., Hall, M., Zheng, G., Dijke, I. E., Aklabi, M. A., Freed, D. H., Rebeyka, I., Gandhi, S., West, L. J., Piret, J. M., Blazar, B. R. & Levings, M. K., Dec 2019, In : Cytotherapy. 21, 12, p. 1216-1233 18 p.

Research output: Contribution to journalArticle

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD

Koehn, B. H., Saha, A., McDonald-Hyman, C., Loschi, M., Thangavelu, G., Ma, L., Zaiken, M., Dysthe, J., Krepps, W., Panthera, J., Hippen, K., Jameson, S. C., Miller, J. S., Cooper, M. A., Farady, C. J., Iwawaki, T., Ting, J. P. Y., Serody, J. S., Murphy, W. J., Hill, G. R. & 5 others, Murray, P. J., Bronte, V., Munn, D. H., Zeiser, R. & Blazar, B. R., Nov 7 2019, In : Blood. 134, 19, p. 1670-1682 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality

Thangavelu, G., Lee, Y. C., Loschi, M., Melanie Schaechter, K., Feser, C. J., Koehn, B., Nowak, E. C., Zeiser, R., Serody, J. S., Murphy, W. J., Munn, D. H., Chambon, P., Noelle, R. J. & Blazar, B. R., May 1 2019, In : Journal of Immunology. 202, 9, p. 2795-2805 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets

Tanimine, N., Germana, S. K., Fan, M., Hippen, K., Blazar, B. R., Markmann, J. F., Turka, L. A. & Priyadharshini, B., Jun 2019, In : PloS one. 14, 6, e0217761.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node

Simon, T., Li, L., Wagner, C., Zhang, T., Saxena, V., Brinkman, C. C., Tostanoski, L. H., Ostrand-Rosenberg, S., Jewell, C., Shea-Donohue, T., Hippen, K., Blazar, B., Abdi, R. & Bromberg, J. S., Oct 1 2019, In : Transplantation. 103, 10, p. 2075-2089 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality

Saha, A., Taylor, P. A., Lees, C. J., Panoskaltsis-Mortari, A., Osborn, M. J., Feser, C. J., Thangavelu, G., Melchinger, W., Refaeli, Y., Hill, G. R., Munn, D. H., Murphy, W. J., Serody, J. S., Maillard, I., Kreymborg, K., van den Brink, M., Dong, C., Huang, S., Zang, X., Allison, J. P. & 2 others, Zeiser, R. & Blazar, B. R., 2019, In : JCI Insight. 4, 19, e127716.

Research output: Contribution to journalArticle

Open Access

Dose-escalated interleukin-2 therapy for refractory chronic graft-versus-host disease in adults and children

Whangbo, J. S., Kim, H. T., Mirkovic, N., Leonard, L., Poryanda, S., Silverstein, S., Kim, S., Reynolds, C. G., Rai, S. C., Verrill, K., Lee, M. A., Margossian, S., Duncan, C., Lehmann, L., Huang, J., Nikiforow, S., Alyea, E. P., Armand, P., Cutler, C. S., Ho, V. T. & 5 others, Blazar, B. R., Antin, J. H., Soiffer, R. J., Ritz, J. & Koreth, J., Sep 10 2019, In : Blood Advances. 3, 17, p. 2550-2561 12 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
1 Scopus citations
Open Access

Early notch signals induce a pathogenic molecular signature during priming of alloantigen-specific conventional CD4+ T cells in graft-versus-host disease

Chung, J., Radojcic, V., Perkey, E., Parnell, T. J., Niknafs, Y., Jin, X., Friedman, A., Labrecque, N., Blazar, B. R., Brennan, T. V., Siebel, C. W. & Maillard, I., 2019, In : Journal of Immunology. 203, 2, p. 557-568 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Efficacy and immunologic effects of extracorporeal photopheresis plus interleukin-2 in chronic graft-versus-host disease

Belizaire, R., Kim, H. T., Poryanda, S. J., Mirkovic, N. V., Hipolito, E., Savage, W. J., Reynolds, C. G., Fields, M. J., Whangbo, J., Kubo, T., Nikiforow, S., Alyea, E. P., Armand, P., Cutler, C. S., Ho, V. T., Blazar, B. R., Antin, J. H., Ritz, J., Soiffer, R. J. & Koreth, J., Apr 9 2019, In : Blood Advances. 3, 7, p. 969-979 11 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

First-in-human trial of rhIL-15 and haploidentical natural killer cell therapy for advanced acute myeloid leukemia

Cooley, S., He, F., Bachanova, V., Vercellotti, G. M., DeFor, T. E., Curtsinger, J. M., Robertson, P., Grzywacz, B., Conlon, K. C., Waldmann, T. A., McKenna, D. H., Blazar, B. R., Weisdorf, D. J. & Miller, J. S., 2019, In : Blood Advances. 3, 13, p. 1970-1980 11 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations