Brian Herman

Willing to speak to media

1977 …2020

Research output per year

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Research Output

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Article
2016

Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment

Lopez-Cruzan, M., Sharma, R., Tiwari, M., Karbach, S., Holstein, D., Martin, C. R., Lechleiter, J. D. & Herman, B., Dec 12 2016, In : Cell Death Discovery. 2, 1, 16005.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations
2015

Caspase-2 modulates osteoclastogenesis through down-regulating oxidative stress

Callaway, D. A., Riquelme, M. A., Sharma, R., Lopez-Cruzan, M., Herman, B. A. & Jiang, J. X., Jul 1 2015, In : Bone. 76, p. 40-48 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

A nonapoptotic role for CASP2/caspase 2: Modulation of autophagy

Tiwari, M., Sharma, L. K., Vanegas, D., Callaway, D. A., Bai, Y., Lechleiter, J. D. & Herman, B., Jun 2014, In : Autophagy. 10, 6, p. 1054-1070 17 p.

Research output: Contribution to journalArticle

35 Scopus citations

Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts

Sharma, R., Callaway, D., Vanegas, D., Bendele, M., Lopez-Cruzan, M., Horn, D., Guda, T., Fajardo, R., Abboud-Werner, S. & Herman, B., Apr 1 2014, In : PloS one. 9, 4, e93696.

Research output: Contribution to journalArticle

14 Scopus citations
2013

Loss of caspase-2 accelerates age-dependent alterations in mitochondrial production of reactive oxygen species

Lopez-Cruzan, M. & Herman, B., Apr 1 2013, In : Biogerontology. 14, 2, p. 121-130 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2011

A knockout of the caspase 2 gene produces increased resistance of the nigrostriatal dopaminergic pathway to MPTP-induced toxicity

Tiwari, M., Herman, B. & Morgan, W. W., Jun 1 2011, In : Experimental Neurology. 229, 2, p. 421-428 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Loss of caspase-2-dependent apoptosis induces autophagy after mitochondrial oxidative stress in primary cultures of young adult cortical neurons

Tiwari, M., Lopez-Cruzan, M., Morgan, W. W. & Herman, B., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 8493-8506 14 p.

Research output: Contribution to journalArticle

53 Scopus citations
2008
11 Scopus citations

Nonlinear scaling analysis of glucose metabolism in normal and cancer cells

Ramanujan, V. K. & Herman, B. A., Dec 1 2008, In : Journal of biomedical optics. 13, 3, 031219.

Research output: Contribution to journalArticle

9 Scopus citations

Spatially resolved fluorescence lifetime mapping of enzyme kinetics in living cells

Ramanujan, V. K., Jo, J. A., Cantu, G. & Herman, B. A., Jun 1 2008, In : Journal of Microscopy. 230, 3, p. 329-338 10 p.

Research output: Contribution to journalArticle

22 Scopus citations
2007

Aging process modulates nonlinear dynamics in liver cell metabolism

Ramanujan, V. K. & Herman, B. A., Jun 29 2007, In : Journal of Biological Chemistry. 282, 26, p. 19217-19226 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Caspase-2 deficiency enhances aging-related traits in mice

Zhang, Y., Padalecki, S. S., Chaudhuri, A. R., De Waal, E., Goins, B. A., Grubbs, B., Ikeno, Y., Richardson, A., Mundy, G. R. & Herman, B., Feb 1 2007, In : Mechanisms of Ageing and Development. 128, 2, p. 213-221 9 p.

Research output: Contribution to journalArticle

60 Scopus citations
2006

ARC protects rat cardiomyocytes against oxidative stress through inhibition of caspase-2 mediated mitochondrial pathway

Zhang, Y. Q. & Herman, B., Oct 1 2006, In : Journal of Cellular Biochemistry. 99, 2, p. 575-588 14 p.

Research output: Contribution to journalArticle

28 Scopus citations

Scaling behavior in mitochondrial redox fluctuations

Ramanujan, V. K., Biener, G. & Herman, B. A., May 2006, In : Biophysical journal. 90, 10, p. L70-L72

Research output: Contribution to journalArticle

17 Scopus citations

Spatio-temporal kinetics of growth hormone receptor signaling in single cells using FRET microscopy

Biener-Ramanujan, E., Ramanujan, V. K., Herman, B. & Gertler, A., Aug 1 2006, In : Growth Hormone and IGF Research. 16, 4, p. 247-257 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Spectral kinetics ratiometry: A simple approach for real-time monitoring of fluorophore distributions in living cells

Ramanujan, V. K., Biener-Ramanujan, E., Armmer, K., Centonze, V. E. & Herman, B. A., Aug 1 2006, In : Cytometry Part A. 69, 8, p. 912-919 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2005

Identification of the hydrophobia strand in the A-B loop of leptin as major binding site III: Implications for large-scale preparation of potent recombinant human and ovine leptin antagonists

Niv-Spector, L., Gonen-Berger, D., Gourdou, I., Biener, E., Gussakovsky, E. E., Benomar, Y., Ramanujan, K. V., Taouis, M., Herman, B., Callebaut, I., Djiane, J. & Gertler, A., Oct 15 2005, In : Biochemical Journal. 391, 2, p. 221-230 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

Monitoring mitochondrial caspase-2 activity in intact cells by streak camera based fluorescence lifetime imaging microscopy

Herman, B. A., Zhang, J. H., Ramanujan, V. K., Lopez-Cruzan, M., Medina, S. & Centonze, V. E., Aug 25 2005, In : Microscopy and Microanalysis. 11, SUPPL. 2, p. 8-9 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Multiphoton fluorescence lifetime contrast in deep tissue imaging: Prospects in redox imaging and disease diagnosis

Ramanujan, V. K., Zhang, J. H., Biener, E. & Herman, B., Sep 1 2005, In : Journal of biomedical optics. 10, 5, 051407.

Research output: Contribution to journalArticle

45 Scopus citations

Quantitative FRET imaging of leptin receptor oligomerization kinetics in single cells

Ramanujan, V. K., Biener, E., Charlier, M., Daniel, N., Eisenberg, A., Herman, B., Djiane, J. & Gertler, A., Aug 25 2005, In : Microscopy and Microanalysis. 11, SUPPL. 2, p. 10-11 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Quantitative FRET imaging of leptin receptor oligomerization kinetics in single cells

Biener, E., Charlier, M., Ramanujan, V. K., Daniel, N., Eisenberg, A., Bjørbaek, C., Herman, B., Gertler, A. & Djiane, J., Dec 1 2005, In : Biology of the Cell. 97, 12, p. 905-919 15 p.

Research output: Contribution to journalArticle

32 Scopus citations
2004

Detection of mitochondrial caspase activity in real time in situ in live cells

Zhang, Y., Haskins, C., Lopez-Cruzan, M., Zhang, J., Centonze, V. E. & Herman, B., Aug 1 2004, In : Microscopy and Microanalysis. 10, 4, p. 442-448 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Discrimination of depolarized from polarized mitochondria by confocal fluorescence resonance energy transfer

Elmore, S. P., Nishimura, Y., Qian, T., Herman, B. & Lemasters, J. J., Feb 15 2004, In : Archives of Biochemistry and Biophysics. 422, 2, p. 145-152 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Oxidative stress-induced apoptosis is associated with alterations in mitochondrial caspase activity and Bcl-2-dependent alterations in mitochondrial pH (pHm)

Takahashi, A., Masuda, A., Sun, M., Centonze, V. E. & Herman, B., Feb 15 2004, In : Brain Research Bulletin. 62, 6, p. 497-504 8 p.

Research output: Contribution to journalArticle

149 Scopus citations

Transactivation of erbB2 by short and long isoforms of leptin receptors

Eisenberg, A., Biener, E., Charlier, M., Krishnan, R. V., Djiane, J., Herman, B. & Gertler, A., May 7 2004, In : FEBS Letters. 565, 1-3, p. 139-142 4 p.

Research output: Contribution to journalArticle

39 Scopus citations

Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis

Ran, Q., Liang, H., Gu, M., Qi, W., Walter, C. A., Roberts, L. J., Herman, B., Richardson, A. & Van Remmen, H., Dec 31 2004, In : Journal of Biological Chemistry. 279, 53, p. 55137-55146 10 p.

Research output: Contribution to journalArticle

152 Scopus citations
2003

Development of a multiphoton fluorescence lifetime imaging microscopy system using a streak camera

Krishnan, R. V., Saitoh, H., Terada, H., Centonze, V. E. & Herman, B., May 1 2003, In : Review of Scientific Instruments. 74, 5, p. 2714-2721 8 p.

Research output: Contribution to journalArticle

91 Scopus citations

Fluorescence resonance energy transfer imaging microscopy

Centonze, V. E., Sun, M., Masuda, A., Gerritsen, H. & Herman, B., Jan 1 2003, In : Methods in Enzymology. 360, p. 542-560 19 p.

Research output: Contribution to journalArticle

38 Scopus citations

FRET and FLIM microscopy in the study of the role of oxidative stress and apoptosis in aging

Zhang, Y., Zhang, J., Masuda, A., Lopez-Cruzan, M., Centonze, V., Krishnan, R. V. & Herman, B., Sep 4 2003, In : Microscopy and Microanalysis. 9, SUPPL. 2, p. 226-227 2 p.

Research output: Contribution to journalArticle

2 Scopus citations
35 Scopus citations

Probing subtle fluorescence dynamics in cellular proteins by streak camera based fluorescence lifetime imaging microscopy

Krishnan, R. V., Biener, E., Zhang, J. H., Heckel, R. & Herman, B., Dec 1 2003, In : Applied Physics Letters. 83, 22, p. 4658-4660 3 p.

Research output: Contribution to journalArticle

25 Scopus citations
2002

Age-associated increases in the activity of multiple caspases in Fisher 344 rat organs

Zhang, Y., Chong, E. & Herman, B., Jun 1 2002, In : Experimental Gerontology. 37, 6, p. 777-789 13 p.

Research output: Contribution to journalArticle

63 Scopus citations

Fluorescence microscopy.

Herman, B., May 2002, In : Current protocols in immunology / edited by John E. Coligan ... [et al.]. Chapter 21, p. Unit 21.2

Research output: Contribution to journalArticle

FRET imaging microscopy

Herman, B., Sun, M., Masuda, A., Gerritsen, H. & Centonze, V., Jan 1 2002, In : Proceedings of SPIE - The International Society for Optical Engineering. 4620, p. 96-105 10 p.

Research output: Contribution to journalArticle

Human papillomavirus type 16 E6 and E7 gene variations in Indian cervical cancer

Pillai, M. R., Sreevidya, S., Pollock, B. H., Jayaprakash, P. G. & Herman, B., Jan 1 2002, In : Gynecologic oncology. 87, 3, p. 268-273 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Polymorphism at codon 72 of p53, human papillomavirus, and cervical cancer in South India

Pillai, M. R., Sreevidya, S., Pollock, B. H., Jayaprakash, P. G. & Herman, B., Dec 19 2002, In : Journal of Cancer Research and Clinical Oncology. 128, 11, p. 627-631 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Preparation and expression of biologically active prolactin and growth hormone receptors and suppressor of cytokine signaling proteins 1, 2, 3, and 6 tagged with cyan and yellow fluorescent proteins

Ben-Yair, L., Slaaby, R., Herman, A., Cohen, Y., Biener, E., Moran, N., Yoshimura, A., Whittaker, J., De Meyts, P., Herman, B. & Gertler, A., Nov 20 2002, In : Protein Expression and Purification. 25, 3, p. 456-464 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
2000

Differential sensitivity of mouse neural crest cells to ethanol-induced toxicity

Chen, S. Y., Periasamy, A., Yang, B., Herman, B., Jacobson, K. & Sulik, K. K., Jan 1 2000, In : Alcohol. 20, 1, p. 75-81 7 p.

Research output: Contribution to journalArticle

46 Scopus citations
35 Scopus citations

Localization of rat liver group IIA phospholipase A2 in secretory pathways: Green fluorescent protein approach

Zhang, Y., Lemasters, J. & Herman, B., Mar 1 2000, In : Microscopy and Microanalysis. 6, 2, p. 150-155 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Quantitative fluorescence microscopy

Centonze, V. E., Takahashi, A., Casanova, E. & Herman, B., Jan 1 2000, In : Journal of Histotechnology. 23, 3, p. 229-234 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
1999

Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death

Lemasters, J. J., Qian, T., Trost, L. C., Herman, B., Cascio, W. E., Bradham, C. A., Brenner, D. A. & Nieminen, A. L., Jan 1 1999, In : Biochemical Society symposium. 66, p. 205-222 18 p.

Research output: Contribution to journalArticle

30 Scopus citations

Novel mutant green fluorescent protein protease substrates reveal the activation of specific caspases during apoptosis

Mahajan, N. P., Harrison-Shostak, D. C., Michaux, J. & Herman, B., Jun 1999, In : Chemistry and Biology. 6, 6, p. 401-409 9 p.

Research output: Contribution to journalArticle

106 Scopus citations

Secretory group IIA phospholipase A2 generates anti-apoptotic survival signals in kidney fibroblasts

Zhang, Y., Lemasters, J. & Herman, B., Sep 24 1999, In : Journal of Biological Chemistry. 274, 39, p. 27726-27733 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187

Qian, T., Herman, B. & Lemasters, J. J., Jan 15 1999, In : Toxicology and Applied Pharmacology. 154, 2, p. 117-125 9 p.

Research output: Contribution to journalArticle

129 Scopus citations
1998

Bcl-2 and bax interactions in mitochondria probed with green fluorescent protein and fluorescence resonance energy transfer

Mahajan, N. P., Linder, K., Berry, G., Gordon, G. W., Heim, R. & Herman, B., Jun 1 1998, In : Nature biotechnology. 16, 6, p. 547-552 6 p.

Research output: Contribution to journalArticle

252 Scopus citations

Mitochondrial Ca2+ transients in cardiac myocytes during the excitation-contraction cycle: Effects of pacing and hormonal stimulation

Ohata, H., Chacon, E., Tesfai, S. A., Harper, I. S., Herman, B. & Lemasters, J. J., Jan 1 1998, In : Journal of Bioenergetics and Biomembranes. 30, 3, p. 207-222 16 p.

Research output: Contribution to journalArticle

49 Scopus citations

Protection against fatal sindbis virus encephalitis by Beclin, a novel Bcl-2-interacting protein

Liang, X. H., Kleeman, L. K., Jiang, H. H., Gordon, G., Goldman, J. E., Berry, G., Herman, B. & Levine, B., Nov 1 1998, In : Journal of virology. 72, 11, p. 8586-8596 11 p.

Research output: Contribution to journalArticle

808 Scopus citations

Quantitative fluorescence resonance energy transfer measurements using fluorescence microscopy

Gordon, G. W., Berry, G., Liang, X. H., Levine, B. & Herman, B., May 1998, In : Biophysical journal. 74, 5, p. 2702-2713 12 p.

Research output: Contribution to journalArticle

664 Scopus citations

Regulation of a calcium-dependent tyrosine kinase in vascular smooth muscle cells by angiotensin II and platelet-derived growth factor. Dependence on calcium and the actin cytoskeleton

Brinson, A. E., Harding, T., Diliberto, P. A., He, Y., Li, X., Hunter, D., Herman, B., Earp, H. S. & Graves, L. M., Jan 16 1998, In : Journal of Biological Chemistry. 273, 3, p. 1711-1718 8 p.

Research output: Contribution to journalArticle

110 Scopus citations