Projects per year
Personal profile
Personal profile
Dr. Brett Napiwocki is currently a Postdoctoral Associate in the Department of Pediatrics, Division of Hematology/Oncology working with Dr. Beau Webber and Dr. Branden Moriarity. He graduated from UW-Madison in 2013 with a BS in Biomedical Engineering and minor degrees in Biology and Spanish. In 2019
he received his PhD in Biomedical Engineering from UW-Madison, where he engineered a biomimetic cell culture platform for cardiac tissue derived from human pluripotent stem cells (hPSCs).
Dr. Napiwocki’s current work is focused on genome engineering and stem cell biology to develop improved cell-based immune and gene therapies. To accomplish these goals, hPSCs are differentiated into cells with an immune fate including hematopoietic stem cells, T cells, Monocytes and Macrophages. Genome engineering technology including CRISPR/Cas9 and rAAV are used on the hPSC-immune cells to provide high frequency gene knockout and knock-in of targeted sequences. The genetically engineered hPSC-immune cells are then validated *in vitro* and *in vivo* systems including mice and pigs.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
-
SDG 3 Good Health and Well-being
Fingerprint
The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Active
-
Developing second generation SCID pig models: filling the gaps to improve translation of therapeutics in regenerative medicine
Webber, B. R. (PI) & Napiwocki, B. N. (Other Role)
IOWA STATE UNIVERSITY, NATIONAL INSTITUTES OF HEALTH (NIH)
8/1/25 → 7/31/26
Project: Research project
-
Midgestational injection of highly expanded human CD34+ cells increases lineages of human immune cells and supports thymic development in RAG2-/-IL2RG-/Y SCID pigs
Forster, A. M., Kress, A. A., Kiupel, M., Cunnick, J., Webster, D. A., Campbell, J. M., Watson, A. L., Gafni, O., Carlson, D. F., Moriarity, B. S., Webber, B. R., Napiwocki, B., Daharsh, L., Ross, J. W., Sauer, M. B. & Tuggle, C. K., 2026, In: Frontiers in immunology. 17, 1751541.Research output: Contribution to journal › Article › peer-review
Open Access -
Micropattern platform promotes extracellular matrix remodeling by human PSC-derived cardiac fibroblasts and enhances contractility of co-cultured cardiomyocytes
Napiwocki, B. N., Stempien, A., Lang, D., Kruepke, R. A., Kim, G., Zhang, J., Eckhardt, L. L., Glukhov, A. V., Kamp, T. J. & Crone, W. C., Oct 2021, In: Physiological Reports. 9, 19, e15045.Research output: Contribution to journal › Article › peer-review
Open Access21 Link opens in a new tab Scopus citations -
Aligned human cardiac syncytium for in vitro analysis of electrical, structural, and mechanical readouts
Napiwocki, B. N., Lang, D., Stempien, A., Zhang, J., Vaidyanathan, R., Makielski, J. C., Eckhardt, L. L., Glukhov, A. V., Kamp, T. J. & Crone, W. C., Oct 13 2020, In: Biotechnology and bioengineering. 118, 1, p. 442-452 11 p.Research output: Contribution to journal › Article › peer-review
18 Link opens in a new tab Scopus citations -
Correction to: Two-Dimensional Culture Systems to Enable Mechanics-Based Assays for Stem Cell-Derived Cardiomyocytes (Experimental Mechanics, (2019), 59, 9, (1235-1248), 10.1007/s11340-019-00473-8)
Notbohm, J., Napiwocki, B. N., de Lange, W. J., Stempien, A., Saraswathibhatla, A., Craven, R. J., Salick, M. R., Ralphe, J. C. & Crone, W. C., Apr 1 2020, In: Experimental Mechanics. 60, 4, p. 571 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Wavy small-diameter vascular graft made of eggshell membrane and thermoplastic polyurethane
Yan, S., Napiwocki, B., Xu, Y., Zhang, J., Zhang, X., Wang, X., Crone, W. C., Li, Q. & Turng, L. S., Feb 2020, In: Materials Science and Engineering C. 107, 110311.Research output: Contribution to journal › Article › peer-review
60 Link opens in a new tab Scopus citations