Research output per year
Research output per year
Personal profile
Personal profile
Dr. Brett Napiwocki is currently a Postdoctoral Associate in the Department of Pediatrics, Division of Hematology/Oncology working with Dr. Beau Webber and Dr. Branden Moriarity. He graduated from UW-Madison in 2013 with a BS in Biomedical Engineering and minor degrees in Biology and Spanish. In 2019
he received his PhD in Biomedical Engineering from UW-Madison, where he engineered a biomimetic cell culture platform for cardiac tissue derived from human pluripotent stem cells (hPSCs).
Dr. Napiwocki’s current work is focused on genome engineering and stem cell biology to develop improved cell-based immune and gene therapies. To accomplish these goals, hPSCs are differentiated into cells with an immune fate including hematopoietic stem cells, T cells, Monocytes and Macrophages. Genome engineering technology including CRISPR/Cas9 and rAAV are used on the hPSC-immune cells to provide high frequency gene knockout and knock-in of targeted sequences. The genetically engineered hPSC-immune cells are then validated *in vitro* and *in vivo* systems including mice and pigs.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Micropattern platform promotes extracellular matrix remodeling by human PSC-derived cardiac fibroblasts and enhances contractility of co-cultured cardiomyocytes
Napiwocki, B. N., Stempien, A., Lang, D., Kruepke, R. A., Kim, G., Zhang, J., Eckhardt, L. L., Glukhov, A. V., Kamp, T. J. & Crone, W. C., Oct 2021, In: Physiological Reports. 9, 19, e15045.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Aligned human cardiac syncytium for in vitro analysis of electrical, structural, and mechanical readouts
Napiwocki, B. N., Lang, D., Stempien, A., Zhang, J., Vaidyanathan, R., Makielski, J. C., Eckhardt, L. L., Glukhov, A. V., Kamp, T. J. & Crone, W. C., Oct 13 2020, In: Biotechnology and bioengineering. 118, 1, p. 442-452 11 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Correction to: Two-Dimensional Culture Systems to Enable Mechanics-Based Assays for Stem Cell-Derived Cardiomyocytes (Experimental Mechanics, (2019), 59, 9, (1235-1248), 10.1007/s11340-019-00473-8)
Notbohm, J., Napiwocki, B. N., de Lange, W. J., Stempien, A., Saraswathibhatla, A., Craven, R. J., Salick, M. R., Ralphe, J. C. & Crone, W. C., Apr 1 2020, In: Experimental Mechanics. 60, 4, p. 571 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Wavy small-diameter vascular graft made of eggshell membrane and thermoplastic polyurethane
Yan, S., Napiwocki, B., Xu, Y., Zhang, J., Zhang, X., Wang, X., Crone, W. C., Li, Q. & Turng, L. S., Feb 2020, In: Materials Science and Engineering C. 107, 110311.Research output: Contribution to journal › Article › peer-review
44 Scopus citations -
Epigenetic Priming of Human Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Accelerates Cardiomyocyte Maturation
Biermann, M., Cai, W., Lang, D., Hermsen, J., Profio, L., Zhou, Y., Czirok, A., Isai, D. G., Napiwocki, B. N., Rodriguez, A. M., Brown, M. E., Woon, M. T., Shao, A., Han, T., Park, D., Hacker, T. A., Crone, W. C., Burlingham, W. J., Glukhov, A. V. & Ge, Y. & 1 others, , Jul 2019, In: STEM CELLS. 37, 7, p. 910-923 14 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations