Brett N Napiwocki

20142020

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Personal profile

Dr. Brett Napiwocki is currently a Postdoctoral Associate in the Department of Pediatrics, Division of Hematology/Oncology working with Dr. Beau Webber and Dr. Branden Moriarity. He graduated from UW-Madison in 2013 with a BS in Biomedical Engineering and minor degrees in Biology and Spanish. In 2019
he received his PhD in Biomedical Engineering from UW-Madison, where he engineered a biomimetic cell culture platform for cardiac tissue derived from human pluripotent stem cells (hPSCs).

Dr. Napiwocki’s current work is focused on genome engineering and stem cell biology to develop improved cell-based immune and gene therapies. To accomplish these goals, hPSCs are differentiated into cells with an immune fate including hematopoietic stem cells, T cells, Monocytes and Macrophages. Genome engineering technology including CRISPR/Cas9 and rAAV are used on the hPSC-immune cells to provide high frequency gene knockout and knock-in of targeted sequences. The genetically engineered hPSC-immune cells are then validated *in vitro* and *in vivo* systems including mice and pigs.

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