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Brenda J Weigel

1998 …2024
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Neoplasms Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Pharmacokinetics Medicine & Life Sciences
Rhabdomyosarcoma Medicine & Life Sciences
temozolomide Medicine & Life Sciences
Acute Myeloid Leukemia Medicine & Life Sciences
irinotecan Medicine & Life Sciences
Disease-Free Survival Medicine & Life Sciences

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Projects 2002 2024

Cancer Center Support Grant

Yee, D., AbuSalah, A. M., Basu, S., Beckman, K. B., Bielinsky, A. K., Cooley, S. A., De For, T. E., Falconer, S. N., Felices, M., Griffin, T. J., Hallstrom, T. C., Hatsukami, D. K., Hendrickson, E. A., Hirsch, B. A., Joseph, A. M., Kirstein, M. N., Konety, B. R., Koopmeiners, J., Kuntz, K. M., Lange, C. A., Largaespada, D. A., Le, C. T., LeBeau, A., Lindgren, B. R., Luo, X., Mc Carthy, J. B., McKenna, D. H., Miller, J. S., Moriarity, B. S., Nelson, H. H., O'Sullivan, G., Ondrey, F. G., Pennell, C. A., Petersen, A. J., Peterson, B. A., Peterson, L. A., Sarver, A. L., Shimizu, Y., Siegfried, J. M., Temiz, N. A., Turesky, R., Vogel, R., Wagner, J. E., Wang, J., Weigel, B. J., Weisdorf, D. J., Woo, J. & Yamamoto, M.

NIH NATIONAL CANCER INSTITUTE (NCI)

2/1/19 → 1/31/24

Project: Research project

Neoplasms

Mechanisms of Resistance to Immunotherapy in Osteosarcoma

Modiano, J., Farrar, M. A., Subramanian, S., Vallera, D. A. & Weigel, B. J.

U.S. DEPARTMENT OF DEFENSE

9/1/18 → 8/31/20

Project: Research project

osteosarcoma
immunotherapy
resistance mechanisms

Phase 1 Open-Label Dose-Escalation Study of Olaratumlab

Weigel, B. J.

Eli Lilly and Company

12/22/15 → 12/22/20

Project: Research project

irinotecan
Ifosfamide
Vincristine
Doxorubicin
Pediatrics

Chart Review Study of Patients who Received IRESSA

Weigel, B. J.

AstraZeneca

12/1/15 → 12/30/20

Project: Research project

Phase I and II Pediatric Oncology Clinical Research Prog

Weigel, B. J. & Greengard, E. G.

ALEXS LEMONADE STAND FDN

7/1/15 → 6/30/20

Project: Research project

Medical Oncology
Pediatrics
Research

Research Output 1998 2019

A phase II study of alisertib in children with recurrent/refractory solid tumors or leukemia: Children's Oncology Group Phase I and pilot Consortium (ADVL0921)

Mosse, Y. P., Fox, E., Teachey, D. T., Reid, J. M., Safgren, S. L., Carol, H., Lock, R. B., Houghton, P. J., Smith, M. A., Hall, D., Barkauskas, D. A., Krailo, M., Voss, S. D., Berg, S. L., Blaney, S. M. & Weigel, B. J., Jun 1 2019, In : Clinical Cancer Research. 25, 11, p. 3229-3238 10 p.

Research output: Contribution to journal › Article

Open Access
Leukemia
Aurora Kinase A
Neoplasms
Pharmacokinetics
Pharmacogenetics

Identification of aggressive Gardner syndrome phenotype associated with a de novo APC variant, c.4666dup

Kiessling, P., Dowling, E., Huang, Y., Ho, M. L., Balakrishnan, K., Weigel, B. J., Highsmith, W. E., Niu, Z. & Schimmenti, L. A., Apr 1 2019, In : Cold Spring Harbor molecular case studies. 5, 2

Research output: Contribution to journal › Article

Open Access
Gardner Syndrome
Phenotype
Tooth Abnormalities
APC Genes
Osteoma
2 Citations (Scopus)

The addition of cixutumumab or temozolomide to intensive multiagent chemotherapy is feasible but does not improve outcome for patients with metastatic rhabdomyosarcoma: A report from the Children’s Oncology Group

Malempati, S., Weigel, B. J., Chi, Y. Y., Tian, J., Anderson, J. R., Parham, D. M., Teot, L. A., Rodeberg, D. A., Yock, T. I., Shulkin, B. L., Spunt, S. L., Meyer, W. H. & Hawkins, D. S., Jan 15 2019, In : Cancer. 125, 2, p. 290-297 8 p.

Research output: Contribution to journal › Article

temozolomide
Rhabdomyosarcoma
Drug Therapy
irinotecan
Vincristine
2 Citations (Scopus)

A phase 1 study of cabozantinib in children and adolescents with recurrent or refractory solid tumors, including CNS tumors: Trial ADVL1211, a report from the Children's Oncology Group

Chuk, M. K., Widemann, B. C., Minard, C. G., Liu, X., Kim, A. R., Bernhardt, M. B., Kudgus, R. A., Reid, J. M., Voss, S. D., Blaney, S., Fox, E. & Weigel, B. J., Aug 1 2018, In : Pediatric Blood and Cancer. 65, 8, e27077.

Research output: Contribution to journal › Article

Open Access
Neoplasms
Maximum Tolerated Dose
Pharmacokinetics
Proteinuria
Fatigue
4 Citations (Scopus)

A phase 1 study of eribulin mesylate (E7389), a novel microtubule-targeting chemotherapeutic agent, in children with refractory or recurrent solid tumors: A Children's Oncology Group Phase 1 Consortium study (ADVL1314)

Schafer, E. S., Rau, R. E., Berg, S., Liu, X., Minard, C. G., D'Adamo, D., Scott, R., Reyderman, L., Martinez, G., Devarajan, S., Reid, J. M., Fox, E., Weigel, B. J. & Blaney, S. M., Aug 1 2018, In : Pediatric Blood and Cancer. 65, 8, e27066.

Research output: Contribution to journal › Article

eribulin
Microtubules
Pharmacokinetics
Neutropenia
Neoplasms