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Brenda J Weigel

1998 …2024
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  • 9 Similar Profiles
Neoplasms Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Pharmacokinetics Medicine & Life Sciences
Rhabdomyosarcoma Medicine & Life Sciences
temozolomide Medicine & Life Sciences
Osteosarcoma Medicine & Life Sciences
Acute Myeloid Leukemia Medicine & Life Sciences
irinotecan Medicine & Life Sciences

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Projects 2002 2024

COG NCTN Integrated Translational Science Center for Hematopoietic Malignancies in Children

Weigel, B. J.

Children's Hospital of Philadelphia

3/1/19 → 2/29/20

Project: Research project

Hematologic Neoplasms

Cancer Center Support Grant

Yee, D., AbuSalah, A. M., Basu, S., Beckman, K. B., Bielinsky, A. K., Cooley, S. A., De For, T. E., Falconer, S. N., Felices, M., Griffin, T. J., Hallstrom, T. C., Hatsukami, D. K., Hendrickson, E. A., Hirsch, B. A., Joseph, A. M., Kirstein, M. N., Konety, B. R., Koopmeiners, J., Kuntz, K. M., Lange, C. A., Largaespada, D. A., Le, C. T., LeBeau, A., Lindgren, B. R., Luo, X., Mc Carthy, J. B., McKenna, D. H., Miller, J. S., Moriarity, B. S., Nelson, H. H., O'Sullivan, G., Ondrey, F. G., Pennell, C. A., Petersen, A. J., Peterson, B. A., Peterson, L. A., Sarver, A. L., Shimizu, Y., Siegfried, J. M., Temiz, N. A., Turesky, R., Vogel, R., Wagner, J. E., Wang, J., Weigel, B. J., Weisdorf, D. J., Woo, J. & Yamamoto, M.

NIH NATIONAL CANCER INSTITUTE (NCI)

2/1/19 → 1/31/24

Project: Research project

Neoplasms

Scientific Programmatic Leadership: NIH Pediatric Early Phase Clinical Trials Network (PEP-CTN) Grant(UM1CA228823)

Weigel, B. J.

Children's Hospital of Philadelphia

9/20/18 → 7/31/23

Project: Research project

Clinical Trials
Pediatrics

Mechanisms of Resistance to Immunotherapy in Osteosarcoma

Modiano, J., Farrar, M. A., Subramanian, S., Vallera, D. A. & Weigel, B. J.

U.S. DEPARTMENT OF DEFENSE

9/1/18 → 8/31/20

Project: Research project

osteosarcoma
immunotherapy
resistance mechanisms

Phase 1 Open-Label Dose-Escalation Study of Olaratumlab

Weigel, B. J.

Eli Lilly and Company

12/22/15 → 12/22/20

Project: Research project

irinotecan
Ifosfamide
Vincristine
Doxorubicin
Pediatrics

Research Output 1998 2019

2 Citations (Scopus)

A phase II study of alisertib in children with recurrent/refractory solid tumors or leukemia: Children's Oncology Group Phase I and pilot Consortium (ADVL0921)

Mosse, Y. P., Fox, E., Teachey, D. T., Reid, J. M., Safgren, S. L., Carol, H., Lock, R. B., Houghton, P. J., Smith, M. A., Hall, D., Barkauskas, D. A., Krailo, M., Voss, S. D., Berg, S. L., Blaney, S. M. & Weigel, B. J., Jun 1 2019, In : Clinical Cancer Research. 25, 11, p. 3229-3238 10 p.

Research output: Contribution to journal › Article

Open Access
Leukemia
Aurora Kinase A
Neoplasms
Pharmacokinetics
Pharmacogenetics

Identification of aggressive Gardner syndrome phenotype associated with a de novo APC variant, c.4666dup

Kiessling, P., Dowling, E., Huang, Y., Ho, M. L., Balakrishnan, K., Weigel, B. J., Edward Highsmith, W., Niu, Z. & Schimmenti, L. A., Jan 1 2019, In : Cold Spring Harbor Molecular Case Studies. 5, 2, a003640.

Research output: Contribution to journal › Article

Open Access
Gardner Syndrome
Tissue
Phenotype
Tooth Abnormalities
APC Genes

Phase II trial of the glycoprotein non-metastatic B-targeted antibody–drug conjugate, glembatumumab vedotin (CDX-011), in recurrent osteosarcoma AOST1521: A report from the Children's Oncology Group

Kopp, L. M., Malempati, S., Krailo, M., Gao, Y., Buxton, A., Weigel, B. J., Hawthorne, T., Crowley, E., Moscow, J. A., Reid, J. M., Villalobos, V., Randall, R. L., Gorlick, R. & Janeway, K. A., Nov 1 2019, In : European Journal of Cancer. 121, p. 177-183 7 p.

Research output: Contribution to journal › Article

Osteosarcoma
Glycoproteins
glembatumumab vedotin
Exanthema
Microtubules
2 Citations (Scopus)

The addition of cixutumumab or temozolomide to intensive multiagent chemotherapy is feasible but does not improve outcome for patients with metastatic rhabdomyosarcoma: A report from the Children’s Oncology Group

Malempati, S., Weigel, B. J., Chi, Y. Y., Tian, J., Anderson, J. R., Parham, D. M., Teot, L. A., Rodeberg, D. A., Yock, T. I., Shulkin, B. L., Spunt, S. L., Meyer, W. H. & Hawkins, D. S., Jan 15 2019, In : Cancer. 125, 2, p. 290-297 8 p.

Research output: Contribution to journal › Article

Open Access
temozolomide
Rhabdomyosarcoma
Drug Therapy
irinotecan
Vincristine
3 Citations (Scopus)

A phase 1 study of cabozantinib in children and adolescents with recurrent or refractory solid tumors, including CNS tumors: Trial ADVL1211, a report from the Children's Oncology Group

Chuk, M. K., Widemann, B. C., Minard, C. G., Liu, X., Kim, A. R., Bernhardt, M. B., Kudgus, R. A., Reid, J. M., Voss, S. D., Blaney, S., Fox, E. & Weigel, B. J., Aug 1 2018, In : Pediatric Blood and Cancer. 65, 8, e27077.

Research output: Contribution to journal › Article

Open Access
Neoplasms
Maximum Tolerated Dose
Pharmacokinetics
Proteinuria
Fatigue