Branden S Moriarity

20072025

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy

Pomeroy, E. J., Hunzeker, J. T., Kluesner, M. G., Lahr, W. S., Smeester, B. A., Crosby, M. R., Lonetree, C. L., Yamamoto, K., Bendzick, L., Miller, J. S., Geller, M. A., Walcheck, B., Felices, M., Webber, B. R., Starr, T. K. & Moriarity, B. S., Jan 8 2020, In : Molecular Therapy. 28, 1

Research output: Contribution to journalArticle

CRISPR/Cas9-Mediated Genome Engineering of Primary Human B Cells

Laoharawee, K., Johnson, M. J. & Moriarity, B. S., Feb 1 2020, In : Methods in molecular biology (Clifton, N.J.). 2115, p. 435-444 10 p.

Research output: Contribution to journalArticle

ORCA/LRWD1 Regulates Homologous Recombination at ALT-Telomeres by Modulating Heterochromatin Organization

Hsu, R. Y. C., Lin, Y. C., Redon, C., Sun, Q., Singh, D. K., Wang, Y., Aggarwal, V., Mitra, J., Matur, A., Moriarity, B., Ha, T., Aladjem, M. I., Prasanth, K. V. & Prasanth, S. G., May 22 2020, In : iScience. 23, 5, 101038.

Research output: Contribution to journalArticle

Open Access

PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma

Smeester, B. A., Slipek, N. J., Pomeroy, E. J., Laoharawee, K., Osum, S. H., Larsson, A. T., Williams, K. B., Stratton, N., Yamamoto, K., Peterson, J. J., Rathe, S. K., Mills, L. J., Hudson, W. A., Crosby, M. R., Wang, M., Rahrmann, E. P., Moriarity, B. S. & Largaespada, D. A., Jul 2020, In : Bone. 136, 115353.

Research output: Contribution to journalArticle

SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis

Smeester, B. A., Slipek, N. J., Pomeroy, E. J., Bomberger, H. E., Shamsan, G. A., Peterson, J. J., Crosby, M. R., Draper, G. M., Becklin, K. L., Rahrmann, E. P., McCarthy, J. B., Odde, D. J., Wood, D. K., Largaespada, D. A. & Moriarity, B. S., Jan 30 2020, In : Oncogene. 39, 5, p. 1049-1062 14 p.

Research output: Contribution to journalArticle

2019
Open Access

Cancer Gene Discovery Utilizing Sleeping Beauty Transposon Mutagenesis

Becklin, K. L., Smeester, B. A. & Moriarity, B. S., Jan 1 2019, In : Methods in Molecular Biology. 1907, p. 161-170 10 p.

Research output: Contribution to journalArticle

Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

Huang, M., Tailor, J., Zhen, Q., Gillmor, A. H., Miller, M. L., Weishaupt, H., Chen, J., Zheng, T., Nash, E. K., McHenry, L. K., An, Z., Ye, F., Takashima, Y., Clarke, J., Ayetey, H., Cavalli, F. M. G., Luu, B., Moriarity, B. S., Ilkhanizadeh, S., Chavez, L. & 18 others, Yu, C., Kurian, K. M., Magnaldo, T., Sevenet, N., Koch, P., Pollard, S. M., Dirks, P., Snyder, M. P., Largaespada, D. A., Cho, Y. J., Phillips, J. J., Swartling, F. J., Morrissy, A. S., Kool, M., Pfister, S. M., Taylor, M. D., Smith, A. & Weiss, W. A., Sep 5 2019, In : Cell Stem Cell. 25, 3, p. 433-446.e7

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

HBx-K130M/V131I promotes liver cancer in transgenic mice via AKT/FOXO1 signaling pathway and arachidonic acid metabolism

Chiu, A. P., Tschida, B. R., Sham, T. T., Lo, L. H., Moriarity, B. S., Li, X. X., Lo, R. C., Hinton, D. E., Rowlands, D. K., Chan, C. O., Mok, D. K. W., Largaespada, D. A., Warner, N. & Keng, V. W., Jul 1 2019, In : Molecular Cancer Research. 17, 7, p. 1582-1593 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors

Webber, B. R., Lonetree, C. L., Kluesner, M. G., Johnson, M. J., Pomeroy, E. J., Diers, M. D., Lahr, W. S., Draper, G. M., Slipek, N. J., Smeester, B. S., Lovendahl, K. N., McElroy, A. N., Gordon, W. R., Osborn, M. J. & Moriarity, B. S., Dec 1 2019, In : Nature communications. 10, 1, 5222.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Identification of candidate neoantigens produced by fusion transcripts in human osteosarcomas

Rathe, S. K., Popescu, F. E., Johnson, J. E., Watson, A. L., Marko, T. A., Moriarity, B. S., Ohlfest, J. R. & Largaespada, D. A., Dec 1 2019, In : Scientific reports. 9, 1, 358.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Sleeping beauty insertional mutagenesis reveals important genetic drivers of central nervous system embryonal tumors

Beckmann, P. J., Larson, J. D., Larsson, A. T., Ostergaard, J. P., Wagner, S., Rahrmann, E. P., Shamsan, G. A., Otto, G. M., Williams, R. L., Wang, J., Lee, C., Tschida, B. R., Das, P., Dubuc, A. M., Moriarity, B. S., Picard, D., Wu, X., Rodriguez, F. J., Rosemarie, Q., Krebs, R. D. & 13 others, Molan, A. M., Demer, A. M., Frees, M. M., Rizzardi, A. E., Schmechel, S. C., Eberhart, C. G., Jenkins, R. B., Wechsler-Reya, R. J., Odde, D. J., Huang, A., Taylor, M. D., Sarver, A. L. & Largaespada, D. A., Mar 1 2019, In : Cancer Research. 79, 5, p. 905-917 13 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Sleeping beauty screen identifies RREB1 and other genetic drivers in human B-cell lymphoma

Rahrmann, E. P., Wolf, N. K., Otto, G. M., Heltemes-Harris, L., Ramsey, L. B., Shu, J., LaRue, R. S., Linden, M. A., Rathe, S. K., Starr, T. K., Farrar, M. A., Moriarity, B. S. & Largaespada, D. A., Feb 2019, In : Molecular Cancer Research. 17, 2, p. 567-582 16 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018
Open Access
27 Scopus citations

CRISPR/Cas9 library screening for drug target discovery

Kurata, M., Yamamoto, K., Moriarity, B. S., Kitagawa, M. & Largaespada, D. A., Feb 1 2018, In : Journal of Human Genetics. 63, 2, p. 179-186 8 p.

Research output: Contribution to journalReview article

15 Scopus citations

EditR: A Method to Quantify Base Editing from Sanger Sequencing

Kluesner, M. G., Nedveck, D. A., Lahr, W. S., Garbe, J. R., Abrahante, J. E., Webber, B. R. & Moriarity, B. S., Jun 1 2018, In : The CRISPR journal. 1, p. 239-250 12 p.

Research output: Contribution to journalArticle

Open Access

Engineering of Primary Human B cells with CRISPR/Cas9 Targeted Nuclease

Johnson, M. J., Laoharawee, K., Lahr, W. S., Webber, B. R. & Moriarity, B. S., Dec 1 2018, In : Scientific reports. 8, 1, 12144.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Highly multiplexed genome engineering using CRISPR/Cas9 gRNA arrays

Kurata, M., Wolf, N. K., Lahr, W. S., Weg, M. T., Kluesner, M. G., Lee, S., Hui, K., Shiraiwa, M., Webber, B. R. & Moriarity, B. S., Sep 2018, In : PloS one. 13, 9, e0198714.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity

Li, Y., Hermanson, D. L., Moriarity, B. S. & Kaufman, D. S., Aug 2 2018, In : Cell Stem Cell. 23, 2, p. 181-192.e5

Research output: Contribution to journalArticle

Open Access
98 Scopus citations

MicroRNA-based attenuation of influenza virus across susceptible hosts

Waring, B. M., Sjaastad, L. E., Fiege, J. K., Fay, E. J., Reyes, I., Moriarity, B. & Langlois, R. A., Jan 1 2018, In : Journal of virology. 92, 2, e01741-17.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

The Molecular Imaging of Natural Killer Cells

Shapovalova, M., Pyper, S. R., Moriarity, B. S. & LeBeau, A., Sep 8 2018, In : Molecular imaging. 17

Research output: Contribution to journalReview article

Open Access
3 Scopus citations
2017

CRISPR/Cas9 genetic modification of CYP3A5 *3 in HuH-7 human hepatocyte cell line leads to cell lines with increased midazolam and tacrolimus metabolism

Dorr, C. R., Remmel, R. P., Muthusamy, A., Fisher, J., Moriarity, B. S., Yasuda, K., Wu, B., Guan, W., Schuetz, E. G., Oetting, W. S., Jacobson, P. A. & Israni, A. K., Aug 1 2017, In : Drug Metabolism and Disposition. 45, 8, p. 957-965 9 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3

Chaudhary, R., Gryder, B., Woods, W. S., Subramanian, M., Jones, M. F., Li, X. L., Jenkins, L. M., Shabalina, S. A., Mo, M., Dasso, M., Yang, Y., Wakefield, L. M., Zhu, Y., Frier, S. M., Moriarity, B. S., Prasanth, K. V., Perez-Pinera, P. & Lal, A., Jun 5 2017, In : eLife. 6, e23244.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Rapid generation of Col7a1 mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells

Webber, B. R., O'Connor, K. T., Mc Elmurry, R. T., Durgin, E. N., Eide, C. R., Lees, C. J., Riddle, M. J., Mathews, W. E., Frank, N. Y., Kluth, M. A., Ganss, C., Moriarity, B. S., Frank, M. H., Osborn, M. J. & Tolar, J., Oct 1 2017, In : Laboratory Investigation. 97, 10, p. 1218-1224 7 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia

Pomeroy, E. J., Lee, L. A., Lee, R. D. W., Schirm, D. K., Temiz, N. A., Ma, J., Gruber, T. A., Diaz-Flores, E., Moriarity, B. S., Downing, J. R., Shannon, K. M., Largaespada, D. A. & Eckfeldt, C. E., Jun 8 2017, In : Oncogene. 36, 23, p. 3263-3273 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Relative importance of βcyto-and γcyto-actin in primary mouse embryonic fibroblasts

Patrinostro, X., O'Rourke, A. R., Chamberlain, C. M., Moriarity, B. S., Perrin, B. J. & Ervasti, J. M., Mar 15 2017, In : Molecular biology of the cell. 28, 6, p. 771-782 12 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2016

A novel role for SALL4 during scar-free wound healing in axolotl

Erickson, J. R., Gearhart, M. D., Honson, D. D., Reid, T. A., Gardner, M. K., Moriarity, B. S. & Echeverri, K., Dec 1 2016, In : Regenerative Medicine. 1, 1

Research output: Contribution to journalArticle

Open Access

mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress

Yun, Y. S., Kim, K. H., Tschida, B., Sachs, Z., Noble-Orcutt, K. E., Moriarity, B. S., Ai, T., Ding, R., Williams, J., Chen, L., Largaespada, D. & Kim, D. H., Feb 18 2016, In : Molecular Cell. 61, 4, p. 625-639 15 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

Phase i trials using sleeping beauty to generate CD19-specific CAR T cells

Kebriaei, P., Singh, H., Huls, M. H., Figliola, M. J., Bassett, R., Olivares, S., Jena, B., Dawson, M. J., Kumaresan, P. R., Su, S., Maiti, S., Dai, J., Moriarity, B., Forget, M. A., Senyukov, V., Orozco, A., Liu, T., McCarty, J., Jackson, R. N., Moyes, J. S. & 19 others, Rondon, G., Qazilbash, M., Ciurea, S., Alousi, A., Nieto, Y., Rezvani, K., Marin, D., Popat, U., Hosing, C., Shpall, E. J., Kantarjian, H., Keating, M., Wierda, W., Do, K. A., Largaespada, D. A., Lee, D. A., Hackett, P. B., Champlin, R. E. & Cooper, L. J. N., Sep 1 2016, In : Journal of Clinical Investigation. 126, 9, p. 3363-3376 14 p.

Research output: Contribution to journalArticle

Open Access
177 Scopus citations

RALB provides critical survival signals downstream of Ras in acute myeloid leukemia

Eckfeldt, C. E., Pomeroy, E. J., Lee, R. D. W., Hazen, K. S., Lee, L. A., Moriarity, B. S. & Largaespada, D. A., Jan 1 2016, In : Oncotarget. 7, 40, p. 65147-65156 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens

Temiz, N. A., Moriarity, B. S., Wolf, N. K., Riordan, J. D., Dupuy, A. J., Largaespada, D. A. & Sarver, A. L., Jan 2016, In : Genome research. 26, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma

Marko, T. A., Shamsan, G. A., Edwards, E. N., Hazelton, P. E., Rathe, S., Cornax, I., Overn, P. R., Varshney, J., Diessner, B. J., Moriarity, B. S., O'Sullivan, G., Odde, D. J. & Largaespada, D. A., Dec 14 2016, In : Scientific reports. 6, 39059.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

Park, J. M., Jung, C. H., Seo, M., Otto, N. M., Grunwald, D., Kim, K. H., Moriarity, B., Kim, Y. M., Starker, C., Nho, R. S., Voytas, D. & Kim, D. H., Apr 5 2016, In : Autophagy. 12, 3, p. 547-564 18 p.

Research output: Contribution to journalArticle

Open Access
91 Scopus citations

Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML

Kurata, M., Rathe, S. K., Bailey, N. J., Aumann, N. K., Jones, J. M., Veldhuijzen, G. W., Moriarity, B. S. & Largaespada, D. A., Nov 3 2016, In : Scientific reports. 6, 36199.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations
2015

A genome-wide scan identifies variants in NFIB associated with metastasis in patients with osteosarcoma

Mirabello, L., Koster, R., Moriarity, B. S., Spector, L. G., Meltzer, P. S., Gary, J., Machiela, M. J., Pankratz, N., Panagiotou, O. A., Largaespada, D., Wang, Z., Gastier-Foster, J. M., Gorlick, R., Khanna, C., de Toledo, S. R. C., Petrilli, A. S., Patiño-Garcia, A., Sierrasesúmaga, L., Lecanda, F., Andrulis, I. L. & 32 others, Wunder, J. S., Gokgoz, N., Serra, M., Hattinger, C., Picci, P., Scotlandi, K., Flanagan, A. M., Tirabosco, R., Amary, M. F., Halai, D., Ballinger, M. L., Thomas, D. M., Davis, S., Barkauskas, D. A., Marina, N., Helman, L., Otto, G. M., Becklin, K. L., Wolf, N. K., Weg, M. T., Tucker, M., Wacholder, S., Fraumeni, J. F., Caporaso, N. E., Boland, J. F., Hicks, B. D., Vogt, A., Burdett, L., Yeager, M., Hoover, R. N., Chanock, S. J. & Savage, S. A., Sep 1 2015, In : Cancer discovery. 5, 9, p. 920-931 12 p.

Research output: Contribution to journalArticle

55 Scopus citations

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

Moriarity, B. S., Otto, G. M., Rahrmann, E. P., Rathe, S. K., Wolf, N. K., Weg, M. T., Manlove, L. A., Larue, R. S., Temiz, N. A., Molyneux, S. D., Choi, K., Holly, K. J., Sarver, A. L., Scott, M. C., Forster, C. L., Modiano, J. F., Khanna, C., Hewitt, S. M., Khokha, R., Yang, Y. & 3 others, Gorlick, R., Dyer, M. A. & Largaespada, D. A., May 27 2015, In : Nature Genetics. 47, 6, p. 615-624 10 p.

Research output: Contribution to journalArticle

117 Scopus citations

Coping with cancer genes altered by copy number

Wolf, N. K., Largaespada, D. A. & Moriarity, B. S., Jan 1 2015, In : Oncotarget. 6, 34, p. 35155-35156 2 p.

Research output: Contribution to journalArticle

2 Scopus citations
23 Scopus citations

Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling

Zuckermann, M., Hovestadt, V., Knobbe-Thomsen, C. B., Zapatka, M., Northcott, P. A., Schramm, K., Belic, J., Jones, D. T. W., Tschida, B., Moriarity, B., Largaespada, D., Roussel, M. F., Korshunov, A., Reifenberger, G., Pfister, S. M., Lichter, P., Kawauchi, D. & Gronych, J., Jun 11 2015, In : Nature communications. 6, 7391.

Research output: Contribution to journalArticle

113 Scopus citations

Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma

Chiu, A. P., Tschida, B. R., Lo, L. H., Moriarity, B. S., Rowlands, D. K., Largaespada, D. A. & Keng, V. W., Nov 14 2015, In : World journal of gastroenterology. 21, 42, p. 12157-12170 14 p.

Research output: Contribution to journalReview article

5 Scopus citations
2014

HomeRun vector assembly system: A flexible and standardized cloning system for assembly of multi-modular DNA constructs

Li, M. V., Shukla, D., Rhodes, B. H., Lall, A., Shu, J., Moriarity, B. S. & Largaespada, D. A., Jun 24 2014, In : PloS one. 9, 6, e100948.

Research output: Contribution to journalArticle

10 Scopus citations

PVT1 dependence in cancer with MYC copy-number increase

Tseng, Y. Y., Moriarity, B. S., Gong, W., Akiyama, R., Tiwari, A., Kawakami, H., Ronning, P., Reuland, B., Guenther, K., Beadnell, T. C., Essig, J., Otto, G. M., O'Sullivan, M. G., Largaespada, D. A., Schwertfeger, K. L., Marahrens, Y., Kawakami, Y. & Bagchi, A., Jan 1 2014, In : Nature. 512, 1, p. 82-86 5 p.

Research output: Contribution to journalArticle

361 Scopus citations

Simple and efficient methods for enrichment and isolation of endonuclease modified cells

Moriarity, B. S., Rahrmann, E. P., Beckmann, D. A., Conboy, C. B., Watson, A. L., Carlson, D. F., Olson, E. R., Hyland, K. A., Fahrenkrug, S. C., Scott McIvor, R. & Largaespada, D. A., May 5 2014, In : PloS one. 9, 5, e96114.

Research output: Contribution to journalArticle

12 Scopus citations

Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis

Rahrmann, E. P., Moriarity, B. S., Otto, G. M., Watson, A. L., Choi, K., Collins, M. H., Wallace, M., Webber, B. R., Forster, C. L., Rizzardi, A. E., Schmechel, S. C., Ratner, N. & Largaespada, D. A., Jul 2014, In : American Journal of Pathology. 184, 7, p. 2082-2098 17 p.

Research output: Contribution to journalArticle

20 Scopus citations

Using RNA-seq and targeted nucleases to identify mechanisms of drug resistance in acute myeloid leukemia

Rathe, S. K., Moriarity, B. S., Stoltenberg, C. B., Kurata, M., Aumann, N. K., Rahrmann, E. P., Bailey, N. J., Melrose, E. G., Beckmann, D. A., Liska, C. R. & Largaespada, D. A., Aug 13 2014, In : Scientific reports. 4, 6048.

Research output: Contribution to journalArticle

21 Scopus citations
2013

Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance

Watson, A. L., Rahrmann, E. P., Moriarity, B. S., Choi, K., Conboy, C. B., Greeley, A. D., Halfond, A. L., Anderson, L. K., Wahl, B. R., Keng, V. W., Rizzardi, A. E., Forster, C. L., Collins, M. H., Sarver, A. L., Wallace, M. R., Schmechel, S. C., Ratner, N. & Largaespada, D. A., 2013, In : Cancer discovery. 3, 6, p. 675-689 15 p.

Research output: Contribution to journalArticle

55 Scopus citations

Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance.

Watson, A. L., Rahrmann, E. P., Moriarity, B. S., Choi, K., Conboy, C. B., Greeley, A. D., Halfond, A. L., Anderson, L. K., Wahl, B. R., Keng, V. W., Rizzardi, A. E., Forster, C. L., Collins, M. H., Sarver, A. L., Wallace, M. R., Schmechel, S. C., Ratner, N. & Largaespada, D. A., Jun 2013, In : Cancer Discovery. 3, 6, p. 674-689 16 p.

Research output: Contribution to journalArticle

Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis

Rahrmann, E. P., Watson, A. L., Keng, V. W., Choi, K., Moriarity, B. S., Beckmann, D. A., Wolf, N. K., Sarver, A., Collins, M. H., Moertel, C. L., Wallace, M. R., Gel, B., Serra, E., Ratner, N. & Largaespada, D. A., Jul 1 2013, In : Nature Genetics. 45, 7, p. 756-766 11 p.

Research output: Contribution to journalArticle

98 Scopus citations

Modular assembly of transposon integratable multigene vectors using RecWay assembly

Moriarity, B. S., Rahrmann, E. P., Keng, V. W., Manlove, L. S., Beckmann, D. A., Wolf, N. K., Khurshid, T., Bell, J. B. & Largaespada, D. A., Apr 1 2013, In : Nucleic acids research. 41, 8, p. e92

Research output: Contribution to journalArticle

9 Scopus citations