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Personal profile

Research interests

  • Crystallography
  • Drug Design
  • Medicinal Chemistry
  • structural biology

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

  • 3 Similar Profiles
Enzymes Medicine & Life Sciences
Biotin Medicine & Life Sciences
Proteins Medicine & Life Sciences
Mycobacterium tuberculosis Medicine & Life Sciences
Crystal structure Chemical Compounds
Ligands Medicine & Life Sciences
Transaminases Medicine & Life Sciences
Crystallization Chemical Compounds

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Projects 2009 2023

Research Output 1980 2018

Structure and Functional Characterization of Human Histidine Triad Nucleotide-Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia

Shah, R. M., Maize, K. M., West, H. T., Strom, A. M., Finzel, B. C. & Wagner, C. R., Aug 17 2018, In : Journal of Molecular Biology. 430, 17, p. 2709-2721 13 p.

Research output: Contribution to journalArticle

Isaacs Syndrome
Mutation
Enzymes
Adenosine Monophosphate
Histidine
2 Citations (Scopus)

A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides

Maize, K. M., Shah, R., Strom, A., Kumarapperuma, S., Zhou, A., Wagner, C. R. & Finzel, B. C., Nov 6 2017, In : Molecular pharmaceutics. 14, 11, p. 3987-3997 11 p.

Research output: Contribution to journalArticle

Nucleosides
nucleoside phosphotransferase
Prodrugs
Nucleotides
Calorimetry
8 Citations (Scopus)
Protons
Trajectories
Catalysis
Proton transfer
Enzymes
1 Citation (Scopus)
Neuralgia
Histidine
Analgesia
Opioid Analgesics
Metal ions
1 Citation (Scopus)
Open Access
Kinetic parameters
Scaffolds
Medicine
Rate constants
Enzymes