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Research Output 1968 2019

2019

Humanized mouse model of HIV-1 latency with enrichment of latent virus in PD-1+ and TIGIT+ CD4 T cells

Llewellyn, G. N., Seclén, E., Wietgrefe, S. W., Liu, S., Chateau, M., Pei, H., Perkey, K., Marsden, M. D., Hinkley, S. J., Paschon, D. E., Holmes, M. C., Zack, J. A., Louie, S. G., Haase, A. T. & Cannona, P. M., May 1 2019, In : Journal of virology. 93, 10, e02086-18.

Research output: Contribution to journalArticle

Human immunodeficiency virus 1
HIV-1
T-lymphocytes
animal models
drug therapy
3 Citations (Scopus)

Impact of Integrase Inhibition Compared with Nonnucleoside Inhibition on HIV Reservoirs in Lymphoid Tissues

Rothenberger, M., Nganou-Makamdop, K., Kityo, C., Ssali, F., Chipman, J. G., Beilman, G. J., Hoskuldsson, T., Anderson, J., Jasurda, J., Schmidt, T. E., Calisto, S. P., Pearson, H., Reimann, T., David, C., Perkey, K., Southern, P., Wietgrefe, S., Helgeson, E., Reilly, C., Haase, A. T. & 3 others, Douek, D. C., Fletcher, C. V. & Schacker, T. W., Jul 1 2019, In : Journal of Acquired Immune Deficiency Syndromes. 81, 3, p. 355-360 6 p.

Research output: Contribution to journalArticle

Integrases
efavirenz
Lymphoid Tissue
HIV
Follicular Dendritic Cells
2018
10 Citations (Scopus)

ALT-803 transiently reduces simian immunodeficiency virus replication in the absence of antiretroviral treatment

Ellis-Connell, A. L., Balgeman, A. J., Zarbock, K. R., Barry, G., Weiler, A., Egan, J. O., Jeng, E. K., Friedrich, T., Miller, J. S., Haase, A. T., Schacker, T. W., Wong, H. C., Rakasz, E. & O'Connor, S. L., Feb 1 2018, In : Journal of virology. 92, 3, e01748-17.

Research output: Contribution to journalArticle

Open Access
Simian immunodeficiency virus
Simian Immunodeficiency Virus
Virus Replication
virus replication
T-lymphocytes
10 Citations (Scopus)

Conflicting evidence for HIV enrichment in CD32+ CD4 T cells

Pérez, L., Anderson, J., Chipman, J. G., Thorkelson, A., Chun, T. W., Moir, S., Haase, A. T., Douek, D. C., Schacker, T. W. & Boritz, E. A., Sep 20 2018, In : Nature. 561, 7723, p. E9-E16

Research output: Contribution to journalArticle

disease incidence
immune system
physiological response
human immunodeficiency virus
immune response

Vaccine-associated maintenance of epithelial integrity correlated with protection against virus entry

Shang, L., Smith, A. J., Duan, L., Perkey, K. E., Wietgrefe, S. W., Zupancic, M., Southern, P., Johnson, R. P., Carlis, J. V. & Haase, A. T., Sep 8 2018, In : Journal of Infectious Diseases. 218, 8, p. 1272-1283 12 p.

Research output: Contribution to journalArticle

Virus Internalization
Vaccines
Maintenance
Bacterial Translocation
Simian Immunodeficiency Virus
2 Citations (Scopus)

Vaccine-modified NF-kB and GR signaling in cervicovaginal epithelium correlates with protection

Shang, L., Smith, A. J., Reilly, C. S., Duan, L., Perkey, K. E., Wietgrefe, S., Zupancic, M., Southern, P. J., Johnson, R. P., Carlis, J. V. & Haase, A. T., Mar 1 2018, In : Mucosal Immunology. 11, 2, p. 512-522 11 p.

Research output: Contribution to journalArticle

NF-kappa B
Glucocorticoid Receptors
Vaccines
Epithelium
Mucosal Immunity
2017
40 Citations (Scopus)

Brain macrophages in simian immunodeficiency virus-infected, antiretroviral-suppressed macaques: A functional latent reservoir

Avalos, C. R., Abreu, C. M., Queen, S. E., Li, M., Price, S., Shirk, E. N., Engle, E. L., Forsyth, E., Bullock, B. T., Gabhann, F. M., Wietgrefe, S. W., Haase, A. T., Zink, M. C., Mankowski, J. L., Clements, J. E. & Gama, L., Jul 1 2017, In : mBio. 8, 4, e01186-17.

Research output: Contribution to journalArticle

Open Access
Simian Immunodeficiency Virus
Macaca
Macrophages
Brain
HIV
76 Citations (Scopus)

Defining total-body AIDS-virus burden with implications for curative strategies

Estes, J. D., Kityo, C., Ssali, F., Swainson, L., Makamdop, K. N., Del Prete, G. Q., Deeks, S. G., Luciw, P. A., Chipman, J. G., Beilman, G. J., Hoskuldsson, T., Khoruts, A., Anderson, J., Deleage, C., Jasurda, J., Schmidt, T. E., Hafertepe, M., Callisto, S. P., Pearson, H., Reimann, T. & 12 others, Schuster, J., Schoephoerster, J., Southern, P., Perkey, K., Shang, L., Wietgrefe, S. W., Fletcher, C. V., Lifson, J. D., Douek, D. C., McCune, J. M., Haase, A. T. & Schacker, T. W., Nov 1 2017, In : Nature Medicine. 23, 11, p. 1271-1276 6 p.

Research output: Contribution to journalArticle

Open Access
Viruses
Lymphoid Tissue
HIV
Tissue
Proviruses
17 Citations (Scopus)

Epithelium-innate immune cell axis in mucosal responses to SIV

Shang, L., Duan, L., Perkey, K. E., Wietgrefe, S., Zupancic, M., Smith, A. J., Southern, P. J., Johnson, R. P. & Haase, A. T., Mar 1 2017, In : Mucosal Immunology. 10, 2, p. 508-519 12 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Epithelium
Chemokines
T-Lymphocytes
Macrophages
1 Citation (Scopus)

Evaluation of Vaginal Drug Levels and Safety of a Locally Administered Glycerol Monolaurate Cream in Rhesus Macaques

Kirtane, A. R., Rothenberger, M. K., Frieberg, A., Nephew, K., Schultz-Darken, N., Schmidt, T., Reimann, T., Haase, A. T. & Panyam, J., Jul 1 2017, In : Journal of Pharmaceutical Sciences. 106, 7, p. 1821-1827 7 p.

Research output: Contribution to journalArticle

Open Access
Drug Evaluation
Macaca mulatta
Safety
Foams and Jellies Vaginal Creams
Intravaginal Administration
19 Citations (Scopus)

Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study

Cummins, N. W., Rizza, S., Litzow, M. R., Hua, S., Lee, G. Q., Einkauf, K., Chun, T. W., Rhame, F., Baker, J. V., Busch, M. P., Chomont, N., Dean, P. G., Fromentin, R., Haase, A. T., Hampton, D., Keating, S. M., Lada, S. M., Lee, T. H., Natesampillai, S., Richman, D. D. & 7 others, Schacker, T. W., Wietgrefe, S. W., Yu, X. G., Yao, J. D., Zeuli, J., Lichterfeld, M. & Badley, A. D., Nov 1 2017, In : PLoS medicine. 14, 11, e1002461.

Research output: Contribution to journalArticle

Open Access
HIV-1
Stem Cells
HIV
Transplants
Stem Cell Transplantation
1 Citation (Scopus)

Lorenzo-Redondo et al. reply

Lorenzo-Redondo, R., Fryer, H. R., Bedford, T., Kim, E. Y., Archer, J., Pond, S. L. K., Chung, Y. S., Penugonda, S., Chipman, J. G., Fletcher, C. V., Schacker, T. W., Malim, M. H., Rambaut, A., Haase, A. T., McLean, A. R. & Wolinsky, S. M., Nov 22 2017, In : Nature. 551, 7681, p. E10

Research output: Contribution to journalComment/debate

51 Citations (Scopus)

Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaques

Gama, L., Abreu, C. M., Shirk, E. N., Price, S. L., Li, M., Laird, G. M., Metcalf Pate, K. A., Wietgrefe, S. W., O'Connor, S. L., Pianowski, L., Haase, A. T., Van Lint, C. & Siliciano, R. F., Jan 1 2017, In : AIDS. 31, 1, p. 5-14 10 p.

Research output: Contribution to journalArticle

Open Access
Simian Immunodeficiency Virus
Macaca
Cerebrospinal Fluid
Brain
Viral Load
2016
99 Citations (Scopus)

Macrophages sustain HIV replication in vivo independently of T cells

Honeycutt, J. B., Wahl, A., Baker, C., Spagnuolo, R. A., Foster, J., Zakharova, O., Wietgrefe, S., Caro-Vegas, C., Madden, V., Sharpe, G., Haase, A. T., Eron, J. J. & Garcia, J. V., Apr 1 2016, In : Journal of Clinical Investigation. 126, 4, p. 1353-1366 14 p.

Research output: Contribution to journalArticle

Macrophages
HIV
T-Lymphocytes
HIV Infections
Monocytes
11 Citations (Scopus)

Mucosal humoral immune response to SIVmac239Δnef vaccination and vaginal challenge

Zeng, M., Smith, A. J., Shang, L., Wietgrefe, S. W., Voss, J. E., Carlis, J. V., Li, Q., Piatak, M., Lifson, J. D., Johnson, R. P. & Haase, A. T., Mar 15 2016, In : Journal of Immunology. 196, 6, p. 2809-2818 10 p.

Research output: Contribution to journalArticle

Mucosal Immunity
Humoral Immunity
HIV-1
AIDS Vaccines
Vaccination
262 Citations (Scopus)

Persistent HIV-1 replication maintains the tissue reservoir during therapy

Lorenzo-Redondo, R., Fryer, H. R., Bedford, T., Kim, E. Y., Archer, J., Kosakovsky Pond, S. L., Chung, Y. S., Penugonda, S., Chipman, J. G., Fletcher, C. V., Schacker, T. W., Malim, M. H., Rambaut, A., Haase, A. T., McLean, A. R. & Wolinsky, S. M., Feb 4 2016, In : Nature. 530, 7588, p. 51-56 6 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
HIV-1
Viruses
Viral RNA
Population Dynamics
14 Citations (Scopus)

Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection

Adnan, S., Reeves, R. K., Gillis, J., Wong, F. E., Yu, Y., Camp, J. V., Li, Q., Connole, M., Li, Y., Piatak, M., Lifson, J. D., Li, W., Keele, B. F., Kozlowski, P. A., Desrosiers, R. C., Haase, A. T. & Johnson, R. P., Dec 13 2016, In : PLoS pathogens. 12, 12, e1006104.

Research output: Contribution to journalArticle

Immunity
Vaccination
Lymphoid Tissue
T-Lymphocytes
Cellular Immunity
5 Citations (Scopus)

Reproducing SIVDnef vaccine correlates of protection: Trimeric gp41 antibody concentrated at mucosal front lines

Voss, J. E., Macauley, M. S., Rogers, K. A., Villinger, F., Duan, L., Shang, L., Fink, E. A., Andrabi, R., Colantonio, A. D., Robinson, J. E., Johnson, P. P., Burton, D. R. & Haase, A. T., Oct 23 2016, In : AIDS. 30, 16, p. 2427-2438 12 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Vaccines
Antibodies
Immunization
AIDS Vaccines
2015
29 Citations (Scopus)

Antifibrotic therapy in simian immunodeficiency virus infection preserves CD4+ T-cell populations and improves immune reconstitution with antiretroviral therapy

Estes, J. D., Reilly, C., Trubey, C. M., Fletcher, C. V., Cory, T. J., Piatak, M., Russ, S., Anderson, J., Reimann, T. G., Star, R., Smith, A., Tracy, R. P., Berglund, A., Schmidt, T., Coalter, V., Chertova, E., Smedley, J., Haase, A. T., Lifson, J. D. & Schacker, T. W., Jan 1 2015, In : Journal of Infectious Diseases. 211, 5, p. 744-754 11 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Diseases
T-Lymphocytes
Population
Therapeutics
55 Citations (Scopus)

Broadly neutralizing human immunodeficiency virus type 1 antibody gene transfer protects nonhuman primates from mucosal simianhuman immunodeficiency virus infection

Saunders, K. O., Wang, L., Joyce, M. G., Yang, Z. Y., Balazs, A. B., Cheng, C., Ko, S. Y., Kong, W. P., Rudicell, R. S., Georgiev, I. S., Duan, L., Foulds, K. E., Donaldson, M., Xu, L., Schmidt, S. D., Todd, J. P., Baltimore, D., Roederer, M., Haase, A. T., Kwong, P. D. & 3 others, Rao, S. S., Mascola, J. R. & Nabel, G. J., Jan 1 2015, In : Journal of virology. 89, 16, p. 8334-8345 12 p.

Research output: Contribution to journalArticle

immunosuppression
Virus Diseases
Human immunodeficiency virus 1
Neutralizing Antibodies
neutralizing antibodies
5 Citations (Scopus)

Characterization of CD8+ T Cell Differentiation following SIVΔnef Vaccination by Transcription Factor Expression Profiling

Billingsley, J. M., Rajakumar, P. A., Connole, M. A., Salisch, N. C., Adnan, S., Kuzmichev, Y. V., Hong, H. S., Reeves, R. K., Kang, H. J., Li, W., Li, Q., Haase, A. T. & Johnson, R. P., Mar 1 2015, In : PLoS pathogens. 11, 3, p. 1-22 22 p., e1004740.

Research output: Contribution to journalArticle

Cell Differentiation
Vaccination
Transcription Factors
T-Lymphocytes
Macaca
1 Citation (Scopus)

Focusing national institutes of health HIV/AIDS research for maximum population impact

Walensky, R. P., Carpenter, C. J., Auerbach, J. D., Agosto-Rosario, M., Averitt, D., Bartlett, J. G., Curran, J. W., DiClemente, R. J., El-Sadr, W., Haase, A. T., Hillier, S., Holmes, K. K. & Volberding, P. A., Jan 1 2015, In : Clinical Infectious Diseases. 60, 6, p. 937-940 4 p.

Research output: Contribution to journalReview article

National Institutes of Health (U.S.)
Acquired Immunodeficiency Syndrome
HIV
Research
Population
9 Citations (Scopus)

Glycerol monolaurate microbicide protection against repeat high-dose SIV vaginal challenge

Haase, A. T., Rakasz, E., Schultz-Darken, N., Nephew, K., Weisgrau, K. L., Reilly, C. S., Li, Q., Southern, P., Rothenberger, M. K., Peterson, M. L. & Schlievert, P. M., Jun 9 2015, In : PloS one. 10, 6, e0129465.

Research output: Contribution to journalArticle

Anti-Infective Agents
glycerol
anti-infective agents
dosage
Anti-Retroviral Agents
121 Citations (Scopus)

Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption

Rothenberger, M. K., Keele, B. F., Wietgrefe, S. W., Fletcher, C. V., Beilman, G. J., Chipman, J. G., Khoruts, A., Estes, J. D., Anderson, J., Callisto, S. P., Schmidt, T. E., Thorkelson, A., Reilly, C., Perkey, K., Reimann, T. G., Utay, N. S., Makamdop, K. N., Stevenson, M., Douek, D. C., Haase, A. T. & 1 others, Schacker, T. W., Mar 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 10, p. E1126-E1134

Research output: Contribution to journalArticle

Lymphoid Tissue
HIV
Viral Load
Infection
Viruses
17 Citations (Scopus)

Site-specific differences in T cell frequencies and phenotypes in the blood and gut of HIV-uninfected and ART-treated HIV+ adults

Yukl, S. A., Shergill, A. K., Girling, V., Li, Q., Killian, M., Epling, L., Li, P., Kaiser, P., Haase, A., Havlir, D. V., McQuaid, K., Sinclair, E. & Wong, J. K., Mar 26 2015, In : PloS one. 10, 3, e0121290.

Research output: Contribution to journalArticle

T-cells
Blood
digestive system
T-lymphocytes
HIV
7 Citations (Scopus)

SIV infection of lung macrophages

Li, Y., Kang, G., Duan, L., Lu, W., Katze, M. G., Lewis, M. G., Haase, A. T. & Li, Q., May 1 2015, In : PloS one. 10, 5, e0125500.

Research output: Contribution to journalArticle

Macrophages
T-cells
macrophages
lungs
T-lymphocytes
55 Citations (Scopus)

Sustained delivery of a broadly neutralizing antibody in nonhuman primates confers long-term protection against simian/human immunodeficiency virus infection

Saunders, K. O., Pegu, A., Georgiev, I. S., Zeng, M., Gordon Joyce, M., Yang, Z. Y., Ko, S. Y., Chen, X., Schmidt, S. D., Haase, A. T., Todd, J. P., Bao, S., Kwong, P. D., Rao, S. S., Mascola, J. R. & Nabel, G. J., Jan 1 2015, In : Journal of virology. 89, 11, p. 5895-5903 9 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
HIV infections
Virus Diseases
Neutralizing Antibodies
neutralizing antibodies
2014
149 Citations (Scopus)

Enhanced neonatal Fc receptor function improves protection against primate SHIV infection

Ko, S. Y., Pegu, A., Rudicell, R. S., Yang, Z. Y., Joyce, M. G., Chen, X., Wang, K., Bao, S., Kraemer, T. D., Rath, T., Zeng, M., Schmidt, S. D., Todd, J. P., Penzak, S. R., Saunders, K. O., Nason, M. C., Haase, A. T., Rao, S. S., Blumberg, R. S., Mascola, J. R. & 1 others, Nabel, G. J., Aug 13 2014, In : Nature. 514, 7524, p. 642-645 4 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Diseases
Primates
HIV-1
HIV
26 Citations (Scopus)

Live simian immunodeficiency virus vaccine correlate of protection: Immune complex-inhibitory fc receptor interactions that reduce target cell availability

Smith, A. J., Wietgrefe, S. W., Shang, L., Reilly, C. S., Southern, P. J., Perkey, K. E., Duan, L., Kohler, H., Müller, S., Robinson, J., Carlis, J. V., Li, Q., Johnson, R. P. & Haase, A. T., Sep 15 2014, In : Journal of Immunology. 193, 6, p. 3126-3133 8 p.

Research output: Contribution to journalArticle

AIDS Vaccines
Simian Immunodeficiency Virus
Fc Receptors
Antigen-Antibody Complex
HIV-1
45 Citations (Scopus)

Live simian immunodeficiency virus vaccine correlate of protection: Local antibody production and concentration on the path of virus entry

Li, Q., Zeng, M., Duan, L., Voss, J. E., Smith, A. J., Pambuccian, S., Shang, L., Wietgrefe, S., Southern, P. J., Reilly, C. S., Skinner, P. J., Zupancic, M. L., Carlis, J. V., Piatak, M., Waterman, D., Reeves, R. K., Masek-Hammerman, K., Derdeyn, C. A., Alpert, M. D., Evans, D. T. & 7 others, Kohler, H., Müller, S., Robinson, J., Lifson, J. D., Burton, D. R., Johnson, R. P. & Haase, A. T., Sep 15 2014, In : Journal of Immunology. 193, 6, p. 3113-3125 13 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Internalization
Antibody Formation
Vaccines
Epithelium
13 Citations (Scopus)

NK cell responses to simian immunodeficiency virus vaginal exposure in naive and vaccinated rhesus macaques

Shang, L., Smith, A. J., Duan, L., Perkey, K. E., Qu, L., Wietgrefe, S., Zupancic, M., Southern, P. J., Masek-Hammerman, K., Reeves, R. K., Johnson, R. P. & Haase, A. T., Jul 1 2014, In : Journal of Immunology. 193, 1, p. 277-284 8 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Macaca mulatta
Natural Killer Cells
Mucous Membrane
Haplorhini
1 Citation (Scopus)

Overview of the Landscape of HIV Prevention

Haase, A. T., Jan 1 2014, In : American Journal of Reproductive Immunology. 71, 6, p. 490-494 5 p.

Research output: Contribution to journalArticle

HIV
Mucosal Immunity
Contraceptive Agents
HIV Infections
Hormones
313 Citations (Scopus)

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

Fletcher, C. V., Staskus, K., Wietgrefe, S. W., Rothenberger, M., Reilly, C., Chipman, J. G., Beilman, G. J., Khoruts, A., Thorkelson, A., Schmidt, T. E., Anderson, J., Perkey, K., Stevenson, M., Perelson, A. S., Douek, D. C., Haase, A. T. & Schacker, T. W., Feb 11 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 6, p. 2307-2312 6 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
HIV-1
Follicular Dendritic Cells
Viral RNA
Virus Replication
9 Citations (Scopus)

Serial cervicovaginal exposures with replication-deficient sivsm induce higher dendritic cell (pDC) and CD4+ T-Cell infiltrates not associated with prevention but a more severe SIVmac251 infection of rhesus macaques

Abdulhaqq, S. A., Martinez, M. I., Kang, G., Foulkes, A. S., Rodriguez, I. V., Nichols, S. M., Hunter, M., Sariol, C. A., Ruiz, L. A., Ross, B. N., Yin, X., Speicher, D. W., Haase, A. T., Marx, P. A., Li, Q., Kraiselburd, E. N. & Montaner, L. J., Apr 1 2014, In : Journal of Acquired Immune Deficiency Syndromes. 65, 4, p. 405-413 9 p.

Research output: Contribution to journalArticle

Macaca mulatta
Simian Immunodeficiency Virus
Dendritic Cells
T-Lymphocytes
Macaca
73 Citations (Scopus)

Targeted Cytotoxic Therapy Kills Persisting HIV Infected Cells During ART

Denton, P. W., Long, J. M., Wietgrefe, S. W., Sykes, C., Spagnuolo, R. A., Snyder, O. D., Perkey, K., Archin, N. M., Choudhary, S. K., Yang, K., Hudgens, M. G., Pastan, I., Haase, A. T., Kashuba, A. D., Berger, E. A., Margolis, D. M. & Garcia, J. V., Jan 1 2014, In : PLoS Pathogens. 10, 1, e1003872.

Research output: Contribution to journalArticle

HIV
Therapeutics
Viral RNA
Thymus Gland
Immunotoxins
2013
159 Citations (Scopus)

Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient

Yukl, S. A., Boritz, E., Busch, M., Bentsen, C., Chun, T. W., Douek, D., Eisele, E., Haase, A. T., Ho, Y. C., Hütter, G., Justement, J. S., Keating, S., Lee, T. H., Li, P., Murray, D., Palmer, S., Pilcher, C., Pillai, S., Price, R. W., Rothenberger, M. K. & 8 others, Schacker, T. W., Siliciano, J., Siliciano, R., Sinclair, E., Strain, M., Wong, J., Richman, D. & Deeks, S. G., May 1 2013, In : PLoS pathogens. 9, 5, e1003347.

Research output: Contribution to journalArticle

Berlin
HIV
Blood Cells
Lymph Nodes
RNA
18 Citations (Scopus)

Location and dynamics of the immunodominant CD8 T cell response to SIVΔnef immunization and SIVmac251 vaginal challenge

Sasikala-Appukuttan, A. K., Kim, H. O., Kinzel, N. J., Hong, J. J., Smith, A. J., Wagstaff, R., Reilly, C., Piatak, M., Lifson, J. D., Reeves, R. K., Johnson, R. P., Haase, A. T. & Skinner, P. J., Dec 9 2013, In : PloS one. 8, 12, e81623.

Research output: Contribution to journalArticle

Immunization
SAIDS Vaccines
T-cells
live vaccines
HIV-1
2012
52 Citations (Scopus)

Critical role of CD4 T cells in maintaining lymphoid tissue structure for immune cell homeostasis and reconstitution

Zeng, M., Paiardini, M., Engram, J. C., Beilman, G. J., Chipman, J. G., Schacker, T. W., Silvestri, G. & Haase, A. T., Aug 30 2012, In : Blood. 120, 9, p. 1856-4867 3012 p.

Research output: Contribution to journalArticle

T-cells
Lymphoid Tissue
Homeostasis
Tissue
T-Lymphocytes
91 Citations (Scopus)
Lymphoid Tissue
HIV Infections
HIV-1
T-Lymphocytes
Highly Active Antiretroviral Therapy
62 Citations (Scopus)

Lymphoid tissue structure and HIV-1 infection: Life or death for T cells

Zeng, M., Haase, A. T. & Schacker, T. W., Jun 1 2012, In : Trends in Immunology. 33, 6, p. 306-314 9 p.

Research output: Contribution to journalReview article

Interleukin-7
Lymphoid Tissue
HIV Infections
HIV-1
T-Lymphocytes
33 Citations (Scopus)

Replicating adenovirus-simian immunodeficiency virus (SIV) vectors efficiently prime siv-specific systemic and mucosal immune responses by targeting myeloid dendritic cells and persisting in rectal macrophages, regardless of immunization route

Patterson, L. J., Kuate, S., Daltabuit-Test, M., Li, Q., Xiao, P., McKinnon, K., DiPasquale, J., Cristillo, A., Venzon, D., Haase, A. T. & Robert-Guroff, M., May 1 2012, In : Clinical and Vaccine Immunology. 19, 5, p. 629-637 9 p.

Research output: Contribution to journalArticle

Immunization
Simian Immunodeficiency Virus
Mucosal Immunity
Macrophages
Myeloid Cells
127 Citations (Scopus)

Vaccine-induced CD8+ T cells control AIDS virus replication

Mudd, P. A., Martins, M. A., Ericsen, A. J., Tully, D. C., Power, K. A., Bean, A. T., Piaskowski, S. M., Duan, L., Seese, A., Gladden, A. D., Weisgrau, K. L., Furlott, J. R., Kim, Y. I., De Santana, M. G. V., Rakasz, E., Iii, S. C., Wilson, N. A., Bonaldo, M. C., Galler, R., Allison, D. B. & 5 others, Piatak, M., Haase, A. T., Lifson, J. D., Allen, T. M. & Watkins, D. I., Nov 1 2012, In : Nature. 491, 7422, p. 129-133 5 p.

Research output: Contribution to journalArticle

Virus Replication
Vaccines
HIV
T-Lymphocytes
Epitopes
2011
182 Citations (Scopus)

Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

Zeng, M., Smith, A. J., Wietgrefe, S. W., Southern, P. J., Schacker, T. W., Reilly, C. S., Estes, J. D., Burton, G. F., Silvestri, G., Lifson, J. D., Carlis, J. V. & Haase, A. T., Mar 1 2011, In : Journal of Clinical Investigation. 121, 3, p. 998-1008 11 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
HIV-1
Fibrosis
T-Lymphocytes
Infection
233 Citations (Scopus)

Early events in sexual transmission of hiv and siv and opportunities for interventions

Haase, A. T., Feb 18 2011, In : Annual review of medicine. 62, p. 127-139 13 p.

Research output: Contribution to journalArticle

Infection
Immunology
Virology
Pandemics
Anti-Infective Agents
29 Citations (Scopus)

The immunosuppressive role of IL-32 in lymphatic tissue during HIV-1 infection

Smith, A. J., Toledo, C. M., Wietgrefe, S. W., Duan, L., Schacker, T. W., Reilly, C. S. & Haase, A. T., Jun 1 2011, In : Journal of Immunology. 186, 11, p. 6576-6584 9 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
Immunosuppressive Agents
HIV Infections
HIV-1
Epithelial Cells
2010
4 Citations (Scopus)

AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4

García, A., Siddappa, N. B., Li, Q., Haase, A. T., Paul, K., Stroud, F., Zhang, X., Fountain, J. A., Villinger, F., Novembre, F. J., Else, J. G., Evan Secor, W. & Ruprecht, R. M., Oct 1 2010, In : Journal of Medical Primatology. 39, 5, p. 356-360 5 p.

Research output: Contribution to journalArticle

Optic Neuritis
Macaca mulatta
optics
Acquired Immunodeficiency Syndrome
Simian Immunodeficiency Virus
32 Citations (Scopus)
Claudin-2
Syndecan-1
HIV Infections
HIV-1
T-Lymphocytes
286 Citations (Scopus)

Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections

Estes, J. D., Harris, L. D., Klatt, N. R., Tabb, B., Pittaluga, S., Paiardini, M., Barclay, G. R., Smedley, J., Pung, R., Oliveira, K. M., Hirsch, V. M., Silvestri, G., Douek, D. C., Miller, C. J., Haase, A. T., Lifson, J. & Brenchley, J. M., Aug 1 2010, In : PLoS Pathogens. 6, 8, p. 49-50 2 p., e1001052.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Diseases
Gastrointestinal Tract
Macaca mulatta
HIV Infections
180 Citations (Scopus)

Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy

Yukl, S. A., Gianella, S., Sinclair, E., Epling, L., Li, Q., Duan, L., Choi, A. L. M., Girling, V., Ho, T., Li, P., Fujimoto, K., Lampiris, H., Hare, C. B., Pandori, M., Haase, A. T., Günthard, H. F., Fischer, M., Shergill, A. K., McQuaid, K., Havlir, D. V. & 1 others, Wong, J. K., Nov 15 2010, In : Journal of Infectious Diseases. 202, 10, p. 1553-1561 9 p.

Research output: Contribution to journalArticle

HIV
T-Lymphocytes
RNA
DNA
Therapeutics
27 Citations (Scopus)

Host genes associated with HIV-1 replication in lymphatic tissue

Smith, A. J., Li, Q., Wietgrefe, S. W., Schacker, T. W., Reilly, C. S. & Haase, A. T., Nov 1 2010, In : Journal of Immunology. 185, 9, p. 5417-5424 8 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
HIV-1
Genes
Viral Load
Heterochromatin