Projects per year
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Research interests
My work focuses on evaluating striated muscle structure-function in both physiological and disease states. To do this I use a FRET-based muscle specific biosensor to track changes in sarcomere activation in intact muscle in real time, while simultaneously measuring force generation.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Projects
- 1 Finished
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FRET-based study of the role of myosin-binding protein C in the structure-function of intact cardiac muscles
AMERICAN HEART ASSOCIATION, INC
4/1/21 → 3/31/23
Project: Research project
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Duchenne muscular dystrophy: disease mechanism and therapeutic strategies
Bez Batti Angulski, A., Hosny, N., Cohen, H., Martin, A. A., Hahn, D., Bauer, J. & Metzger, J. M., 2023, In: Frontiers in Physiology. 14, 1183101.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
Interrogation of skeletal muscle activation in an intact system via a myofilament incorporated FRET biosensor
Martin, A. A., Thompson, B. R. & Metzger, J. M., Feb 10 2023, In: Biophysical journal. 122, 3S1, p. 28aResearch output: Contribution to journal › Article › peer-review
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Cardiac Sarcomere Signaling in Health and Disease
Martin, A. A., Thompson, B. R., Hahn, D., Angulski, A. B. B., Hosny, N., Cohen, H. & Metzger, J. M., Dec 2022, In: International journal of molecular sciences. 23, 24, 16223.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Sarcomere dynamics revealed by a myofilament integrated FRET-based biosensor in live skeletal muscle fibers
Martin, A. A., Thompson, B. R., Davis, J. P., Vang, H., Hahn, D. & Metzger, J. M., Dec 2022, In: Scientific reports. 12, 1, 18116.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Dysregulation of calcium handling in duchenne muscular dystrophy-associated dilated cardiomyopathy: Mechanisms and experimental therapeutic strategies
Law, M. L., Cohen, H., Martin, A. A., Angulski, A. B. B. & Metzger, J. M., Feb 2020, In: Journal of Clinical Medicine. 9, 2, 520.Research output: Contribution to journal › Review article › peer-review
Open Access41 Scopus citations