Anthony Baughn

20022021
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Personal profile

Research interests

The ability of Mycobacterium tuberculosis (Mtb) to persist in the presence of anti-mycobacterial drugs and immune effector functions is the greatest obstacle in our attempt to eradicate tuberculosis (TB). My laboratory is investigating the hypothesis that persistence is enabled by entrance into and maintenance of a physiological state that is metabolically distinct from that of actively replicating bacilli. The aim of this work is to define this state (or series of states) and characterize pathways that are essential for its establishment and maintenance. My laboratory uses a variety of classical and novel approaches in mycobacterial genetics, biochemistry, physiology, and metabolomics to characterize i) novel aspects of intermediary metabolism in Mtb, ii) metabolic requirements for phenotypic drug tolerance, and iii) drug targets and drug-like compounds effective against persistent bacilli. While these studies address basic science questions about unique aspects of Mtb, they will also provide important contributions to the collaborative and global effort to eradicate TB.

Research interests

  • drug discovery
  • microbial genetics
  • metabolomics
  • tuberculosis
  • microbiology
  • drug mechanism
  • metabolism
  • drug resistance
  • tb

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Projects 2011 2021

Pyrazinamide
Mycobacterium tuberculosis
Drug Tolerance
chelation
metals
Cyclic Peptides
Tuberculosis
Pharmaceutical Preparations
Mycobacterium tuberculosis

Research Output 2002 2019

1 Citation (Scopus)

Genomewide assessment of mycobacterium tuberculosis conditionally essential metabolic pathways

Minato, Y., Gohl, D. M., Thiede, J. M., Chacón, J. M., Harcombe, W. R., Maruyama, F., Baughn, A. D. & Dorrestein, P. C., Jun 25 2019, In : mSystems. 4, 4, e00070-19.

Research output: Contribution to journalArticle

Open Access
Tuberculosis
tuberculosis
Mycobacterium tuberculosis
Metabolic Networks and Pathways
biochemical pathways

Revitalizing antifolates through understanding mechanisms that govern susceptibility and resistance

Kordus, S. L. & Baughn, A., Jan 1 2019, In : MedChemComm. 10, 6, p. 880-895 16 p.

Research output: Contribution to journalReview article

Folic Acid Antagonists
Folic Acid
Biosynthesis
Proton-Coupled Folate Transporter
Purines
4 Citations (Scopus)

Methionine Antagonizes para-Aminosalicylic Acid Activity via Affecting Folate Precursor Biosynthesis in Mycobacterium tuberculosis

Howe, M. D., Kordus, S. L., Cole, M. S., Bauman, A. A., Aldrich, C., Baughn, A. & Minato, Y., Nov 12 2018, In : Frontiers in cellular and infection microbiology. 8, 1 p.

Research output: Contribution to journalArticle

Open Access
Aminosalicylic Acid
Mycobacterium tuberculosis
Folic Acid
Methionine
4-Aminobenzoic Acid
4 Citations (Scopus)

Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole

Minato, Y., Dawadi, S., Kordus, S. L., Sivanandam, A., Aldrich, C. C. & Baughn, A. D., Mar 8 2018, In : Nature Communications. 9, 1

Research output: Contribution to journalArticle