Anna Sundborger-Lunna

Assistant Professor

Accepting PhD Students

PhD projects

The role of dynamin family members in innate immunity

20052015

Research output per year

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Personal profile

Research interests

The goal of the Sundborger-Lunna lab is to unravel the molecular mechanisms controlling essential intracellular membrane remodeling and trafficking events, such as endo-lysosomal trafficking, apoptosis, autophagy and regulation of mitochondrial dynamics. Our main focus is to characterize structure and function of macromolecular protein complexes involved in the regulation of these pathways using Cryo-Electron Microscopy (Cryo-EM) in combination with biochemical assays and functional cell models. We are especially interested in how membrane bending BAR-domain proteins and members of the dynamin family of large GTPases, responsible for membrane fission and fusion, assemble into large complexes and coordinate their efforts to regulate fundamental cellular events. Long-term, we aim to investigate how dysregulation of intracellular membrane remodeling processes may contribute to infectious diseases and cancer.

Research interests

  • structural biology
  • cryo-electron microscopy
  • Membranes and Vesicles
  • BAR proteins
  • apoptosis
  • Cancer cell biology

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

Research Output

Adult-onset autosomal dominant spastic paraplegia linked to a GTPase-effector domain mutation of dynamin 2

Sambuughin, N., Goldfarb, L. G., Sivtseva, T. M., Davydova, T. K., Vladimirtsev, V. A., Osakovskiy, V. L., Danilova, A. P., Nikitina, R. S., Ylakhova, A. N., Diachkovskaya, M. P., Sundborger, A. C., Renwick, N. M., Platonov, F. A., Hinshaw, J. E. & Toro, C., Oct 30 2015, In : BMC Neurology. 15, 1, 223.

Research output: Contribution to journalArticle

Open Access
  • 15 Scopus citations

    A hemi-fission intermediate links two mechanistically distinct stages of membrane fission

    Mattila, J. P., Shnyrova, A. V., Sundborger, A. C., Hortelano, E. R., Fuhrmans, M., Neumann, S., Müller, M., Hinshaw, J. E., Schmid, S. L. & Frolov, V. A., Aug 6 2015, In : Nature. 524, 7563, p. 109-113 5 p.

    Research output: Contribution to journalArticle

  • 53 Scopus citations

    Dynamins and BAR proteins—Safeguards against cancer

    Sundborger, A. C. & Hinshaw, J. E., Jan 1 2015, In : Critical Reviews in Oncogenesis. 20, 5-6, p. 475-484 10 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    A dynamin mutant defines a superconstricted prefission state

    Sundborger, A. C., Fang, S., Heymann, J. A., Ray, P., Chappie, J. S. & Hinshaw, J. E., Aug 7 2014, In : Cell reports. 8, 3, p. 734-742 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • 49 Scopus citations

    Regulating dynamin dynamics during endocytosis

    Sundborger, A. C. & Hinshaw, J. E., Oct 1 2014, In : F1000Prime Reports. 6, 85.

    Research output: Contribution to journalReview article

  • 19 Scopus citations