Anna M Lee

20062024
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Research Output 2006 2018

2018
3 Citations (Scopus)

Novel Small-Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice

Blasio, A., Wang, J., Wang, D., Varodayan, F. P., Pomrenze, M. B., Miller, J., Lee, A. M., McMahon, T., Gyawali, S., Wang, H. Y., Roberto, M., McHardy, S., Pleiss, M. A. & Messing, R. O., Aug 1 2018, In : Biological Psychiatry. 84, 3, p. 193-201 9 p.

Research output: Contribution to journalArticle

Open Access
Protein Kinase C-epsilon
Ethanol
Alcohol Drinking
Sucrose
Phosphotransferases

The nicotinic receptor drug sazetidine-A reduces alcohol consumption in mice without affecting concurrent nicotine consumption

Touchette, J. C., Maertens, J. J., Mason, M. M., O'Rourke, K. Y. & Lee, A. M., May 1 2018, In : Neuropharmacology. 133, p. 63-74 12 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Nicotine
Alcohol Drinking
Pharmaceutical Preparations
Alcohols
2017

Assessing alcohol and nicotine co-consumption in mice

Touchette, J. C. & Lee, A. M., Jan 1 2017, In : Oncotarget. 8, 4, p. 5684-5685 2 p.

Research output: Contribution to journalEditorial

Neurosciences
Nicotine
Sex Characteristics
Alcohols
2016
4 Citations (Scopus)

Voluntary co-consumption of alcohol and nicotine: Effects of abstinence, intermittency, and withdrawal in mice

O'Rourke, K. Y., Touchette, J. C., Hartell, E. C., Bade, E. J. & Lee, A. M., Oct 1 2016, In : Neuropharmacology. 109, p. 236-246 11 p.

Research output: Contribution to journalArticle

Nicotine
Alcohol Drinking
Alcohols
Alcohol Abstinence
Pharmaceutical Preparations
2015
9 Citations (Scopus)

PKCε phosphorylates α4β2 nicotinic ACh receptors and promotes recovery from desensitization

Lee, A. M., Wu, D. F., Dadgar, J., Wang, D., McMahon, T. & Messing, R. O., Sep 1 2015, In : British Journal of Pharmacology. 172, 17, p. 4430-4441 12 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Cholinergic Receptors
Phosphorylation
Induced Hypothermia
Synaptosomes
2014
10 Citations (Scopus)

Deletion of Prkcz Increases Intermittent Ethanol Consumption in Mice

Lee, A. M., Zou, M. E., Lim, J. P., Stecher, J., Mcmahon, T. & Messing, R. O., Jan 1 2014, In : Alcoholism: Clinical and Experimental Research. 38, 1, p. 170-178 9 p.

Research output: Contribution to journalArticle

Protein Kinase C
Ethanol
Drinking
Proteins
PC12 Cells
2013
156 Citations (Scopus)

Prkcz null mice show normal learning and memory

Lee, A. M., Kanter, B. R., Wang, D., Lim, J. P., Zou, M. E., Qiu, C., McMahon, T., Dadgar, J., Fischbach-Weiss, S. C. & Messing, R. O., Jan 17 2013, In : Nature. 493, 7432, p. 416-419 4 p.

Research output: Contribution to journalArticle

Protein Kinase C
Learning
Peptides
Cocaine
Long-Term Memory
2011
16 Citations (Scopus)
Protein Kinase C-epsilon
Nucleus Accumbens
Nicotine
Reward
Dopamine
2008
54 Citations (Scopus)

Induction of the drug metabolizing enzyme CYP2D in monkey brain by chronic nicotine treatment

Mann, A., Miksys, S., Lee, A., Mash, D. C. & Tyndale, R. F., Dec 1 2008, In : Neuropharmacology. 55, 7, p. 1147-1155 9 p.

Research output: Contribution to journalArticle

Nicotine
Haplorhini
Cytochrome P-450 CYP2D6
Brain
Enzymes
55 Citations (Scopus)

Protein kinases and addiction

Lee, A. M. & Messing, R. O., Oct 2008, Addiction Reviews 2008. Blackwell Publishing Inc, p. 22-57 36 p. (Annals of the New York Academy of Sciences; vol. 1141).

Research output: Chapter in Book/Report/Conference proceedingChapter

Protein Kinases
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Street Drugs
Substance-Related Disorders
Calcium-Calmodulin-Dependent Protein Kinase Kinase
2007
93 Citations (Scopus)

CYP2B6 Genotype Alters Abstinence Rates in a Bupropion Smoking Cessation Trial

Lee, A. M., Jepson, C., Hoffmann, E., Epstein, L., Hawk, L. W., Lerman, C. & Tyndale, R. F., Sep 15 2007, In : Biological Psychiatry. 62, 6, p. 635-641 7 p.

Research output: Contribution to journalArticle

Bupropion
Smoking Cessation
Genotype
Placebos
Therapeutics
35 Citations (Scopus)

CYP2B6 genotype does not alter nicotine metabolism, plasma levels, or abstinence with nicotine replacement therapy

Lee, A. M., Jepson, C., Shields, P. G., Benowitz, N., Lerman, C. & Tyndale, R. F., Jun 1 2007, In : Cancer Epidemiology Biomarkers and Prevention. 16, 6, p. 1312-1314 3 p.

Research output: Contribution to journalArticle

N Demethylating Oxidoreductases
Inhalation Administration
Nicotinic Agonists
Cutaneous Administration
Aryl Hydrocarbon Hydroxylases
2006
36 Citations (Scopus)

CYP2B6 is expressed in African Green monkey brain and is induced by chronic nicotine treatment

Lee, A. M., Miksys, S., Palmour, R. & Tyndale, R. F., Mar 1 2006, In : Neuropharmacology. 50, 4, p. 441-450 10 p.

Research output: Contribution to journalArticle

Cercopithecus aethiops
Nicotine
Brain
Haplorhini
Bupropion
19 Citations (Scopus)

Drugs and genotypes: How pharmacogenetic information could improve smoking cessation treatment

Lee, A. M. & Tyndale, R. F., Jul 1 2006, In : Journal of Psychopharmacology. 20, 4 SUPPL., p. 7-14 8 p.

Research output: Contribution to journalReview article

Withholding Treatment
Pharmacogenetics
Smoking Cessation
Genotype
Pharmaceutical Preparations
19 Citations (Scopus)
Chlorzoxazone
Cercopithecus aethiops
Cytochrome P-450 CYP2E1
Nicotine
Metabolism
16 Citations (Scopus)

Phenobarbital increases monkey in vivo nicotine disposition and induces liver and brain CYP2B6 protein

Lee, A. M., Miksys, S. & Tyndale, R. F., Jul 22 2006, In : British Journal of Pharmacology. 148, 6, p. 786-794 9 p.

Research output: Contribution to journalArticle

Phenobarbital
Nicotine
Haplorhini
Liver
Brain
9 Citations (Scopus)

Phenobarbital induces monkey brain CYP2E1 protein but not hepatic CYP2E1, in vitro or in vivo chlorzoxazone metabolism

Lee, A. M., Joshi, M., Yue, J. & Tyndale, R. F., Dec 15 2006, In : European Journal of Pharmacology. 552, 1-3, p. 151-158 8 p.

Research output: Contribution to journalArticle

Chlorzoxazone
Cytochrome P-450 CYP2E1
Phenobarbital
Haplorhini
Liver