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Personal profile

Research interests

My research is focused on bacterial host engineering for biosynthesis of secondary metabolites, biomaterials and protein scaffolds. I have a background of metabolic  engineering of bacterial species and fine tuning of the regulatory pathways for improving the titer of secondary metabolites. Furthermore, I am interested in post biosynthetic modification of natural products.

I completed my BSc and MSc at Kathmandu University (Nepal) and obtained my PhD from Institute of Biomolecules Reconstruction, Sun Moon University, South Korea. During PhD, my research projects were focused on genetic engineering of bacterial systems for production of therapeutic small molecules.

In July 2018, I joined University of South Florida as a Postdoctoral researcher and worked on a research project involving screening of MDR bacterial species on wastewater for development of efficient drug delivery systems for targeted nanormediation.

In February 2019, I joined the Schmidt-Dannert lab as a Postdoctoral Research Associate. My current research project involves engineering microbial platform strains for different biomanufacturing applications and development of efficient synthetic biology tools for strain engineering.

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

research projects Agriculture & Biology
engineering Agriculture & Biology
secondary metabolites Agriculture & Biology
scaffolding proteins Agriculture & Biology
synthetic biology Agriculture & Biology
drug delivery systems Agriculture & Biology
metabolic engineering Agriculture & Biology
biocompatible materials Agriculture & Biology

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Research Output 2014 2019

Engineering Streptomyces peucetius for Doxorubicin and Daunorubicin Biosynthesis

Shrestha, B., Pokhrel, A. R., Darsandhari, S., Parajuli, P., Sohng, J. K. & Pandey, R. P., 2019, Engineering Streptomyces peucetius for Doxorubicin and Daunorubicin Biosynthesis. Springer Nature, p. 191-209 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Genome-guided exploration of metabolic features of Streptomyces peucetius ATCC 27952: past, current, and prospect

Thuan, N. H., Dhakal, D., Pokhrel, A. R., Luan, L. C., Pham, T. T. V., Shrestha, A. & Sohng, J. K., 2018, In : Applied Microbiology and Biotechnology.

Research output: Contribution to journalArticle

Implication of orphan histidine kinase (OhkAsp) in biosynthesis of doxorubicin and daunorubicin in Streptomyces peucetius ATCC 27952

Pokhrel, A. R., Nguyen, T. H., Dhakal, D., Chaudhary, A. K. & Sohng, J. K., 2018, In : Microbiological Research.

Research output: Contribution to journalArticle

Modular pathway engineering for resveratrol and piceatannol production in engineered Escherichia coli

Shrestha, A., Pandey, R. P., Pokhrel, A. R., Dhakal, D., Luan, L. C. & Sohng, J. K., 2018, In : Applied Microbiology and Biotechnology.

Research output: Contribution to journalArticle