Projects per year
Personal profile
Research interests
Dr. Widge's research focuses on brain stimulation for severe and treatment-resistant mental illness, with particular emphasis on deep brain stimulation and related implantable technologies. Technologies from his lab are in development to treat depression, obsessive-compulsive disorder, post-traumatic stress disorder, and addiction.
Dr. Widge's recent work has demonstrated new algorithms for closed-loop brain stimulation and stimulation methods for modifying connectivity in the distributed circuits of mental illness. His laboratory studies rodent models for prototyping these new technologies and human patients to identify biomarkers and targets for future intervention. He also co-leads programs to design new neurostimulation technologies in the central and peripheral nervous systems, to evaluate technologies for safety and efficacy in humans, and to improve the quality of clinical biomarker research nationwide.
Certifications and Licenses
Dr. Widge is a board-certified psychiatrist with clinical expertise in brain stimulation, including deep brain stimulation (DBS), vagus nerve stimulation (VNS), and transcranial magnetic stimulation (TMS). He leads clinical trials and applies these technologies in routine treatment.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 4 Quality Education
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SDG 5 Gender Equality
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SDG 7 Affordable and Clean Energy
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SDG 9 Industry, Innovation, and Infrastructure
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SDG 10 Reduced Inequalities
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Collaborations and top research areas from the last five years
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Suicide-related Experience Reduction via Enhancement of Neuroplasticity (SERENE)
Bronstein, M. (PI), Fair, D. A. (PI), Kummerfeld, E. (PI), Lim, H. H. (PI), Nelson, S. M. (PI), Netoff, T. I. (PI), Opitz, A. (PI), Albott, C. S. (CoI), Camchong, J. (CoI), Conelea, C. A. (CoI), Demro, C. L. (CoI), Fisher, M. A. (CoI), Fitzpatrick, K. R. (CoI), Lewis, C. P. (CoI), Lim, K. O. (CoI), Ma, S. (CoI), Nahas, Z. (CoI), Sponheim, S. R. (CoI), Tervo-Clemmens, B. C. (CoI), Vinogradov, S. (CoI), Wilson, S. R. (CoI), Yu, C. C. (CoI), Widge, A. S. (Co-Principal Investigator), Brown, B. (Other Role), Freedman, M. (Other Role), Goodman Keiser, M. D. (Other Role) & Lieske, A. J. (Other Role)
ADV RESEARCH PROJECTS AGENCY FOR HEALTH
7/28/26 → 10/27/27
Project: Research project
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Using Data Science to Reveal Within-Person Causal Pathways to Suicide Ideation
Bronstein, M. (PI), Kummerfeld, E. (CoI), Lim, K. O. (CoI), Widge, A. S. (CoI) & Freedman, M. (Other Role)
AMERICAN FDN FOR SUICIDE PREVENTION
3/1/26 → 2/29/28
Project: Research project
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Optimized, Personalized, and Mechanism-based Depression Treatment (OPTIM-D)
Darrow, D. (PI), Netoff, T. I. (PI), Widge, A. S. (PI), Nagrale, S. S. (Graduate Student) & Sretavan Wong, K. K. (Graduate Student)
DR. RALPH & MARIAN FALK MED RES TRUST
11/30/25 → 11/29/28
Project: Research project
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Ultrasound for Cognitive Flexibility
Widge, A. S. (PI)
MINNESOTA OFFICE OF HIGHER EDUCATION
9/1/25 → 6/30/27
Project: Research project
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Framewise Integrated Real-Time MRI Monitoring (FIRMM) software commercialization readiness for clinical care
Widge, A. S. (PI)
TURING MEDICAL TECHNOLOGIES, INC
10/1/24 → 3/31/27
Project: Research project
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Author Correction: Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation (Nature Biomedical Engineering, (2024), 9, 5, (606-617), 10.1038/s41551-024-01314-3)
Herron, J., Kullmann, A., Denison, T., Goodman, W. K., Gunduz, A., Neumann, W. J., Provenza, N. R., Shanechi, M. M., Sheth, S. A., Starr, P. A. & Widge, A. S., Mar 2026, In: Nature Biomedical Engineering. 10, 3, p. 603 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access1 Link opens in a new tab Scopus citations -
DBS in psychiatric disorders
Dastin-Van Rijn, E. M., Mensinger, M., Dougherty, D. D. & Widge, A. S., Jan 1 2026, The Neuroscience of Deep Brain Stimulation: Research and Clinical Applications. Elsevier, p. 209-270 62 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
1 Link opens in a new tab Scopus citations -
Exploring TMS treatment barriers in TRD: A novel clinical population study on anticipated and experienced treatment barriers
Caola, L. R., Sullivan, C. R. P., Widge, A. S., Cabrera, L. Y. & Wilson, S. R., Mar 2026, In: Transcranial Magnetic Stimulation. 6, 100206.Research output: Contribution to journal › Article › peer-review
Open Access -
Female rats adopt a safety-first strategy in a high-conflict platform mediated avoidance task
Reimer, A. E., Li, C. J., Hu, S. M., Pineda, D., Chang, J. L., Angstman, M. R., Dastin-van Rijn, E. M. & Widge, A. S., 2026, In: Frontiers in Behavioral Neuroscience. 20, 1758605.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Mental Health Parity in Interventional Psychiatry: Access, Ethical and Policy Implications
Cabrera, L. Y., Fleck, L. M. & Widge, A. S., Dec 2026, In: Current psychiatry reports. 28, 1, 52.Research output: Contribution to journal › Review article › peer-review
Open Access
Datasets
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Pybehave: a hardware agnostic, Python-based framework for controlling behavioral neuroscience experiments
Dastin-van Rijn, E. M., Nielsen, J., Sachse, E. M., Li, C., Mensinger, M. E., Simpson, S. G., Buccini, M. C., Iacobucci, F. A., Titus, D. J. & Widge, A. S., ZENODO, May 22 2024
DOI: 10.5281/zenodo.11244351, https://zenodo.org/records/11244351
Dataset
Press/Media
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U of M research team hopes to develop an implantable device to treat mental illness — thanks to a $6.6 million grant
Widge, A. S. & Molnar, G. F.
9/21/20
1 item of Media coverage
Press/Media: Research