Projects per year
Personal profile
Research interests
Dr. Widge's research focuses on brain stimulation for severe and treatment-resistant mental illness, with particular emphasis on deep brain stimulation and related implantable technologies. Technologies from his lab are in development to treat depression, obsessive-compulsive disorder, post-traumatic stress disorder, and addiction.
Dr. Widge's recent work has demonstrated new algorithms for closed-loop brain stimulation and stimulation methods for modifying connectivity in the distributed circuits of mental illness. His laboratory studies rodent models for prototyping these new technologies and human patients to identify biomarkers and targets for future intervention. He also co-leads programs to design new neurostimulation technologies in the central and peripheral nervous systems, to evaluate technologies for safety and efficacy in humans, and to improve the quality of clinical biomarker research nationwide.
Certifications and Licenses
Dr. Widge is a board-certified psychiatrist with clinical expertise in brain stimulation, including deep brain stimulation (DBS), vagus nerve stimulation (VNS), and transcranial magnetic stimulation (TMS). He leads clinical trials and applies these technologies in routine treatment.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Framewise Integrated Real-Time MRI Monitoring (FIRMM) software commercialization readiness for clinical care
Widge, A. S. (PI)
TURING MEDICAL TECHNOLOGIES, INC
10/1/24 → 3/31/26
Project: Research project
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Circuit and Cognitive Mechanisms of Striatal Deep Brain Stimulation
Widge, A. S. (PI)
NIH NAT INST OF NEURO DISORDERS & STROKE
9/1/24 → 8/31/26
Project: Research project
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Treatment Resistant Depression Subcallosal Cingulate Network DBS
Widge, A. S. (PI)
3/29/24 → 1/26/26
Project: Research project
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Glutamatergic plasticity that drives cannabinoid withdrawal and craving
Spencer, S. (PI) & Widge, A. S. (CoI)
9/1/23 → 7/31/28
Project: Research project
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Commercialization readiness of visual biofeedback to reduce head motion during MRI scans
Widge, A. S. (PI)
TURING MEDICAL TECHNOLOGIES, INC
9/1/23 → 11/30/25
Project: Research project
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Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation
Herron, J., Kullmann, A., Denison, T., Goodman, W. K., Gunduz, A., Neumann, W. J., Provenza, N. R., Shanechi, M. M., Sheth, S. A., Starr, P. A. & Widge, A. S., May 2025, In: Nature Biomedical Engineering. 9, 5, p. 606-617 12 p., 2997.Research output: Contribution to journal › Article › peer-review
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Closed-loop control of theta oscillations enhances human hippocampal network connectivity
Kragel, J. E., Lurie, S. M., Issa, N. P., Haider, H. A., Wu, S., Tao, J. X., Warnke, P. C., Schuele, S., Rosenow, J. M., Zelano, C., Schatza, M., Disterhoft, J. F., Widge, A. S. & Voss, J. L., Dec 2025, In: Nature communications. 16, 1, 4061.Research output: Contribution to journal › Article › peer-review
Open Access -
Deep transcranial magnetic stimulation for adolescents with treatment-resistant depression: Behavioral and neural correlates of clinical improvement
Nair, A. U., Klimes-Dougan, B., Silamongkol, T., Başgöze, Z., Roediger, D. J., Mueller, B. A., Albott, C. S., Croarkin, P. E., Lim, K. O., Widge, A. S., Nahas, Z., Eberly, L. E., Cullen, K. R. & Thai, M. E., Mar 1 2025, In: Journal of Affective Disorders. 372, p. 665-675 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Deviation from Nash mixed equilibrium in repeated rock–scissors–paper reflect individual traits
Arai, K., Jacob, S., Widge, A. S. & Yousefi, A., Dec 2025, In: Scientific reports. 15, 1, 14955.Research output: Contribution to journal › Article › peer-review
Open Access -
Neurostimulation to improve cognitive flexibility
Sachse, E. M. & Widge, A. S., Apr 2025, In: Current Opinion in Behavioral Sciences. 62, 101484.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations
Datasets
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Pybehave: a hardware agnostic, Python-based framework for controlling behavioral neuroscience experiments
Dastin-van Rijn, E. M., Nielsen, J., Sachse, E. M., Li, C., Mensinger, M. E., Simpson, S. G., Buccini, M. C., Iacobucci, F. A., Titus, D. J. & Widge, A. S., ZENODO, May 22 2024
DOI: 10.5281/zenodo.11244351, https://zenodo.org/records/11244351
Dataset
Press/Media
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U of M research team hopes to develop an implantable device to treat mental illness — thanks to a $6.6 million grant
Widge, A. S. & Molnar, G. F.
9/21/20
1 item of Media coverage
Press/Media: Research