Projects per year
Personal profile
Research interests
Dr. Widge's research focuses on brain stimulation for severe and treatment-resistant mental illness, with particular emphasis on deep brain stimulation and related implantable technologies. Technologies from his lab are in development to treat depression, obsessive-compulsive disorder, post-traumatic stress disorder, and addiction.
Dr. Widge's recent work has demonstrated new algorithms for closed-loop brain stimulation and stimulation methods for modifying connectivity in the distributed circuits of mental illness. His laboratory studies rodent models for prototyping these new technologies and human patients to identify biomarkers and targets for future intervention. He also co-leads programs to design new neurostimulation technologies in the central and peripheral nervous systems, to evaluate technologies for safety and efficacy in humans, and to improve the quality of clinical biomarker research nationwide.
Certifications and Licenses
Dr. Widge is a board-certified psychiatrist with clinical expertise in brain stimulation, including deep brain stimulation (DBS), vagus nerve stimulation (VNS), and transcranial magnetic stimulation (TMS). He leads clinical trials and applies these technologies in routine treatment.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Network
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Neural Mechanisms of Closed-loop Phase-locked Transcranial Magnetic Stimulation
12/1/22 → 11/30/23
Project: Research project
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Rational, Targeted Electrical Brain Circuit Intervention for Mental Illness
DR. RALPH & MARIAN FALK MED RES TRUST
11/30/22 → 11/30/24
Project: Research project
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Maladaptive avoidance and associated circuitry disruption following repetitive mild TBI
Titus, D. J., Grande, A. W. & Widge, A. S.
10/17/22 → 6/30/23
Project: Research project
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Explainable Machine Learning to Guide Prefrontal Brain Stimulation
7/15/22 → 5/31/27
Project: Research project
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A 16-Channel Low-Power Neural Connectivity Extraction and Phase-Locked Deep Brain Stimulation SoC
Shin, U., Ding, C., Woods, V., Widge, A. S. & Shoaran, M., 2023, In: IEEE Solid-State Circuits Letters. 6, p. 21-24 4 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Causally mapping human threat extinction relevant circuits with depolarizing brain stimulation methods
Webler, R. D., Oathes, D. J., van Rooij, S. J. H., Gewirtz, J. C., Nahas, Z., Lissek, S. M. & Widge, A. S., Jan 2023, In: Neuroscience and Biobehavioral Reviews. 144, 105005.Research output: Contribution to journal › Review article › peer-review
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Closed-loop enhancement and neural decoding of cognitive control in humans
Basu, I., Yousefi, A., Crocker, B., Zelmann, R., Paulk, A. C., Peled, N., Ellard, K. K., Weisholtz, D. S., Cosgrove, G. R., Deckersbach, T., Eden, U. T., Eskandar, E. N., Dougherty, D. D., Cash, S. S. & Widge, A. S., Apr 2023, In: Nature Biomedical Engineering. 7, 4, p. 576-588 13 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Hybrid Decoders for Marked Point Process Observations and External Influences
Wickramasuriya, D. S., Crofford, L. J., Widge, A. S. & Faghih, R. T., Jan 1 2023, In: IEEE Transactions on Biomedical Engineering. PP, 1, p. 343-353 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
In Search of Biomarkers to Guide Interventions in Autism Spectrum Disorder: A Systematic Review
Parellada, M., Andreu-Bernabeu, Á., Burdeus, M., San José Cáceres, A., Urbiola, E., Carpenter, L. L., Kraguljac, N. V., McDonald, W. M., Nemeroff, C. B., Rodriguez, C. I., Widge, A. S., State, M. W. & Sanders, S. J., Jan 1 2023, In: The American journal of psychiatry. 180, 1, p. 23-40 18 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Press/Media
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U of M research team hopes to develop an implantable device to treat mental illness — thanks to a $6.6 million grant
Alik S Widge & Gregory F Molnar
9/21/20
1 item of Media coverage
Press/Media: Research