Alfonso Araque

1991 …2024
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Research Output 1991 2019

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2019

GABA Regulation of Burst Firing in Hippocampal Astrocyte Neural Circuit: A Biophysical Model

Liu, J., McDaid, L., Araque, A., Wade, J., Harkin, J., Karim, S., Henshall, D. C., Connolly, N. M. C., Johnson, A. P., Tyrrell, A. M., Timmis, J., Millard, A. G., Hilder, J. & Halliday, D. M., Jul 23 2019, In : Frontiers in Cellular Neuroscience. 13, 335.

Research output: Contribution to journalArticle

Open Access
Interneurons
Astrocytes
Weights and Measures
Inositol 1,4,5-Trisphosphate
Synaptic Transmission
3 Citations (Scopus)

G i/o protein-coupled receptors inhibit neurons but activate astrocytes and stimulate gliotransmission

Durkee, C. A., Covelo, A., Lines, J., Kofuji, P., Aguilar, J. & Araque, A., Jun 1 2019, In : Glia. 67, 6, p. 1076-1093 18 p.

Research output: Contribution to journalArticle

Gi-Go GTP-Binding Protein alpha Subunits
Astrocytes
G-Protein-Coupled Receptors
Neurons
Brain

In vivo knockdown of astroglial glutamate transporters GLT-1 and GLAST increases excitatory neurotransmission in mouse infralimbic cortex: Relevance for depressive-like phenotypes

Fullana, M. N., Covelo, A., Bortolozzi, A., Araque, A. & Artigas, F., Jan 1 2019, (Accepted/In press) In : European Neuropsychopharmacology.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Major Depressive Disorder
Synaptic Transmission
Small Interfering RNA
Gyrus Cinguli
1 Citation (Scopus)

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

Singh, B., Covelo, A., Martell-Martínez, H., Nanclares, C., Sherman, M. A., Okematti, E., Meints, J., Teravskis, P. J., Gallardo, C., Savonenko, A. V., Benneyworth, M. A., Lesne, S. E., Liao, D., Araque, A. & Lee, M. K., Jan 1 2019, In : Acta Neuropathologica.

Research output: Contribution to journalArticle

Memory Disorders
Transgenic Mice
Lewy Body Disease
Parkinson Disease
Dementia
2018
2 Citations (Scopus)

A53t mutant alpha-synuclein induces tau-dependent postsynaptic impairment independently of neurodegenerative changes

Teravskis, P. J., Covelo, A., Miller, E. C., Singh, B., Martell-Martínez, H. A., Benneyworth, M. A., Gallardo, C., Oxnard, B. R., Araque, A., Lee, M. K. & Liao, D., Nov 7 2018, In : Journal of Neuroscience. 38, 45, p. 9754-9767 14 p.

Research output: Contribution to journalArticle

Synucleins
alpha-Synuclein
Parkinson Disease
Pathology
Glycogen Synthase Kinase 3
20 Citations (Scopus)

Astroglial CB1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory

Robin, L. M., Oliveira da Cruz, J. F., Langlais, V. C., Martin Fernandez, M., Metna-Laurent, M., Busquets-Garcia, A., Bellocchio, L., Soria-Gomez, E., Papouin, T., Varilh, M., Sherwood, M. W., Belluomo, I., Balcells, G., Matias, I., Bosier, B., Drago, F., Van Eeckhaut, A., Smolders, I., Georges, F., Araque, A. & 3 others, Panatier, A., Oliet, S. H. R. & Marsicano, G., Jun 6 2018, In : Neuron. 98, 5, p. 935-944.e5

Research output: Contribution to journalArticle

Cannabinoid Receptor CB1
Serine
N-Methyl-D-Aspartate Receptors
Long-Term Potentiation
Neuronal Plasticity
21 Citations (Scopus)

Neuronal activity determines distinct gliotransmitter release from a single astrocyte

Covelo, A. & Araque, A., Jan 30 2018, In : eLife. 7, e32237.

Research output: Contribution to journalArticle

Open Access
Astrocytes
Synapses
gamma-Aminobutyric Acid
Glutamic Acid
Endocannabinoids
2017
22 Citations (Scopus)

Insulin regulates astrocytic glucose handling through cooperation with IGF-I

Fernandez, A. M., Hernandez-Garzón, E., Perez-Domper, P., Perez-Alvarez, A., Mederos, S., Matsui, T., Santi, A., Trueba-Saiz, A., García-Guerra, L., Pose-Utrilla, J., Fielitz, J., Olson, E. N., De La Rosa, R. F., Garcia, L. G., Pozo, M. A., Iglesias, T., Araque, A., Soya, H., Perea, G., Martin, E. D. & 1 others, Aleman, I. T., Jan 1 2017, In : Diabetes. 66, 1, p. 64-74 11 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Insulin
Glucose
Brain
Proteins
18 Citations (Scopus)

Neuron–astrocyte signaling is preserved in the aging brain

Gómez-Gonzalo, M., Martin Fernandez, M., Martínez-Murillo, R., Mederos, S., Hernández-Vivanco, A., Jamison, S., Fernandez, A. P., Serrano, J., Calero, P., Futch, H. S., Corpas, R., Sanfeliu, C., Perea, G. & Araque, A., Apr 1 2017, In : GLIA. 65, 4, p. 569-580 12 p.

Research output: Contribution to journalArticle

Open Access
Astrocytes
Brain
Neurotransmitter Agents
Amyloid Plaques
Neurodegenerative Diseases
29 Citations (Scopus)

Synapse-specific astrocyte gating of amygdala-related behavior

Martin Fernandez, M., Jamison, S., Robin, L. M., Zhao, Z., Martin, E. D., Aguilar, J., Benneyworth, M. A., Marsicano, G. & Araque, A., Jan 1 2017, In : Nature Neuroscience. 20, 11, p. 1540-1548 9 p.

Research output: Contribution to journalArticle

Amygdala
Astrocytes
Synapses
Fear
Neurons
1 Citation (Scopus)

Synapse-specific regulation revealed at single synapses is concealed when recording multiple synapses

Lines, J., Covelo Fernández, A., Gómez, R., Liu, L. & Araque, A., Nov 23 2017, In : Frontiers in Cellular Neuroscience. 11, 367.

Research output: Contribution to journalArticle

Open Access
Synapses
Endocannabinoids
Neuronal Plasticity
Patch-Clamp Techniques
Synaptic Transmission
2016
34 Citations (Scopus)

Activity-dependent switch of gabaergic inhibition into glutamatergic excitation in astrocyte-neuron networks

Perea, G., Gómez, R., Mederos, S., Covelo Fernández, A., Ballesteros, J. J., Schlosser, L., Hernández-Vivanco, A., Martin Fernandez, M., Quintana, R., Rayan, A., Díez, A., Fuenzalida, M., Agarwal, A., Bergles, D. E., Bettler, B., Manahan-Vaughan, D., Martín, E. D., Kirchhoff, F. & Araque, A., Dec 24 2016, In : eLife. 5, DECEMBER2016, e20362.

Research output: Contribution to journalArticle

Astrocytes
Neurons
Interneurons
Switches
GABA Agents
15 Citations (Scopus)

Lateral regulation of synaptic transmission by astrocytes

Covelo Fernández, A. & Araque, A., May 26 2016, In : Neuroscience. 323, p. 62-66 5 p.

Research output: Contribution to journalArticle

Synaptic Transmission
Astrocytes
Synapses
Autocrine Communication
Neurons
17 Citations (Scopus)

The insulin-like growth factor I receptor regulates glucose transport by astrocytes

Hernandez-Garzón, E., Fernandez, A. M., Perez-Alvarez, A., Genis, L., Bascuñana, P., Fernandez de la Rosa, R., Delgado, M., Angel Pozo, M., Moreno, E., McCormick, P. J., Santi, A., Trueba-Saiz, A., Garcia-Caceres, C., Tschöp, M. H., Araque, A., Martin, E. D. & Torres Aleman, I., Nov 1 2016, In : GLIA. 64, 11, p. 1962-1971 10 p.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Astrocytes
Facilitative Glucose Transport Proteins
Glucose
Somatosensory Cortex
2015
99 Citations (Scopus)

Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways

Martín, R., Bajo-Grañeras, R., Moratalla, R., Perea, G. & Araque, A., Aug 14 2015, In : Science. 349, 6249, p. 730-734 5 p.

Research output: Contribution to journalArticle

Basal Ganglia
Astrocytes
Neurons
Synapses
Metabotropic Glutamate Receptors
42 Citations (Scopus)

Endocannabinoids induce lateral long-term potentiation of transmitter release by stimulation of gliotransmission

Gómez-Gonzalo, M., Navarrete, M., Perea, G., Covelo, A., Martín-Fernández, M., Shigemoto, R., Luján, R. & Araque, A., Oct 1 2015, In : Cerebral Cortex. 25, 10, p. 3699-3712 14 p.

Research output: Contribution to journalArticle

Endocannabinoids
Long-Term Potentiation
Astrocytes
Synapses
Neuronal Plasticity
2014
25 Citations (Scopus)

Functional MRI in mice lacking IP3-dependent calcium signaling in astrocytes

Jego, P., Pacheco-Torres, J., Araque, A. & Canals, S., Oct 1 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, 10, p. 1599-1603 5 p.

Research output: Contribution to journalArticle

Calcium Signaling
Astrocytes
Magnetic Resonance Imaging
Calcium
Inositol 1,4,5-Trisphosphate Receptors
72 Citations (Scopus)

Glial biology in learning and cognition

Fields, R. D., Araque, A., Johansen-Berg, H., Lim, S. S., Lynch, G., Nave, K. A., Nedergaard, M., Perez, R., Sejnowski, T. & Wake, H., Oct 1 2014, In : Neuroscientist. 20, 5, p. 426-431 6 p.

Research output: Contribution to journalArticle

Neuroglia
Cognition
Oligodendroglia
Learning
Microglia
101 Citations (Scopus)

Structural and functional plasticity of astrocyte processes and dendritic spine interactions

Perez-Alvarez, A., Navarrete, M., Covelo Fernández, A., Martin, E. D. & Araque, A., Sep 17 2014, In : Journal of Neuroscience. 34, 38, p. 12738-12744 7 p.

Research output: Contribution to journalArticle

Dendritic Spines
Astrocytes
Neuronal Plasticity
Synaptic Transmission
Synapses
2013
64 Citations (Scopus)

Astrocyte calcium signal and gliotransmission in human brain tissue

Navarrete, M., Perea, G., Maglio, L., Pastor, J., García De Sola, R. & Araque, A., May 1 2013, In : Cerebral Cortex. 23, 5, p. 1240-1246 7 p.

Research output: Contribution to journalArticle

Astrocytes
Calcium
Brain
Neurons
N-Methyl-D-Aspartate Receptors
51 Citations (Scopus)

Astrocyte-neuron interaction at tripartite synapses

Pérez-Alvarez, A. & Araque, A., Nov 25 2013, In : Current Drug Targets. 14, 11, p. 1220-1224 5 p.

Research output: Contribution to journalArticle

Astrocytes
Synapses
Neurons
Physiology
Brain
12 Citations (Scopus)

Confocal microscopy for astrocyte in vivo imaging: Recycle and reuse in microscopy

Perez-Alvarez, A., Araque, A. & Martin, E. D., Apr 7 2013, In : Frontiers in Cellular Neuroscience. APR

Research output: Contribution to journalArticle

Confocal Microscopy
Astrocytes
Microscopy
Brain
Dendritic Spines
2012
206 Citations (Scopus)

Astrocytes mediate in vivo cholinergic-induced synaptic plasticity

Navarrete, M., Perea, G., de Sevilla, D. F., Gómez-Gonzalo, M., Núñez, A., Martín, E. D. & Araque, A., Feb 1 2012, In : PLoS biology. 10, 2, e1001259.

Research output: Contribution to journalArticle

Neuronal Plasticity
astrocytes
cholinergic agents
Astrocytes
Cholinergic Agents
175 Citations (Scopus)

Astroglial excitability and gliotransmission: An appraisal of Ca 2+ as a signalling route

Zorec, R., Araque, A., Carmignoto, G., Haydon, P. G., Verkhratsky, A. & Parpura, V., 2012, In : ASN Neuro. 4, 2, p. 103-119 17 p.

Research output: Contribution to journalArticle

Astrocytes
Neuronal Plasticity
Exocytosis
Neurons
Synaptic Transmission
2011
46 Citations (Scopus)

Artificial astrocytes improve neural network performance

Porto-Pazos, A. B., Veiguela, N., Mesejo, P., Navarrete, M., Alvarellos, A., Ibáñez, O., Pazos, A. & Araque, A., May 3 2011, In : PloS one. 6, 4, e19109.

Research output: Contribution to journalArticle

astrocytes
Network performance
Astrocytes
neural networks
Neurons
2010
242 Citations (Scopus)

Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes

Navarrete, M. & Araque, A., Oct 6 2010, In : Neuron. 68, 1, p. 113-126 14 p.

Research output: Contribution to journalArticle

Endocannabinoids
Synaptic Transmission
Astrocytes
Neurons
Cannabinoid Receptor CB1
2008
34 Citations (Scopus)

DREAM mediates cAMP-dependent, Ca2+-induced stimulation of GFAP gene expression and regulates cortical astrogliogenesis

Cebolla, B., Fernández-Pérez, A., Perea, G., Araque, A. & Vallejo, M., Jun 25 2008, In : Journal of Neuroscience. 28, 26, p. 6703-6713 11 p.

Research output: Contribution to journalArticle

Kv Channel-Interacting Proteins
Glial Fibrillary Acidic Protein
Pituitary Adenylate Cyclase-Activating Polypeptide
Astrocytes
Gene Expression
271 Citations (Scopus)

Endocannabinoids Mediate Neuron-Astrocyte Communication

Navarrete, M. & Araque, A., Mar 27 2008, In : Neuron. 57, 6, p. 883-893 11 p.

Research output: Contribution to journalArticle

Endocannabinoids
Astrocytes
Neurons
Cannabinoids
Cannabinoid Receptors
2007
139 Citations (Scopus)

Adenosine released by astrocytes contributes to hypoxia-induced modulation of synaptic transmission

Martín, E. D., Fernández, M., Perea, G., Pascual, O., Haydon, P. G., Araque, A. & Ceña, V., Jan 1 2007, In : GLIA. 55, 1, p. 36-45 10 p.

Research output: Contribution to journalArticle

Synaptic Transmission
Astrocytes
Adenosine
Adenosine A1 Receptors
Adenosine Triphosphate
14 Citations (Scopus)

A new hybrid evolutionary mechanism based on unsupervised learning for Connectionist Systems

Porto, A., Araque, A., Rabuñal, J., Dorado, J. & Pazos, A., Oct 1 2007, In : Neurocomputing. 70, 16-18, p. 2799-2808 10 p.

Research output: Contribution to journalArticle

Unsupervised learning
Brain
Learning
Multilayers
Genetic algorithms
419 Citations (Scopus)

Astrocytes potentiate transmitter release at single hippocampal synapses

Perea, G. & Araque, A., Aug 24 2007, In : Science. 317, 5841, p. 1083-1086 4 p.

Research output: Contribution to journalArticle

Astrocytes
Synapses
SNARE Proteins
Metabotropic Glutamate Receptors
Neuronal Plasticity
2006
44 Citations (Scopus)

Synaptic information processing by astrocytes

Perea, G. & Araque, A., Mar 1 2006, In : Journal of Physiology Paris. 99, 2-3, p. 92-97 6 p.

Research output: Contribution to journalArticle

Automatic Data Processing
Astrocytes
Nervous System
Neuroglia
Neurons
2005
145 Citations (Scopus)

Glial calcium signaling and neuron-glia communication

Perea, G. & Araque, A., Jan 1 2005, In : Cell Calcium. 38, 3-4 SPEC. ISS., p. 375-382 8 p.

Research output: Contribution to journalArticle

Calcium Signaling
Neuroglia
Astrocytes
Neurons
Synapses
304 Citations (Scopus)

Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes

Perea, G. & Araque, A., Mar 2 2005, In : Journal of Neuroscience. 25, 9, p. 2192-2203 12 p.

Research output: Contribution to journalArticle

Automatic Data Processing
Astrocytes
Calcium
Glutamic Acid
Pyramidal Cells
32 Citations (Scopus)

Synaptic regulation of the astrocyte calcium signal

Perea, G. & Araque, A., Jan 1 2005, In : Journal of Neural Transmission. 112, 1, p. 127-135 9 p.

Research output: Contribution to journalArticle

Astrocytes
Calcium
Synapses
Nervous System Physiological Phenomena
Synaptic Transmission
2003
68 Citations (Scopus)

Estradiol regulates the slow Ca2+-activated K+ current in hippocampal pyramidal neurons

Carrer, H. F., Araque, A. & Buño, W., Jul 16 2003, In : Journal of Neuroscience. 23, 15, p. 6338-6344 7 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Estradiol
Neurons
Neuronal Plasticity
Aptitude
2002
62 Citations (Scopus)

Communication between astrocytes and neurons: A complex language

Perea, G. & Araque, A., Apr 1 2002, In : Journal of Physiology Paris. 96, 3-4, p. 199-207 9 p.

Research output: Contribution to journalArticle

Astrocytes
Language
Communication
Neurons
Synapses
200 Citations (Scopus)

Synaptically Released Acetylcholine Evokes Ca2+ Elevations in Astrocytes in Hippocampal Slices

Araque, A., Martín, E. D., Perea, G., Arellano, J. I. & Buño, W., Apr 1 2002, In : Journal of Neuroscience. 22, 7, p. 2443-2450 8 p.

Research output: Contribution to journalArticle

Astrocytes
Acetylcholine
Amino Acid Transport System X-AG
Excitatory Amino Acid Antagonists
Muscarinic Receptors
2001
61 Citations (Scopus)

Synaptic regulation of the slow Ca2+-activated K+ current in hippocampal CA1 pyramidal neurons: Implication in epileptogenesis

Martín, E. D., Araque, A. & Bunõ, W., Dec 27 2001, In : Journal of neurophysiology. 86, 6, p. 2878-2886 9 p.

Research output: Contribution to journalArticle

4-Aminopyridine
Pyramidal Cells
Epilepsy
Excitatory Amino Acid Antagonists
Metabotropic Glutamate Receptors
2000
331 Citations (Scopus)

SNARE protein-dependent glutamate release from astrocytes

Araque, A., Li, N., Doyle, R. T. & Haydon, P. G., Jan 15 2000, In : Journal of Neuroscience. 20, 2, p. 666-673 8 p.

Research output: Contribution to journalArticle

SNARE Proteins
Astrocytes
Glutamic Acid
Amino Acid Transport System X-AG
R-SNARE Proteins
1999
122 Citations (Scopus)

Astrocyte-induced modulation of synaptic transmission

Araque, A., Sanzgiri, R. P., Parpura, V. & Haydon, P. G., Jan 1 1999, In : Canadian Journal of Physiology and Pharmacology. 77, 9, p. 699-706 8 p.

Research output: Contribution to journalArticle

Synaptic Transmission
Astrocytes
Neurons
Metabotropic Glutamate Receptors
Glutamic Acid
2 Citations (Scopus)

Fast BK-type channel mediates the Ca2+-activated K+ current in crayfish muscle

Araque, A. & Buño, W., Jan 1 1999, In : Journal of neurophysiology. 82, 4, p. 1655-1661 7 p.

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
Astacoidea
Ion Channels
Muscles
Ethane
106 Citations (Scopus)

Prostaglandin E2 stimulates glutamate receptor-dependent astrocyte neuromodulation in cultured hippocampal cells

Sanzgiri, R. P., Araque, A. & Haydon, P. G., Nov 1 1999, In : Journal of Neurobiology. 41, 2, p. 221-229 9 p.

Research output: Contribution to journalArticle

Glutamate Receptors
Dinoprostone
Astrocytes
Cultured Cells
Neurons
1998
329 Citations (Scopus)

Calcium elevation in astrocytes causes an NMDA receptordependent increase in the frequency of miniature synaptic currents in cultured hippocampal neurons

Araque, A., Sanzgiri, R. P., Parpura, V. & Haydon, P. G., Sep 1 1998, In : Journal of Neuroscience. 18, 17, p. 6822-6829 8 p.

Research output: Contribution to journalArticle

N-Methylaspartate
Astrocytes
Calcium
Neurons
N-Methyl-D-Aspartate Receptors
395 Citations (Scopus)

Glutamate-dependent astrocyte modulation of synaptic transmission between cultured hippocampal neurons

Araque, A., Parpura, V., Sanzgiri, R. P. & Haydon, P. G., Jan 1 1998, In : European Journal of Neuroscience. 10, 6, p. 2129-2142 14 p.

Research output: Contribution to journalArticle

Synaptic Transmission
Astrocytes
Glutamic Acid
Neurons
Calcium
7 Citations (Scopus)

Voltage-gated and Ca2+-activated conductances mediating and controlling graded electrical activity in crayfish muscle

Araque, A., Marchand, A. & Buño, W., Jan 1 1998, In : Journal of neurophysiology. 79, 5, p. 2338-2344 7 p.

Research output: Contribution to journalArticle

Astacoidea
Action Potentials
Muscles
Electrodes
1997
4 Citations (Scopus)

Sustained GABA-induced regulation of the L-type Ca2+ conductance in crustacean muscle fibers

Castellote, J., Araque, A. & Buño, W., Jul 14 1997, In : Pflugers Archiv European Journal of Physiology. 434, 3, p. 272-279 8 p.

Research output: Contribution to journalArticle

gamma-Aminobutyric Acid
Muscle
Muscles
Fibers
Aminobutyrates
1995
6 Citations (Scopus)

Cd2+ regulation of the hyperpolarization-activated current IAB in crayfish muscle

Araque, A., Catfaert, D. & Buiño, W., Jun 1 1995, In : Journal of General Physiology. 105, 6, p. 725-744 20 p.

Research output: Contribution to journalArticle

Astacoidea
Permeability
Muscles
Neurosciences
Electrodes
17 Citations (Scopus)

Fast, persistent, Ca2+-dependent K+ current controls graded electrical activity in crayfish muscle

Araque, A. & Buño, W., Aug 1 1995, In : Pflügers Archiv European Journal of Physiology. 430, 4, p. 541-551 11 p.

Research output: Contribution to journalArticle

Charybdotoxin
Astacoidea
Tetraethylammonium
Electric current control
Muscle
6 Citations (Scopus)

Selective block of Ca2+‐dependent K+ current in crayfish neuromuscular system and chromaffin cells by sea anemone Bunodosoma cangicum venom

Araque, A., Urbano, F. J., Cerveñansky, C., Gandía, L. & Buño, W., Jan 1 1995, In : Journal of Neuroscience Research. 42, 4, p. 539-546 8 p.

Research output: Contribution to journalArticle

Sea Anemones
Astacoidea
Chromaffin Cells
Venoms
Muscles