Alfonso Araque

1991 …2024
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Research Output 1991 2019

2019
5 Citations (Scopus)

Diversity and Specificity of Astrocyte–neuron Communication

Durkee, C. A. & Araque, A., Jan 1 2019, In : Neuroscience. 396, p. 73-78 6 p.

Research output: Contribution to journalReview article

Astrocytes
Synapses
Communication
Animal Behavior
Neurotransmitter Agents

GABA Regulation of Burst Firing in Hippocampal Astrocyte Neural Circuit: A Biophysical Model

Liu, J., McDaid, L., Araque, A., Wade, J., Harkin, J., Karim, S., Henshall, D. C., Connolly, N. M. C., Johnson, A. P., Tyrrell, A. M., Timmis, J., Millard, A. G., Hilder, J. & Halliday, D. M., Jul 23 2019, In : Frontiers in Cellular Neuroscience. 13, 335.

Research output: Contribution to journalArticle

Open Access
Interneurons
Astrocytes
Weights and Measures
Inositol 1,4,5-Trisphosphate
Synaptic Transmission
3 Citations (Scopus)

G i/o protein-coupled receptors inhibit neurons but activate astrocytes and stimulate gliotransmission

Durkee, C. A., Covelo, A., Lines, J., Kofuji, P., Aguilar, J. & Araque, A., Jun 1 2019, In : Glia. 67, 6, p. 1076-1093 18 p.

Research output: Contribution to journalArticle

Gi-Go GTP-Binding Protein alpha Subunits
Astrocytes
G-Protein-Coupled Receptors
Neurons
Brain

In vivo knockdown of astroglial glutamate transporters GLT-1 and GLAST increases excitatory neurotransmission in mouse infralimbic cortex: Relevance for depressive-like phenotypes

Fullana, M. N., Covelo, A., Bortolozzi, A., Araque, A. & Artigas, F., Jan 1 2019, (Accepted/In press) In : European Neuropsychopharmacology.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Major Depressive Disorder
Synaptic Transmission
Small Interfering RNA
Gyrus Cinguli
9 Citations (Scopus)

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

García-Cáceres, C., Balland, E., Prevot, V., Luquet, S., Woods, S. C., Koch, M., Horvath, T. L., Yi, C. X., Chowen, J. A., Verkhratsky, A., Araque, A., Bechmann, I. & Tschöp, M. H., Jan 1 2019, In : Nature neuroscience. 22, 1, p. 7-14 8 p.

Research output: Contribution to journalReview article

Ependymoglial Cells
Microglia
Astrocytes
Brain
Energy Metabolism

Swelling Gliotransmission by SWELL1 Channels

Kofuji, P. & Araque, A., May 22 2019, In : Neuron. 102, 4, p. 711-713 3 p.

Research output: Contribution to journalShort survey

Astrocytes
Glutamic Acid
Synaptic Transmission
Synapses
Anions
1 Citation (Scopus)

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

Singh, B., Covelo, A., Martell-Martínez, H., Nanclares, C., Sherman, M. A., Okematti, E., Meints, J., Teravskis, P. J., Gallardo, C., Savonenko, A. V., Benneyworth, M. A., Lesne, S. E., Liao, D., Araque, A. & Lee, M. K., Jan 1 2019, In : Acta Neuropathologica.

Research output: Contribution to journalArticle

Memory Disorders
Transgenic Mice
Lewy Body Disease
Parkinson Disease
Dementia
2018
2 Citations (Scopus)

A53t mutant alpha-synuclein induces tau-dependent postsynaptic impairment independently of neurodegenerative changes

Teravskis, P. J., Covelo, A., Miller, E. C., Singh, B., Martell-Martínez, H. A., Benneyworth, M. A., Gallardo, C., Oxnard, B. R., Araque, A., Lee, M. K. & Liao, D., Nov 7 2018, In : Journal of Neuroscience. 38, 45, p. 9754-9767 14 p.

Research output: Contribution to journalArticle

Synucleins
alpha-Synuclein
Parkinson Disease
Pathology
Glycogen Synthase Kinase 3
20 Citations (Scopus)

Astroglial CB1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory

Robin, L. M., Oliveira da Cruz, J. F., Langlais, V. C., Martin Fernandez, M., Metna-Laurent, M., Busquets-Garcia, A., Bellocchio, L., Soria-Gomez, E., Papouin, T., Varilh, M., Sherwood, M. W., Belluomo, I., Balcells, G., Matias, I., Bosier, B., Drago, F., Van Eeckhaut, A., Smolders, I., Georges, F., Araque, A. & 3 others, Panatier, A., Oliet, S. H. R. & Marsicano, G., Jun 6 2018, In : Neuron. 98, 5, p. 935-944.e5

Research output: Contribution to journalArticle

Cannabinoid Receptor CB1
Serine
N-Methyl-D-Aspartate Receptors
Long-Term Potentiation
Neuronal Plasticity
21 Citations (Scopus)

Neuronal activity determines distinct gliotransmitter release from a single astrocyte

Covelo, A. & Araque, A., Jan 30 2018, In : eLife. 7, e32237.

Research output: Contribution to journalArticle

Open Access
Astrocytes
Synapses
gamma-Aminobutyric Acid
Glutamic Acid
Endocannabinoids
1 Citation (Scopus)

Stimulating Astrocytes to Remember

Covelo, A. & Araque, A., Jun 28 2018, In : Cell. 174, 1, p. 12-13 2 p.

Research output: Contribution to journalShort survey

Astrocytes
Animal Behavior
Physiology
Synaptic Transmission
Neurons
2017
22 Citations (Scopus)

Insulin regulates astrocytic glucose handling through cooperation with IGF-I

Fernandez, A. M., Hernandez-Garzón, E., Perez-Domper, P., Perez-Alvarez, A., Mederos, S., Matsui, T., Santi, A., Trueba-Saiz, A., García-Guerra, L., Pose-Utrilla, J., Fielitz, J., Olson, E. N., De La Rosa, R. F., Garcia, L. G., Pozo, M. A., Iglesias, T., Araque, A., Soya, H., Perea, G., Martin, E. D. & 1 others, Aleman, I. T., Jan 1 2017, In : Diabetes. 66, 1, p. 64-74 11 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Insulin
Glucose
Brain
Proteins
18 Citations (Scopus)

Neuron–astrocyte signaling is preserved in the aging brain

Gómez-Gonzalo, M., Martin Fernandez, M., Martínez-Murillo, R., Mederos, S., Hernández-Vivanco, A., Jamison, S., Fernandez, A. P., Serrano, J., Calero, P., Futch, H. S., Corpas, R., Sanfeliu, C., Perea, G. & Araque, A., Apr 1 2017, In : GLIA. 65, 4, p. 569-580 12 p.

Research output: Contribution to journalArticle

Open Access
Astrocytes
Brain
Neurotransmitter Agents
Amyloid Plaques
Neurodegenerative Diseases
29 Citations (Scopus)

Synapse-specific astrocyte gating of amygdala-related behavior

Martin Fernandez, M., Jamison, S., Robin, L. M., Zhao, Z., Martin, E. D., Aguilar, J., Benneyworth, M. A., Marsicano, G. & Araque, A., Jan 1 2017, In : Nature Neuroscience. 20, 11, p. 1540-1548 9 p.

Research output: Contribution to journalArticle

Open Access
Amygdala
Astrocytes
Synapses
Fear
Neurons
1 Citation (Scopus)

Synapse-specific regulation revealed at single synapses is concealed when recording multiple synapses

Lines, J., Covelo Fernández, A., Gómez, R., Liu, L. & Araque, A., Nov 23 2017, In : Frontiers in Cellular Neuroscience. 11, 367.

Research output: Contribution to journalArticle

Open Access
Synapses
Endocannabinoids
Neuronal Plasticity
Patch-Clamp Techniques
Synaptic Transmission
38 Citations (Scopus)

Synaptic functions of endocannabinoid signaling in health and disease

Araque, A., Castillo, P. E., Manzoni, O. J. & Tonini, R., Sep 15 2017, In : Neuropharmacology. 124, p. 13-24 12 p.

Research output: Contribution to journalReview article

Open Access
Endocannabinoids
Neuronal Plasticity
Health
Cannabinoid Receptor CB1
Neurobiology
2016
34 Citations (Scopus)

Activity-dependent switch of gabaergic inhibition into glutamatergic excitation in astrocyte-neuron networks

Perea, G., Gómez, R., Mederos, S., Covelo Fernández, A., Ballesteros, J. J., Schlosser, L., Hernández-Vivanco, A., Martin Fernandez, M., Quintana, R., Rayan, A., Díez, A., Fuenzalida, M., Agarwal, A., Bergles, D. E., Bettler, B., Manahan-Vaughan, D., Martín, E. D., Kirchhoff, F. & Araque, A., Dec 24 2016, In : eLife. 5, DECEMBER2016, e20362.

Research output: Contribution to journalArticle

Astrocytes
Neurons
Interneurons
Switches
GABA Agents
15 Citations (Scopus)

Lateral regulation of synaptic transmission by astrocytes

Covelo Fernández, A. & Araque, A., May 26 2016, In : Neuroscience. 323, p. 62-66 5 p.

Research output: Contribution to journalArticle

Synaptic Transmission
Astrocytes
Synapses
Autocrine Communication
Neurons
17 Citations (Scopus)

The insulin-like growth factor I receptor regulates glucose transport by astrocytes

Hernandez-Garzón, E., Fernandez, A. M., Perez-Alvarez, A., Genis, L., Bascuñana, P., Fernandez de la Rosa, R., Delgado, M., Angel Pozo, M., Moreno, E., McCormick, P. J., Santi, A., Trueba-Saiz, A., Garcia-Caceres, C., Tschöp, M. H., Araque, A., Martin, E. D. & Torres Aleman, I., Nov 1 2016, In : GLIA. 64, 11, p. 1962-1971 10 p.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Astrocytes
Facilitative Glucose Transport Proteins
Glucose
Somatosensory Cortex
2015
99 Citations (Scopus)

Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways

Martín, R., Bajo-Grañeras, R., Moratalla, R., Perea, G. & Araque, A., Aug 14 2015, In : Science. 349, 6249, p. 730-734 5 p.

Research output: Contribution to journalArticle

Basal Ganglia
Astrocytes
Neurons
Synapses
Metabotropic Glutamate Receptors
55 Citations (Scopus)

Do stars govern our actions? Astrocyte involvement in rodent behavior

Oliveira, J. F., Sardinha, V. M., Guerra-Gomes, S., Araque, A. & Sousa, N., Sep 1 2015, In : Trends in Neurosciences. 38, 9, p. 535-549 15 p.

Research output: Contribution to journalReview article

Astrocytes
Rodentia
Neurons
Automatic Data Processing
Cognition
42 Citations (Scopus)

Endocannabinoids induce lateral long-term potentiation of transmitter release by stimulation of gliotransmission

Gómez-Gonzalo, M., Navarrete, M., Perea, G., Covelo, A., Martín-Fernández, M., Shigemoto, R., Luján, R. & Araque, A., Oct 1 2015, In : Cerebral Cortex. 25, 10, p. 3699-3712 14 p.

Research output: Contribution to journalArticle

Endocannabinoids
Long-Term Potentiation
Astrocytes
Synapses
Neuronal Plasticity
2014
38 Citations (Scopus)

Astrocytes in endocannabinoid signalling

Navarrete, M., Díez, A. & Araque, A., Oct 19 2014, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1654

Research output: Contribution to journalReview article

Endocannabinoids
astrocytes
Astrocytes
synapse
Synapses
25 Citations (Scopus)

Functional MRI in mice lacking IP3-dependent calcium signaling in astrocytes

Jego, P., Pacheco-Torres, J., Araque, A. & Canals, S., Oct 1 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, 10, p. 1599-1603 5 p.

Research output: Contribution to journalArticle

Calcium Signaling
Astrocytes
Magnetic Resonance Imaging
Calcium
Inositol 1,4,5-Trisphosphate Receptors
72 Citations (Scopus)

Glial biology in learning and cognition

Fields, R. D., Araque, A., Johansen-Berg, H., Lim, S. S., Lynch, G., Nave, K. A., Nedergaard, M., Perez, R., Sejnowski, T. & Wake, H., Oct 1 2014, In : Neuroscientist. 20, 5, p. 426-431 6 p.

Research output: Contribution to journalArticle

Neuroglia
Cognition
Oligodendroglia
Learning
Microglia
416 Citations (Scopus)

Gliotransmitters travel in time and space

Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R. & Volterra, A., Feb 19 2014, In : Neuron. 81, 4, p. 728-739 12 p.

Research output: Contribution to journalReview article

Astrocytes
Neurons
Brain
Synapses
99 Citations (Scopus)

Neuron-glia networks: Integral gear of brain function

Perea, G., Sur, M. & Araque, A., Nov 6 2014, In : Frontiers in Cellular Neuroscience. 8, November, p. 1-8 8 p., 378.

Research output: Contribution to journalReview article

Neuroglia
Astrocytes
Neurons
Brain
Synapses
101 Citations (Scopus)

Structural and functional plasticity of astrocyte processes and dendritic spine interactions

Perez-Alvarez, A., Navarrete, M., Covelo Fernández, A., Martin, E. D. & Araque, A., Sep 17 2014, In : Journal of Neuroscience. 34, 38, p. 12738-12744 7 p.

Research output: Contribution to journalArticle

Dendritic Spines
Astrocytes
Neuronal Plasticity
Synaptic Transmission
Synapses
20 Citations (Scopus)

The Cajal school and the physiological role of astrocytes: A way of thinking

Navarrete, M. & Araque, A., May 19 2014, In : Frontiers in Neuroanatomy. 8, MAY, 33.

Research output: Contribution to journalReview article

Neuroglia
Astrocytes
Brain
Nervous System
Neurosciences
2013
64 Citations (Scopus)

Astrocyte calcium signal and gliotransmission in human brain tissue

Navarrete, M., Perea, G., Maglio, L., Pastor, J., García De Sola, R. & Araque, A., May 1 2013, In : Cerebral Cortex. 23, 5, p. 1240-1246 7 p.

Research output: Contribution to journalArticle

Astrocytes
Calcium
Brain
Neurons
N-Methyl-D-Aspartate Receptors
51 Citations (Scopus)

Astrocyte-neuron interaction at tripartite synapses

Pérez-Alvarez, A. & Araque, A., Nov 25 2013, In : Current Drug Targets. 14, 11, p. 1220-1224 5 p.

Research output: Contribution to journalArticle

Astrocytes
Synapses
Neurons
Physiology
Brain
12 Citations (Scopus)

Confocal microscopy for astrocyte in vivo imaging: Recycle and reuse in microscopy

Perez-Alvarez, A., Araque, A. & Martin, E. D., Apr 7 2013, In : Frontiers in Cellular Neuroscience. APR

Research output: Contribution to journalArticle

Confocal Microscopy
Astrocytes
Microscopy
Brain
Dendritic Spines
2012
206 Citations (Scopus)

Astrocytes mediate in vivo cholinergic-induced synaptic plasticity

Navarrete, M., Perea, G., de Sevilla, D. F., Gómez-Gonzalo, M., Núñez, A., Martín, E. D. & Araque, A., Feb 1 2012, In : PLoS biology. 10, 2, e1001259.

Research output: Contribution to journalArticle

Neuronal Plasticity
astrocytes
cholinergic agents
Astrocytes
Cholinergic Agents
175 Citations (Scopus)

Astroglial excitability and gliotransmission: An appraisal of Ca 2+ as a signalling route

Zorec, R., Araque, A., Carmignoto, G., Haydon, P. G., Verkhratsky, A. & Parpura, V., 2012, In : ASN Neuro. 4, 2, p. 103-119 17 p.

Research output: Contribution to journalArticle

Astrocytes
Neuronal Plasticity
Exocytosis
Neurons
Synaptic Transmission
2011
46 Citations (Scopus)

Artificial astrocytes improve neural network performance

Porto-Pazos, A. B., Veiguela, N., Mesejo, P., Navarrete, M., Alvarellos, A., Ibáñez, O., Pazos, A. & Araque, A., May 3 2011, In : PloS one. 6, 4, e19109.

Research output: Contribution to journalArticle

astrocytes
Network performance
Astrocytes
neural networks
Neurons
15 Citations (Scopus)

Basal synaptic transmission: Astrocytes rule!

Navarrete, M. & Araque, A., Sep 2 2011, In : Cell. 146, 5, p. 675-677 3 p.

Research output: Contribution to journalShort survey

Synaptic Transmission
Astrocytes
Neurophysiology
Calcium
Action Potentials
5 Citations (Scopus)

Electrically driven insulation in the central nervous system

Araque, A. & Navarrete, M., Sep 16 2011, In : Science. 333, 6049, p. 1587-1588 2 p.

Research output: Contribution to journalShort survey

Axons
Central Nervous System
2010
242 Citations (Scopus)

Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes

Navarrete, M. & Araque, A., Oct 6 2010, In : Neuron. 68, 1, p. 113-126 14 p.

Research output: Contribution to journalArticle

Endocannabinoids
Synaptic Transmission
Astrocytes
Neurons
Cannabinoid Receptor CB1
129 Citations (Scopus)

Glial cells in neuronal network function

Araque, A. & Navarrete, M., Aug 12 2010, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 365, 1551, p. 2375-2381 7 p.

Research output: Contribution to journalReview article

astrocytes
neuroglia
Neuroglia
Astrocytes
Neurology
145 Citations (Scopus)

GLIA modulates synaptic transmission

Perea, G. & Araque, A., May 1 2010, In : Brain Research Reviews. 63, 1-2, p. 93-102 10 p.

Research output: Contribution to journalReview article

Synaptic Transmission
Astrocytes
Neuroglia
Neurons
Nervous System Physiological Phenomena
2009
4 Citations (Scopus)

Astrocyte: Calcium signaling

Deitmer, J. W. & Araque, A., Jan 1 2009, Encyclopedia of Neuroscience. Elsevier Ltd, p. 565-572 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Calcium Signaling
Astrocytes
Cerebrovascular Circulation
Prostaglandin-Endoperoxide Synthases
Neuroglia
2 Citations (Scopus)

Synaptic information processing by astrocytes

Perea, G. & Araque, A., Jan 1 2009, Astrocytes in (Patho)Physiology of the Nervous System. Springer US, p. 287-300 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Automatic Data Processing
Astrocytes
Neuroglia
Neurons
Ion Channels
787 Citations (Scopus)

Tripartite synapses: astrocytes process and control synaptic information

Perea, G., Navarrete, M. & Araque, A., Aug 1 2009, In : Trends in Neurosciences. 32, 8, p. 421-431 11 p.

Research output: Contribution to journalReview article

Astrocytes
Synapses
Neurons
Synaptic Transmission
Neuronal Plasticity
2008
70 Citations (Scopus)

Astrocytes process synaptic information

Araque, A., Feb 1 2008, In : Neuron Glia Biology. 4, 1, p. 3-10 8 p.

Research output: Contribution to journalReview article

Astrocytes
Automatic Data Processing
Neurons
Nervous System
Nervous System Physiological Phenomena
34 Citations (Scopus)

DREAM mediates cAMP-dependent, Ca2+-induced stimulation of GFAP gene expression and regulates cortical astrogliogenesis

Cebolla, B., Fernández-Pérez, A., Perea, G., Araque, A. & Vallejo, M., Jun 25 2008, In : Journal of Neuroscience. 28, 26, p. 6703-6713 11 p.

Research output: Contribution to journalArticle

Kv Channel-Interacting Proteins
Glial Fibrillary Acidic Protein
Pituitary Adenylate Cyclase-Activating Polypeptide
Astrocytes
Gene Expression
271 Citations (Scopus)

Endocannabinoids Mediate Neuron-Astrocyte Communication

Navarrete, M. & Araque, A., Mar 27 2008, In : Neuron. 57, 6, p. 883-893 11 p.

Research output: Contribution to journalArticle

Endocannabinoids
Astrocytes
Neurons
Cannabinoids
Cannabinoid Receptors
2007
139 Citations (Scopus)

Adenosine released by astrocytes contributes to hypoxia-induced modulation of synaptic transmission

Martín, E. D., Fernández, M., Perea, G., Pascual, O., Haydon, P. G., Araque, A. & Ceña, V., Jan 1 2007, In : GLIA. 55, 1, p. 36-45 10 p.

Research output: Contribution to journalArticle

Synaptic Transmission
Astrocytes
Adenosine
Adenosine A1 Receptors
Adenosine Triphosphate
14 Citations (Scopus)

A new hybrid evolutionary mechanism based on unsupervised learning for Connectionist Systems

Porto, A., Araque, A., Rabuñal, J., Dorado, J. & Pazos, A., Oct 1 2007, In : Neurocomputing. 70, 16-18, p. 2799-2808 10 p.

Research output: Contribution to journalArticle

Unsupervised learning
Brain
Learning
Multilayers
Genetic algorithms
419 Citations (Scopus)

Astrocytes potentiate transmitter release at single hippocampal synapses

Perea, G. & Araque, A., Aug 24 2007, In : Science. 317, 5841, p. 1083-1086 4 p.

Research output: Contribution to journalArticle

Astrocytes
Synapses
SNARE Proteins
Metabotropic Glutamate Receptors
Neuronal Plasticity
2006
40 Citations (Scopus)

Astrocyte-neuron signaling in the brain - Implications for disease

Araque, A., Jul 1 2006, In : Current Opinion in Investigational Drugs. 7, 7, p. 619-624 6 p.

Research output: Contribution to journalReview article

Brain Diseases
Astrocytes
Neurons
Nervous System Physiological Phenomena
Nervous System