Alexey Benumov

Assistant Professor

1982 …2019
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Research Output 1982 2018

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Article
2018
5 Citations (Scopus)

Dicer1 deficiency in the idiopathic pulmonary fibrosis fibroblastic focus promotes fibrosis by suppressing MicroRNA biogenesis

Herrera, J., Beisang, D. J., Peterson, M., Forster, C., Gilbertsen, A. J., Benyumov, A., Smith, K., Korenczuk, C. E., Barocas, V. H., Guenther, K., Hite, R., Zhang, L., Henke, C. A. & Bitterman, P. B., Aug 15 2018, In : American journal of respiratory and critical care medicine. 198, 4, p. 486-496 11 p.

Research output: Contribution to journalArticle

Open Access
Idiopathic Pulmonary Fibrosis
MicroRNAs
Extracellular Matrix
Fibrosis
Fibroblasts
8 Citations (Scopus)
Open Access
Idiopathic Pulmonary Fibrosis
Mesenchymal Stromal Cells
Interleukin-8
Macrophages
Interleukin-8A Receptors
2017
16 Citations (Scopus)
Open Access
Idiopathic Pulmonary Fibrosis
Calcium-Binding Proteins
Mesenchymal Stromal Cells
Fibrosis
Myofibroblasts
2015
9 Citations (Scopus)

EIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells

Avdulov, S. V., Herrera, J., Smith, K., Peterson, M., Gomez-Garcia, J., Beadnell, T. C., Schwertfeger, K., Benyumov, A., Manivel, J. C., Li, S., Bielinsky, A. K., Yee, D., Bitterman, P. B. & Polunovsky, V. A., Feb 15 2015, In : Cancer Research. 75, 4, p. 687-697 11 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4E
Breast
Stem Cells
DNA Replication
Lactation
17 Citations (Scopus)

Transforming Growth Factor-β1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E

Smith, K. A., Zhou, B., Avdulov, S., Benyumov, A., Peterson, M., Liu, Y., Okon, A., Hergert, P., Braziunas, J., Wagner, C. R., Borok, Z. & Bitterman, P. B., Dec 18 2015, In : Scientific reports. 5, 18233.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Transforming Growth Factors
Transforming Growth Factor beta
Fibrosis
Epithelial Cells
2014
25 Citations (Scopus)

Identification of a cell-of-origin for fibroblasts comprising the fibrotic reticulum in idiopathic pulmonary fibrosis

Xia, H., Bodempudi, V., Benyumov, A., Hergert, P., Tank, D., Herrera, J., Braziunas, J., Larsson, O., Parker, M., Rossi, D., Smith, K., Peterson, M., Limper, A., Jessurun, J., Connett, J. E., Ingbar, D. H., Phan, S., Bitterman, P. B. & Henke, C. A., Jan 1 2014, In : American Journal of Pathology. 184, 5, p. 1369-1383 15 p.

Research output: Contribution to journalArticle

Reticulum
Idiopathic Pulmonary Fibrosis
Fibroblasts
Lung
Mesenchymal Stromal Cells
2013
6 Citations (Scopus)

Targeted delivery of antisense oligonucleotides by chemically self-assembled nanostructures

Gangar, A., Fegan, A., Kumarapperuma, S. C., Huynh, P., Benyumov, A. & Wagner, C. R., Sep 3 2013, In : Molecular Pharmaceutics. 10, 9, p. 3514-3518 5 p.

Research output: Contribution to journalArticle

Nanostructures
Antisense Oligonucleotides
Nucleic Acids
Methotrexate
Eukaryotic Initiation Factor-4E
2011
3 Citations (Scopus)

Combinatorial Pharmacologic Effects of Gemcitabine and its Metabolite dFdU

Benyumov, A., Gurvich, V. J., Lis, L. G., Williams, B. W. & Kirstein, M. N., Mar 7 2011, In : ChemMedChem. 6, 3, p. 457-464 8 p.

Research output: Contribution to journalArticle

gemcitabine
Metabolites
Zebrafish
Tumor Cell Line
Drug Interactions
2009
56 Citations (Scopus)

Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation

Ghosh, B., Benyumov, A., Ghosh, P., Jia, Y., Avdulov, S. V., Dahlberg, P. S., Peterson, M., Smith, K., Polunovsky, V. A., Bitterman, P. B. & Wagner, C. R., May 15 2009, In : ACS Chemical Biology. 4, 5, p. 367-377 11 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Tissue
Messenger RNA
Prodrugs
Zebrafish
2007
48 Citations (Scopus)

Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK)

Uckun, F. M., Dibirdik, I., Qazi, S., Vassilev, A., Ma, H., Mao, C., Benyumov, A. & Emami, K. H., Jan 15 2007, In : Bioorganic and Medicinal Chemistry. 15, 2, p. 800-814 15 p.

Research output: Contribution to journalArticle

Phosphotransferases
Breast Neoplasms
Cells
gemcitabine
Cell Division
9 Citations (Scopus)

Stereochemistry as a determinant of the anti-leukemic potency of halopyridyl and thiazolyl thiourea compounds

Venkatachalam, T. K., Vassilev, A. O., Benyunov, A., Grigoriants, O. O., Tibbles, H. E. & Uckun, F. M., Jul 1 2007, In : Letters in Drug Design and Discovery. 4, 5, p. 318-326 9 p.

Research output: Contribution to journalArticle

Benzyl Compounds
Thiourea
Tubulin
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Human Activities
2005
4 Citations (Scopus)

Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds: Studies using human acute lymphoblastic leukemia cells and the zebrafish model

Benyumov, A. O., Venkatachalam, T. K., Grigoriants, O. O., Vassilev, A. O., Tibbles, H. E., Downs, S., Dumez, D. & Uckun, F. M., Mar 17 2005, In : Arzneimittel-Forschung/Drug Research. 55, 2, p. 114-122 9 p.

Research output: Contribution to journalArticle

Zidovudine
Zebrafish
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Caspase 6
Cell Line
2001
57 Citations (Scopus)

Vanadocenes as potent anti-proliferative agents disrupting mitotic spindle formation in cancer cells

Navara, C. S., Benyumov, A., Vassilev, A., Narla, R. K., Ghosh, P. & Uckun, F. M., May 29 2001, In : Anti-Cancer Drugs. 12, 4, p. 369-376 8 p.

Research output: Contribution to journalArticle

Spindle Apparatus
Cell Division
Tubulin
Organometallic Compounds
Neoplasms
27 Citations (Scopus)
Bioactivity
X-Rays
X rays
Neoplasms
Atoms
1997
63 Citations (Scopus)

Anf: A novel class of vertebrate homeobox genes expressed at the anterior end of the main embryonic axis

Kazanskaya, O. V., Severtzova, E. A., Barth, K. A., Ermakova, G. V., Lukyanov, S. A., Benyumov, A. O., Pannese, M., Boncinelli, E., Wilson, S. W. & Zaraisky, A. G., Oct 24 1997, In : Gene. 200, 1-2, p. 25-34 10 p.

Research output: Contribution to journalArticle

Homeobox Genes
Vertebrates
Genes
Salamandridae
Zebrafish
1996

A Recombinant Construct with the Silver Carp Somatotropin Gene Can Be Used for Production of Transgenic Carps

Benyumov, A. O., Golichenkov, V. A., L'vov, Y. B., Rotkina, G. V., Zinov'eva, N. A., Hong, J., Schartl, M. & Brem, G., Dec 1 1996, In : Ontogenez. 27, 5, p. 286-287 2 p.

Research output: Contribution to journalArticle

Carps
Growth Hormone
Genes
Embryo Loss
Zygote
1991
42 Citations (Scopus)

The delivery of foreign genes into fertilized fish eggs using high-velocity microprojectiles

Zelenin, A. V., Alimov, A. A., Barmintzev, V. A., Beniumov, A. O., Zelenina, I. A., Krasnov, A. M. & Kolesnikov, V. A., Aug 5 1991, In : FEBS Letters. 287, 1-2, p. 118-120 3 p.

Research output: Contribution to journalArticle

Zygote
Zebrafish
Kanamycin Kinase
Cypriniformes
Fish
1990
6 Citations (Scopus)

High velocity mechanical injection of foreign DNA into fish oocytes

Kolesnikov, V. A., Alimov, A. A., Barmintsev, V. A., Benyumov, A. O., Zelenina, I. A., Krasnov, A. M., Dzhabur, R. & Zelenin, A. V., Dec 1 1990, In : Genetika. 26, 12, p. 2122-2126 5 p.

Research output: Contribution to journalArticle

Kanamycin Kinase
Cypriniformes
Tungsten
Trout
Microinjections
1989
4 Citations (Scopus)

Integratsiia i ékspressiia gena somatotropnogo gormona cheloveka u kostistykh ryb.

Translated title of the contribution: Integration and expression of the human somatotropic hormone gene in TeleosteiBeniumov, A. O., Enikolopov, G. N., Barmintsev, V. A., Zelenina, I. A. & Sleptsova, L. A., Jan 1 1989, In : Genetika. 25, 1, p. 24-35 12 p.

Research output: Contribution to journalArticle

Cypriniformes
Fishes
Hormones
Plasmids
RNA
1988

Operezhaiushchiǐ rost transgennykh ryb, soderzhashchikh gen somatotropina cheloveka.

Translated title of the contribution: Accelerated growth of transgenic fishes carrying human somatotropin geneEnikolopov, G. N., Beniumov, A. O., Barmintsev, V. A., Zelenina, I. A. & Sleptsova, L. A., Dec 1 1988, In : Doklady Akademii nauk SSSR. 301, 3, p. 724-727 4 p.

Research output: Contribution to journalArticle

Mice (computer peripherals)
Gene expression regulation
Cypriniformes
Genetic Vectors
Genetically Modified Animals

Vnutrikletochnaia lokalizatsiia kazeinovoǐ kinazy tipa II v ootsitakh Rana temporaria.

Translated title of the contribution: Intracellular localization of casein kinase of type II in oocytes of Rana temporariaKandror, K. V., Beniumov, A. O. & Stepanov, A. S., Jul 1 1988, In : Molekulyarnaya Biologiya. 22, 4, p. 1097-1107 11 p.

Research output: Contribution to journalArticle

Rana temporaria
Casein Kinase II
Oocytes
Amphibians
Autoradiography
1984

Effect of microinjections of cAMP-dependent protein kinase subunits on macromolecular syntheses in loach Misgurnus fossilis L. embryos.

Glukhov, A. I., Benyumov, A. O., Gazaryan, K. G., Nesterova, M. V. & Severin, E. S., Jul 1 1984, In : Biochemistry International. 9, 1, p. 83-91 9 p.

Research output: Contribution to journalArticle

Cypriniformes
Protein Subunits
Microinjections
Cyclic AMP-Dependent Protein Kinases
Embryonic Structures
1982
2 Citations (Scopus)

Synthesis and funding of nuclear non-histone proteins in the loach oocytes and early embryos

Knyazeva, E. F., Benyumov, A. & Kostomarova, A. A., Jan 1 1982, In : Ontogenez. 13, 5, p. 500-508 9 p.

Research output: Contribution to journalArticle

Cypriniformes
Nuclear Proteins
Oocytes
Embryonic Structures
Blastomeres