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Alena Talkachova

1995 …2021

Research output per year

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Research Output

Article

Action potential duration restitution portraits of mammalian ventricular myocytes: Role of calcium current

Tolkacheva, E. G., Anumonwo, J. M. B. & Jalife, J., Oct 2006, In : Biophysical journal. 91, 7, p. 2735-2745 11 p.

Research output: Contribution to journal › Article

43 Scopus citations

Analysis of the Fenton-Karma model through an approximation by a one-dimensional map

Tolkacheva, E. G., Schaeffer, D. G., Gauthier, D. J. & Mitchell, C. C., Dec 2002, In : Chaos. 12, 4, p. 1034-1042 9 p.

Research output: Contribution to journal › Article

28 Scopus citations

An ionically based mapping model with memory for cardiac restitution

Schaeffer, D. G., Cain, J. W., Gauthier, D. J., Kalb, S. S., Oliver, R. A., Tolkacheva, E. G., Ying, W. & Krassowska, W., Feb 1 2007, In : Bulletin of mathematical biology. 69, 2, p. 459-482 24 p.

Research output: Contribution to journal › Article

21 Scopus citations

Arrhythmogenic mechanisms in a mouse model of catecholaminergic polymorphic ventricular tachycardia

Cerrone, M., Noujaim, S. F., Tolkacheva, E. G., Talkachou, A., O'Connell, R., Berenfeld, O., Anumonwo, J., Pandit, S. V., Vikstrom, K., Napolitano, C., Priori, S. G. & Jalife, J., Nov 1 2007, In : Circulation research. 101, 10, p. 1039-1048 10 p.

Research output: Contribution to journal › Article

197 Scopus citations

Atrial GIRK channels mediate the effects of vagus nerve stimulation on heart rate dynamics and arrhythmogenesis

Lee, S. W., Anderson, A., Guzman, P. A., Nakano, A., Tolkacheva, E. G. & Wickman, K., Jul 19 2018, In : Frontiers in Physiology. 9, JUL, 943.

Research output: Contribution to journal › Article

Open Access
4 Scopus citations

Characterizing Spatial Dynamics of Bifurcation to Alternans in Isolated Whole Rabbit Hearts Based on Alternate Pacing

Kulkarni, K., Visweswaran, R., Zhao, X. & Tolkacheva, E. G., Jan 1 2015, In : BioMed Research International. 2015, 170768.

Research output: Contribution to journal › Article

5 Scopus citations

Chronic cyclic vagus nerve stimulation has beneficial electrophysiological effects on healthy hearts in the absence of autonomic imbalance

Lee, S. W., Li, Q., Libbus, I., Xie, X., Kenknight, B. H., Garry, M. G. & Talkachova, A., May 1 2016, In : Physiological Reports. 4, 9, p. 1-8 8 p.

Research output: Contribution to journal › Article

Open Access
10 Scopus citations

Chronic low-level vagus nerve stimulation improves long-term survival in salt-sensitive hypertensive rats

Annoni, E. M., Van Helden, D., Guo, Y., Levac, B., Libbus, I., KenKnight, B. H., Osborn, J. W. & Tolkacheva, E. G., Jan 1 2019, In : Frontiers in Physiology. 10, JAN, 25.

Research output: Contribution to journal › Article

Open Access

Condition for alternans and its control in a two-dimensional mapping model of paced cardiac dynamics

Tolkacheva, E. G., Romeo, M. M., Guerraty, M. & Gauthier, D. J., Mar 2004, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 69, 3, p. 31904 1 p., 031904.

Research output: Contribution to journal › Article

47 Scopus citations

Condition for alternans and stability of the 1: 1 response pattern in a "memory" model of paced cardiac dynamics

Tolkacheva, E. G., Schaeffer, D. G., Gauthier, D. J. & Krassowska, W., Mar 1 2003, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 67, 3, p. 31904 1 p.

Research output: Contribution to journal › Article

86 Scopus citations

Constant DI pacing suppresses cardiac alternans formation in numerical cable models

Zlochiver, S., Johnson, C. & Tolkacheva, E. G., Sep 1 2017, In : Chaos. 27, 9, 093903.

Research output: Contribution to journal › Article

6 Scopus citations

Control of cardiac alternans in a mapping model with memory

Tolkacheva, E. G., Romeo, M. M. & Gauthier, D. J., Jul 15 2004, In : Physica D: Nonlinear Phenomena. 194, 3-4, p. 385-391 7 p.

Research output: Contribution to journal › Article

9 Scopus citations

Effect of chirped laser pulse narrowing by reflection from a nonlinear DFB structure

Afanas'ev, A. A., Samson, B. A. & Tolkacheva, E. G., Jan 1998, In : Journal of Modern Optics. 45, 1, p. 91-101 11 p.

Research output: Contribution to journal › Article

1 Scopus citations

Evaluation of Multiscale Frequency Approach for Visualizing Rotors in Patients with Atrial Fibrillation

Ravikumar, V., Annoni, E. M., Mulpuru, S. K., Roukoz, H. & Tolkacheva, E. G., Jul 1 2018, In : Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2018, p. 5986-5989 4 p.

Research output: Contribution to journal › Article

Expression and relevance of the G protein-gated K+ channel in the mouse ventricle

Anderson, A., Kulkarni, K., Marron Fernandez De Velasco, E., Carlblom, N., Xia, Z., Nakano, A., Martemyanov, K. A., Tolkacheva, E. G. & Wickman, K., Dec 1 2018, In : Scientific reports. 8, 1, 1192.

Research output: Contribution to journal › Article

Open Access
5 Scopus citations

Free fatty acid effects on the atrial myocardium: Membrane ionic currents are remodeled by the disruption of T-tubular architecture

O'Connell, R. P., Musa, H., Gomez, M. S. M., Avula, U. M., Herron, T. J., Kalifa, J., Anumonwo, J. M. B. & Talkachova, A., Aug 14 2015, In : PloS one. 10, 8, e0133052.

Research output: Contribution to journal › Article

15 Scopus citations

Heart rate variability and alternans formation in the heart: The role of feedback in cardiac dynamics

McIntyre, S. D., Kakade, V., Mori, Y. & Tolkacheva, E. G., Jun 7 2014, In : Journal of Theoretical Biology. 350, p. 90-97 8 p.

Research output: Contribution to journal › Article

18 Scopus citations

Improved multiscale entropy technique with nearest-neighbor moving-average kernel for nonlinear and nonstationary short-time biomedical signal analysis

Arunachalam, S. P., Kapa, S., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Jan 1 2018, In : Journal of healthcare engineering. 2018, 8632436.

Research output: Contribution to journal › Article

Open Access
1 Scopus citations

Intermittent electrical stimulation of the right cervical vagus nerve in salt-sensitive hypertensive rats: Effects on blood pressure, arrhythmias, and ventricular electrophysiology

Annoni, E. M., Xie, X., Lee, S. W., Libbus, I., KenKnight, B. H., Osborn, J. W. & Tolkacheva, E. G., Jan 1 2015, In : Physiological Reports. 3, 8, e12476.

Research output: Contribution to journal › Article

18 Scopus citations

Intermittent vagus nerve stimulation reflexively modulates heart rate variability in rats with chronic ischemic heart failure

Ippolito, J., Xie, X., KenKnight, B. H. & Tolkacheva, E. G., Jul 3 2013, In : Journal of Medical Devices, Transactions of the ASME. 7, 3, 030905.

Research output: Contribution to journal › Article

1 Scopus citations

Interplay between ephaptic coupling and complex geometry of border zone during acute myocardial ischemia: Effect on arrhythmogeneity

Wei, N. & Tolkacheva, E. G., Mar 1 2020, In : Chaos. 30, 3, 033111.

Research output: Contribution to journal › Article

Interventricular heterogeneity as a substrate for arrhythmogenesis of decoupled mitochondria during ischemia in the whole heart

Smith, R. M., Velamakanni, S. S. & Tolkacheva, E. G., Jul 15 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 303, 2, p. H224-H233

Research output: Contribution to journal › Article

15 Scopus citations

Kir2.3 isoform confers pH sensitivity to heteromeric Kir2.1/Kir2.3 channels in HEK293 cells

Muñoz, V., Vaidyanathan, R., Tolkacheva, E. G., Dhamoon, A. S., Taffet, S. M. & Anumonwo, J. M. B., Apr 1 2007, In : Heart Rhythm. 4, 4, p. 487-496 10 p.

Research output: Contribution to journal › Article

15 Scopus citations

Mechanisms underlying the antifibrillatory action of hyperkalemia in guinea pig hearts

Pandit, S. V., Warren, M., Mironov, S., Tolkacheva, E. G., Kalifa, J., Berenfeld, O. & Jalife, J., May 19 2010, In : Biophysical journal. 98, 10, p. 2091-2101 11 p.

Research output: Contribution to journal › Article

23 Scopus citations

Miniaturized radio frequency telemetric pacemaker with anti-arrhythmic pacing protocol

Kulkarni, K., Tan, S. Y. & Tolkacheva, E. G., Jan 1 2014, In : Journal of Medical Devices, Transactions of the ASME. 8, 2, 020909.

Research output: Contribution to journal › Article

Novel multiscale frequency approach to identify the pivot point of the rotor

Arunachalam, S. P., Annoni, E. M., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Jun 1 2016, In : Journal of Medical Devices, Transactions of the ASME. 10, 2, 020948.

Research output: Contribution to journal › Article

7 Scopus citations

Novel quantitative analytical approaches for rotor identification and associated implications for mapping

Annoni, E. M., Arunachalam, S. P., Kapa, S., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Feb 2018, In : IEEE Transactions on Biomedical Engineering. 65, 2, p. 273-281 9 p., 8068247.

Research output: Contribution to journal › Article

10 Scopus citations

Rate-dependent propagation of cardiac action potentials in a one-dimensional fiber

Cain, J. W., Tolkacheva, E. G., Schaeffer, D. G. & Gauthier, D. J., Jan 1 2004, In : Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics. 70, 6, 1 p.

Research output: Contribution to journal › Article

16 Scopus citations

Real-Time Closed Loop Diastolic Interval Control Prevents Cardiac Alternans in Isolated Whole Rabbit Hearts

Kulkarni, K., Lee, S. W., Kluck, R. & Tolkacheva, E. G., Apr 1 2018, In : Annals of Biomedical Engineering. 46, 4, p. 555-566 12 p.

Research output: Contribution to journal › Article

4 Scopus citations

Restitution in mapping models with an arbitrary amount of memory

Kalb, S. S., Tolkacheva, E. G., Schaeffer, D. G., Gauthier, D. J. & Krassowska, W., Jun 2005, In : Chaos. 15, 2, 023701.

Research output: Contribution to journal › Article

23 Scopus citations

Role of conduction velocity restitution and short-term memory in the development of action potential duration alternans in isolated rabbit hearts

Mironov, S., Jalife, J. & Tolkacheva, E. G., Jul 1 2008, In : Circulation. 118, 1, p. 17-25 9 p.

Research output: Contribution to journal › Article

94 Scopus citations

Spatial instability of counterpropagating waves in nonlinear distributed feedback structures

Afanas’ev, A. A., Tolkacheva, E. G., Tredicce, J. & Volkov, V. M., Jan 1 1999, In : Physical Review A - Atomic, Molecular, and Optical Physics. 60, 3, p. 2375-2379 5 p.

Research output: Contribution to journal › Article

1 Scopus citations

Spatial modulation of a light beam reflected from a nonlinear DFB-structure

Afanas'ev, A. A., Dritz, V. V. & Tolkacheva, E. G., Mar 15 1998, In : Optics Communications. 148, 4-6, p. 236-241 6 p.

Research output: Contribution to journal › Article

1 Scopus citations

Spatiotemporal evolution and prediction of [Ca2+]i and APD alternans in isolated rabbit hearts

Visweswaran, R., McIntyre, S. D., Ramkrishnan, K., Zhao, X. & Tolkacheva, E. G., Nov 1 2013, In : Journal of cardiovascular electrophysiology. 24, 11, p. 1287-1295 9 p.

Research output: Contribution to journal › Article

13 Scopus citations

Stochastic vagus nerve stimulation affects acute heart rate dynamics in rats

Lee, S. W., Kulkarni, K., Annoni, E. M., Libbus, I., KenKnight, B. H. & Tolkacheva, E. G., Mar 2018, In : PloS one. 13, 3, e0194910.

Research output: Contribution to journal › Article

Open Access
3 Scopus citations

The distributed feedback of counter-propagating waves in a periodically modulated medium with relaxing cubic nonlinearity

Afanas’ev, A. A., Samson, B. A. & Tolkacheva, E. G., Jan 1 1995, In : Journal of Modern Optics. 42, 11, p. 2285-2294 10 p.

Research output: Contribution to journal › Article

8 Scopus citations

The dual effect of ephaptic coupling on cardiac conduction with heterogeneous expression of connexin 43

Wei, N., Mori, Y. & Tolkacheva, E. G., May 21 2016, In : Journal of Theoretical Biology. 397, p. 103-114 12 p.

Research output: Contribution to journal › Article

Open Access
6 Scopus citations

The effect of cardiac sympathetic denervation through bilateral stellate ganglionectomy on electrical properties of the heart

Xie, X., Visweswaran, R., Guzman, P. A., Smith, R. M., Osborn Jr, J. W. & Talkachova, A., Jul 1 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 301, 1

Research output: Contribution to journal › Article

14 Scopus citations

The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart

Kulkarni, K., Xie, X., De Velasco, E. M. F., Anderson, A., Martemyanov, K. A., Wickman, K. & Tolkacheva, E. G., Apr 2018, In : PloS one. 13, 4, e0193798.

Research output: Contribution to journal › Article

Open Access

Theory of stationary generation of a laser with a nonlinear bragg reflector

Afanas'ev, A. A. & Tolkacheva, E. G., Oct 1 1996, In : IEEE Journal of Quantum Electronics. 32, 10, p. 1740-1745 6 p.

Research output: Contribution to journal › Article

3 Scopus citations

The rate- and species-dependence of short-term memory in cardiac myocytes

Tolkacheva, E. G., Feb 1 2007, In : Journal of Biological Physics. 33, 1, p. 35-47 13 p.

Research output: Contribution to journal › Article

7 Scopus citations

The restitution portrait: A new method for investigating rate-dependent restitution

Kalb, S. S., Dobrovolny, H. M., Tolkacheva, E. G., Idriss, S. F., Krassowska, W. & Gauthier, D. J., Jun 1 2004, In : Journal of cardiovascular electrophysiology. 15, 6, p. 698-709 12 p.

Research output: Contribution to journal › Article

87 Scopus citations

The role of short term memory and conduction velocity restitution in alternans formation

Wei, N., Mori, Y. & Tolkacheva, E. G., Feb 1 2015, In : Journal of Theoretical Biology. 367, p. 21-28 8 p.

Research output: Contribution to journal › Article

7 Scopus citations

Toward prediction of the local onset of alternans in the heart

Cram, A. R., Rao, H. M. & Tolkacheva, E. G., Feb 16 2011, In : Biophysical journal. 100, 4, p. 868-874 7 p.

Research output: Contribution to journal › Article

12 Scopus citations

Uncoupling the mitochondria facilitates alternans formation in the isolated rabbit heart

Smith, R. M., Visweswaran, R., Talkachova, I., Wothe, J. K. & Tolkacheva, E. G., Jul 1 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 1, p. H9-H18

Research output: Contribution to journal › Article

12 Scopus citations

Using dominant eigenvalue analysis to predict formation of alternans in the heart

Kakade, V., Zhao, X. & Tolkacheva, E. G., Nov 22 2013, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 88, 5, 052716.

Research output: Contribution to journal › Article

1 Scopus citations

Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart

Smith, R. M., Black, A. J., Velamakanni, S. S., Akkin, T. & Tolkacheva, E. G., May 10 2012, In : Applied Optics. 51, 14, p. 2713-2721 9 p.

Research output: Contribution to journal › Article

5 Scopus citations
Chapter

Benchtop optical mapping approaches to study arrhythmias

Kulkarni, K., Lee, S. W. & Tolkacheva, E. G., Jan 1 2018, Engineering in Medicine: Advances and Challenges. Elsevier, p. 35-54 20 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Comment/debate

Correction: The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart (PLoS ONE (2018) 13: 4 (e0193798) DOI: 10.1371/journal.pone.0193798)

Kulkarni, K., Xie, X., De Velasco, E. M. F., Anderson, A., Martemyanov, K. A., Wickman, K. & Tolkacheva, E. G., Jul 2018, In : PloS one. 13, 7, e0200553.

Research output: Contribution to journal › Comment/debate

Open Access
Conference contribution

Acute cardiovascular and hemodynamic effects of vagus nerve stimulation in conscious hypertensive rats

Annoni, E. M. & Tolkacheva, E. G., Oct 26 2018, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc., p. 3685-3688 4 p. 8513025. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; vol. 2018-July).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations