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Alena Talkachova

1995 …2021
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Research Output 1995 2019

Article
42 Citations (Scopus)

Action potential duration restitution portraits of mammalian ventricular myocytes: Role of calcium current

Tolkacheva, E. G., Anumonwo, J. M. B. & Jalife, J., Jan 1 2006, In : Biophysical journal. 91, 7, p. 2735-2745 11 p.

Research output: Contribution to journal › Article

Muscle Cells
Action Potentials
Calcium
Cardiac Myocytes
Guinea Pigs
27 Citations (Scopus)

Analysis of the Fenton-Karma model through an approximation by a one-dimensional map

Tolkacheva, E. G., Schaeffer, D. G., Gauthier, D. J. & Mitchell, C. C., Dec 2002, In : Chaos. 12, 4, p. 1034-1042 9 p.

Research output: Contribution to journal › Article

One-dimensional Maps
Action Potential
Approximation
approximation
Cardiac
21 Citations (Scopus)

An ionically based mapping model with memory for cardiac restitution

Schaeffer, D. G., Cain, J. W., Gauthier, D. J., Kalb, S. S., Oliver, R. A., Tolkacheva, E. G., Ying, W. & Krassowska, W., Feb 1 2007, In : Bulletin of mathematical biology. 69, 2, p. 459-482 24 p.

Research output: Contribution to journal › Article

Cardiac
Data storage equipment
Action Potentials
Rana catesbeiana
Action Potential
191 Citations (Scopus)

Arrhythmogenic mechanisms in a mouse model of catecholaminergic polymorphic ventricular tachycardia

Cerrone, M., Noujaim, S. F., Tolkacheva, E. G., Talkachou, A., O'Connell, R., Berenfeld, O., Anumonwo, J., Pandit, S. V., Vikstrom, K., Napolitano, C., Priori, S. G. & Jalife, J., Nov 1 2007, In : Circulation research. 101, 10, p. 1039-1048 10 p.

Research output: Contribution to journal › Article

Ryanodine Receptor Calcium Release Channel
Ventricular Tachycardia
Cardiac Arrhythmias
Ventricular Fibrillation
Polymorphic catecholergic ventricular tachycardia
2 Citations (Scopus)

Atrial GIRK channels mediate the effects of vagus nerve stimulation on heart rate dynamics and arrhythmogenesis

Lee, S. W., Anderson, A., Guzman, P. A., Nakano, A., Tolkacheva, E. G. & Wickman, K., Jul 19 2018, In : Frontiers in Physiology. 9, JUL, 943.

Research output: Contribution to journal › Article

Open Access
Vagus Nerve Stimulation
Heart Rate
Cardiovascular Diseases
Muscarinic Receptors
GTP-Binding Proteins
4 Citations (Scopus)

Characterizing Spatial Dynamics of Bifurcation to Alternans in Isolated Whole Rabbit Hearts Based on Alternate Pacing

Kulkarni, K., Visweswaran, R., Zhao, X. & Tolkacheva, E. G., Jan 1 2015, In : BioMed Research International. 2015, 170768.

Research output: Contribution to journal › Article

Rabbits
Heart Ventricles
Sudden Cardiac Death
Ventricular Fibrillation
Action Potentials
9 Citations (Scopus)

Chronic cyclic vagus nerve stimulation has beneficial electrophysiological effects on healthy hearts in the absence of autonomic imbalance

Lee, S. W., Li, Q., Libbus, I., Xie, X., Kenknight, B. H., Garry, M. G. & Talkachova, A., May 1 2016, In : Physiological Reports. 4, 9, p. 1-8 8 p.

Research output: Contribution to journal › Article

Vagus Nerve Stimulation
pamidronate
Action Potentials
Vagus Nerve
Autonomic Nervous System

Chronic low-level vagus nerve stimulation improves long-term survival in salt-sensitive hypertensive rats

Annoni, E. M., Van Helden, D., Guo, Y., Levac, B., Libbus, I., KenKnight, B. H., Osborn, J. W. & Tolkacheva, E. G., Jan 1 2019, In : Frontiers in Physiology. 10, JAN, 25.

Research output: Contribution to journal › Article

Open Access
Vagus Nerve Stimulation
Salts
Hypertension
Therapeutics
Heart Rate
46 Citations (Scopus)

Condition for alternans and its control in a two-dimensional mapping model of paced cardiac dynamics

Tolkacheva, E. G., Romeo, M. M., Guerraty, M. & Gauthier, D. J., Mar 2004, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 69, 3, p. 31904 1 p., 031904.

Research output: Contribution to journal › Article

Cardiac
Slope
Action Potential
slopes
intervals
85 Citations (Scopus)

Condition for alternans and stability of the 1: 1 response pattern in a "memory" model of paced cardiac dynamics

Tolkacheva, E. G., Schaeffer, D. G., Gauthier, D. J. & Krassowska, W., Mar 1 2003, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 67, 3, p. 31904 1 p.

Research output: Contribution to journal › Article

Memory Model
Cardiac
Action Potentials
Myocardium
Slope
5 Citations (Scopus)

Constant DI pacing suppresses cardiac alternans formation in numerical cable models

Zlochiver, S., Johnson, C. & Talkachova, A., Sep 1 2017, In : Chaos. 27, 9, 093903.

Research output: Contribution to journal › Article

Cable
Cardiac
cables
Cables
intervals
9 Citations (Scopus)

Control of cardiac alternans in a mapping model with memory

Tolkacheva, E. G., Romeo, M. M. & Gauthier, D. J., Jul 15 2004, In : Physica D: Nonlinear Phenomena. 194, 3-4, p. 385-391 7 p.

Research output: Contribution to journal › Article

feedback control
physiological responses
myocardium
muscles
maintenance
1 Citation (Scopus)

Effect of chirped laser pulse narrowing by reflection from a nonlinear DFB structure

Afanas'ev, A. A., Samson, B. A. & Tolkacheva, E. G., Jan 1 1998, In : Journal of Modern Optics. 45, 1, p. 91-101 11 p.

Research output: Contribution to journal › Article

pulses
lasers
forbidden bands
reflected waves
chirp

Evaluation of Multiscale Frequency Approach for Visualizing Rotors in Patients with Atrial Fibrillation

Ravikumar, V., Annoni, E. M., Mulpuru, S. K., Roukoz, H. & Tolkacheva, E. G., Jul 1 2018, In : Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2018, p. 5986-5989 4 p.

Research output: Contribution to journal › Article

Ablation
Atrial Fibrillation
Cardiac Electrophysiologic Techniques
Pulmonary Veins
Rotors
5 Citations (Scopus)

Expression and relevance of the G protein-gated K + channel in the mouse ventricle

Anderson, A., Kulkarni, K., Marron Fernandez De Velasco, E., Carlblom, N., Xia, Z., Nakano, A., Martemyanov, K. A., Tolkacheva, E. G. & Wickman, K., Dec 1 2018, In : Scientific reports. 8, 1, 1192.

Research output: Contribution to journal › Article

Open Access
Inwardly Rectifying Potassium Channel
GTP-Binding Proteins
Carbachol
Muscle Cells
Heart Rate
14 Citations (Scopus)

Free fatty acid effects on the atrial myocardium: Membrane ionic currents are remodeled by the disruption of T-tubular architecture

O'Connell, R. P., Musa, H., Gomez, M. S. M., Avula, U. M., Herron, T. J., Kalifa, J., Anumonwo, J. M. B. & Talkachova, A., Aug 14 2015, In : PloS one. 10, 8, e0133052.

Research output: Contribution to journal › Article

myocardium
Nonesterified Fatty Acids
free fatty acids
Myocardium
myocytes
16 Citations (Scopus)

Heart rate variability and alternans formation in the heart: The role of feedback in cardiac dynamics

McIntyre, S. D., Kakade, V., Mori, Y. & Talkachova, A., Jun 7 2014, In : Journal of Theoretical Biology. 350, p. 90-97 8 p.

Research output: Contribution to journal › Article

Heart Rate Variability
Cardiac
Action Potential
heart rate
action potentials
1 Citation (Scopus)

Improved multiscale entropy technique with nearest-neighbor moving-average kernel for nonlinear and nonstationary short-time biomedical signal analysis

Arunachalam, S. P., Kapa, S., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Jan 1 2018, In : Journal of healthcare engineering. 2018, 8632436.

Research output: Contribution to journal › Article

Signal analysis
Entropy
Electrocardiography
Rotors
Atrial Fibrillation
16 Citations (Scopus)

Intermittent electrical stimulation of the right cervical vagus nerve in salt-sensitive hypertensive rats: Effects on blood pressure, arrhythmias, and ventricular electrophysiology

Annoni, E. M., Xie, X., Lee, S. W., Libbus, I., KenKnight, B. H., Osborn, J. W. & Tolkacheva, E. G., Jan 1 2015, In : Physiological Reports. 3, 8, e12476.

Research output: Contribution to journal › Article

Vagus Nerve
Electrophysiology
Electric Stimulation
Vagus Nerve Stimulation
Cardiac Arrhythmias
1 Citation (Scopus)

Intermittent vagus nerve stimulation reflexively modulates heart rate variability in rats with chronic ischemic heart failure

Ippolito, J., Xie, X., KenKnight, B. H. & Tolkacheva, E. G., Jul 3 2013, In : Journal of Medical Devices, Transactions of the ASME. 7, 3, 030905.

Research output: Contribution to journal › Article

Vagus Nerve Stimulation
Rats
Heart Failure
Heart Rate
14 Citations (Scopus)

Interventricular heterogeneity as a substrate for arrhythmogenesis of decoupled mitochondria during ischemia in the whole heart

Smith, R. M., Velamakanni, S. S. & Tolkacheva, E. G., Jul 15 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 303, 2, p. H224-H233

Research output: Contribution to journal › Article

Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone
Ventricular Fibrillation
Mitochondria
Ischemia
Heart Ventricles
15 Citations (Scopus)

Kir2.3 isoform confers pH sensitivity to heteromeric Kir2.1/Kir2.3 channels in HEK293 cells

Muñoz, V., Vaidyanathan, R., Tolkacheva, E. G., Dhamoon, A. S., Taffet, S. M. & Anumonwo, J. M. B., Apr 1 2007, In : Heart Rhythm. 4, 4, p. 487-496 10 p.

Research output: Contribution to journal › Article

HEK293 Cells
Protein Isoforms
Sheep
Kir2.1 channel
Cardiac Myocytes
21 Citations (Scopus)

Mechanisms underlying the antifibrillatory action of hyperkalemia in guinea pig hearts

Pandit, S. V., Warren, M., Mironov, S., Talkachova, A., Kalifa, J., Berenfeld, O. & Jalife, J., May 19 2010, In : Biophysical Journal. 98, 10, p. 2091-2101 11 p.

Research output: Contribution to journal › Article

Hyperkalemia
Ventricular Fibrillation
Guinea Pigs
Heart Ventricles
Constriction

Miniaturized radio frequency telemetric pacemaker with anti-arrhythmic pacing protocol

Kulkarni, K., Tan, S. Y. & Tolkacheva, E. G., Jan 1 2014, In : Journal of Medical Devices, Transactions of the ASME. 8, 2, 020909.

Research output: Contribution to journal › Article

Pacemakers
Anti-Arrhythmia Agents
Radio
6 Citations (Scopus)

Novel multiscale frequency approach to identify the pivot point of the rotor

Arunachalam, S. P., Annoni, E. M., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Jun 1 2016, In : Journal of Medical Devices, Transactions of the ASME. 10, 2, 020948.

Research output: Contribution to journal › Article

Rotors
8 Citations (Scopus)

Novel quantitative analytical approaches for rotor identification and associated implications for mapping

Annoni, E. M., Arunachalam, S. P., Kapa, S., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Feb 1 2018, In : IEEE Transactions on Biomedical Engineering. 65, 2, p. 273-281 9 p., 8068247.

Research output: Contribution to journal › Article

Rotors
Entropy
Ablation
Signal analysis
16 Citations (Scopus)

Rate-dependent propagation of cardiac action potentials in a one-dimensional fiber

Cain, J. W., Tolkacheva, E. G., Schaeffer, D. G. & Gauthier, D. J., Jan 1 2004, In : Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics. 70, 6, 1 p.

Research output: Contribution to journal › Article

Action Potential
Cardiac
Fiber
Propagation
fibers
2 Citations (Scopus)

Real-Time Closed Loop Diastolic Interval Control Prevents Cardiac Alternans in Isolated Whole Rabbit Hearts

Kulkarni, K., Lee, S. W., Kluck, R. & Talkachova, A., Apr 1 2018, In : Annals of Biomedical Engineering. 46, 4, p. 555-566 12 p.

Research output: Contribution to journal › Article

Feedback
Electrocardiography
Closed loop systems
Modulation
Tissue
23 Citations (Scopus)

Restitution in mapping models with an arbitrary amount of memory

Kalb, S. S., Tolkacheva, E. G., Schaeffer, D. G., Gauthier, D. J. & Krassowska, W., Jun 2005, In : Chaos. 15, 2, 023701.

Research output: Contribution to journal › Article

Data storage equipment
Curve
Action Potential
Arbitrary
curves
90 Citations (Scopus)

Role of conduction velocity restitution and short-term memory in the development of action potential duration alternans in isolated rabbit hearts

Mironov, S., Jalife, J. & Tolkacheva, E. G., Jul 1 2008, In : Circulation. 118, 1, p. 17-25 9 p.

Research output: Contribution to journal › Article

Short-Term Memory
Action Potentials
Rabbits
Epicardial Mapping
Cardiac Arrhythmias
1 Citation (Scopus)

Spatial instability of counterpropagating waves in nonlinear distributed feedback structures

Afanas’ev, A. A., Talkachova, A., Tredicce, J. & Volkov, V. M., Jan 1 1999, In : Physical Review A - Atomic, Molecular, and Optical Physics. 60, 3, p. 2375-2379 5 p.

Research output: Contribution to journal › Article

perturbation
thresholds
1 Citation (Scopus)

Spatial modulation of a light beam reflected from a nonlinear DFB-structure

Afanas'ev, A. A., Dritz, V. V. & Tolkacheva, E. G., Mar 15 1998, In : Optics Communications. 148, 4-6, p. 236-241 6 p.

Research output: Contribution to journal › Article

reflected waves
light beams
Modulation
modulation
Radiation
11 Citations (Scopus)

Spatiotemporal evolution and prediction of [Ca2+]i and APD alternans in isolated rabbit hearts

Visweswaran, R., McIntyre, S. D., Ramkrishnan, K., Zhao, X. & Tolkacheva, E. G., Nov 1 2013, In : Journal of cardiovascular electrophysiology. 24, 11, p. 1287-1295 9 p.

Research output: Contribution to journal › Article

Action Potentials
Rabbits
Calcium
Ventricular Fibrillation

Stochastic vagus nerve stimulation affects acute heart rate dynamics in rats

Lee, S. W., Kulkarni, K., Annoni, E. M., Libbus, I., KenKnight, B. H. & Tolkacheva, E. G., Mar 2018, In : PloS one. 13, 3, e0194910.

Research output: Contribution to journal › Article

vagus nerve
Vagus Nerve Stimulation
Rats
heart rate
Heart Rate
8 Citations (Scopus)

The distributed feedback of counter-propagating waves in a periodically modulated medium with relaxing cubic nonlinearity

Afanas’ev, A. A., Samson, B. A. & Tolkacheva, E. G., Jan 1 1995, In : Journal of Modern Optics. 42, 11, p. 2285-2294 10 p.

Research output: Contribution to journal › Article

counters
nonlinearity
gratings
coupling coefficients
continuous radiation
4 Citations (Scopus)

The dual effect of ephaptic coupling on cardiac conduction with heterogeneous expression of connexin 43

Wei, N., Mori, Y. & Talkachova, A., May 21 2016, In : Journal of Theoretical Biology. 397, p. 103-114 12 p.

Research output: Contribution to journal › Article

connexins
Connexin 43
Conduction
Cardiac
Gap Junction
13 Citations (Scopus)

The effect of cardiac sympathetic denervation through bilateral stellate ganglionectomy on electrical properties of the heart

Xie, X., Visweswaran, R., Guzman, P. A., Smith, R. M., Osborn Jr, J. W. & Talkachova, A., Jul 1 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 301, 1

Research output: Contribution to journal › Article

Ganglionectomy
Sympathectomy
Ventricular Fibrillation
Action Potentials
Atenolol

The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart

Kulkarni, K., Xie, X., De Velasco, E. M. F., Anderson, A., Martemyanov, K. A., Wickman, K. & Tolkacheva, E. G., Apr 2018, In : PloS one. 13, 4, e0193798.

Research output: Contribution to journal › Article

Open Access
carbachol
Carbachol
heart
mice
action potentials
3 Citations (Scopus)

Theory of stationary generation of a laser with a nonlinear bragg reflector

Afanas'ev, A. A. & Tolkacheva, E. G., Oct 1 1996, In : IEEE Journal of Quantum Electronics. 32, 10, p. 1740-1745 6 p.

Research output: Contribution to journal › Article

Bragg reflectors
Lasers
Laser radiation
Laser modes
lasers
7 Citations (Scopus)

The rate- and species-dependence of short-term memory in cardiac myocytes

Tolkacheva, E. G., Feb 1 2007, In : Journal of Biological Physics. 33, 1, p. 35-47 13 p.

Research output: Contribution to journal › Article

muscle cells
Short-Term Memory
Cardiac Myocytes
cycles
Action Potentials
87 Citations (Scopus)

The restitution portrait: A new method for investigating rate-dependent restitution

Kalb, S. S., Dobrovolny, H. M., Tolkacheva, E. G., Idriss, S. F., Krassowska, W. & Gauthier, D. J., Jun 1 2004, In : Journal of cardiovascular electrophysiology. 15, 6, p. 698-709 12 p.

Research output: Contribution to journal › Article

Action Potentials
pamidronate
Rana catesbeiana
Myocardium
Observation
7 Citations (Scopus)

The role of short term memory and conduction velocity restitution in alternans formation

Wei, N., Mori, Y. & Tolkacheva, E. G., Feb 1 2015, In : Journal of Theoretical Biology. 367, p. 21-28 8 p.

Research output: Contribution to journal › Article

Memory Term
Action Potential
action potentials
Short-Term Memory
Conduction
12 Citations (Scopus)

Toward prediction of the local onset of alternans in the heart

Cram, A. R., Rao, H. M. & Talkachova, A., Feb 16 2011, In : Biophysical journal. 100, 4, p. 868-874 7 p.

Research output: Contribution to journal › Article

Action Potentials
Ventricular Fibrillation
Muscle Cells
Rabbits
Isolated Heart Preparation
12 Citations (Scopus)

Uncoupling the mitochondria facilitates alternans formation in the isolated rabbit heart

Smith, R. M., Visweswaran, R., Talkachova, I., Wothe, J. K. & Tolkacheva, E. G., Jul 1 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 1, p. H9-H18

Research output: Contribution to journal › Article

Action Potentials
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone
Mitochondria
Rabbits
Ischemia
1 Citation (Scopus)

Using dominant eigenvalue analysis to predict formation of alternans in the heart

Kakade, V., Zhao, X. & Tolkacheva, E. G., Nov 22 2013, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 88, 5, 052716.

Research output: Contribution to journal › Article

Eigenvalue Analysis
eigenvalues
Predict
Action Potential
Cycle Length
4 Citations (Scopus)

Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart

Smith, R. M., Black, A. J., Velamakanni, S. S., Akkin, T. & Tolkacheva, E. G., May 10 2012, In : Applied Optics. 51, 14, p. 2713-2721 9 p.

Research output: Contribution to journal › Article

rabbits
borders
arrhythmia
Tissue
Geometry
Comment/debate

Correction: The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart (PLoS ONE (2018) 13: 4 (e0193798) DOI: 10.1371/journal.pone.0193798)

Kulkarni, K., Xie, X., De Velasco, E. M. F., Anderson, A., Martemyanov, K. A., Wickman, K. & Tolkacheva, E. G., Jul 2018, In : PloS one. 13, 7, e0200553.

Research output: Contribution to journal › Comment/debate

Open Access
Names
heart
mice
4-iodo-2,5-dimethoxyphenylisopropylamine
Conference contribution
1 Citation (Scopus)

Acute cardiovascular and hemodynamic effects of vagus nerve stimulation in conscious hypertensive rats

Annoni, E. M. & Talkachova, A., Oct 26 2018, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc., p. 3685-3688 4 p. 8513025. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; vol. 2018-July).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Vagus Nerve Stimulation
Blood pressure
Hemodynamics
Rats
Blood Pressure

A reduced order model for spatiotemporal dynamics and control of cardiac alternans

Zhao, X. & Talkachova, A., Jan 1 2018, Advances in Control Design Methods; Advances in Nonlinear Control; Advances in Robotics; Assistive and Rehabilitation Robotics; Automotive Dynamics and Emerging Powertrain Technologies; Automotive Systems; Bio Engineering Applications; Bio-Mechatronics and Physical Human Robot Interaction; Biomedical and Neural Systems; Biomedical and Neural Systems Modeling, Diagnostics, and Healthcare. American Society of Mechanical Engineers (ASME), (ASME 2018 Dynamic Systems and Control Conference, DSCC 2018; vol. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Bioelectric potentials
Electrocardiography
Feedback control
Fibers
1 Citation (Scopus)

Effects of space modulation of laser beams in a nonlinear DFB-structure

Afanas'ev, A. A., Dritz, V. V., Samson, B. A. & Tolkacheva, E. G., Jan 1 1996, Technical Digest - European Quantum Electronics Conference. 1 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

laser beams
modulation
numerical analysis
counters
envelopes