1995 …2021

Research output per year

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Research Output

2019

Chronic low-level vagus nerve stimulation improves long-term survival in salt-sensitive hypertensive rats

Annoni, E. M., Van Helden, D., Guo, Y., Levac, B., Libbus, I., KenKnight, B. H., Osborn, J. W. & Tolkacheva, E. G., Jan 1 2019, In : Frontiers in Physiology. 10, JAN, 25.

Research output: Contribution to journalArticle

Open Access
2018

Acute cardiovascular and hemodynamic effects of vagus nerve stimulation in conscious hypertensive rats

Annoni, E. M. & Tolkacheva, E. G., Oct 26 2018, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc., p. 3685-3688 4 p. 8513025. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; vol. 2018-July).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

A reduced order model for spatiotemporal dynamics and control of cardiac alternans

Zhao, X. & Tolkacheva, E. G., Jan 1 2018, Advances in Control Design Methods; Advances in Nonlinear Control; Advances in Robotics; Assistive and Rehabilitation Robotics; Automotive Dynamics and Emerging Powertrain Technologies; Automotive Systems; Bio Engineering Applications; Bio-Mechatronics and Physical Human Robot Interaction; Biomedical and Neural Systems; Biomedical and Neural Systems Modeling, Diagnostics, and Healthcare. American Society of Mechanical Engineers (ASME), (ASME 2018 Dynamic Systems and Control Conference, DSCC 2018; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Atrial GIRK channels mediate the effects of vagus nerve stimulation on heart rate dynamics and arrhythmogenesis

Lee, S. W., Anderson, A., Guzman, P. A., Nakano, A., Tolkacheva, E. G. & Wickman, K., Jul 19 2018, In : Frontiers in Physiology. 9, JUL, 943.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
Open Access

Expression and relevance of the G protein-gated K+ channel in the mouse ventricle

Anderson, A., Kulkarni, K., Marron Fernandez De Velasco, E., Carlblom, N., Xia, Z., Nakano, A., Martemyanov, K. A., Tolkacheva, E. G. & Wickman, K., Dec 1 2018, In : Scientific reports. 8, 1, 1192.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Improved multiscale entropy technique with nearest-neighbor moving-average kernel for nonlinear and nonstationary short-time biomedical signal analysis

Arunachalam, S. P., Kapa, S., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Jan 1 2018, In : Journal of healthcare engineering. 2018, 8632436.

Research output: Contribution to journalArticle

1 Scopus citations

Modified Sequence Method to Assess Baroreflex Sensitivity in Rats

Schultz, J., Annoni, E. M. & Tolkacheva, E. G., Oct 26 2018, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc., p. 2764-2767 4 p. 8512734. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; vol. 2018-July).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Novel quantitative analytical approaches for rotor identification and associated implications for mapping

Annoni, E. M., Arunachalam, S. P., Kapa, S., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Feb 2018, In : IEEE Transactions on Biomedical Engineering. 65, 2, p. 273-281 9 p., 8068247.

Research output: Contribution to journalArticle

9 Scopus citations

Real-Time Closed Loop Diastolic Interval Control Prevents Cardiac Alternans in Isolated Whole Rabbit Hearts

Kulkarni, K., Lee, S. W., Kluck, R. & Tolkacheva, E. G., Apr 1 2018, In : Annals of Biomedical Engineering. 46, 4, p. 555-566 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Stochastic vagus nerve stimulation affects acute heart rate dynamics in rats

Lee, S. W., Kulkarni, K., Annoni, E. M., Libbus, I., KenKnight, B. H. & Tolkacheva, E. G., Mar 2018, In : PloS one. 13, 3, e0194910.

Research output: Contribution to journalArticle

1 Scopus citations

The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart

Kulkarni, K., Xie, X., De Velasco, E. M. F., Anderson, A., Martemyanov, K. A., Wickman, K. & Tolkacheva, E. G., Apr 2018, In : PloS one. 13, 4, e0193798.

Research output: Contribution to journalArticle

Open Access

Vagus nerve stimulation for blood pressure and heart rate regulation

O'Clock, G. D., KenKnight, B. H. & Tolkacheva, E. G., Jan 1 2018.

Research output: Contribution to conferencePaper

2017

Computational and Mathematical Methods in Cardiovascular Diseases

Tolkacheva, E. G., Zhao, X., Zlochiver, S. & Mori, Y., Jan 1 2017, In : Computational and mathematical methods in medicine. 2017, 4205735.

Research output: Contribution to journalEditorial

1 Scopus citations

Constant DI pacing suppresses cardiac alternans formation in numerical cable models

Zlochiver, S., Johnson, C. & Tolkacheva, E. G., Sep 1 2017, In : Chaos. 27, 9, 093903.

Research output: Contribution to journalArticle

6 Scopus citations

Multiscale frequency technique robustly discriminates normal sinus rhythm and atrial fibrillation on a single lead electrocardiogram

Arunachalam, S. P., Annoni, E. M., Kapa, S., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Jan 1 2017, 54th Annual Rocky Mountain Bioengineering Symposium, RMBS 2017 and 54th International ISA Biomedical Sciences Instrumentation Symposium 2017. International Society of Automation (ISA), (54th Annual Rocky Mountain Bioengineering Symposium, RMBS 2017 and 54th International ISA Biomedical Sciences Instrumentation Symposium 2017; vol. 2017-March).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Robust discrimination of normal sinus rhythm and atrial fibrillation on ECG using a multiscale frequency technique

Arunachalam, S. P., Annoni, E. M., Kapa, S., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Jan 1 2017, Frontiers in Biomedical Devices, BIOMED - 2017 Design of Medical Devices Conference, DMD 2017. American Society of Mechanical Engineers, (Frontiers in Biomedical Devices, BIOMED - 2017 Design of Medical Devices Conference, DMD 2017).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Rotor pivot point identification using recurrence period density entropy

Arunachalam, S. P., Kapa, S., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Jan 1 2017, 54th Annual Rocky Mountain Bioengineering Symposium, RMBS 2017 and 54th International ISA Biomedical Sciences Instrumentation Symposium 2017. International Society of Automation (ISA), (54th Annual Rocky Mountain Bioengineering Symposium, RMBS 2017 and 54th International ISA Biomedical Sciences Instrumentation Symposium 2017; vol. 2017-March).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations
2016

Chronic cyclic vagus nerve stimulation has beneficial electrophysiological effects on healthy hearts in the absence of autonomic imbalance

Lee, S. W., Li, Q., Libbus, I., Xie, X., Kenknight, B. H., Garry, M. G. & Talkachova, A., May 1 2016, In : Physiological Reports. 4, 9, p. 1-8 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Intelligent fractional-order PID (FOPID) heart rate controller for cardiac pacemaker

Arunachalam, S. P., Kapa, S., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Dec 27 2016, 2016 IEEE Healthcare Innovation Point-of-Care Technologies Conference, HI-POCT 2016. Institute of Electrical and Electronics Engineers Inc., p. 105-108 4 p. 7797708. (2016 IEEE Healthcare Innovation Point-of-Care Technologies Conference, HI-POCT 2016).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Kurtosis as a statistical approach to identify the pivot point of the rotor

Arunachalam, S. P., Annoni, E. M., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Oct 13 2016, 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc., p. 497-500 4 p. 7590748. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; vol. 2016-October).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Novel multiscale frequency approach to identify the pivot point of the rotor

Arunachalam, S. P., Annoni, E. M., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Jun 1 2016, In : Journal of Medical Devices, Transactions of the ASME. 10, 2, 020948.

Research output: Contribution to journalArticle

7 Scopus citations

Pro-arrhythmic effect of heart rate variability during periodic pacing

Kulkarni, K., Lee, S. W. & Tolkacheva, E. G., Oct 13 2016, 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc., p. 149-152 4 p. 7590662. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; vol. 2016-October).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Rotor pivot point identification with intrinsic mode function complexity index using empirical mode decomposition

Arunachalam, S. P., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Jul 8 2016, 2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 7508597. (2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

The dual effect of ephaptic coupling on cardiac conduction with heterogeneous expression of connexin 43

Wei, N., Mori, Y. & Tolkacheva, E. G., May 21 2016, In : Journal of Theoretical Biology. 397, p. 103-114 12 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2015

Characterizing Spatial Dynamics of Bifurcation to Alternans in Isolated Whole Rabbit Hearts Based on Alternate Pacing

Kulkarni, K., Visweswaran, R., Zhao, X. & Tolkacheva, E. G., Jan 1 2015, In : BioMed Research International. 2015, 170768.

Research output: Contribution to journalArticle

4 Scopus citations

Feasibility of visualizing higher regions of Shannon entropy in atrial fibrillation patients

Arunachalam, S. P., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Nov 4 2015, 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Institute of Electrical and Electronics Engineers Inc., p. 4499-4502 4 p. 7319394. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; vol. 2015-November).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Scopus citations

Free fatty acid effects on the atrial myocardium: Membrane ionic currents are remodeled by the disruption of T-tubular architecture

O'Connell, R. P., Musa, H., Gomez, M. S. M., Avula, U. M., Herron, T. J., Kalifa, J., Anumonwo, J. M. B. & Talkachova, A., Aug 14 2015, In : PloS one. 10, 8, e0133052.

Research output: Contribution to journalArticle

14 Scopus citations
16 Scopus citations

Real-time feedback based control of cardiac restitution using optical mapping

Kulkarni, K. & Tolkacheva, E. G., Nov 4 2015, 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Institute of Electrical and Electronics Engineers Inc., p. 5920-5923 4 p. 7319739. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; vol. 2015-November).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

The role of short term memory and conduction velocity restitution in alternans formation

Wei, N., Mori, Y. & Tolkacheva, E. G., Feb 1 2015, In : Journal of Theoretical Biology. 367, p. 21-28 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Heart rate variability and alternans formation in the heart: The role of feedback in cardiac dynamics

McIntyre, S. D., Kakade, V., Mori, Y. & Tolkacheva, E. G., Jun 7 2014, In : Journal of Theoretical Biology. 350, p. 90-97 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Intermittent vagal nerve stimulation alters the electrophysiological properties of atrium in the myocardial infarction rat model

Xie, X., Lee, S. W., Johnson, C., Ippolito, J., Kenknight, B. H. & Tolkacheva, E. G., Nov 2 2014, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., Vol. 2014. p. 1575-1578 4 p. 6943904. (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Miniaturized radio frequency telemetric pacemaker with anti-arrhythmic pacing protocol

Kulkarni, K., Tan, S. Y. & Tolkacheva, E. G., Jan 1 2014, In : Journal of Medical Devices, Transactions of the ASME. 8, 2, 020909.

Research output: Contribution to journalArticle

2013
1 Scopus citations

Spatiotemporal evolution and prediction of [Ca2+]i and APD alternans in isolated rabbit hearts

Visweswaran, R., McIntyre, S. D., Ramkrishnan, K., Zhao, X. & Tolkacheva, E. G., Nov 1 2013, In : Journal of cardiovascular electrophysiology. 24, 11, p. 1287-1295 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Uncoupling the mitochondria facilitates alternans formation in the isolated rabbit heart

Smith, R. M., Visweswaran, R., Talkachova, I., Wothe, J. K. & Tolkacheva, E. G., Jul 1 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 1, p. H9-H18

Research output: Contribution to journalArticle

12 Scopus citations
1 Scopus citations
2012
14 Scopus citations

Nonlinear dynamics of periodically paced cardiac tissue

Tolkacheva, E. G. & Zhao, X., May 1 2012, In : Nonlinear Dynamics. 68, 3, p. 347-363 17 p.

Research output: Contribution to journalReview article

10 Scopus citations

The effect of feedback on alternans formation in the heart

McIntyre, S. D., Mori, Y. & Tolkacheva, E. G., Dec 1 2012, ASME 2012 5th Annual Dynamic Systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012. p. 585-589 5 p. (ASME 2012 5th Annual Dynamic Systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart

Smith, R. M., Black, A. J., Velamakanni, S. S., Akkin, T. & Tolkacheva, E. G., May 10 2012, In : Applied Optics. 51, 14, p. 2713-2721 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
2011

Local onset of voltage and calcium alternans in the heart

McIntyre, S. D., Mori, Y. & Tolkacheva, E. G., Dec 1 2011, ASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control, DSCC 2011. p. 607-610 4 p. (ASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control, DSCC 2011; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Scopus citations

Toward prediction of the local onset of alternans in the heart

Cram, A. R., Rao, H. M. & Tolkacheva, E. G., Feb 16 2011, In : Biophysical journal. 100, 4, p. 868-874 7 p.

Research output: Contribution to journalArticle

12 Scopus citations
2010

Mechanisms underlying the antifibrillatory action of hyperkalemia in guinea pig hearts

Pandit, S. V., Warren, M., Mironov, S., Tolkacheva, E. G., Kalifa, J., Berenfeld, O. & Jalife, J., May 19 2010, In : Biophysical journal. 98, 10, p. 2091-2101 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
2009

Optical mapping of electrical heterogeneities in the heart during global ischemia

Matiukas, A., Pertsov, A. M., Kothari, P., Cram, A. & Tolkacheva, E. G., 2009, Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, p. 6321-6324 4 p. 5333176. (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Scopus citations
2008

Role of conduction velocity restitution and short-term memory in the development of action potential duration alternans in isolated rabbit hearts

Mironov, S., Jalife, J. & Tolkacheva, E. G., Jul 1 2008, In : Circulation. 118, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

93 Scopus citations
2007

An ionically based mapping model with memory for cardiac restitution

Schaeffer, D. G., Cain, J. W., Gauthier, D. J., Kalb, S. S., Oliver, R. A., Tolkacheva, E. G., Ying, W. & Krassowska, W., Feb 1 2007, In : Bulletin of mathematical biology. 69, 2, p. 459-482 24 p.

Research output: Contribution to journalArticle

21 Scopus citations