1995 …2021
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Research Output 1995 2019

2019

Chronic low-level vagus nerve stimulation improves long-term survival in salt-sensitive hypertensive rats

Annoni, E. M., Van Helden, D., Guo, Y., Levac, B., Libbus, I., KenKnight, B. H., Osborn Jr, J. W. & Talkachova, A., Jan 1 2019, In : Frontiers in Physiology. 10, JAN, 25.

Research output: Contribution to journalArticle

Open Access
Vagus Nerve Stimulation
Salts
Hypertension
Therapeutics
Heart Rate
2018
1 Citation (Scopus)

Acute cardiovascular and hemodynamic effects of vagus nerve stimulation in conscious hypertensive rats

Annoni, E. M. & Talkachova, A., Oct 26 2018, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc., p. 3685-3688 4 p. 8513025. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; vol. 2018-July).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Vagus Nerve Stimulation
Blood pressure
Hemodynamics
Rats
Blood Pressure

A reduced order model for spatiotemporal dynamics and control of cardiac alternans

Zhao, X. & Talkachova, A., Jan 1 2018, Advances in Control Design Methods; Advances in Nonlinear Control; Advances in Robotics; Assistive and Rehabilitation Robotics; Automotive Dynamics and Emerging Powertrain Technologies; Automotive Systems; Bio Engineering Applications; Bio-Mechatronics and Physical Human Robot Interaction; Biomedical and Neural Systems; Biomedical and Neural Systems Modeling, Diagnostics, and Healthcare. American Society of Mechanical Engineers (ASME), (ASME 2018 Dynamic Systems and Control Conference, DSCC 2018; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bioelectric potentials
Electrocardiography
Feedback control
Fibers
2 Citations (Scopus)

Atrial GIRK channels mediate the effects of vagus nerve stimulation on heart rate dynamics and arrhythmogenesis

Lee, S. W., Anderson, A., Guzman, P. A., Nakano, A., Talkachova, A. & Wickman, K. D., Jul 19 2018, In : Frontiers in Physiology. 9, JUL, 943.

Research output: Contribution to journalArticle

Open Access
Vagus Nerve Stimulation
Heart Rate
Cardiovascular Diseases
Muscarinic Receptors
GTP-Binding Proteins
Open Access
Names
heart
mice
4-iodo-2,5-dimethoxyphenylisopropylamine
Ablation
Atrial Fibrillation
Cardiac Electrophysiologic Techniques
Pulmonary Veins
Rotors
5 Citations (Scopus)

Expression and relevance of the G protein-gated K + channel in the mouse ventricle

Anderson, A., Kulkarni, K., Marron Fernandez de Velasco, E., Carlblom, N., Xia, Z., Nakano, A., Martemyanov, K. A., Talkachova, A. & Wickman, K. D., Dec 1 2018, In : Scientific reports. 8, 1, 1192.

Research output: Contribution to journalArticle

Open Access
Inwardly Rectifying Potassium Channel
GTP-Binding Proteins
Carbachol
Muscle Cells
Heart Rate
1 Citation (Scopus)

Improved multiscale entropy technique with nearest-neighbor moving-average kernel for nonlinear and nonstationary short-time biomedical signal analysis

Arunachalam, S. P., Kapa, S., Mulpuru, S. K., Friedman, P. A. & Talkachova, A., Jan 1 2018, In : Journal of healthcare engineering. 2018, 8632436.

Research output: Contribution to journalArticle

Signal analysis
Entropy
Electrocardiography
Rotors
Atrial Fibrillation

Modified Sequence Method to Assess Baroreflex Sensitivity in Rats

Schultz, J., Annoni, E. M. & Talkachova, A., Oct 26 2018, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc., p. 2764-2767 4 p. 8512734. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; vol. 2018-July).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Baroreflex
Rats
Blood pressure
Pressoreceptors
Physiology
8 Citations (Scopus)

Novel quantitative analytical approaches for rotor identification and associated implications for mapping

Annoni, E. M., Arunachalam, S. P., Kapa, S., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Feb 1 2018, In : IEEE Transactions on Biomedical Engineering. 65, 2, p. 273-281 9 p., 8068247.

Research output: Contribution to journalArticle

Rotors
Entropy
Ablation
Signal analysis
2 Citations (Scopus)

Real-Time Closed Loop Diastolic Interval Control Prevents Cardiac Alternans in Isolated Whole Rabbit Hearts

Kulkarni, K., Lee, S. W., Kluck, R. & Talkachova, A., Apr 1 2018, In : Annals of Biomedical Engineering. 46, 4, p. 555-566 12 p.

Research output: Contribution to journalArticle

Feedback
Electrocardiography
Closed loop systems
Modulation
Tissue

Stochastic vagus nerve stimulation affects acute heart rate dynamics in rats

Lee, S. W., Kulkarni, K., Annoni, E. M., Libbus, I., KenKnight, B. H. & Talkachova, A., Mar 1 2018, In : PloS one. 13, 3, e0194910.

Research output: Contribution to journalArticle

vagus nerve
Vagus Nerve Stimulation
Rats
heart rate
Heart Rate

The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart

Kulkarni, K., Xie, X., Marron Fernandez de Velasco, E., Anderson, A., Martemyanov, K. A., Wickman, K. D. & Talkachova, A., Apr 1 2018, In : PloS one. 13, 4, e0193798.

Research output: Contribution to journalArticle

Open Access
carbachol
Carbachol
heart
mice
action potentials

Vagus nerve stimulation for blood pressure and heart rate regulation

O'Clock, G. D., KenKnight, B. H. & Talkachova, A., Jan 1 2018.

Research output: Contribution to conferencePaper

Blood pressure
2017
1 Citation (Scopus)

Computational and Mathematical Methods in Cardiovascular Diseases

Talkachova, A., Zhao, X., Zlochiver, S. & Mori, Y., Jan 1 2017, In : Computational and Mathematical Methods in Medicine. 2017, 4205735.

Research output: Contribution to journalEditorial

Mathematics
Computational Biology
Cardiovascular Diseases
Human
5 Citations (Scopus)

Constant DI pacing suppresses cardiac alternans formation in numerical cable models

Zlochiver, S., Johnson, C. & Talkachova, A., Sep 1 2017, In : Chaos. 27, 9, 093903.

Research output: Contribution to journalArticle

Cable
Cardiac
cables
Cables
intervals
1 Citation (Scopus)

Multiscale frequency technique robustly discriminates normal sinus rhythm and atrial fibrillation on a single lead electrocardiogram

Arunachalam, S. P., Annoni, E. M., Kapa, S., Mulpuru, S. K., Friedman, P. A. & Talkachova, A., Jan 1 2017, 54th Annual Rocky Mountain Bioengineering Symposium, RMBS 2017 and 54th International ISA Biomedical Sciences Instrumentation Symposium 2017. International Society of Automation (ISA), Vol. 2017-March.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

fibrillation
electrocardiography
sinuses
rhythm
Electrocardiography
2 Citations (Scopus)

Robust discrimination of normal sinus rhythm and atrial fibrillation on ECG using a multiscale frequency technique

Arunachalam, S. P., Annoni, E. M., Kapa, S., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Jan 1 2017, Frontiers in Biomedical Devices, BIOMED - 2017 Design of Medical Devices Conference, DMD 2017. American Society of Mechanical Engineers, (Frontiers in Biomedical Devices, BIOMED - 2017 Design of Medical Devices Conference, DMD 2017).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Electrocardiography
2 Citations (Scopus)

Rotor pivot point identification using recurrence period density entropy

Arunachalam, S. P., Kapa, S., Mulpuru, S. K., Friedman, P. A. & Talkachova, A., Jan 1 2017, 54th Annual Rocky Mountain Bioengineering Symposium, RMBS 2017 and 54th International ISA Biomedical Sciences Instrumentation Symposium 2017. International Society of Automation (ISA), Vol. 2017-March.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

pivots
Entropy
fibrillation
rotors
Atrial Fibrillation
2016
9 Citations (Scopus)

Chronic cyclic vagus nerve stimulation has beneficial electrophysiological effects on healthy hearts in the absence of autonomic imbalance

Lee, S. W., Li, Q., Libbus, I., Xie, X., Kenknight, B. H., Garry, M. G. & Talkachova, A., May 1 2016, In : Physiological Reports. 4, 9, p. 1-8 8 p.

Research output: Contribution to journalArticle

Vagus Nerve Stimulation
pamidronate
Action Potentials
Vagus Nerve
Autonomic Nervous System
2 Citations (Scopus)

Intelligent fractional-order PID (FOPID) heart rate controller for cardiac pacemaker

Arunachalam, S. P., Kapa, S., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Dec 27 2016, 2016 IEEE Healthcare Innovation Point-of-Care Technologies Conference, HI-POCT 2016. Institute of Electrical and Electronics Engineers Inc., p. 105-108 4 p. 7797708

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fuzzy Logic
Heart Rate
Intelligence
1 Citation (Scopus)

Kurtosis as a statistical approach to identify the pivot point of the rotor

Arunachalam, S. P., Annoni, E. M., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Oct 13 2016, 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc., Vol. 2016-October. p. 497-500 4 p. 7590748

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Atrial Fibrillation
Rotors
Catheters
Ablation
Cardiac Electrophysiologic Techniques
6 Citations (Scopus)

Novel multiscale frequency approach to identify the pivot point of the rotor

Arunachalam, S. P., Annoni, E. M., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Jun 1 2016, In : Journal of Medical Devices, Transactions of the ASME. 10, 2, 020948.

Research output: Contribution to journalArticle

Rotors
2 Citations (Scopus)

Pro-arrhythmic effect of heart rate variability during periodic pacing

Kulkarni, K., Lee, S. W. & Talkachova, A., Oct 13 2016, 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc., Vol. 2016-October. p. 149-152 4 p. 7590662

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Heart Rate
Cardiac Arrhythmias
Heart Diseases
Anti-Arrhythmia Agents
Computer simulation
1 Citation (Scopus)

Rotor pivot point identification with intrinsic mode function complexity index using empirical mode decomposition

Arunachalam, S. P., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Jul 8 2016, 2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 7508597

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Atrial Fibrillation
Rotors
Decomposition
Ablation
stroke
4 Citations (Scopus)

The dual effect of ephaptic coupling on cardiac conduction with heterogeneous expression of connexin 43

Wei, N., Mori, Y. & Talkachova, A., May 21 2016, In : Journal of Theoretical Biology. 397, p. 103-114 12 p.

Research output: Contribution to journalArticle

connexins
Connexin 43
Conduction
Cardiac
Gap Junction
2015
4 Citations (Scopus)

Characterizing Spatial Dynamics of Bifurcation to Alternans in Isolated Whole Rabbit Hearts Based on Alternate Pacing

Kulkarni, K., Visweswaran, R., Zhao, X. & Talkachova, A., Jan 1 2015, In : BioMed Research International. 2015, 170768.

Research output: Contribution to journalArticle

Rabbits
Heart Ventricles
Sudden Cardiac Death
Ventricular Fibrillation
Action Potentials
12 Citations (Scopus)

Feasibility of visualizing higher regions of Shannon entropy in atrial fibrillation patients

Arunachalam, S. P., Mulpuru, S. K., Friedman, P. A. & Tolkacheva, E. G., Nov 4 2015, 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Institute of Electrical and Electronics Engineers Inc., Vol. 2015-November. p. 4499-4502 4 p. 7319394

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Pulmonary Veins
Entropy
Atrial Fibrillation
Rotors
Catheter Ablation
14 Citations (Scopus)

Free fatty acid effects on the atrial myocardium: Membrane ionic currents are remodeled by the disruption of T-tubular architecture

O'Connell, R. P., Musa, H., Gomez, M. S. M., Avula, U. M., Herron, T. J., Kalifa, J., Anumonwo, J. M. B. & Talkachova, A., Aug 14 2015, In : PloS one. 10, 8, e0133052.

Research output: Contribution to journalArticle

myocardium
Nonesterified Fatty Acids
free fatty acids
Myocardium
myocytes
16 Citations (Scopus)
Vagus Nerve
Electrophysiology
Electric Stimulation
Vagus Nerve Stimulation
Cardiac Arrhythmias
3 Citations (Scopus)

Real-time feedback based control of cardiac restitution using optical mapping

Kulkarni, K. & Talkachova, A., Nov 4 2015, 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Institute of Electrical and Electronics Engineers Inc., Vol. 2015-November. p. 5920-5923 4 p. 7319739

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Action Potentials
Feedback
pamidronate
Anti-Arrhythmia Agents
Microelectrodes
7 Citations (Scopus)

The role of short term memory and conduction velocity restitution in alternans formation

Wei, N., Mori, Y. & Tolkacheva, E. G., Feb 1 2015, In : Journal of Theoretical Biology. 367, p. 21-28 8 p.

Research output: Contribution to journalArticle

Memory Term
Action Potential
action potentials
Short-Term Memory
Conduction
2014
16 Citations (Scopus)

Heart rate variability and alternans formation in the heart: The role of feedback in cardiac dynamics

McIntyre, S. D., Kakade, V., Mori, Y. & Talkachova, A., Jun 7 2014, In : Journal of Theoretical Biology. 350, p. 90-97 8 p.

Research output: Contribution to journalArticle

Heart Rate Variability
Cardiac
Action Potential
heart rate
action potentials
6 Citations (Scopus)

Intermittent vagal nerve stimulation alters the electrophysiological properties of atrium in the myocardial infarction rat model

Xie, X., Lee, S. W., Johnson, C., Ippolito, J., Kenknight, B. H. & Tolkacheva, E. G., Nov 2 2014, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., Vol. 2014. p. 1575-1578 4 p. 6943904. (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

pamidronate
Vagus Nerve Stimulation
Rats
Myocardial Infarction
Electrocardiography

Miniaturized radio frequency telemetric pacemaker with anti-arrhythmic pacing protocol

Kulkarni, K., Tan, S. Y. & Talkachova, A., Jan 1 2014, In : Journal of Medical Devices, Transactions of the ASME. 8, 2, 020909.

Research output: Contribution to journalArticle

Pacemakers
Anti-Arrhythmia Agents
Radio
2013
1 Citation (Scopus)
Vagus Nerve Stimulation
Rats
Heart Failure
Heart Rate
11 Citations (Scopus)

Spatiotemporal evolution and prediction of [Ca2+]i and APD alternans in isolated rabbit hearts

Visweswaran, R., McIntyre, S. D., Ramkrishnan, K., Zhao, X. & Talkachova, A., Nov 1 2013, In : Journal of cardiovascular electrophysiology. 24, 11, p. 1287-1295 9 p.

Research output: Contribution to journalArticle

Action Potentials
Rabbits
Calcium
Ventricular Fibrillation
12 Citations (Scopus)

Uncoupling the mitochondria facilitates alternans formation in the isolated rabbit heart

Smith, R. M., Visweswaran, R., Talkachova, I., Wothe, J. K. & Talkachova, A., Jul 1 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 1

Research output: Contribution to journalArticle

Action Potentials
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone
Mitochondria
Rabbits
Ischemia
1 Citation (Scopus)

Using dominant eigenvalue analysis to predict formation of alternans in the heart

Kakade, V., Zhao, X. & Talkachova, A., Nov 22 2013, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 88, 5, 052716.

Research output: Contribution to journalArticle

Eigenvalue Analysis
eigenvalues
Predict
Action Potential
Cycle Length
2012
14 Citations (Scopus)
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone
Ventricular Fibrillation
Mitochondria
Ischemia
Heart Ventricles
9 Citations (Scopus)

Nonlinear dynamics of periodically paced cardiac tissue

Talkachova, A. & Zhao, X., May 1 2012, In : Nonlinear Dynamics. 68, 3, p. 347-363 17 p.

Research output: Contribution to journalReview article

Cardiac
Nonlinear Dynamics
Tissue
Calcium
Bifurcation
1 Citation (Scopus)

The effect of feedback on alternans formation in the heart

McIntyre, S. D., Mori, Y. & Talkachova, A., Dec 1 2012, ASME 2012 5th Annual Dynamic Systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012. p. 585-589 5 p. (ASME 2012 5th Annual Dynamic Systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Feedback
4 Citations (Scopus)

Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart

Smith, R. M., Black, A. J., Velamakanni, S. S., Akkin, T. & Talkachova, A., May 10 2012, In : Applied Optics. 51, 14, p. 2713-2721 9 p.

Research output: Contribution to journalArticle

rabbits
borders
arrhythmia
Tissue
Geometry
2011

Local onset of voltage and calcium alternans in the heart

McIntyre, S. D., Mori, Y. & Talkachova, A., Dec 1 2011, ASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control, DSCC 2011. p. 607-610 4 p. (ASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control, DSCC 2011; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Calcium
Depolarization
Electric potential
Tissue
13 Citations (Scopus)
Ganglionectomy
Sympathectomy
Ventricular Fibrillation
Action Potentials
Atenolol
12 Citations (Scopus)

Toward prediction of the local onset of alternans in the heart

Cram, A. R., Rao, H. M. & Talkachova, A., Feb 16 2011, In : Biophysical journal. 100, 4, p. 868-874 7 p.

Research output: Contribution to journalArticle

Action Potentials
Ventricular Fibrillation
Muscle Cells
Rabbits
Isolated Heart Preparation
2010
21 Citations (Scopus)

Mechanisms underlying the antifibrillatory action of hyperkalemia in guinea pig hearts

Pandit, S. V., Warren, M., Mironov, S., Talkachova, A., Kalifa, J., Berenfeld, O. & Jalife, J., May 19 2010, In : Biophysical Journal. 98, 10, p. 2091-2101 11 p.

Research output: Contribution to journalArticle

Hyperkalemia
Ventricular Fibrillation
Guinea Pigs
Heart Ventricles
Constriction
2009
13 Citations (Scopus)

Optical mapping of electrical heterogeneities in the heart during global ischemia

Matiukas, A., Pertsov, A. M., Kothari, P., Cram, A. & Tolkacheva, E. G., 2009, Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, p. 6321-6324 4 p. 5333176. (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ischemia
Reperfusion
Heart Ventricles
Ventricular Fibrillation
Action Potentials
2008
90 Citations (Scopus)

Role of conduction velocity restitution and short-term memory in the development of action potential duration alternans in isolated rabbit hearts

Mironov, S., Jalife, J. & Tolkacheva, E. G., Jul 1 2008, In : Circulation. 118, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

Short-Term Memory
Action Potentials
Rabbits
Epicardial Mapping
Cardiac Arrhythmias
2007
21 Citations (Scopus)

An ionically based mapping model with memory for cardiac restitution

Schaeffer, D. G., Cain, J. W., Gauthier, D. J., Kalb, S. S., Oliver, R. A., Tolkacheva, E. G., Ying, W. & Krassowska, W., Feb 1 2007, In : Bulletin of mathematical biology. 69, 2, p. 459-482 24 p.

Research output: Contribution to journalArticle

Cardiac
Data storage equipment
Action Potentials
Rana catesbeiana
Action Potential