Aaron L Sarver

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Research Output 2001 2019

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2019

Comparative genomics reveals shared mutational landscape in canine hemangiosarcoma and human angiosarcoma

Megquier, K., Turner-Maier, J., Swofford, R., Kim, J. H., Sarver, A. L., Wang, C., Sakthikumar, S., Johnson, J., Koltookian, M., Lewellen, M., Scott, M. C., Schulte, A. J., Borst, L., Tonomura, N., Alfoldi, J., Painter, C., Thomas, R., Karlsson, E. K., Breen, M., Modiano, J. F. & 2 others, Elvers, I. & Lindblad-Toh, K., Jan 1 2019, In : Molecular Cancer Research. 17, 12, p. 2410-2421 12 p.

Research output: Contribution to journalArticle

Open Access
Hemangiosarcoma
Genomics
Canidae
Dogs
Exome

Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice

Loeb, K. R., Hughes, B. T., Fissel, B. M., Osteen, N. J., Knoblaugh, S. E., Grim, J. E., Drury, L. J., Sarver, A., Dupuy, A. J. & Clurman, B. E., Dec 1 2019, In : Scientific reports. 9, 1, 5488.

Research output: Contribution to journalArticle

Open Access
Beauty
Cyclin E
Leukemia, Erythroblastic, Acute
Insertional Mutagenesis
Oncogenes
1 Citation (Scopus)

Sleeping beauty insertional mutagenesis reveals important genetic drivers of central nervous system embryonal tumors

Beckmann, P. J., Larson, J. D., Larsson, A. T., Ostergaard, J. P., Wagner, S., Rahrmann, E. P., Shamsan, G. A., Otto, G. M., Williams, R. L., Wang, J., Lee, C., Tschida, B. R., Das, P., Dubuc, A. M., Moriarity, B. S., Picard, D., Wu, X., Rodriguez, F. J., Rosemarie, Q., Krebs, R. D. & 13 others, Molan, A. M., Demer, A. M., Frees, M. M., Rizzardi, A. E., Schmechel, S. C., Eberhart, C. G., Jenkins, R. B., Wechsler-Reya, R. J., Odde, D. J., Huang, A., Taylor, M. D., Sarver, A. L. & Largaespada, D. A., Mar 1 2019, In : Cancer Research. 79, 5, p. 905-917 13 p.

Research output: Contribution to journalArticle

Beauty
Central Nervous System Neoplasms
Medulloblastoma
Insertional Mutagenesis
Primitive Neuroectodermal Tumors
2 Citations (Scopus)
Open Access
Pets
Glioma
Vaccination
Dogs
Antigen-Presenting Cells
2018
16 Citations (Scopus)
Open Access
Gene Expression Profiling
Osteosarcoma
Survival
Multigene Family
Neoplasms
1 Citation (Scopus)
fatty acid metabolism
Fatty Acids
Dogs
neoplasms
dogs
2 Citations (Scopus)

OMCD: OncomiR Cancer Database

Sarver, A. L., Sarver, A. E., Yuan, C. & Subramanian, S., Dec 6 2018, In : BMC Cancer. 18, 1, 5085.

Research output: Contribution to journalArticle

Open Access
Databases
MicroRNAs
Neoplasms
Atlases
Genome
2017
2 Citations (Scopus)

Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235

Xie, C., Freeman, M. J., Lu, H., Wang, X., Forster, C. L., Sarver, A. L. & Hallstrom, T. C., Jan 1 2017, In : Oncotarget. 8, 24, p. 38084-38098 15 p.

Research output: Contribution to journalArticle

Open Access
Phosphatidylinositol 3-Kinase
Retinoblastoma
Apoptosis
Topotecan
Carboplatin
11 Citations (Scopus)

Safe and effective sarcoma therapy through bispecific targeting of EGFR and uPAR

Borgatti, A., Koopmeiners, J. S., Sarver, A. L., Winter, A. L., Stuebner, K., Todhunter, D., Rizzardi, A. E., Henriksen, J. C., Schmechel, S., Forster, C. L., Kim, J. H., Froelich, J., Walz, J., Henson, M. S., Breen, M., Lindblad-Toh, K., Oh, F., Pilbeam, K., Modiano, J. F. & Vallera, D. A., May 1 2017, In : Molecular Cancer Therapeutics. 16, 5, p. 956-965 10 p.

Research output: Contribution to journalArticle

Open Access
Sarcoma
Dogs
Hemangiosarcoma
Therapeutics
Canidae
8 Citations (Scopus)

Sleeping beauty insertional mutagenesis in mice identifies drivers of steatosis-associated hepatic tumors

Tschida, B. R., Temiz, N. A., Kuka, T. P., Lee, L. A., Riordan, J. D., Tierrablanca, C. A., Hullsiek, R., Wagner, S., Hudson, W. A., Linden, M. A., Amin, K., Beckmann, P. J., Heuer, R. A., Sarver, A. L., Yang, J. D., Roberts, L. R., Nadeau, J. H., Dupuy, A. J., Keng, V. W. & Largaespada, D. A., Dec 1 2017, In : Cancer Research. 77, 23, p. 6576-6588 13 p.

Research output: Contribution to journalArticle

Beauty
Insertional Mutagenesis
Hepatocellular Carcinoma
Liver
Neoplasms
2016
15 Citations (Scopus)

Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer

Trott, J. F., Kim, J., Aboud, O. A., Wettersten, H., Stewart, B., Berryhill, G., Uzal, F., Hovey, R. C., Chen, C. H., Anderson, K., Graef, A., Sarver, A. L., Modiano, J. & Weiss, R. H., Jan 1 2016, In : Oncotarget. 7, 41, p. 66540-66557 18 p.

Research output: Contribution to journalArticle

Kidney Neoplasms
Renal Cell Carcinoma
Tryptophan
Interferons
Indoleamine-Pyrrole 2,3,-Dioxygenase
7 Citations (Scopus)

Insulin receptor substrate adaptor proteins mediate prognostic gene expression profiles in breast cancer

Becker, M. A., Ibrahim, Y. H., Oh, A. S., Fagan, D. H., Byron, S. A., Sarver, A. L., Lee, A. V., Shaw, L. M., Fan, C., Perou, C. M. & Yee, D., Mar 2016, In : PloS one. 11, 3, e0150564.

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Insulin Receptor
Transcriptome
Gene expression
breast neoplasms
19 Citations (Scopus)

MYC and PVT1 synergize to regulate RSPO1 levels in breast cancer

Sarver, A. L., Murray, C. D., Temiz, N. A., Tseng, Y. Y. & Bagchi, A., Apr 2 2016, In : Cell Cycle. 15, 7, p. 881-885 5 p.

Research output: Contribution to journalArticle

Plasmacytoma
Breast Neoplasms
Neoplasms
Oncogenes
Breast
15 Citations (Scopus)

RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens

Temiz, N. A., Moriarity, B. S., Wolf, N. K., Riordan, J. D., Dupuy, A. J., Largaespada, D. A. & Sarver, A. L., Jan 2016, In : Genome research. 26, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Beauty
Ligation
RNA
Polymerase Chain Reaction
9 Citations (Scopus)

Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia

Heltemes-Harris, L. M., Larson, J. D., Starr, T. K., Hubbard, G. K., Sarver, A. L., Largaespada, D. A. & Farrar, M. A., Jun 30 2016, In : Oncogene. 35, 26, p. 3454-3464 11 p.

Research output: Contribution to journalArticle

STAT5 Transcription Factor
Beauty
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Transcriptional Activation
B-Lymphocytes
2015
15 Citations (Scopus)

Aberrant retinoblastoma (RB)-E2F transcriptional regulation defines molecular phenotypes of osteosarcoma

Scott, M. C., Sarver, A. L., Tomiyasu, H., Cornax, I., Van Etten, J., Varshney, J., O'Sullivan, M. G., Subramanian, S. & Modiano, J. F., Nov 20 2015, In : Journal of Biological Chemistry. 290, 47, p. 28070-28083 14 p.

Research output: Contribution to journalArticle

Retinoblastoma
Osteosarcoma
Gene expression
Tumors
Deregulation
39 Citations (Scopus)

A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer

Rad, R., Rad, L., Wang, W., Strong, A., Ponstingl, H., Bronner, I. F., Mayho, M., Steiger, K., Weber, J., Hieber, M., Veltkamp, C., Eser, S., Geumann, U., Öllinger, R., Zukowska, M., Barenboim, M., Maresch, R., Cadiñanos, J., Friedrich, M., Varela, I. & 25 others, Constantino-Casas, F., Sarver, A., Ten Hoeve, J., Prosser, H., Seidler, B., Bauer, J., Heikenwälder, M., Metzakopian, E., Krug, A., Ehmer, U., Schneider, G., Knösel, T., Rümmele, P., Aust, D., Grützmann, R., Pilarsky, C., Ning, Z., Wessels, L., Schmid, R. M., Quail, M. A., Vassiliou, G., Esposito, I., Liu, P., Saur, D. & Bradley, A., Jan 2015, In : Nature Genetics. 47, 1, p. 47-56 10 p.

Research output: Contribution to journalArticle

Genetic Testing
Pancreatic Neoplasms
Neoplasm Genes
Neoplasms
Genome
111 Citations (Scopus)

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

Moriarity, B. S., Otto, G. M., Rahrmann, E. P., Rathe, S. K., Wolf, N. K., Weg, M. T., Manlove, L. A., Larue, R. S., Temiz, N. A., Molyneux, S. D., Choi, K., Holly, K. J., Sarver, A. L., Scott, M. C., Forster, C. L., Modiano, J. F., Khanna, C., Hewitt, S. M., Khokha, R., Yang, Y. & 3 others, Gorlick, R., Dyer, M. A. & Largaespada, D. A., May 27 2015, In : Nature Genetics. 47, 6, p. 615-624 10 p.

Research output: Contribution to journalArticle

Beauty
Osteosarcoma
Neoplasm Metastasis
Genes
Oncogenes
29 Citations (Scopus)

Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers

Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., Sarver, A. L., Swofford, R., Frantz, A. M., Ito, D., Mauceli, E., Arendt, M., Noh, H. J., Koltookian, M., Biagi, T., Fryc, S., Williams, C., Avery, A. C., Kim, J. H., Barber, L. & 7 others, Burgess, K., Lander, E. S., Karlsson, E. K., Azuma, C., Modiano, J. F., Breen, M. & Lindblad-Toh, K., Jan 1 2015, In : PLoS genetics. 11, 2, p. 1-24 24 p., e1004922.

Research output: Contribution to journalArticle

Golden Retriever
Genome-Wide Association Study
B-Cell Lymphoma
B-lymphocytes
Hemangiosarcoma
5 Citations (Scopus)

Identification, by systematic RNA sequencing, of novel candidate biomarkers and therapeutic targets in human soft tissue tumors

Sarver, A. E., Sarver, A. L., Thayanithy, V. & Subramanian, S., Sep 28 2015, In : Laboratory Investigation. 95, 9, p. 1077-1088 12 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Sarcoma
Biomarkers
Neoplasms
MicroRNAs
23 Citations (Scopus)

Transposon mutagenesis screen identifies potential lung cancer drivers and CUL3 as a tumor suppressor

Dorr, C., Janik, C., Weg, M., Been, R. A., Bader, J., Kang, R., Ng, B., Foran, L., Landman, S. R., O'Sullivan, M. G., Steinbach, M., Sarver, A. L., Silverstein, K. A. T., Largaespada, D. A. & Starr, T. K., Aug 1 2015, In : Molecular Cancer Research. 13, 8, p. 1238-1247 10 p.

Research output: Contribution to journalArticle

Mutagenesis
Lung Neoplasms
Beauty
Non-Small Cell Lung Carcinoma
Neoplasms
2014
10 Citations (Scopus)

Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice

Been, R. A., Linden, M. A., Hager, C. J., DeCoursin, K. J., Abrahante, J. E., Landman, S. R., Steinbach, M., Sarver, A. L., Largaespada, D. A. & Starr, T. K., May 14 2014, In : PloS one. 9, 5, e97280.

Research output: Contribution to journalArticle

Histiocytic Sarcoma
Beauty
sarcoma
transposons
Mutagenesis
36 Citations (Scopus)

Identification of three molecular and functional subtypes in canine hemangiosarcoma through gene expression profiling and progenitor cell characterization

Gorden, B. H., Kim, J. H., Sarver, A. L., Frantz, A. M., Breen, M., Lindblad-Toh, K., O'Brien, T. D., Sharkey, L. C., Modiano, J. F. & Dickerson, E. B., Apr 2014, In : American Journal of Pathology. 184, 4, p. 985-995 11 p.

Research output: Contribution to journalArticle

Hemangiosarcoma
Gene Expression Profiling
Canidae
Stem Cells
Neoplasms
14 Citations (Scopus)

NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

Sachs, Z., LaRue, R. S., Nguyen, H. T., Sachs, K., Noble, K. E., Hassan, N. A. M., Diaz-Flores, E., Rathe, S. K., Sarver, A. L., Bendall, S. C., Ha, N. A., Diers, M. D., Nolan, G. P., Shannon, K. M. & Largaespada, D. A., Nov 20 2014, In : Blood. 124, 22, p. 3274-3283 10 p.

Research output: Contribution to journalArticle

Oncogenes
Acute Myeloid Leukemia
Gene expression
Leukemia
Stem cells
39 Citations (Scopus)

Sequential expression of miR-182 and miR-503 cooperatively targets FBXW7, contributing to the malignant transformation of colon adenoma to adenocarcinoma

Li, L., Sarver, A. L., Khatri, R., Hajeri, P. B., Kamenev, I., French, A. J., Thibodeau, S. N., Steer, C. J. & Subramanian, S., Dec 1 2014, In : Journal of Pathology. 234, 4, p. 488-501 14 p.

Research output: Contribution to journalArticle

Adenoma
Colon
Adenocarcinoma
Colonic Neoplasms
MicroRNAs
45 Citations (Scopus)

The role of KCNQ1 in mouse and human gastrointestinal cancers

Than, B. L. N., Goos, J. A. C. M., Sarver, A. L., O'Sullivan, G., Rod, A., Starr, T., Fijneman, R. J. A., Meijer, G. A., Zhao, L., Zhang, Y., Largaespada, D. A., Scott, P. M. & Cormier, R. T., Jul 17 2014, In : Oncogene. 33, 29, p. 3861-3868 8 p.

Research output: Contribution to journalArticle

Gastrointestinal Neoplasms
Organoids
Colon
Genes
Small Intestine
2013
75 Citations (Scopus)

BRCA1 is a negative modulator of the PRC2 complex

Wang, L., Zeng, X., Chen, S., Ding, L., Zhong, J., Zhao, J. C., Wang, L., Sarver, A., Koller, A., Zhi, J., Ma, Y., Yu, J., Chen, J. & Huang, H., May 29 2013, In : EMBO Journal. 32, 11, p. 1584-1597 14 p.

Research output: Contribution to journalArticle

Polycomb Repressive Complex 2
Modulators
Stem cells
Breast Neoplasms
Cell Differentiation
49 Citations (Scopus)

Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance

Watson, A. L., Rahrmann, E. P., Moriarity, B. S., Choi, K., Conboy, C. B., Greeley, A. D., Halfond, A. L., Anderson, L. K., Wahl, B. R., Keng, V. W., Rizzardi, A. E., Forster, C. L., Collins, M. H., Sarver, A. L., Wallace, M. R., Schmechel, S. C., Ratner, N. & Largaespada, D. A., 2013, In : Cancer discovery. 3, 6, p. 675-689 15 p.

Research output: Contribution to journalArticle

Catenins
Schwann Cells
Neurilemmoma
Neurofibroma
Maintenance

Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance.

Watson, A. L., Rahrmann, E. P., Moriarity, B. S., Choi, K., Conboy, C. B., Greeley, A. D., Halfond, A. L., Anderson, L. K., Wahl, B. R., Keng, V. W., Rizzardi, A. E., Forster, C. L., Collins, M. H., Sarver, A. L., Wallace, M. R., Schmechel, S. C., Ratner, N. & Largaespada, D. A., Jun 2013, In : Cancer Discovery. 3, 6, p. 674-689 16 p.

Research output: Contribution to journalArticle

Catenins
Schwann Cells
Neurilemmoma
Maintenance
Neurofibroma
92 Citations (Scopus)

Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis

Rahrmann, E. P., Watson, A. L., Keng, V. W., Choi, K., Moriarity, B. S., Beckmann, D. A., Wolf, N. K., Sarver, A., Collins, M. H., Moertel, C. L., Wallace, M. R., Gel, B., Serra, E., Ratner, N. & Largaespada, D. A., Jul 1 2013, In : Nature Genetics. 45, 7, p. 756-766 11 p.

Research output: Contribution to journalArticle

Neurilemmoma
Carcinogenesis
Proto-Oncogenes
Genes
Beauty
25 Citations (Scopus)

Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line

Krentz, A. D., Murphy, M. W., Zhang, T., Sarver, A. L., Jain, S., Griswold, M. D., Bardwell, V. J. & Zarkower, D., May 1 2013, In : Developmental Biology. 377, 1, p. 67-78 12 p.

Research output: Contribution to journalArticle

Germ Cells
Testis
Teratoma
Neoplasms
Glial Cell Line-Derived Neurotrophic Factor
63 Citations (Scopus)

MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma.

Sarver, A. L., Thayanithy, V., Scott, M. C., Cleton-Jansen, A. M., Hogendoorn, P. C. W., Modiano, J. F. & Subramanian, S., 2013, In : Unknown Journal. 8

Research output: Contribution to journalArticle

Open Access
Osteosarcoma
MicroRNAs
Canidae
Neoplasms
Down-Regulation
55 Citations (Scopus)

Molecular profiling reveals prognostically significant subtypes of canine lymphoma

Frantz, A. M., Sarver, A. L., Ito, D., Phang, T. L., Karimpour-Fard, A., Scott, M. C., Valli, V. E. O., Lindblad-Toh, K., Burgess, K. E., Husbands, B. D., Henson, M. S., Borgatti, A., Kisseberth, W. C., Hunter, L. E., Breen, M., O'Brien, T. D. & Modiano, J. F., Aug 1 2013, In : Veterinary pathology. 50, 4, p. 693-703 11 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
lymphoma
Canidae
Lymphoma
T-Cell Lymphoma
41 Citations (Scopus)

Profiling bortezomib resistance identifies secondary therapies in a mouse myeloma model

Stessman, H. A. F., Baughn, L. B., Sarver, A., Xia, T., Deshpande, R., Mansoor, A., Walsh, S. A., Sunderland, J. J., Dolloff, N. G., Linden, M. A., Zhan, F., Janz, S., Myers, C. L. & Van Ness, B. G., Jun 1 2013, In : Molecular Cancer Therapeutics. 12, 6, p. 1140-1150 11 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Histone Deacetylase Inhibitors
Proteasome Inhibitors
Therapeutics
Gene Expression Profiling
35 Citations (Scopus)

Sex bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated with EGFR

Keng, V. W., Sia, D., Sarver, A. L., Tschida, B. R., Fan, D., Alsinet, C., Solé, M., Lee, W. L., Kuka, T. P., Moriarity, B. S., Villanueva, A., Dupuy, A. J., Riordan, J. D., Bell, J. B., Silverstein, K. A., Llovet, J. M. & Largaespada, D. A., Jan 1 2013, In : Hepatology. 57, 1, p. 120-130 11 p.

Research output: Contribution to journalArticle

Sexism
Hepatocellular Carcinoma
Beauty
Neoplasms
Liver Neoplasms
80 Citations (Scopus)

Triptolide induces the expression of miR-142-3p: A negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation

MacKenzie, T. N., Mujumdar, N., Banerjee, S., Sangwan, V., Sarver, A., Vickers, S., Subramanian, S. & Saluja, A. K., Jul 1 2013, In : Molecular Cancer Therapeutics. 12, 7, p. 1266-1275 10 p.

Research output: Contribution to journalArticle

HSP70 Heat-Shock Proteins
Pancreatic Neoplasms
Cell Proliferation
Adenocarcinoma
MicroRNAs
2012
12 Citations (Scopus)

An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model

Bergerson, R. J., Collier, L. S., Sarver, A. L., Been, R. A., Lugthart, S., Diers, M. D., Zuber, J., Rappaport, A. R., Nixon, M. J., Silverstein, K. A. T., Fan, D., Lamblin, A. F. J., Wolff, L., Kersey, J. H., Delwel, R., Lowe, S. W., O'Sullivan, M. G., Kogan, S. C., Adams, D. J. & Largaespada, D. A., May 10 2012, In : Blood. 119, 19, p. 4512-4523 12 p.

Research output: Contribution to journalArticle

Mutagenesis
Insertional Mutagenesis
Myeloid Leukemia
Oncogene Fusion
Genes
282 Citations (Scopus)

Clonal selection drives genetic divergence of metastatic medulloblastoma

Wu, X., Northcott, P. A., Dubuc, A., Dupuy, A. J., Shih, D. J. H., Witt, H., Croul, S., Bouffet, E., Fults, D. W., Eberhart, C. G., Garzia, L., Van Meter, T., Zagzag, D., Jabado, N., Schwartzentruber, J., Majewski, J., Scheetz, T. E., Pfister, S. M., Korshunov, A., Li, X. N. & 12 others, Scherer, S. W., Cho, Y. J., Akagi, K., MacDonald, T. J., Koster, J., McCabe, M. G., Sarver, A. L., Collins, V. P., Weiss, W. A., Largaespada, D. A., Collier, L. S. & Taylor, M. D., Feb 23 2012, In : Nature. 482, 7386, p. 529-533 5 p.

Research output: Contribution to journalArticle

Medulloblastoma
Neoplasm Metastasis
Cerebrospinal Fluid
Neoplasms
Spinal Cord
39 Citations (Scopus)

Combinatorial Treatment of DNA and Chromatin-Modifying Drugs Cause Cell Death in Human and Canine Osteosarcoma Cell Lines

Thayanithy, V., Park, C., Sarver, A. L., Kartha, R. V., Korpela, D. M., Graef, A. J., Steer, C. J., Modiano, J. F. & Subramanian, S., Sep 5 2012, In : PloS one. 7, 9, e43720.

Research output: Contribution to journalArticle

osteosarcoma
Cell death
Osteosarcoma
MicroRNAs
microRNA
65 Citations (Scopus)

Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcoma

Li, L., Sarver, A. L., Alamgir, S. & Subramanian, S., Apr 1 2012, In : Laboratory Investigation. 92, 4, p. 571-583 13 p.

Research output: Contribution to journalArticle

Rhabdomyosarcoma
MicroRNAs
Down-Regulation
cdc Genes
Alveolar Rhabdomyosarcoma
94 Citations (Scopus)

Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma

Thayanithy, V., Sarver, A. L., Kartha, R. V., Li, L., Angstadt, A. Y., Breen, M., Steer, C. J., Modiano, J. F. & Subramanian, S., Jan 1 2012, In : Bone. 50, 1, p. 171-181 11 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Osteosarcoma
MicroRNAs
Down-Regulation
DNA Copy Number Variations
34 Citations (Scopus)
Poisson Distribution
Poisson distribution
Network Connectivity
Insertion
Annotation
202 Citations (Scopus)

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

Pérez-Mancera, P. A., Rust, A. G., Van Der Weyden, L., Kristiansen, G., Li, A., Sarver, A. L., Silverstein, K. A. T., Grützmann, R., Aust, D., Rümmele, P., Knösel, T., Herd, C., Stemple, D. L., Kettleborough, R., Brosnan, J. A., Li, A., Morgan, R., Knight, S., Yu, J., Stegeman, S. & 135 others, Collier, L. S., Ten Hoeve, J. J., De Ridder, J., Klein, A. P., Goggins, M., Hruban, R. H., Chang, D. K., Biankin, A. V. W., Grimmond, S. M., Wessels, L. F. A., Wood, S. A., Iacobuzio-Donahue, C. A., Pilarsky, C., Largaespada, D. A., Adams, D. J., Tuveson, D. A., Bienkin, A. V., Johns, A. L., Mawson, A., Cheng, D. K., Brancato, M. A. L., Rowe, S. J., Simpson, S. L., Martyn-Smith, M., Chantrill, L. A., Chin, V. T., Chou, A., Cowley, M. J., Humphris, J. L., Jones, M. D., Scott Mead, R., Nagrial, A. M., Pajic, M., Pettit, J., Pinese, M., Rooman, I., Wu, J., Daly, R. J., Musgrove, E. A., Sutherland, R. L., Grimond, S. M., Waddell, N., Kassahn, K. S., Miller, D. K., Wilson, P. J., Patch, A. M., Song, S., Harliwong, I., Idrisoglu, S., Nourse, C., Nourbakhsh, E., Manning, S., Wani, S., Gongora, M., Anderson, M., Holmes, O., Leonard, C., Taylor, D., Wood, S., Xu, C., Nones, K., Lynn Fink, J., Christ, A., Bruxner, T., Cloonan, N., Newell, F., Pearson, J. V., Samra, J. S., Gill, A. J., Pavlakis, N., Guminski, A., Toon, C., Blankin, A. V., Asghari, R., Merrett, N. D., Pavey, D. A., Das, A., Cosman, P. H., Ismail, K., O'Connor, C., Lam, V. W., McLeod, D., Pleass, H. C., James, V., Kench, J. G., Cooper, C. L., Joseph, D., Sandroussi, C., Crawford, M., Texler, M., Forrest, C., Laycock, A., Epari, K. P., Ballal, M., Fletcher, D. R., Mukhedkar, S., Spry, N. A., Deboer, B., Chai, M., Feeney, K., Zeps, N., Beilin, M., Nguyen, N. Q., Ruszkiewicz, A. R., Worthley, C., Tan, C. P., Debrencini, T., Chen, J., Brooke-Smith, M. E., Papangelis, V., Tang, H., Barbour, A. P., Clouston, A. D., Martin, P., O'Rourke, T. J., Chiang, A., Fawcett, J. W., Slater, K., Yeung, S., Hatzifotis, M., Hodgkinson, P., Christophi, C., Nikfarjam, M., Cancer Biobank, V., Eshleman, J. R., Maitra, A., Schulick, R. D., Wolfgang, C. L., Morgan, R. A., Lawlor, R. T., Beghelli, S., Corbo, V., Scardoni, M., Bassi, C. & Tempero, M. A., Jun 14 2012, In : Nature. 486, 7402, p. 266-270 5 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasms
trichostatin A
Carcinogenesis
Anoikis
2011
52 Citations (Scopus)
APC Genes
Beauty
Adenomatous Polyposis Coli
Carcinogenesis
Colorectal Neoplasms
302 Citations (Scopus)

DMRT1 prevents female reprogramming in the postnatal mammalian testis

Matson, C. K., Murphy, M. W., Sarver, A. L., Griswold, M. D., Bardwell, V. J. & Zarkower, D., Aug 4 2011, In : Nature. 476, 7358, p. 101-105 5 p.

Research output: Contribution to journalArticle

Sertoli Cells
Granulosa Cells
Testis
Gonads
Mammals
72 Citations (Scopus)

DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary

Krentz, A. D., Murphy, M. W., Sarver, A. L., Griswold, M. D., Bardwell, V. J. & Zarkower, D. A., Aug 1 2011, In : Developmental Biology. 356, 1, p. 63-70 8 p.

Research output: Contribution to journalArticle

Oogenesis
Transcriptional Activation
Ovary
Germ Cells
Testis
109 Citations (Scopus)

MiRNA expression in colon polyps provides evidence for a Multihit model of colon cancer

Oberg, A. L., French, A. J., Sarver, A. L., Subramanian, S., Morlan, B. W., Riska, S. M., Borralho, P. M., Cunningham, J. M., Boardman, L. A., Wang, L., Smyrk, T. C., Asmann, Y., Steer, C. J. & Thibodeau, S. N., Jun 15 2011, In : PloS one. 6, 6, e20465.

Research output: Contribution to journalArticle

DNA Mismatch Repair
Polyps
colorectal neoplasms
Colonic Neoplasms
colon
69 Citations (Scopus)

Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach

Scott, M. C., Sarver, A. L., Gavin, K. J., Thayanithy, V., Getzy, D. M., Newman, R. A., Cutter, G. R., Lindblad-Toh, K., Kisseberth, W. C., Hunter, L. E., Subramanian, S., Breen, M. & Modiano, J. F., Sep 1 2011, In : Bone. 49, 3, p. 356-367 12 p.

Research output: Contribution to journalArticle

Osteosarcoma
Dogs
Neoplasms
Gene Expression
Gene Expression Profiling
14 Citations (Scopus)

Oxygen is a master regulator of the immunogenicity of primary human glioma cells

Olin, M. R., Andersen, B. M., Litterman, A. J., Grogan, P. T., Sarver, A. L., Robertson, P. T., Liang, X., Chen, W., Parney, I. F., Hunt, M. A., Blazar, B. R. & Ohlfest, J. R., Nov 1 2011, In : Cancer Research. 71, 21, p. 6583-6589 7 p.

Research output: Contribution to journalArticle

Glioma
Dendritic Cells
Oxygen
Cancer Vaccines
Vaccines
10 Citations (Scopus)

The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice

Billington, C. J., Ng, B., Forsman, C., Schmidt, B., Bagchi, A., Symer, D. E., Schotta, G., Gopalakrishnan, R., Sarver, A. L. & Petryk, A., Jul 1 2011, In : Developmental Biology. 355, 1, p. 21-31 11 p.

Research output: Contribution to journalArticle

Gastrulation
Phenotype
Embryonic Structures
Genes
Gene Expression