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Research Output 2000 2019

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2019

Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors

Kearse, M. G., Goldman, D. H., Choi, J., Nwaezeapu, C., Liang, D., Green, K. M., Goldstrohm, A., Todd, P. K., Green, R. & Wilusz, J. E., Jul 1 2019, In : Genes & development. 33, 13-14, p. 871-885 15 p.

Research output: Contribution to journalArticle

Open Access
Protein Synthesis Inhibitors
Initiator Codon
Ribosomes
Cycloheximide
Messenger RNA
2018
8 Citations (Scopus)

Identification of diverse target RNAs that are functionally regulated by human pumilio proteins

Bohn, J. A., Van Etten, J. L., Schagat, T. L., Bowman, B. M., McEachin, R. C., Freddolino, P. L. & Goldstrohm, A., Jan 1 2018, In : Nucleic acids research. 46, 1, p. 362-386 25 p.

Research output: Contribution to journalArticle

Open Access
RNA
Response Elements
Untranslated RNA
Messenger RNA
RNA-Binding Proteins
5 Citations (Scopus)

The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells

Abshire, E. T., Chasseur, J., Bohn, J. A., Del Rizzo, P. A., Freddolino, P. L., Goldstrohm, A. & Trievel, R. C., Jul 6 2018, In : Nucleic acids research. 46, 12, p. 6257-6270 14 p.

Research output: Contribution to journalArticle

Open Access
Ribonucleases
Exoribonucleases
Catalytic Domain
Messenger RNA
nocturnin
2017
22 Citations (Scopus)

RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response

Green, K. M., Glineburg, M. R., Kearse, M. G., Flores, B. N., Linsalata, A. E., Fedak, S. J., Goldstrohm, A. C., Barmada, S. J. & Todd, P. K., Dec 1 2017, In : Nature communications. 8, 1, 2005.

Research output: Contribution to journalArticle

Open Access
Initiator Codon
expansion
Poisons
Protein Biosynthesis
Neurodegenerative Diseases
2016
47 Citations (Scopus)

CGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic Proteins

Kearse, M. G., Green, K. M., Krans, A., Rodriguez, C. M., Linsalata, A. E., Goldstrohm, A. & Todd, P. K., Apr 21 2016, In : Molecular Cell. 62, 2, p. 314-322 9 p.

Research output: Contribution to journalArticle

Initiator Codon
Poisons
Reading Frames
Proteins
Nucleotides
23 Citations (Scopus)

Drosophila nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of pumilio

Weidmann, C. A., Qiu, C., Arvola, R. M., Lou, T. F., Killingsworth, J., Campbell, Z. T., Tanaka Hall, T. M. & Goldstrohm, A., Aug 2 2016, In : eLife. 5, AUGUST, e17096.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Clamping devices
Drosophila
RNA
Messenger RNA
2014
1 Citation (Scopus)

In vitro analysis of RNA degradation catalyzed by deadenylase enzymes

Hrit, J., Raynard, N., Van Etten, J., Sankar, K., Petterson, A. & Goldstrohm, A. C., Jan 1 2014, In : Methods in Molecular Biology. 1125, p. 325-339 15 p.

Research output: Contribution to journalArticle

RNA Stability
Messenger RNA
Enzymes
Adenosine
Exoribonucleases
27 Citations (Scopus)

The RNA binding domain of Pumilio antagonizes poly-adenosine binding protein and accelerates deadenylation

Weidmann, C. A., Raynard, N. A., Blewett, N. H., Van Etten, J. & Goldstrohm, A. C., Jan 1 2014, In : RNA. 20, 8, p. 1298-1319 22 p.

Research output: Contribution to journalArticle

Adenosine
Carrier Proteins
Messenger RNA
Poly A
Drosophila
2013
10 Citations (Scopus)

A guide to design and optimization of reporter assays for 3' untranslated region mediated regulation of mammalian messenger RNAs

Van Etten, J., Schagat, T. L. & Goldstrohm, A. C., Sep 15 2013, In : Methods. 63, 2, p. 110-118 9 p.

Research output: Contribution to journalArticle

3' Untranslated Regions
Assays
Ribonucleic Acid Regulatory Sequences
RNA
Messenger RNA
2012
33 Citations (Scopus)

A eukaryotic translation initiation factor 4E-binding protein promotes mRNA decapping and is required for PUF repression

Blewett, N. H. & Goldstrohm, A. C., Oct 1 2012, In : Molecular and Cellular Biology. 32, 20, p. 4181-4194 14 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factors
Carrier Proteins
Messenger RNA
RNA Stability
35 Citations (Scopus)
Brain Neoplasms
Messenger RNA
Proteins
RNA-Binding Proteins
RNA Stability
84 Citations (Scopus)

Human pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs

Van Etten, J., Schagat, T. L., Hrit, J., Weidmann, C. A., Brumbaugh, J., Coon, J. J. & Goldstrohm, A. C., Oct 19 2012, In : Journal of Biological Chemistry. 287, 43, p. 36370-36383 14 p.

Research output: Contribution to journalArticle

Messenger RNA
RNA Stability
Proteins
RNA-Binding Proteins
RNA
2011
16 Citations (Scopus)

A quantitative assay for measuring mRNA decapping by splinted ligation reverse transcription polymerase chain reaction: qSL-RT-PCR

Blewett, N., Coller, J. & Goldstrohm, A., Mar 1 2011, In : RNA. 17, 3, p. 535-543 9 p.

Research output: Contribution to journalArticle

Reverse Transcription
Ligation
Polymerase Chain Reaction
Messenger RNA
RNA Stability
2009
85 Citations (Scopus)

FBF and its dual control of gld-1 expression in the Caenorhabditis elegans germline

Suh, N., Crittenden, S. L., Goldstrohm, A., Hook, B., Thompson, B., Wickens, M. & Kimble, J., Apr 1 2009, In : Genetics. 181, 4, p. 1249-1260 12 p.

Research output: Contribution to journalArticle

Polynucleotide Adenylyltransferase
Caenorhabditis elegans
Meiosis
Mitosis
Polyadenylation
2007
112 Citations (Scopus)

PUF protein-mediated deadenylation is catalyzed by Ccr4p

Goldstrohm, A. C., Seay, D. J., Hook, B. A. & Wickens, M., Jan 5 2007, In : Journal of Biological Chemistry. 282, 1, p. 109-114 6 p.

Research output: Contribution to journalArticle

Messenger RNA
Proteins
RNA Stability
Fungal Proteins
3' Untranslated Regions
69 Citations (Scopus)

Two yeast PUF proteins negatively regulate a single mRNA

Hook, B. A., Goldstrohm, A. C., Seay, D. J. & Wickens, M., May 25 2007, In : Journal of Biological Chemistry. 282, 21, p. 15430-15438 9 p.

Research output: Contribution to journalArticle

Fungal Proteins
Messenger RNA
Proteins
RNA Stability
3' Untranslated Regions
2006
43 Citations (Scopus)
Peptide Elongation Factors
Terminal Repeat Sequences
RNA Polymerase II
Transcription Factors
RNA Polymerase III
211 Citations (Scopus)

PUF proteins bind Pop2p to regulate messenger RNAs

Goldstrohm, A. C., Hook, B. A., Seay, D. J. & Wickens, M., Jun 26 2006, In : Nature Structural and Molecular Biology. 13, 6, p. 533-539 7 p.

Research output: Contribution to journalArticle

Messenger RNA
RNA Stability
Proteins
Fungal Proteins
RNA-Binding Proteins
2001
94 Citations (Scopus)

The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1

Goldstrohm, A. C., Albrecht, T. R., Suñé, C., Bedford, M. T. & Garcia-Blanco, M. A., Nov 1 2001, In : Molecular and Cellular Biology. 21, 22, p. 7617-7628 12 p.

Research output: Contribution to journalArticle

Peptide Elongation Factors
RNA Polymerase II
RNA Precursors
Transcription Factors
Proline
2000
13 Citations (Scopus)
Equine infectious anemia virus
Peptide Elongation Factors
HIV-1
Transcription Factors
Proteins
71 Citations (Scopus)

Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II

Carty, S. M., Goldstrohm, A. C., Suñé, C., Garcia-Blanco, M. A. & Greenleaf, A. L., Aug 1 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 16, p. 9015-9020 6 p.

Research output: Contribution to journalArticle

RNA Polymerase II
Terminal Repeat Sequences
Nuclear Proteins
Proteins
Recombinant Proteins