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Research Output 2000 2019

Article
35 Citations (Scopus)

A eukaryotic translation initiation factor 4E-binding protein promotes mRNA decapping and is required for PUF repression

Blewett, N. H. & Goldstrohm, A. C., Oct 1 2012, In : Molecular and cellular biology. 32, 20, p. 4181-4194 14 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factors
Carrier Proteins
Messenger RNA
RNA Stability
10 Citations (Scopus)

A guide to design and optimization of reporter assays for 3' untranslated region mediated regulation of mammalian messenger RNAs

Van Etten, J., Schagat, T. L. & Goldstrohm, A. C., Sep 15 2013, In : Methods. 63, 2, p. 110-118 9 p.

Research output: Contribution to journalArticle

3' Untranslated Regions
Assays
Ribonucleic Acid Regulatory Sequences
RNA
Messenger RNA
13 Citations (Scopus)
Equine infectious anemia virus
Peptide Elongation Factors
HIV-1
Transcription Factors
Proteins
16 Citations (Scopus)

A quantitative assay for measuring mRNA decapping by splinted ligation reverse transcription polymerase chain reaction: qSL-RT-PCR

Blewett, N., Coller, J. & Goldstrohm, A., Mar 1 2011, In : RNA. 17, 3, p. 535-543 9 p.

Research output: Contribution to journalArticle

Reverse Transcription
Ligation
Polymerase Chain Reaction
Messenger RNA
RNA Stability
52 Citations (Scopus)

CGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic Proteins

Kearse, M. G., Green, K. M., Krans, A., Rodriguez, C. M., Linsalata, A. E., Goldstrohm, A. & Todd, P. K., Apr 21 2016, In : Molecular Cell. 62, 2, p. 314-322 9 p.

Research output: Contribution to journalArticle

Initiator Codon
Poisons
Reading Frames
Proteins
Nucleotides
27 Citations (Scopus)

Drosophila nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of pumilio

Weidmann, C. A., Qiu, C., Arvola, R. M., Lou, T. F., Killingsworth, J., Campbell, Z. T., Tanaka Hall, T. M. & Goldstrohm, A., Aug 2 2016, In : eLife. 5, AUGUST, e17096.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Clamping devices
Drosophila
RNA
Messenger RNA
37 Citations (Scopus)
Brain Neoplasms
Messenger RNA
Proteins
RNA-Binding Proteins
RNA Stability
86 Citations (Scopus)

FBF and its dual control of gld-1 expression in the Caenorhabditis elegans germline

Suh, N., Crittenden, S. L., Goldstrohm, A., Hook, B., Thompson, B., Wickens, M. & Kimble, J., Apr 1 2009, In : Genetics. 181, 4, p. 1249-1260 12 p.

Research output: Contribution to journalArticle

Polynucleotide Adenylyltransferase
Caenorhabditis elegans
Meiosis
Mitosis
Polyadenylation
88 Citations (Scopus)

Human pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs

Van Etten, J., Schagat, T. L., Hrit, J., Weidmann, C. A., Brumbaugh, J., Coon, J. J. & Goldstrohm, A. C., Oct 19 2012, In : Journal of Biological Chemistry. 287, 43, p. 36370-36383 14 p.

Research output: Contribution to journalArticle

Messenger RNA
RNA Stability
Proteins
RNA-Binding Proteins
RNA
45 Citations (Scopus)
Peptide Elongation Factors
Terminal Repeat Sequences
RNA Polymerase II
Transcription Factors
RNA Polymerase III
11 Citations (Scopus)

Identification of diverse target RNAs that are functionally regulated by human pumilio proteins

Bohn, J. A., Van Etten, J. L., Schagat, T. L., Bowman, B. M., McEachin, R. C., Freddolino, P. L. & Goldstrohm, A., Jan 1 2018, In : Nucleic acids research. 46, 1, p. 362-386 25 p.

Research output: Contribution to journalArticle

Open Access
RNA
Response Elements
Untranslated RNA
Messenger RNA
RNA-Binding Proteins
1 Citation (Scopus)

In vitro analysis of RNA degradation catalyzed by deadenylase enzymes

Hrit, J., Raynard, N., Van Etten, J., Sankar, K., Petterson, A. & Goldstrohm, A. C., Jan 1 2014, In : Methods in Molecular Biology. 1125, p. 325-339 15 p.

Research output: Contribution to journalArticle

RNA Stability
Messenger RNA
Enzymes
Adenosine
Exoribonucleases
72 Citations (Scopus)

Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II

Carty, S. M., Goldstrohm, A. C., Suñé, C., Garcia-Blanco, M. A. & Greenleaf, A. L., Aug 1 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 16, p. 9015-9020 6 p.

Research output: Contribution to journalArticle

RNA Polymerase II
Terminal Repeat Sequences
Nuclear Proteins
Proteins
Recombinant Proteins
113 Citations (Scopus)

PUF protein-mediated deadenylation is catalyzed by Ccr4p

Goldstrohm, A. C., Seay, D. J., Hook, B. A. & Wickens, M., Jan 5 2007, In : Journal of Biological Chemistry. 282, 1, p. 109-114 6 p.

Research output: Contribution to journalArticle

Messenger RNA
Proteins
RNA Stability
Fungal Proteins
3' Untranslated Regions
213 Citations (Scopus)

PUF proteins bind Pop2p to regulate messenger RNAs

Goldstrohm, A. C., Hook, B. A., Seay, D. J. & Wickens, M., Jun 26 2006, In : Nature Structural and Molecular Biology. 13, 6, p. 533-539 7 p.

Research output: Contribution to journalArticle

Messenger RNA
RNA Stability
Proteins
Fungal Proteins
RNA-Binding Proteins
29 Citations (Scopus)

RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response

Green, K. M., Glineburg, M. R., Kearse, M. G., Flores, B. N., Linsalata, A. E., Fedak, S. J., Goldstrohm, A. C., Barmada, S. J. & Todd, P. K., Dec 1 2017, In : Nature communications. 8, 1, 2005.

Research output: Contribution to journalArticle

Open Access
Initiator Codon
expansion
Poisons
Protein Biosynthesis
Neurodegenerative Diseases
2 Citations (Scopus)

Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors

Kearse, M. G., Goldman, D. H., Choi, J., Nwaezeapu, C., Liang, D., Green, K. M., Goldstrohm, A., Todd, P. K., Green, R. & Wilusz, J. E., Jul 1 2019, In : Genes and Development. 33, 13-14, p. 871-885 15 p.

Research output: Contribution to journalArticle

Open Access
Protein Synthesis Inhibitors
Initiator Codon
Ribosomes
Cycloheximide
Messenger RNA
28 Citations (Scopus)

The RNA binding domain of Pumilio antagonizes poly-adenosine binding protein and accelerates deadenylation

Weidmann, C. A., Raynard, N. A., Blewett, N. H., Van Etten, J. & Goldstrohm, A. C., Jan 1 2014, In : RNA. 20, 8, p. 1298-1319 22 p.

Research output: Contribution to journalArticle

Adenosine
Carrier Proteins
Messenger RNA
Poly A
Drosophila
5 Citations (Scopus)

The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells

Abshire, E. T., Chasseur, J., Bohn, J. A., Del Rizzo, P. A., Freddolino, P. L., Goldstrohm, A. & Trievel, R. C., Jul 6 2018, In : Nucleic acids research. 46, 12, p. 6257-6270 14 p.

Research output: Contribution to journalArticle

Open Access
Ribonucleases
Exoribonucleases
Catalytic Domain
Messenger RNA
nocturnin
95 Citations (Scopus)

The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1

Goldstrohm, A. C., Albrecht, T. R., Suñé, C., Bedford, M. T. & Garcia-Blanco, M. A., Nov 1 2001, In : Molecular and cellular biology. 21, 22, p. 7617-7628 12 p.

Research output: Contribution to journalArticle

Peptide Elongation Factors
RNA Polymerase II
RNA Precursors
Transcription Factors
Proline
69 Citations (Scopus)

Two yeast PUF proteins negatively regulate a single mRNA

Hook, B. A., Goldstrohm, A. C., Seay, D. J. & Wickens, M., May 25 2007, In : Journal of Biological Chemistry. 282, 21, p. 15430-15438 9 p.

Research output: Contribution to journalArticle

Fungal Proteins
Messenger RNA
Proteins
RNA Stability
3' Untranslated Regions
Book

Post-transcriptional mechanisms in endocrine regulation

Menon, K. M. J. & Goldstrohm, A. C., Jan 1 2015, Springer International Publishing. 341 p.

Research output: Book/ReportBook

Hormones
Literature
Signal transduction
Untranslated RNA
Peptides
Chapter
9 Citations (Scopus)

Chapter 5 Regulated Deadenylation In Vitro

Goldstrohm, A. C., Hook, B. A. & Wickens, M., Dec 24 2008, RNA Turnover in Eukaryotes: Nucleases, Pathways and Anaylsis of mRNA Decay. Maquat, L. & Kiledjian, M. (eds.). p. 77-106 30 p. (Methods in Enzymology; vol. 448).

Research output: Chapter in Book/Report/Conference proceedingChapter

RNA-Binding Proteins
Messenger RNA
3' Untranslated Regions
MicroRNAs
Yeast

Mechanisms of post-transcriptional gene regulation

Arvola, R., Abshire, E., Bohn, J. & Goldstrohm, A., Jan 1 2015, Post-Transcriptional Mechanisms in Endocrine Regulation. Springer International Publishing, p. 1-36 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

RNA Stability
Gene expression
Untranslated RNA
Messenger RNA
Endocrine System

Preparation of cooperative RNA recognition complexes for crystallographic structural studies

Qiu, C., Goldstrohm, A. & Tanaka Hall, T. M., Jan 1 2019, Methods in Enzymology. Hargrove, A. E. (ed.). Academic Press Inc., p. 1-22 22 p. (Methods in Enzymology; vol. 623).

Research output: Chapter in Book/Report/Conference proceedingChapter

RNA
Messenger RNA
RNA-Binding Proteins
Crystal structure
Crystallization
Comment/debate
226 Citations (Scopus)

Multifunctional deadenylase complexes diversify mRNA control

Goldstrohm, A. & Wickens, M., Apr 1 2008, In : Nature Reviews Molecular Cell Biology. 9, 4, p. 337-344 8 p.

Research output: Contribution to journalComment/debate

Messenger RNA
RNA Stability
Protein Stability
Enzymes
mRNA deadenylase
Editorial

Biochemical and Next Generation Sequencing Approaches to Study RNA Regulation

Wagner, E. J. & Goldstrohm, A., Feb 15 2019, In : Methods. 155, p. 1-2 2 p.

Research output: Contribution to journalEditorial

RNA
Foreword/postscript

Preface

Menon, K. M. J. & Goldstrohm, A. C., Jan 1 2015, Post-Transcriptional Mechanisms in Endocrine Regulation. Springer International Publishing, p. v-viii

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Review article
18 Citations (Scopus)

Combinatorial control of messenger RNAs by Pumilio, Nanos and Brain Tumor Proteins

Arvola, R. M., Weidmann, C. A., Tanaka Hall, T. M. & Goldstrohm, A., Nov 2 2017, In : RNA Biology. 14, 11, p. 1445-1456 12 p.

Research output: Contribution to journalReview article

Open Access
RNA-Binding Proteins
Brain Neoplasms
Messenger RNA
Proteins
RNA
133 Citations (Scopus)

Co-transcriptional splicing of pre-messenger RNAs: Considerations for the mechanism of alternative splicing

Goldstrohm, A. C., Greenleaf, A. L. & Garcia-Blanco, M. A., Oct 17 2001, In : Gene. 277, 1-2, p. 31-47 17 p.

Research output: Contribution to journalReview article

RNA Splicing
RNA Splice Sites
RNA Precursors
Alternative Splicing
Introns

Global analysis of RNA metabolism using bio-orthogonal labeling coupled with next-generation RNA sequencing

Wolfe, M. B., Goldstrohm, A. & Freddolino, P. L., Feb 15 2019, In : Methods. 155, p. 88-103 16 p.

Research output: Contribution to journalReview article

Open Access
RNA Sequence Analysis
Metabolism
Labeling
RNA
RNA Stability
1 Citation (Scopus)

Inhibiting transcription in cultured metazoan cells with actinomycin D to monitor mRNA turnover

Lai, W. S., Arvola, R. M., Goldstrohm, A. & Blackshear, P. J., Feb 15 2019, In : Methods. 155, p. 77-87 11 p.

Research output: Contribution to journalReview article

Open Access
RNA Stability
Dactinomycin
Transcription
Cultured Cells
Messenger RNA
13 Citations (Scopus)

Integrated analysis of RNA-binding protein complexes using in vitro selection and high-throughput sequencing and sequence specificity landscapes (SEQRS)

Lou, T. F., Weidmann, C. A., Killingsworth, J., Tanaka Hall, T. M., Goldstrohm, A. C. & Campbell, Z. T., Apr 15 2017, In : Methods. 118-119, p. 171-181 11 p.

Research output: Contribution to journalReview article

Open Access
RNA-Binding Proteins
Throughput
RNA
Proteins
Drosophila Proteins
33 Citations (Scopus)

Molecular biology: A place to die, a place to sleep

Wickens, M. & Goldstrohm, A., May 2 2003, In : Science. 300, 5620, p. 753-755 3 p.

Research output: Contribution to journalReview article

Fungal RNA
RNA Caps
DEAD-box RNA Helicases
Exoribonucleases
Endoribonucleases
10 Citations (Scopus)

Post-transcriptional Regulatory Functions of Mammalian Pumilio Proteins

Goldstrohm, A. C., Hall, T. M. T. & McKenney, K. M., Dec 1 2018, In : Trends in Genetics. 34, 12, p. 972-990 19 p.

Research output: Contribution to journalReview article

Open Access
Proteins
Untranslated RNA
RNA-Binding Proteins
RNA Stability
Movement Disorders
1 Citation (Scopus)

Regulatory roles of vertebrate Nocturnin: insights and remaining mysteries

Hughes, K. L., Abshire, E. T. & Goldstrohm, A., Oct 3 2018, In : RNA Biology. 15, 10, p. 1255-1267 13 p.

Research output: Contribution to journalReview article

Open Access
Vertebrates
Messenger RNA
RNA Stability
Adipogenesis
Osteogenesis