Aaron Goldstrohm

Ph.D., Associate Professor

20002022

Research output per year

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Research Output

2019

Biochemical and Next Generation Sequencing Approaches to Study RNA Regulation

Wagner, E. J. & Goldstrohm, A. C., Feb 15 2019, In : Methods. 155, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Global analysis of RNA metabolism using bio-orthogonal labeling coupled with next-generation RNA sequencing

Wolfe, M. B., Goldstrohm, A. C. & Freddolino, P. L., Feb 15 2019, In : Methods. 155, p. 88-103 16 p.

Research output: Contribution to journalReview article

Open Access

Inhibiting transcription in cultured metazoan cells with actinomycin D to monitor mRNA turnover

Lai, W. S., Arvola, R. M., Goldstrohm, A. C. & Blackshear, P. J., Feb 15 2019, In : Methods. 155, p. 77-87 11 p.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Preparation of cooperative RNA recognition complexes for crystallographic structural studies

Qiu, C., Goldstrohm, A. C. & Tanaka Hall, T. M., 2019, Methods in Enzymology. Hargrove, A. E. (ed.). Academic Press Inc., p. 1-22 22 p. (Methods in Enzymology; vol. 623).

Research output: Chapter in Book/Report/Conference proceedingChapter

Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors

Kearse, M. G., Goldman, D. H., Choi, J., Nwaezeapu, C., Liang, D., Green, K. M., Goldstrohm, A. C., Todd, P. K., Green, R. & Wilusz, J. E., Jul 2019, In : Genes and Development. 33, 13-14, p. 871-885 15 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2018

Identification of diverse target RNAs that are functionally regulated by human pumilio proteins

Bohn, J. A., Van Etten, J. L., Schagat, T. L., Bowman, B. M., McEachin, R. C., Freddolino, P. L. & Goldstrohm, A., Jan 1 2018, In : Nucleic acids research. 46, 1, p. 362-386 25 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Post-transcriptional Regulatory Functions of Mammalian Pumilio Proteins

Goldstrohm, A. C., Hall, T. M. T. & McKenney, K. M., Dec 2018, In : Trends in Genetics. 34, 12, p. 972-990 19 p.

Research output: Contribution to journalReview article

Open Access
13 Scopus citations

Regulatory roles of vertebrate Nocturnin: insights and remaining mysteries

Hughes, K. L., Abshire, E. T. & Goldstrohm, A. C., Oct 3 2018, In : RNA Biology. 15, 10, p. 1255-1267 13 p.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells

Abshire, E. T., Chasseur, J., Bohn, J. A., Del Rizzo, P. A., Freddolino, P. L., Goldstrohm, A. C. & Trievel, R. C., Jul 6 2018, In : Nucleic acids research. 46, 12, p. 6257-6270 14 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2017

Combinatorial control of messenger RNAs by Pumilio, Nanos and Brain Tumor Proteins

Arvola, R. M., Weidmann, C. A., Tanaka Hall, T. M. & Goldstrohm, A. C., Nov 2 2017, In : RNA Biology. 14, 11, p. 1445-1456 12 p.

Research output: Contribution to journalReview article

Open Access
20 Scopus citations

Integrated analysis of RNA-binding protein complexes using in vitro selection and high-throughput sequencing and sequence specificity landscapes (SEQRS)

Lou, T. F., Weidmann, C. A., Killingsworth, J., Tanaka Hall, T. M., Goldstrohm, A. C. & Campbell, Z. T., Apr 15 2017, In : Methods. 118-119, p. 171-181 11 p.

Research output: Contribution to journalReview article

Open Access
15 Scopus citations

RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response

Green, K. M., Glineburg, M. R., Kearse, M. G., Flores, B. N., Linsalata, A. E., Fedak, S. J., Goldstrohm, A. C., Barmada, S. J. & Todd, P. K., Dec 1 2017, In : Nature communications. 8, 1, 2005.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations
2016

CGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic Proteins

Kearse, M. G., Green, K. M., Krans, A., Rodriguez, C. M., Linsalata, A. E., Goldstrohm, A. C. & Todd, P. K., Apr 21 2016, In : Molecular Cell. 62, 2, p. 314-322 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

Drosophila nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of pumilio

Weidmann, C. A., Qiu, C., Arvola, R. M., Lou, T. F., Killingsworth, J., Campbell, Z. T., Tanaka Hall, T. M. & Goldstrohm, A., Aug 2 2016, In : eLife. 5, AUGUST, e17096.

Research output: Contribution to journalArticle

31 Scopus citations
2015

Mechanisms of post-transcriptional gene regulation

Arvola, R., Abshire, E., Bohn, J. & Goldstrohm, A., Jan 1 2015, Post-Transcriptional Mechanisms in Endocrine Regulation. Springer International Publishing, p. 1-36 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Post-transcriptional mechanisms in endocrine regulation

Menon, K. M. J. & Goldstrohm, A. C., Jan 1 2015, Springer International Publishing. 341 p.

Research output: Book/ReportBook

Preface

Menon, K. M. J. & Goldstrohm, A. C., Jan 1 2015, Post-Transcriptional Mechanisms in Endocrine Regulation. Springer International Publishing, p. v-viii

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

2014

In vitro analysis of RNA degradation catalyzed by deadenylase enzymes

Hrit, J., Raynard, N., Van Etten, J., Sankar, K., Petterson, A. & Goldstrohm, A. C., Jan 1 2014, In : Methods in Molecular Biology. 1125, p. 325-339 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

The RNA binding domain of Pumilio antagonizes poly-adenosine binding protein and accelerates deadenylation

Weidmann, C. A., Raynard, N. A., Blewett, N. H., Van Etten, J. & Goldstrohm, A. C., Aug 2014, In : RNA. 20, 8, p. 1298-1319 22 p.

Research output: Contribution to journalArticle

30 Scopus citations
2013

A guide to design and optimization of reporter assays for 3' untranslated region mediated regulation of mammalian messenger RNAs

Van Etten, J., Schagat, T. L. & Goldstrohm, A. C., Sep 15 2013, In : Methods. 63, 2, p. 110-118 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2012

A eukaryotic translation initiation factor 4E-binding protein promotes mRNA decapping and is required for PUF repression

Blewett, N. H. & Goldstrohm, A. C., Oct 1 2012, In : Molecular and cellular biology. 32, 20, p. 4181-4194 14 p.

Research output: Contribution to journalArticle

36 Scopus citations
38 Scopus citations

Human pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs

Van Etten, J., Schagat, T. L., Hrit, J., Weidmann, C. A., Brumbaugh, J., Coon, J. J. & Goldstrohm, A. C., Oct 19 2012, In : Journal of Biological Chemistry. 287, 43, p. 36370-36383 14 p.

Research output: Contribution to journalArticle

94 Scopus citations
2011

A quantitative assay for measuring mRNA decapping by splinted ligation reverse transcription polymerase chain reaction: qSL-RT-PCR

Blewett, N., Coller, J. & Goldstrohm, A., Mar 1 2011, In : RNA. 17, 3, p. 535-543 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2009

FBF and its dual control of gld-1 expression in the Caenorhabditis elegans germline

Suh, N., Crittenden, S. L., Goldstrohm, A., Hook, B., Thompson, B., Wickens, M. & Kimble, J., Apr 1 2009, In : Genetics. 181, 4, p. 1249-1260 12 p.

Research output: Contribution to journalArticle

89 Scopus citations
2008

Chapter 5 Regulated Deadenylation In Vitro

Goldstrohm, A. C., Hook, B. A. & Wickens, M., Dec 24 2008, RNA Turnover in Eukaryotes: Nucleases, Pathways and Anaylsis of mRNA Decay. Maquat, L. & Kiledjian, M. (eds.). p. 77-106 30 p. (Methods in Enzymology; vol. 448).

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Multifunctional deadenylase complexes diversify mRNA control

Goldstrohm, A. C. & Wickens, M., Apr 1 2008, In : Nature Reviews Molecular Cell Biology. 9, 4, p. 337-344 8 p.

Research output: Contribution to journalComment/debate

229 Scopus citations
2007

PUF protein-mediated deadenylation is catalyzed by Ccr4p

Goldstrohm, A. C., Seay, D. J., Hook, B. A. & Wickens, M., Jan 5 2007, In : Journal of Biological Chemistry. 282, 1, p. 109-114 6 p.

Research output: Contribution to journalArticle

114 Scopus citations

Two yeast PUF proteins negatively regulate a single mRNA

Hook, B. A., Goldstrohm, A. C., Seay, D. J. & Wickens, M., May 25 2007, In : Journal of Biological Chemistry. 282, 21, p. 15430-15438 9 p.

Research output: Contribution to journalArticle

69 Scopus citations
2006
46 Scopus citations

PUF proteins bind Pop2p to regulate messenger RNAs

Goldstrohm, A. C., Hook, B. A., Seay, D. J. & Wickens, M., Jun 26 2006, In : Nature Structural and Molecular Biology. 13, 6, p. 533-539 7 p.

Research output: Contribution to journalArticle

215 Scopus citations
2003

Molecular biology: A place to die, a place to sleep

Wickens, M. & Goldstrohm, A., May 2 2003, In : Science. 300, 5620, p. 753-755 3 p.

Research output: Contribution to journalReview article

33 Scopus citations
2001

Co-transcriptional splicing of pre-messenger RNAs: Considerations for the mechanism of alternative splicing

Goldstrohm, A. C., Greenleaf, A. L. & Garcia-Blanco, M. A., Oct 17 2001, In : Gene. 277, 1-2, p. 31-47 17 p.

Research output: Contribution to journalReview article

134 Scopus citations

The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1

Goldstrohm, A. C., Albrecht, T. R., Suñé, C., Bedford, M. T. & Garcia-Blanco, M. A., Nov 1 2001, In : Molecular and cellular biology. 21, 22, p. 7617-7628 12 p.

Research output: Contribution to journalArticle

97 Scopus citations
2000
13 Scopus citations

Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II

Carty, S. M., Goldstrohm, A. C., Suñé, C., Garcia-Blanco, M. A. & Greenleaf, A. L., Aug 1 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 16, p. 9015-9020 6 p.

Research output: Contribution to journalArticle

72 Scopus citations