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Research Output 2008 2019

2008
18 Citations (Scopus)

Submicromolar, selective G-quadruplex ligands from one pot: Thermodynamic and structural studies of human telomeric DNA binding by azacyanines

Çetinkol, Ö. P., Engelhart, A. E., Nanjunda, R. K., Wilson, W. D. & Hud, N. V., Aug 12 2008, In : ChemBioChem. 9, 12, p. 1889-1892 4 p.

Research output: Contribution to journalArticle

Aza Compounds
G-Quadruplexes
Drug Design
Fluorescence Spectrometry
Telomere
2009
31 Citations (Scopus)

Conformational variants of duplex DNA correlated with cytosine-rich chromosomal fragile sites

Tsai, A. G., Engelhart, A. E., Hatmal, M. M., Houston, S. I., Hud, N. V., Haworth, I. S. & Lieber, M. R., Mar 13 2009, In : Journal of Biological Chemistry. 284, 11, p. 7157-7164 8 p.

Research output: Contribution to journalArticle

Cytosine
DNA
Chromosome Fragility
Plasmids
A-Form DNA
16 Citations (Scopus)

Evidence of strong hydrogen bonding by 8-aminoguanine

Engelhart, A. E., Morton, T. H. & Hud, N. V., Feb 2 2009, In : Chemical Communications. 6, p. 647-649 3 p.

Research output: Contribution to journalArticle

Oligonucleotides
Hydrogen bonds
DNA
8-aminoguanine
2010
115 Citations (Scopus)

DNA and RNA in anhydrous media: Duplex, triplex, and G-quadruplex secondary structures in a deep eutectic solvent

Mamajanov, I., Engelhart, A. E., Bean, H. D. & Hud, N. V., Aug 23 2010, In : Angewandte Chemie - International Edition. 49, 36, p. 6310-6314 5 p.

Research output: Contribution to journalArticle

Nucleic acids
RNA
Eutectics
Nucleic Acids
DNA
31 Citations (Scopus)

Intercalation as a means to suppress cyclization and promote polymerization of base-pairing oligonucleotides in a prebiotic world

Horowitz, E. D., Engelhart, A. E., Chen, M. C., Quarles, K. A., Smith, M. W., Lynn, D. G. & Hud, N. V., Mar 23 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 12, p. 5288-5293 6 p.

Research output: Contribution to journalArticle

Intercalating Agents
Prebiotics
Cyclization
Oligonucleotides
Base Pairing
57 Citations (Scopus)

Primitive genetic polymers.

Engelhart, A. E. & Hud, N. V., Dec 1 2010, In : Cold Spring Harbor Perspectives in Biology. 2, 12, p. a002196

Research output: Contribution to journalReview article

Polymers
RNA
Nucleic Acids
Physical Chemistry
Organic Chemistry
2012
12 Citations (Scopus)

Nonenzymatic Ligation of DNA with a Reversible Step and a Final Linkage that Can Be Used in PCR

Engelhart, A. E., Cafferty, B. J., Okafor, C. D., Chen, M. C., Williams, L. D., Lynn, D. G. & Hud, N. V., May 1 2012, In : ChemBioChem. 13, 8, p. 1121-1124 4 p.

Research output: Contribution to journalArticle

Combinatorial Chemistry Techniques
Morpholines
Polymerase chain reaction
DNA Probes
DNA-Directed DNA Polymerase
2013
61 Citations (Scopus)

Functional RNAs exhibit tolerance for non-heritable 2′-5′ versus 3′-5′ backbone heterogeneity

Engelhart, A. E., Powner, M. W. & Szostak, J. W., Mar 24 2013, In : Nature Chemistry. 5, 5, p. 390-394 5 p.

Research output: Contribution to journalArticle

RNA
Prebiotics
Molecular recognition
Catalytic RNA
Copying
2014
40 Citations (Scopus)

Ester formation and hydrolysis during wet-dry cycles: Generation of far-from-equilibrium polymers in a model prebiotic reaction

Mamajanov, I., Macdonald, P. J., Ying, J., Duncanson, D. M., Dowdy, G. R., Walker, C. A., Engelhart, A. E., Fernández, F. M., Grover, M. A., Hud, N. V. & Schork, F. J., Feb 25 2014, In : Macromolecules. 47, 4, p. 1334-1343 10 p.

Research output: Contribution to journalArticle

Prebiotics
Hydrolysis
Esters
Polymers
Biopolymers
21 Citations (Scopus)

Structural insights into the effects of 2′-5′ linkages on the RNA duplex

Sheng, J., Li, L., Engelhart, A. E., Gan, J., Wang, J. & Szostak, J. W., Feb 25 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 8, p. 3050-3055 6 p.

Research output: Contribution to journalArticle

RNA
Nucleotide Aptamers
Catalytic RNA
Molecular Dynamics Simulation
Nucleotides
2015
6 Citations (Scopus)

Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations

Adamala, K., Engelhart, A. E., Kamat, N. P., Jin, L. & Szostak, J. W., Jun 30 2015, In : Nature Protocols. 10, 6, p. 927-938 12 p.

Research output: Contribution to journalArticle

Dialysis
Liposomes
Curing
Microscopy
Microscopic examination
14 Citations (Scopus)

Generation of functional RNAs from inactive oligonucleotide complexes by non-enzymatic primer extension

Adamala, K., Engelhart, A. E. & Szostak, J. W., Jan 14 2015, In : Journal of the American Chemical Society. 137, 1, p. 483-489 7 p.

Research output: Contribution to journalArticle

Oligonucleotides
RNA
Polymerization
Catalytic RNA
Copying
2016
34 Citations (Scopus)

A simple physical mechanism enables homeostasis in primitive cells

Engelhart, A. E., Adamala, K. P. & Szostak, J. W., May 1 2016, In : Nature Chemistry. 8, 5, p. 448-453 6 p.

Research output: Contribution to journalArticle

Catalytic RNA
Oligonucleotides
RNA
Dilution
MicroRNAs
24 Citations (Scopus)

Collaboration between primitive cell membranes and soluble catalysts

Adamala, K. P., Engelhart, A. E. & Szostak, J. W., Mar 21 2016, In : Nature communications. 7, 11041.

Research output: Contribution to journalArticle

Artificial Cells
Cell membranes
Catalytic RNA
Cell Membrane
lipids
2017
3 Citations (Scopus)

RNA imaging: A tale of two G-quadruplexes

Engelhart, A. E., Nov 1 2017, In : Nature Chemical Biology. 13, 11, p. 1140-1141 2 p.

Research output: Contribution to journalShort survey

G-Quadruplexes
RNA
2018
3 Citations (Scopus)

Catalysis of Template-Directed Nonenzymatic RNA Copying by Iron(II)

Jin, L., Engelhart, A. E., Zhang, W., Adamala, K. & Szostak, J. W., Nov 7 2018, In : Journal of the American Chemical Society. 140, 44, p. 15016-15021 6 p.

Research output: Contribution to journalArticle

Copying
Prebiotics
RNA
Catalysis
Iron
2 Citations (Scopus)

Preparation, purification, and use of fatty acid-containing liposomes

Jin, L., Engelhart, A. E., Adamala, K. P. & Szostak, J. W., Feb 9 2018, In : Journal of Visualized Experiments. 2018, 132, e57324.

Research output: Contribution to journalArticle

Amphiphiles
Liposomes
Fatty acids
Purification
Fatty Acids
2 Citations (Scopus)

Real-Time Visualization of in Vitro Transcription of a Fluorescent RNA Aptamer: An Experiment for the Upper-Division Undergraduate or First-Year Graduate Laboratory

Heili, J. M., Gomez-Garcia, J., Gaut, N. J., Cash, B. W., Aufdembrink, L. M., Heffron, B. A., Shirley, J. D., Carlson, E. E., Adamala, K. P. & Engelhart, A. E., Oct 9 2018, In : Journal of Chemical Education. 95, 10, p. 1867-1871 5 p.

Research output: Contribution to journalArticle

Nucleotide Aptamers
Transcription
visualization
Visualization
graduate
2019

Methods for thermal denaturation studies of nucleic acids in complex with fluorogenic dyes

Aufdembrink, L. M., Hoog, T. G., Pawlak, M. R., Bachan, B. F., Heili, J. M. & Engelhart, A. E., 2019, Methods in Enzymology. Hargrove, A. E. (ed.). Academic Press Inc., p. 23-43 21 p. (Methods in Enzymology; vol. 623).

Research output: Chapter in Book/Report/Conference proceedingChapter

Nucleic Acid Denaturation
Denaturation
Nucleic Acids
Coloring Agents
Hot Temperature