Research Output 1992 2020

2020

Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity

Corkrum, M., Covelo, A., Lines, J., Bellocchio, L., Pisansky, M., Loke, K., Quintana, R., Rothwell, P. E., Lujan, R., Marsicano, G., Martin, E. D., Thomas, M. J., Kofuji, P. & Araque, A., Jan 1 2020, In : Neuron.

Research output: Contribution to journalArticle

Photodynamic Therapy for the Treatment of Glioblastoma

Cramer, S. W. & Chen, C. C., Jan 21 2020, In : Frontiers in Surgery. 6

Research output: Contribution to journalArticle

Topoisomerase II SUMOylation activates a metaphase checkpoint via Haspin and Aurora B kinases

Pandey, N., Keifenheim, D., Yoshida, M. M., Hassebroek, V. A., Soroka, C., Azuma, Y. & Clarke, D. J., Jan 6 2020, In : The Journal of cell biology. 219, 1

Research output: Contribution to journalArticle

Open Access
Aurora Kinase B
Sumoylation
Type II DNA Topoisomerase
Metaphase
Centromere
Spiders
Tyrosine 3-Monooxygenase
Central Nervous System
Neurons
Catecholamines
2019

A conserved mechanism of APOBEC3 relocalization by herpesviral ribonucleotide reductase large subunits

Cheng, A. Z., Moraes, S. N., Attarian, C., Yockteng-Melgar, J., Jarvis, M. C., Biolatti, M., Galitska, G., Dell'Oste, V., Frappier, L., Bierle, C. J., Rice, S. A. & Harris, R. S., Dec 1 2019, In : Journal of virology. 9, 23, e01539-19.

Research output: Contribution to journalArticle

ribonucleotide reductase
Ribonucleotide Reductases
Human herpesvirus 1
Human Herpesvirus 1
Human herpesvirus 8
2 Citations (Scopus)

An integrated platform for mucin-type O-glycosylation network generation and visualization

Le, T., O’Brien, C., Gupta, U., Sousa, G., Daoutidis, P. & Hu, W-S., Jun 2019, In : Biotechnology and bioengineering. 116, 6, p. 1341-1354 14 p.

Research output: Contribution to journalArticle

Glycosylation
Mucins
Polysaccharides
Visualization
Enzymes

A Tissue- and Temporal-Specific Autophagic Switch Controls Drosophila Pre-metamorphic Nutritional Checkpoints

Pan, X., Neufeld, T. P. & O'Connor, M. B., Sep 9 2019, In : Current Biology. 29, 17, p. 2840-2851.e4

Research output: Contribution to journalArticle

Steroid hormones
autophagy
Autophagy
Drosophila
Switches
2 Citations (Scopus)

Cortex-wide neural interfacing via transparent polymer skulls

Ghanbari, L., Carter, R. E., Rynes, M. L., Dominguez, J., Chen, G., Naik, A., Hu, J., Sagar, M. A. K., Haltom, L., Mossazghi, N., Gray, M. M., West, S. L., Eliceiri, K. W., Ebner, T. J. & Bangalore Kodandaramaiah, S., Dec 1 2019, In : Nature communications. 10, 1, 1500.

Research output: Contribution to journalArticle

Open Access
skull
cortexes
Skull
Polymers
Imaging techniques
3 Citations (Scopus)

Craniobot: A computer numerical controlled robot for cranial microsurgeries

Ghanbari, L., Rynes, M. L., Hu, J., Schulman, D. S., Johnson, G. W., Laroque, M., Shull, G. M. & Bangalore Kodandaramaiah, S., Dec 1 2019, In : Scientific reports. 9, 1, 1023.

Research output: Contribution to journalArticle

Microsurgery
Skull
Craniotomy
Brain
Bone and Bones
1 Citation (Scopus)

CtIP is essential for telomere replication

Stroik, S., Kurtz, K. & Hendrickson, E. A., Sep 26 2019, In : Nucleic acids research. 47, 17, p. 8927-8940 14 p.

Research output: Contribution to journalArticle

Open Access
Telomere
Telomere Shortening
Genomic Instability
Telomere Homeostasis
Double-Stranded DNA Breaks
2 Citations (Scopus)

Dentin Priming with Amphipathic Antimicrobial Peptides

Moussa, D. G., Kirihara, J. A., Ye, Z., Fischer, N. G., Khot, J., Witthuhn, B. A. & Aparicio, C., Sep 1 2019, In : Journal of dental research. 98, 10, p. 1112-1121 10 p.

Research output: Contribution to journalArticle

Dentin
Peptides
Minerals
Collagen
Multimodal Imaging
1 Citation (Scopus)

Developing a Protein Scaffolding System for Rapid Enzyme Immobilization and Optimization of Enzyme Functions for Biocatalysis

Zhang, G., Johnston, T., Quin, M. B. & Schmidt-Dannert, C., Aug 16 2019, In : ACS Synthetic Biology. 8, 8, p. 1867-1876 10 p.

Research output: Contribution to journalArticle

Biocatalysis
Enzyme immobilization
Biocatalysts
Immobilization
Enzymes

Development of a Biolabeling System Using Ferromagnetic Nanowires

Zhou, W., Um, J., Zhang, Y., Nelson, A. P., Nemati, Z., Modiano, J., Stadler, B. J. & Franklin, R. R., Jun 2019, In : IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology. 3, 2, p. 134-142 9 p., 8585028.

Research output: Contribution to journalArticle

Nanowires
nanowires
Cell Separation
Cobalt
Nickel

Development of a cross-reactive monoclonal antibody for detecting the tumor stroma

Hintz, H. M., Cowan, A. E., Shapovalova, M. & LeBeau, A., May 15 2019, In : Bioconjugate Chemistry. 30, 5, p. 1466-1476 11 p.

Research output: Contribution to journalArticle

Monoclonal antibodies
Fibroblasts
Tumors
Immunoglobulin G
Monoclonal Antibodies

Discovery of HSPG2 (Perlecan) as a Therapeutic Target in Triple Negative Breast Cancer

Kalscheuer, S., Khanna, V., Kim, H., Li, S., Sachdev, D., DeCarlo, A., Yang, D. & Panyam, J., Dec 1 2019, In : Scientific reports. 9, 1, 12492.

Research output: Contribution to journalArticle

Open Access
Triple Negative Breast Neoplasms
Antibodies
Antibody-Dependent Cell Cytotoxicity
Therapeutics
Neoplasms

Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality

Saha, A., Taylor, P. A., Lees, C. J., Panoskaltsis-Mortari, A., Osborn, M. J., Feser, C. J., Thangavelu, G., Melchinger, W., Refaeli, Y., Hill, G. R., Munn, D. H., Murphy, W. J., Serody, J. S., Maillard, I., Kreymborg, K., van den Brink, M., Dong, C., Huang, S., Zang, X., Allison, J. P. & 2 others, Zeiser, R. & Blazar, B. R., Jan 1 2019, In : JCI Insight. 4, 19, e127716.

Research output: Contribution to journalArticle

Open Access
Graft vs Host Disease
T-Lymphocytes
Mortality
Metabolic Networks and Pathways
Oxygen Consumption
Carboxypeptidase H
Carboxypeptidases
Proinsulin
Insulin
Medical problems
8 Citations (Scopus)

Epstein–Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity

Cheng, A. Z., Yockteng-Melgar, J., Jarvis, M. C., Malik-Soni, N., Borozan, I., Carpenter, M. A., McCann, J. L., Ebrahimi, D., Shaban, N. M., Marcon, E., Greenblatt, J., Brown, W. L., Frappier, L. & Harris, R., Jan 1 2019, In : Nature Microbiology. 4, 1, p. 78-88 11 p.

Research output: Contribution to journalLetter

Viral Genome
Viruses
Cytosine Deaminase
Herpesviridae
RNA Editing

Functional analysis and development of a CRISPR/Cas9 allelic series for a CPR5 ortholog necessary for proper growth of soybean trichomes

Campbell, B. W., Hoyle, J. W., Bucciarelli, B., Stec, A. O., Samac, D. A., Parrott, W. A. & Stupar, R. M., Dec 1 2019, In : Scientific reports. 9, 1, 14757.

Research output: Contribution to journalArticle

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Trichomes
Soybeans
Fast Neutrons
Growth
4 Citations (Scopus)

G i/o protein-coupled receptors inhibit neurons but activate astrocytes and stimulate gliotransmission

Durkee, C. A., Covelo, A., Lines, J., Kofuji, P., Aguilar, J. & Araque, A., Jun 2019, In : Glia. 67, 6, p. 1076-1093 18 p.

Research output: Contribution to journalArticle

Gi-Go GTP-Binding Protein alpha Subunits
Astrocytes
G-Protein-Coupled Receptors
Neurons
Brain
Inwardly Rectifying Potassium Channel
Ventral Tegmental Area
Dopaminergic Neurons
Cocaine
Dopamine
1 Citation (Scopus)

Glycopolycation-DNA Polyplex Formulation N/P Ratio Affects Stability, Hemocompatibility, and in Vivo Biodistribution

Phillips, H. R., Tolstyka, Z. P., Hall, B. C., Hexum, J. K., Hackett, P. B. & Reineke, T. M., Apr 8 2019, In : Biomacromolecules. 20, 4, p. 1530-1544 15 p.

Research output: Contribution to journalArticle

Methacrylates
DNA
Polymers
Genes
Coagulation

Imaging the distribution of iron oxide nanoparticles in hypothermic perfused tissues

Ring, H. L., Gao, Z., Sharma, A., Han, Z., Lee, C., Brockbank, K. G. M., Greene, E. D., Helke, K. L., Chen, Z., Campbell, L. H., Weegman, B., Davis, M., Taylor, M., Giwa, S., Fahy, G. M., Wowk, B., Pagotan, R., Bischof, J. C. & Garwood, M., Jan 1 2019, (Accepted/In press) In : Magnetic resonance in medicine. 83, 5, p. 1750-1759 10 p.

Research output: Contribution to journalArticle

Composite Tissue Allografts
Nanoparticles
Cryopreservation
Microcomputers
Hindlimb
4 Citations (Scopus)

Improving payload capacity and anti-tumor efficacy of mesenchymal stem cells using tat peptide functionalized polymeric nanoparticles

Moku, G., Layek, B., Trautman, L., Putnam, S., Panyam, J. & Prabha, S., Apr 2019, In : Cancers. 11, 4, 491.

Research output: Contribution to journalArticle

Open Access
Mesenchymal Stromal Cells
Nanoparticles
Peptides
Trans-Activators
Neoplasms
1 Citation (Scopus)

Intercellular transfer of oncogenic KRAS via tunneling nanotubes introduces intracellular mutational heterogeneity in colon cancer cells

Desir, S., Wong, P., Turbyville, T., Chen, D., Shetty, M., Clark, C., Zhai, E., Romin, Y., Manova-Todorova, K., Starr, T., Nissley, D. V., Steer, C. J., Subramanian, S. & Lou, E., Jul 2019, In : Cancers. 11, 7, 892.

Research output: Contribution to journalArticle

Open Access
Kirsten murine sarcoma virus
Nanotubes
Oncogenic Viruses
Parvovirus
Colonic Neoplasms
2 Citations (Scopus)

Mast cells induce blood brain barrier damage in SCD by causing endoplasmic reticulum stress in the endothelium

Tran, H., Mittal, A., Sagi, V., Luk, K., Nguyen, A., Gupta, M., Nguyen, J., Lamarre, Y., Lei, J., Guedes, A. & Gupta, K., Jan 29 2019, In : Frontiers in Cellular Neuroscience. 13, p. 1-12 12 p., 56.

Research output: Contribution to journalArticle

Open Access
Endoplasmic Reticulum Stress
Sickle Cell Anemia
Blood-Brain Barrier
Mast Cells
Endothelium

MCPH1 is essential for cellular adaptation to the G2-phase decatenation checkpoint

Arroyo, M., Kuriyama, R., Guerrero, I., Keifenheim, D., Cañuelo, A., Calahorra, J., Sánchez, A., Clarke, D. J. & Marchal, J. A., Jul 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 7, p. 8363-8374 12 p.

Research output: Contribution to journalArticle

G2 Phase Cell Cycle Checkpoints
Mitosis
Ataxia Telangiectasia
Type II DNA Topoisomerase
DNA
2 Citations (Scopus)

Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density

Csizmar, C. M., Petersburg, J. R., Perry, T. J., Rozumalski, L., Hackel, B. J. & Wagner, C. R., Jan 9 2019, In : Journal of the American Chemical Society. 141, 1, p. 251-261 11 p.

Research output: Contribution to journalArticle

Cell Adhesion Molecules
Cell membranes
Antigens
Ligands
Cell Membrane

Mutation of a Conserved Motif of PP2C.D Phosphatases Confers SAUR Immunity and Constitutive Activity

Wong, J. H., Spartz, A. K., Park, M., Du, M. & Gray, W. M., Sep 1 2019, In : Plant physiology. 181, 1, p. 353-366 14 p.

Research output: Contribution to journalArticle

Open Access
Proton-Translocating ATPases
Phosphoric Monoester Hydrolases
Immunity
immunity
Cell Membrane

NanoSIMS imaging reveals metabolic stratification within current-producing biofilms

Chadwick, G. L., Otero, F. J., Gralnick, J. A., Bond, D. R. & Orphan, V. J., Oct 8 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 41, p. 20716-20724 9 p.

Research output: Contribution to journalArticle

Open Access
Biofilms
Electrodes
Electrons
Oxidation-Reduction
Microbiological Phenomena

Novel long-range inhibitory nNOS-expressing hippocampal cells

Wick, Z. C., Tetzlaff, M. R. & Krook-Magnuson, E., Oct 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Nitric Oxide Synthase Type I
Neurons
Muscarinic Receptors
Somatostatin
Brain

Optimized filopodia formation requires myosin tail domain cooperation

Arthur, A. L., Songster, L. D., Sirkia, H., Bhattacharya, A., Kikuti, C., Borrega, F. P., Houdusse, A. & Titus, M. A., Oct 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 44, p. 22196-22204 9 p.

Research output: Contribution to journalArticle

Pseudopodia
Myosins
Dimerization
Amoebozoa
Actins
Optogenetics
Brown Adipose Tissue
Thermogenesis
Tissue
Chemical activation

PEG10 promoter-driven expression of reporter genes enables molecular imaging of lethal prostate cancer

Shapovalova, M., Lee, J. K., Li, Y., Griend, D. J. V., Coleman, I. M., Nelson, P. S., Dehm, S. M. & LeBeau, A. M., Nov 1 2019, In : Cancer Research. 79, 21, p. 5668-5680 13 p.

Research output: Contribution to journalArticle

Molecular Imaging
Reporter Genes
Prostatic Neoplasms
Androgen Receptors
Genes
Open Access
Parkinson Disease
Hippocampus
Pharmacology
Designer Drugs
Inflammation
1 Citation (Scopus)

Sleeping beauty insertional mutagenesis reveals important genetic drivers of central nervous system embryonal tumors

Beckmann, P. J., Larson, J. D., Larsson, A. T., Ostergaard, J. P., Wagner, S., Rahrmann, E. P., Shamsan, G. A., Otto, G. M., Williams, R. L., Wang, J., Lee, C., Tschida, B. R., Das, P., Dubuc, A. M., Moriarity, B. S., Picard, D., Wu, X., Rodriguez, F. J., Rosemarie, Q., Krebs, R. D. & 13 others, Molan, A. M., Demer, A. M., Frees, M. M., Rizzardi, A. E., Schmechel, S. C., Eberhart, C. G., Jenkins, R. B., Wechsler-Reya, R. J., Odde, D. J., Huang, A., Taylor, M. D., Sarver, A. L. & Largaespada, D. A., Mar 1 2019, In : Cancer Research. 79, 5, p. 905-917 13 p.

Research output: Contribution to journalArticle

Beauty
Central Nervous System Neoplasms
Medulloblastoma
Insertional Mutagenesis
Primitive Neuroectodermal Tumors
2 Citations (Scopus)

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

Singh, B., Covelo, A., Martell-Martínez, H., Nanclares, C., Sherman, M. A., Okematti, E., Meints, J., Teravskis, P. J., Gallardo, C., Savonenko, A. V., Benneyworth, M. A., Lesne, S. E., Liao, D., Araque, A. & Lee, M. K., Oct 1 2019, In : Acta Neuropathologica. 138, 4, p. 551-574 24 p.

Research output: Contribution to journalArticle

Memory Disorders
Transgenic Mice
Lewy Body Disease
Parkinson Disease
Dementia

The DNA deaminase APOBEC3B interacts with the cell-cycle protein CDK4 and disrupts CDK4-mediated nuclear import of cyclin D1

McCann, J. L., Klein, M. M., Leland, E. M., Law, E. K., Brown, W. L., Salamango, D. J. & Harris, R., Jan 1 2019, In : Journal of Biological Chemistry. 294, 32, p. 12099-12111 13 p.

Research output: Contribution to journalArticle

Open Access
Cyclin-Dependent Kinase 4
Cell Cycle Proteins
Cell Nucleus Active Transport
Cyclin D1
Protein Kinases
1 Citation (Scopus)

The impact of TCR signal strength on resident memory T cell formation during influenza virus infection

Fiege, J. K., Stone, I. A., Fay, E. J., Markman, M. W., Wijeyesinghe, S., Macchietto, M., Shen, S., Masopust, D. & Langlois, R. A., Aug 15 2019, In : Journal of Immunology. 203, 4, p. 936-945 10 p.

Research output: Contribution to journalArticle

Virus Diseases
Orthomyxoviridae
Influenza A virus
T-Lymphocytes
Lung

The Role of RNA in HIV-1 Vif-Mediated Degradation of APOBEC3H

Wang, J., Becker, J. T., Shi, K., Lauer, K. V., Salamango, D. J., Aihara, H., Shaban, N. M. & Harris, R. S., Dec 6 2019, In : Journal of Molecular Biology. 431, 24, p. 5019-5031 13 p.

Research output: Contribution to journalArticle

HIV-1
RNA
Cytosine Deaminase
vif Gene Products
Host-Pathogen Interactions
3 Citations (Scopus)

Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mesoderm

Magli, A., Baik, J., Mills, L. J., Kwak, I., Dillon, B. S., Mondragon Gonzalez, R., Stafford, D. A., Swanson, S. A., Stewart, R., Thomson, J. A., Garry, D. J., Dynlacht, B. D., Perlingeiro, R. C. R. & Becker, P. B. (ed.), Feb 26 2019, In : PLoS Biology. 17, 2, e3000153.

Research output: Contribution to journalArticle

Open Access
Chromatin Assembly and Disassembly
Mesoderm
Chromatin
chromatin
Homeobox Genes

Transplantation studies reveal internuclear transfer of toxic RNA in engrafted muscles of myotonic dystrophy 1 mice

Mondragon-Gonzalez, R., Azzag, K., Selvaraj, S., Yamamoto, A. & Perlingeiro, R., Sep 2019, In : EBioMedicine. 47, p. 553-562 10 p.

Research output: Contribution to journalArticle

Open Access
Myotonic Dystrophy
Poisons
Transfer RNA
Muscle
Muscular Dystrophies
3 Citations (Scopus)

UNC-45A is a novel microtubule-associated protein and regulator of paclitaxel sensitivity in ovarian cancer cells

Mooneyham, A., Iizuka, Y., Yang, Q., Coombes, C., McClellan, M., Shridhar, V., Emmings, E., Shetty, M., Chen, L., Ai, T., Meints, J., Lee, M. K., Gardner, M. K. & Bazzaro, M., Feb 2019, In : Molecular Cancer Research. 17, 2, p. 370-383 14 p.

Research output: Contribution to journalArticle

Open Access
Microtubule-Associated Proteins
Paclitaxel
Ovarian Neoplasms
Spindle Apparatus
Microtubules

UNC-45A is preferentially expressed in epithelial cells and binds to and co-localizes with interphase MTs

Habicht, J., Mooneyham, A., Shetty, M., Zhang, X., Shridhar, V., Winterhoff, B., Zhang, Y., Cepela, J., Starr, T., Lou, E. & Bazzaro, M., 2019, In : Cancer biology & therapy. 20, 10, p. 1304-1313 10 p.

Research output: Contribution to journalArticle

Open Access
Actomyosin
Interphase
Spindle Apparatus
Epithelial Cells
Paclitaxel
2018
9 Citations (Scopus)

Acidic pH-responsive polymer nanoparticles as a TLR7/8 agonist delivery platform for cancer immunotherapy

Kim, H., Sehgal, D., Kucaba, T. A., Ferguson, D. M., Griffith, T. S. & Panyam, J., Nov 28 2018, In : Nanoscale. 10, 44, p. 20851-20862 12 p.

Research output: Contribution to journalArticle

Polymers
Nanoparticles
T-cells
Gases
Antigens
3 Citations (Scopus)

Alignment of collagen matrices using magnetic nanowires and magnetic barcode readout using first order reversal curves (FORC) (invited)

Sharma, A., DiVito, M. D., Shore, D. E., Block, A. D., Pollock, K., Solheid, P., Feinberg, J. M., Modiano, J., Lam, C. H., Hubel, A. & Stadler, B. J. H., Aug 1 2018, In : Journal of Magnetism and Magnetic Materials. 459, p. 176-181 6 p.

Research output: Contribution to journalArticle

collagens
Collagen
Nanowires
readout
nanowires
11 Citations (Scopus)

Bacterial Adhesion to Ultrafiltration Membranes: Role of Hydrophilicity, Natural Organic Matter, and Cell-Surface Macromolecules

Binahmed, S., Hasane, A., Wang, Z., Mansurov, A. & Romero Vargas Castrillon, S., Jan 2 2018, In : Environmental Science and Technology. 52, 1, p. 162-172 11 p.

Research output: Contribution to journalArticle

Hydrophilicity
Ultrafiltration
ultrafiltration
Macromolecules
adhesion
6 Citations (Scopus)

Bimodal sensing of guidance cues in mechanically distinct microenvironments

Tabdanov, E. D. & Provenzano, P., Nov 20 2018, In : Nature Communications.

Research output: Contribution to journalArticle

cues
Fluidics
Cadherins
Cues
Adhesion
7 Citations (Scopus)

Cellular and molecular networking within the ecosystem of cancer cell communication via tunneling nanotubes

Lou, E., Zhai, E., Sarkari, A., Desir, S., Wong, P., Iizuka, Y., Yang, J., Subramanian, S., McCarthy, J., Bazzaro, M. & Steer, C. J., Oct 2 2018, In : Frontiers in Cell and Developmental Biology. 6, OCT, 95.

Research output: Contribution to journalArticle

Open Access
Nanotubes
Cell Communication
Ecosystem
Neoplasms
Interdisciplinary Studies