Organization profile

Organization profile

Overview

The University Imaging Centers cover over 11,000 square feet of resources in three primary sites on the University of Minnesota-Twin Cities campuses. Snyder Hall on the St. Paul campus, Jackson Hall on the Minneapolis East Bank campus, and the Cancer and Cardiovascular Research Building located in the Biomedical Discovery District on the East Bank campus. The network of facilities offers instrumentation and support for light and electron microscopy, in-vivo imaging from sub-cellular to whole animal, and image analysis/visualization. The UIC is a Nikon Center of Excellence.

Operating under the direction of Mark Sanders the UIC has six full-time staff members, three part-time as well as multiple undergraduate employees that can assist in experimental design, probe and labeling selection, sample handling, tissue clearing, as well as data analysis and interpretation.

The University Imaging Centers is supported by the College of Biological Sciences and AHC/Medical School and is advised by a 13-member University-wide Advisory Panel.

Optical Systems include:

  • Laser scanning confocal microscopes with multiphoton capabilities (two)
  • Single photon confocal microscopes (six, three with spectral unmixing)
  • Super resolution Structured Illumination Microscopy (SIM)
  • Spinning disk confocal microscope
  • Total Internal Reflection Fluorescence (TIRF) Microscope
  • Fluorescent spectral meso-confocal
  • Automated widefield microscopes
  • High speed ribbon confocal
  • LightSheet

Also available at UIC facilities:

  • Spectral scans
  • Deconvolution
  • High-content widefield and confocal plate imaging
  • FRET (Fluorescence Resonance Energy Transfer)
  • FRAP (Fluorescence Recover After Photobleaching)
  • FLIM (Fluorescence Lifetime Imaging
  • SHG (Second Harmonic Generation) Imaging
  • Multi-channel live cell time-lapse
  • Small animal/bioluminescence / fluorescence (four, on with X-ray)
  • BSL-2 cabinets
  • Phosphor / fluorescence scanners for molecular biology
  • Bioluminescence and fluorescence in-vivo small animal imagers
  • microPET/CT
  • diSPIM light sheet
  • Tissue clearing
  • Large format poster printing
  • 3D printing
  • Brightfield and fluorescence slide scanning.

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Tumors Chemical Compounds
Chlamydomonas reinhardtii Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Proteins Medicine & Life Sciences
Sterol Esterase Medicine & Life Sciences
Mesenchymal Stromal Cells Medicine & Life Sciences
Fatty Acid-Binding Proteins Medicine & Life Sciences
Cells Chemical Compounds

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Research Output 1992 2019

1 Citations

Epstein–Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity

Cheng, A. Z., Yockteng-Melgar, J., Jarvis, M. C., Malik-Soni, N., Borozan, I., Carpenter, M. A., McCann, J. L., Ebrahimi, D., Shaban, N. M., Marcon, E., Greenblatt, J., Brown, W. L., Frappier, L. & Harris, R., Jan 1 2019, In : Nature Microbiology. 4, 1, p. 78-88 11 p.

Research output: Contribution to journalLetter

Viral Genome
Human Herpesvirus 4
Cytosine Deaminase
Viruses
Herpesviridae

Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density

Csizmar, C. M., Petersburg, J. R., Perry, T. J., Rozumalski, L., Hackel, B. J. & Wagner, C. R., Jan 9 2019, In : Journal of the American Chemical Society. 141, 1, p. 251-261 11 p.

Research output: Contribution to journalArticle

Cell membranes
Antigens
Ligands
Nanorings
Cell Membrane

Acidic pH-responsive polymer nanoparticles as a TLR7/8 agonist delivery platform for cancer immunotherapy

Kim, H., Sehgal, D., Kucaba, T. A., Ferguson, D. M., Griffith, T. S. & Panyam, J., Nov 28 2018, In : Nanoscale. 10, 44, p. 20851-20862 12 p.

Research output: Contribution to journalArticle

Polymers
Nanoparticles
T-cells
Gases
Antigens