Transplant and Cellular Therapy

Finished

Engineering NK cells for Immunotherapy

Moriarity, B. S. (PI) & Webber, B. R. (Other Role)

CATAMARAN BIO, INC

4/3/20 → 11/28/23

Project: Research project

Blue Rock Development Phase I

Wagner, J. E. (PI) & Brunstein, C. G. (CoI)

BLUEROCK THERAPEUTICS GP LLC

3/15/20 → 9/14/20

Project: Research project

m6A modification of fusion gene mRNAs

Kikyo, N. J. (PI)

NIH NATIONAL CANCER INSTITUTE (NCI)

3/1/20 → 2/28/23

Project: Research project

Rheos compound study

Blazar, B. R. (PI)

RHEOS MEDICINES, INC.

2/11/20 → 10/11/22

Project: Research project

Long Term Outcomes in Mucopolysaccharidosis Type I-Hurler (MPS I-H) PatientsAfter Hematopoietic Stem Cell Transplantation (HSCT)

Gupta, A. O. (PI)

SANOFI-AVENTIS US

1/9/20 → 12/31/20

Project: Research project

Development of NK Cell Therapeutics

Miller, J. S. (PI), Cichocki, F. M. (CoI) & Felices, M. (CoI)

FATE THERAPEUTICS, INC.

1/1/20 → 12/31/22

Project: Research project

Nongenotoxic Conditioning for Gene Therapy and Allogeneic Transplantation in Fanconi Anemia

Blazar, B. R. (PI)

FRED HUTCHINSON CANCER CENTER, NIH NAT'L HEART, LUNG, AND BLOOD INSTITU

12/20/19 → 11/30/21

Project: Research project

Antiviral Cellular Therapy for Enhancing T-cell Reconstitution Following Hematopoietic Stem CellTransplantation (ACES)

Ebens, C. (PI)

CHILDREN'S HOSPITAL LOS ANGELES, CALIFORNIA INST. FOR REGENERATIVE MED.

12/12/19 → 12/19/21

Project: Research project

Determining the cell of origin in Ewing sarcoma through genomic analysis

Spector, L. G. (PI), Pankratz, N. D. (CoI) & Webber, B. R. (CoI)

NIH NATIONAL CANCER INSTITUTE (NCI)

12/6/19 → 11/30/22

Project: Research project

Targeting mechanisms contributing to vascular dysfunction and pain in sickle cell disease

Guedes, A. (PI), Belcher, J. D. (CoI) & Vercellotti, G. M. (CoI)

UNIVERSITY OF CALIFORNIA, IRVINE, NATIONAL INSTITUTES OF HEALTH (NIH)

12/5/19 → 3/31/23

Project: Research project

Naturally inspired approach to preserving cellular therapies

Hubel, A. (PI)

THE NATIONAL SCIENCE FOUNDATION

12/1/19 → 5/31/21

Project: Research project

BMT Outcomes

Weisdorf, D. J. (PI) & El Jurdi, N. (CoI)

INCYTE CORPORATION

11/20/19 → 11/20/21

Project: Research project

PACT - Preclinical development of PB-drevived iTregs

McKenna, D. H. (PI)

NIH NAT'L HEART, LUNG, AND BLOOD INSTITU

11/1/19 → 3/31/22

Project: Research project

Creation and Characterization of a Biopolymer-bioink Hybrid Tissue Engineered Vascular Graft

Panoskaltsis-Mortari, A. (PI)

MEDTRONIC INC

10/1/19 → 2/28/21

Project: Research project

Incyte Research Consulting

Weisdorf, D. J. (PI)

INCYTE CORPORATION

9/26/19 → 9/25/20

Project: Research project

Circulating Endothelial Cells and Microvesicles as Biomarkers for Gene Therapy in Sickle Cell Disease

Belcher, J. D. (PI), Beckman, J. D. (CoI), Hebbel, R. P. (CoI) & Vercellotti, G. M. (CoI)

NIH NAT'L HEART, LUNG, AND BLOOD INSTITU

9/20/19 → 6/30/21

Project: Research project

Preclinical Studies in Pluripotent Stem Cell-Derived Myogenic Progenitors to Enable a First-in-Human Phase 1 Safety/Dose Escalation Trial for Duchenne Muscular Dystrophy

Perlingeiro, R. (PI), Karachunski, P. I. (CoI), McKenna, D. H. (CoI), Schumacher, R. J. (CoI) & Wagner, J. E. (CoI)

DUCHENNE UK

9/15/19 → 7/31/23

Project: Research project

Stem Cells for Treating Acute Stroke

Low, W. C. (PI), Grande, A. (CoI), Hubel, A. (CoI), Jagadeesan, B. D. (CoI) & McKenna, D. H. (CoI)

SANERON CCEL THERAPEUTICS, INC., NIH NAT INST OF NEURO DISORDERS & STROKE

9/15/19 → 2/28/23

Project: Research project

An Open-Label, Single-Arm, Multicenter Study of Combination anti-CD3/CD7 Immunotoxin (T-Guard) for Steroid-Refractory Acute Graft-versus-Host Disease.

MacMillan, M. L. (PI)

NATIONAL MARROW DONOR PROGRAM

9/13/19 → 3/31/21

Project: Research project

Pediatric Ohio-New York Cancer (Peds-ONC) Immunotherapy Center

Moriarity, B. S. (PI)

NATIONWIDE CHILDREN'S HOSPITAL, NIH NATIONAL CANCER INSTITUTE (NCI)

9/12/19 → 8/31/24

Project: Research project

m6A mRNA modifications and myogenesis

Kikyo, N. J. (PI)

NIH NIAMS NATL INST OF ARTHRIT

9/9/19 → 8/31/22

Project: Research project

Biomarkers in MPS

Lund, T. C. (PI)

SHIRE HUMAN GENETIC THERAPIES, INC.

9/3/19 → 6/25/20

Project: Research project

Exposure-response of combination pre-transplant conditioning (cPTC) regiments in pediatric patientsundergoing hematopoietic cell transplantation (HCT) Master PK Protocol

Gupta, A. O. (PI)

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

9/1/19 → 6/30/24

Project: Research project

An Open-Label, Single-Arm, Phase 1/2 Study Evaluating the Safety and Efficacy of Itacitinib in Combination With Corticosteroids for the Treatment of Steroid-Naive Acute Graft-Versus-Host Disease inPediatric Subjects

MacMillan, M. L. (PI)

INCYTE CORPORATION

9/1/19 → 8/31/23

Project: Research project

Services Agreement Rider for Painless Bone Marrow Harvest Project

Wagner, J. E. (PI)

NATIONAL MARROW DONOR PROGRAM

9/1/19 → 6/19/20

Project: Research project

T Cell Costimulatory Pathways: Functions and Interactions (Project 2 -- Role of Novel Pathways in Regulating Allogeneic Immune Responses)

Blazar, B. R. (PI)

HARVARD MEDICAL SCHOOL, NIH Nat'l Inst of Allergy & Infect Dis

9/1/19 → 8/31/24

Project: Research project

PRescribing INterventions for Chronic pain via the Electronic medical record (PRINCE)

Golberstein, E. (PI), Karaca Mandic, P. (CoI), Markowitz, R. L. (CoI), Melton-Meaux, G. B. (CoI), Neprash, H. T. (CoI), Rothman, A. J. (CoI), Satin, D. J. (CoI) & Vock, D. M. (CoI)

NIH NIDA NATL INST ON DRUG AB

9/1/19 → 8/31/24

Project: Research project

Project 2: (Bhatia/Bhatia) Therapy-related leukemia following autologous transplantation for lymphoma

Weisdorf, D. J. (PI) & Arora, M. (Prior Principal Investigator)

THE UNIVERSITY OF ALABAMA AT BIRMINGHAM, NIH NATIONAL CANCER INSTITUTE (NCI)

9/1/19 → 8/31/23

Project: Research project

MASTER: National Marrow Donor Program Services Agreement

Wagner, J. E. (PI)

NATIONAL MARROW DONOR PROGRAM

9/1/19 → 6/19/20

Project: Research project

A Clinical Indications Prediction (CLIP) Scale for Human Mesenchymal Stem Cells

McKenna, D. H. (PI)

SCRIPPS RESEARCH INSTITUTE DBA CALIBR, NIH NAT'L HEART, LUNG, AND BLOOD INSTITU

9/1/19 → 4/1/22

Project: Research project

An open-label, multicenter study in male pediatric patients with cerebral x-linked adrenoleukodystrophy (cald) to assess the effects of min-102 treatment on disease progression prior to human stem cell transplant (hsct)

Orchard, P. J. (PI)

MINORYX THERAPEUTICS

8/22/19 → 7/1/21

Project: Research project

A Double-Blind Placebo-Controlled Phase 2 Study of VE303 for Prevention of Recurrent Clostridium(Clostridioides) Difficile Infection

Young, J.-A. H. (PI)

VEDANTA BIOSCIENCES, INC

8/22/19 → 8/30/24

Project: Research project

A Phase 2 Randomized, Dose-blind, Multicenter Study to Evaluate the Safety and Efficacy of KZR-616 in the Treatment of Patients with Autoimmune Hemolytic Anemia and Immune Thrombocytopenia

Vercellotti, G. M. (PI) & Mazepa, M. (Prior Principal Investigator)

KEZAR LIFE SCIENCES, INC

8/20/19 → 9/1/20

Project: Research project

MT2019-09: A randomized trial of low versus moderate exposure busulfan for infants with severecombined immunodeficiency (SCID) receiving TCR????+/CD19+ depleted transplantation: A Phase II studyby the Primary Immune Deficiency Treatment Consortium (PID

Ebens, C. (PI) & Smith, A. R. (Prior Principal Investigator)

CHILDREN'S HOSPITAL LOS ANGELES, NIH Nat'l Inst of Allergy & Infect Dis

8/16/19 → 5/31/24

Project: Research project

Preclinical Testing of Tunable Cytokine Receptors

Moriarity, B. S. (PI) & Felices, M. (CoI)

OBSIDIAN THERAPEUTICS, INC

8/14/19 → 1/22/21

Project: Research project

CD133-Targeted Natural Killer Cell Therapy for Aggressive Prostate Cancer

LeBeau, A. (PI) & Moriarity, B. S. (CoI)

U.S. DEPARTMENT OF DEFENSE

8/1/19 → 4/30/21

Project: Research project

Novel Intervention Approaches to Alleviate Allogeneic Transplant-Related Morbidity and Mortality

Weisdorf, D. J. (PI) & Arora, M. (Prior Principal Investigator)

FRED HUTCHINSON CANCER CENTER, NIH NATIONAL CANCER INSTITUTE (NCI)

8/1/19 → 3/31/22

Project: Research project

A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Clinical Outcomes, Antiviral Activity, Safety, Tolerability, Pharmacokinetics, and Pharmacokinetics/Pharmacodynamics of JNJ-53718678 in Adult and Adolescent Hematopoietic Stem Cell Tran

Young, J.-A. H. (PI)

JANSSEN RESEARCH & DEVELOPMENT, LLC

7/31/19 → 7/31/24

Project: Research project

Multilineage 3-dimensional Brain Organoids to Model Intracranial Pressure Linked to Chronic Traumatic Encephalopathy

Crane, A. T. (PI) & O'Brien, T. D. (CoI)

MN OFFICE OF HIGHER EDUCATION

7/23/19 → 6/30/22

Project: Research project

A Phase 2, Open-Label, Single-ArmStudy to Evaluate the Efficacy and Safety of Camidanlumab Tesirine (ADCT-301) in Patientswith Relapsed or Refractory Hodgkin Lymphoma

Bachanova, V. (PI)

ADC THERAPEUTICS SA

7/16/19 → 7/31/24

Project: Research project

Enhancing the ability of natural killer cells to kill renal cell carcinoma

Merino, A. M. (PI)

AMERICAN SOCIETY OF CLINICAL ONCOLOGY

7/1/19 → 12/31/20

Project: Research project

Longterm Follow-up of Subjects With Cerebral Adrenoleukodystrophy Who Were Treated With Lenti-D Drug Product

Orchard, P. J. (PI)

BLUEBIRD BIO, INC.

7/1/19 → 6/30/24

Project: Research project

Regulation of hypoxic response by HIF isomerization

Kikyo, N. J. (PI)

NIH NATIONAL CANCER INSTITUTE (NCI)

7/1/19 → 6/30/22

Project: Research project

IMD-002: A FOLLOW-UP STUDY TO EVALUATE THE SAFETY AND CLINICAL OUTCOMES OF PATIENTS WITH NON-MALIGNANT DISEASES WHO HAVE UNDERGONE HEMATOPOIETIC STEM CELL TRANSPLANTATION WITH MGTA-456

Orchard, P. J. (PI)

MAGENTA THERAPEUTICS

7/1/19 → 6/30/24

Project: Research project

iNK research, SOW8

McKenna, D. H. (PI)

FATE THERAPEUTICS, INC.

7/1/19 → 3/31/22

Project: Research project

An Interventional, Multicenter, Single Arm, Phase I/IIA Clinical Trial to Investigate the Efficacy and Safety of Allo-APZ2-EB on Epidermolysis Bullosa (EB)

Ebens, C. (PI)

RHEACELL GMBH & CO KG

7/1/19 → 6/30/24

Project: Research project

A Phase 2, multicenter, randomized, placebo-controlled, doubleblind study in patients with acquired thrombotic thrombocytopenic purpura (aTTP) to evaluate the pharmacokinetics, safety, and efficacy of rADAMTS-13 (SHP655) administered in addition to stand

Datta, Y. H. (PI) & Mazepa, M. (Prior Principal Investigator)

BAXALTA US INC.

7/1/19 → 7/30/24

Project: Research project

Development of Cellular Products for Allogeneic Transplantation

Wagner, J. E. (PI) & Blazar, B. R. (CoI)

BLUEROCK THERAPEUTICS GP LLC

6/19/19 → 6/18/22

Project: Research project

Training for the Adult Subspecialist in Inherited Metabolic Disorders

Braunlin, E. A. (PI) & Orchard, P. J. (CoI)

GENZYME CORPORATION

6/17/19 → 6/17/19

Project: Research project

Optimizing cervical cancer screening for HPV-vaccinated women: Evaluation of post-vaccination cervical cancer screening test

Teoh, D. G. (PI), Kulasingam, S. L. (CoI), Melton-Meaux, G. B. (CoI) & Vogel, R. (CoI)

U.S. DEPT OF HEALTH & HUMAN SERV AHRQ

6/1/19 → 5/31/21

Project: Research project

Transplant and Cellular Therapy

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