Transplant and Cellular Therapy

Active

HM2023-05: GTB-3650 (CD16/IL-15/CD33) Tri-Specific Killer Engager (TriKE??) for the Treatment of High Risk Myelodysplastic Syndromes (MDS), Refractory/Relapsed Acute Myeloid Leukemia (AML), and Minimal Residual Disease in AML

Juckett, M. B. (PI)

GT BIOPHARMA, INC

11/18/24 → 10/31/33

Project: Research project

Circumventing Pediatric Solid Tumor Microenvironment Resistance by Combinatorial CAR NK and Immunomodulating Therapy

Miller, J. S. (PI)

NEW YORK MEDICAL COLLEGE, ALEX'S LEMONADE STAND FOUNDATION

11/1/24 → 10/31/25

Project: Research project

Allogeneic, multiplex base edited, dual-targeted gamma delta CAR-T cell development for metastatic castration-resistant prostate cancer

Moriarity, B. S. (PI) & Webber, B. R. (CoI)

US DEPT OF DEFENSE ARMY

9/30/24 → 9/29/27

Project: Research project

MT2024-06: Phase 1/2 Study of Donor-Derived Anti-CD33 Chimeric Antigen Receptor Expressing T Cells(VCAR33) in Patients with Relapsed or Refractory Acute Myeloid Leukemia After Allogeneic HematopoieticCell Transplantation

Maakaron, J. (PI)

VOR BIOPHARMA, INC

8/12/24 → 2/28/34

Project: Research project

Immune Cell therapy for RDEB

Tolar, J. (PI) & Osborn, M. J. (CoI)

CURE EB

7/22/24 → 7/21/25

Project: Research project

MT2024-01:A First-In-Human, Open-Label, Multicenter Study of VOR33 in Patients with Acute Myeloid Leukemia who are at High-Risk for Leukemia Relapse following Hematopoietic Cell Transplantation

Maakaron, J. (PI)

VOR BIOPHARMA, INC

7/10/24 → 9/30/25

Project: Research project

Trapping Inhibitory Signals in Synergy with Cytokine Signaling to Maximize NK Cell Immunotherapy in Ovarian Cancer

Geller, M. A. (PI) & Vogel, R. (CoI)

US DEPT OF DEFENSE ARMY

7/1/24 → 6/30/28

Project: Research project

ALD Mouse Gavage Project

Lund, T. C. (PI)

CELLARITY, INC

7/1/24 → 6/30/25

Project: Research project

Trapping Inhibitory Signals in Synergy with Cytokine Signaling to Maximize NK Cell Immunotherapy in Ovarian Cancer

Felices, M. (PI) & Miller, J. S. (CoI)

US DEPT OF DEFENSE ARMY

7/1/24 → 6/30/28

Project: Research project

A randomized, double-blind, placebo- controlled study of LMN-201 for prevention of C. difficile infection recurrence (RePreve)

Young, J.-A. H. (PI)

Lumen Biomedical, Inc.

6/5/24 → 6/5/35

Project: Research project

Effects of ATIII and C1-INH therapy on thrombo-inflammation and vaso-occlusion in sickle cell disease mice

Belcher, J. D. (PI) & Vercellotti, G. M. (CoI)

OCTAPHARMA USA, INC.

6/1/24 → 9/30/25

Project: Research project

MT2014-05: A Phase I, First in Human Open Label Study to Evaluate the Safety and Tolerability of TRX103cell infusion in subjects with hematological malignancies undergoing HLA-mismatched related orunrelated hematopoietic stem cell transplantation (HSCT

Juckett, M. B. (PI)

TR1X, INC

4/30/24 → 1/31/34

Project: Research project

Wastewater Surveillance Testing

Osborn, M. J. (PI) & Doss, C. R. (CoI)

MN DEPARTMENT OF HEALTH, U.S. DEPARTMENT OF HEALTH & HUMAN SVCS

4/8/24 → 7/31/26

Project: Research project

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE 3 STUDY OF VE303 FORPREVENTION OF RECURRENT CLOSTRIDIOIDES DIFFICILE INFECTION:THE RESTORATIVE303 STUDY

Young, J.-A. H. (PI)

VEDANTA BIOSCIENCES, INC

4/4/24 → 4/30/34

Project: Research project

Developing Data-Driven Clinical Signatures for People who Experience Hallucinations

Pakhomov, S. V. (PI) & Michalowski, M. (CoI)

UNIVERSITY OF WASHINGTON, NATIONAL INSTITUTES OF HEALTH (NIH)

4/2/24 → 1/31/29

Project: Research project

Dissecting mechanisms of sensitivity to B7-H3 (CD276)-targeted therapeutics in prostate cancer (PC)

Hwang, J. (PI), Antonarakis, E. (CoI) & Zorko, N. A. (CoI)

NIH NATIONAL CANCER INSTITUTE (NCI)

4/1/24 → 3/31/29

Project: Research project

Phase 1 Clinical Trial of Myogenic Progenitors for DMD

Kang, P. B. (PI), Cheng, E. Y. (CoI), Karachunski, P. I. (CoI), McKenna, D. H. (CoI), Perlingeiro, R. (CoI) & Wagner, J. E. (CoI)

DUCHENNE UK

3/4/24 → 3/3/27

Project: Research project

Center for Functional Genomics of Immunotherapy (CFGI)

Largaespada, D. A. (PI), Moriarity, B. S. (CoI) & Stromnes, I. M. (CoI)

STATE OF MINNESOTA

3/1/24 → 3/31/26

Project: Research project

Transforming treatment of inherited bone marrow failure in Fanconi anemia by in vivo precise genome editing

Moriarity, B. S. (PI), Wagner, J. E. (CoI) & Webber, B. R. (CoI)

FANCONI CANCER FOUNDATION

2/1/24 → 1/31/26

Project: Research project

Improving safety and access to immune effector cell therapy with artificial intelligence technology???

Bachanova, V. (PI)

NIH NATIONAL CANCER INSTITUTE (NCI)

2/1/24 → 1/31/26

Project: Research project

Cancer Center Support Grant

Yee, D. (PI), Antonarakis, E. (CoI), Beckman, K. B. (CoI), Betts, B. (CoI), Blaes, A. H. (CoI), Eaton, A. (CoI), Ellis, K. M. (CoI), Felices, M. (CoI), Geller, M. A. (CoI), Ghebre, R. G. (CoI), Griffin, T. J. (CoI), Hallstrom, T. C. (CoI), Harki, D. A. (CoI), Hatsukami, D. K. (CoI), Hirsch, B. A. (CoI), Huang, R. S. S. (CoI), Johnson, S. (CoI), Juckett, M. B. (CoI), Lange, C. A. (CoI), Le, C. T. (CoI), Luo, X. (CoI), McKenna, D. H. (CoI), Miller, J. S. (CoI), Moriarity, B. S. (CoI), Muretta, J. M. (CoI), Murray, T. (CoI), Nelson, H. H. (CoI), Ondrey, F. G. (CoI), Patel, M. R. (CoI), Pennell, C. A. (CoI), Petersen, A. J. (CoI), Peterson, L. A. (CoI), Poynter, J. (CoI), Pratt, R. J. (CoI), Sarver, A. L. (CoI), Schendzielos, D. L. (CoI), Schilz, A. (CoI), Schwertfeger, K. (CoI), Seelig, D. (CoI), Shimizu, Y. (CoI), Stepanov, I. (CoI), Temiz, N. A. (CoI), Ventz, S. (CoI), Villalta, P. W. (CoI), Vogel, R. (CoI), Wagner, J. E. (CoI), Wang, J. (CoI), Webber, B. R. (CoI), Weigel, B. J. (CoI), Yamamoto, M. (CoI) & Zhang, L. (CoI)

NIH NATIONAL CANCER INSTITUTE (NCI)

2/1/24 → 1/31/29

Project: Research project

Ice Control Enhancement with Closed Loop Molecular Design (ICECycle)

Hubel, A. (PI)

UNIVERSITY OF MICHIGAN, USDOD DEFENSE ADV RES PROJECTS

1/26/24 → 7/25/25

Project: Research project

OPTIMIZE: A Phase II Study of Reduced Dose Post Transplantation Cyclophosphamide as GvHDProphylaxis in Adult Patients with Hematologic Malignancies Receiving HLA-Mismatched Unrelated DonorPeripheral Blood Stem Cell Transplantation

Juckett, M. B. (PI)

NATIONAL MARROW DONOR PROGRAM

1/23/24 → 1/22/34

Project: Research project

Phase 1/2 Study of REGN5668 (MUC16 X CD28, a Costimulatory Bispecific) Administered in Combination with Cemiplimab or REGN4018 (MUC16 X CD3)

Geller, M. A. (PI)

REGENERON PHARMACEUTICALS, INC.

1/17/24 → 1/17/34

Project: Research project

Learning Health System Embedded Scientist Training and Research (LHS E-STaR) of the North (LEaRN)

Beebe, T. J. (PI), Dudley, A. (CoI), Fu, S. S. (CoI), Gaugler, J. E. (CoI), Johnson, K. (CoI), Melton-Meaux, G. B. (CoI) & Shippee, N. D. (CoI)

U.S. DEPT OF HEALTH & HUMAN SERV AHRQ

1/1/24 → 12/31/28

Project: Research project

Development and Pilot Testing of a mLearning Intervention to Address Sexual Health Needs of Gynecologic Cancer Survivors

Girard, A. (PI), Geller, M. A. (CoI), Pratt, R. J. (CoI), Rider, G. N. (CoI) & Vogel, R. (CoI)

AMERICAN CANCER SOCIETY, INC

1/1/24 → 12/31/27

Project: Research project

Preclinical Testing of Therapeutic Candidates

Schumacher, R. J. (PI)

CELCUITY LLC

1/1/24 → 12/31/29

Project: Research project

Orthogonal IL2 Receptor Transduced Regulatory T Cells for Clinical Application

Blazar, B. R. (PI) & Hippen, K. L. (CoI)

STANFORD UNIVERSITY, CALIFORNIA INST. FOR REGENERATIVE MED.

1/1/24 → 12/31/25

Project: Research project

A Phase 3, Multicenter, Randomized, Double-Blind Study of the Efficacy and Safety of Rezafungin forInjection Versus the Standard Antimicrobial Regimen to Prevent Invasive Fungal Diseases in AdultsUndergoing Allogeneic Blood and Marrow Transplantation

Young, J.-A. H. (PI)

CIDARA THERAPEUTICS, INC.

12/14/23 → 12/31/33

Project: Research project

Rocuronium Bromide for Non Melanoma Skin Cancer Prevention

Bode, A. M. (PI), Gurvich, V. J. (CoI), Schumacher, R. J. (CoI) & Zhang, T. (CoI)

VENN FOUNDATION

12/1/23 → 11/30/25

Project: Research project

Aerosolized Thyroid Hormone Treatment of Acute Lung Injury & Pulmonary Edema

Ingbar, D. H. (PI) & Schumacher, R. J. (CoI)

DR. RALPH & MARIAN FALK MED RES TRUST

11/30/23 → 11/30/25

Project: Research project

AN INTERVENTIONAL PHASE 2/3, ADAPTIVE, MULTI-CENTER, RANDOMIZED, DOUBLE-BLIND STUDY TOINVESTIGATE EFFICACY AND SAFETY OF ORAL SISUNATOVIR COMPARED WITH PLACEBO INNONHOSPITALIZED SYMPTOMATIC ADULTS WITH RESPIRATORY SYNCYTIAL VIRUS INFECTION WHOARE AT

Young, J.-A. H. (PI)

PFIZER, INC.

11/7/23 → 6/30/25

Project: Research project

A Phase 2, Single-Arm Study of the CXCR1/2 Inhibitor SX-682 Plus Enzalutamide in Men with Abiraterone-Resistant Metastatic Castration Resistant Prostate Cancer, the SYNERGY-201 Trial

Zorko, N. A. (PI)

SYNTRIX BIOSYSTEMS INC

11/1/23 → 11/30/33

Project: Research project

Pathogen Genomics Centers of Excellence (PGCoE) Network: Projects 2,7

Thielen, B. K. (PI)

MN DEPARTMENT OF HEALTH, CENTERS FOR DISEASE CONTROL & PREVENTION

10/16/23 → 8/31/25

Project: Research project

Pathogen Genomics Centers of Excellence (PGCoE) Network: Projects 1,3,4,5,6

Thielen, B. K. (PI)

MN DEPARTMENT OF HEALTH, CENTERS FOR DISEASE CONTROL & PREVENTION

10/16/23 → 8/31/25

Project: Research project

Base Editing and Prime Editing for HIV/SCD Cures

Osborn, M. J. (PI)

THE BROAD INSTITUTE, INC., BILL & MELINDA GATES FOUNDATION

10/1/23 → 9/30/26

Project: Research project

Development of an Off the Shelf Erythrocyte-Based Resuscitation Fluid for Hemostasis and Improved Oxygen Delivery

Osborn, M. J. (PI)

THE HENRY M. JACKSON FOUNDATION, U.S. DEPARTMENT OF DEFENSE

9/30/23 → 9/29/27

Project: Research project

Managing Perioperative Pain with Abdominal Laparoscopic Surgery: A Collaborative to Develop, Disseminate, and Evaluate Evidence-Based Practices (M-PALS Collaborative)

Southwell, B. J. (PI), Berg, A. A. (CoI), Butler, M. E. (CoI), Duval, S. (CoI), Evans, R. L. (CoI), Grande, S. (CoI), Huling, J. D. (CoI), Melton-Meaux, G. B. (CoI), Pestka, D. (CoI), Sultan, S. (CoI), Tignanelli, C. J. (CoI) & Wilt, T. J. (CoI)

DHHS FOOD & DRUG ADMINISTRATION (FDA)

9/25/23 → 9/24/26

Project: Research project

Human Organ-on-Chip Platforms for Assessment and Development of Countermeasures for Radiation Exposure

Panoskaltsis-Mortari, A. (PI), Azarin, S. M. (CoI), Bigliardi Qi, M. (CoI) & Ogle, B. M. (CoI)

THE GENEVA FOUNDATION, UNIFORMED SVC UNIV OF THE HEALTH SCI

9/25/23 → 9/24/27

Project: Research project

A Phase 2, Open-Label, Multi-Center Study of Innate Cell Engager AFM13 in Combination with Allogeneic Natural Killer Cells (AB-101) in Subjects with Recurrent or Refractory Hodgkin Lymphoma and CD30-Positive Peripheral T-Cell Lymphoma (LuminICE-203)

Maakaron, J. (PI)

AFFIMED GMBH

9/21/23 → 9/30/33

Project: Research project

Increasing access to cancer trials in Minnesota (InACT-MN)

Erickson, B. K. (PI), Geller, M. A. (CoI), Greeno, E. W. (CoI), Kratzke, R. A. (CoI), Ondrey, F. G. (CoI), Teoh, D. G. (CoI) & Yee, D. (CoI)

NIH NATIONAL CANCER INSTITUTE (NCI)

9/18/23 → 8/31/28

Project: Research project

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)

Blazar, B. R. (PI), Beebe, T. J. (CoI), Bellin, M. D. (CoI), Berge, J. M. (CoI), Billings, J. L. (CoI), Bischof, J. C. (CoI), Brearley, A. M. (CoI), Call, K. T. (CoI), Fu, S. S. (CoI), Fulkerson, J. (CoI), Guan, W. (CoI), Hardeman, R. R. (CoI), Haynes, D. A. (CoI), Henning-Smith, C. E. (CoI), Johnson, S. (CoI), Jones-Webb, R. J. (CoI), Kozhimannil, K. B. (CoI), Langworthy, B. (CoI), Lim, H. H. (CoI), Melton-Meaux, G. B. (CoI), Nunez, A. (CoI), Pakhomov, S. V. (CoI), Pieczkiewicz, D. S. (CoI), Randolph, A. C. (CoI), Riggs, S. (CoI), Rudser, K. (CoI), Schleiss, M. R. (CoI), Shen, S. (CoI), Vaughn, B. P. (CoI) & Vock, D. M. (CoI)

NIH NAT'L CTR FOR ADVANCING TRAN SCIENCE

9/18/23 → 7/31/30

Project: Research project

MT2023-36: A Postmarketing, Prospective, Multicenter, Observational, Long-Term Safety and EffectivenessRegistry Study of Patients with Cerebral Adrenoleukodystrophy (CALD) Treated with ElivaldogeneAutotemcel (Stargazer)

Lund, T. C. (PI)

BLUEBIRD BIO, INC.

9/14/23 → 9/30/33

Project: Research project

Retrospective Convenience Samples Collaboration

Young, J.-A. H. (PI)

ZEPTO LIFE TECHNOLOGY, LLC

9/6/23 → 9/6/26

Project: Research project

Analysis of long-term somatic and functional outcomes of hematopoietic cell transplantation (HCT) for alpha-mannosidosis, with consideration of prospects for gene therapy

Eisengart, J. (PI), Lund, T. C. (CoI) & Yund, B. D. (CoI)

INTL SOCIETY FOR MANNOSIDOSIS & RELATED

9/1/23 → 8/31/25

Project: Research project

REST-PSLL: Re-engineering Surgical Recovery and Transitions Using Technology Patient Safety Learning Laboratory

Melton-Meaux, G. B. (PI), Adam, T. J. (CoI), Marquard, J. L. (CoI), Martin, C. L. (CoI), Morse, L. (CoI), Pestka, D. (CoI), Tignanelli, C. J. (CoI) & Toure, D. (CoI)

U.S. DEPT OF HEALTH & HUMAN SERV AHRQ

9/1/23 → 6/30/27

Project: Research project

Development of a Data Platform in a Post-transplant Population with Cytomegalovirus: Patterns andOutcomes from a Non-Interventional Dataset (CMV OMNI-PLATFORM)

Young, J.-A. H. (PI)

TAKEDA CAMBRIDGE LTD

8/30/23 → 8/31/33

Project: Research project

A multi-center, randomized, active controlled clinical trial to evaluate the efficacy and safety of OTL-203 in subjects with mucopolysaccharidosis type I, Hurler syndrome (MPS-IH) compared to standard of care with allogeneic hematopoietic stem cell trans

Gupta, A. O. (PI)

ORCHARD THERAPEUTICS

8/14/23 → 8/30/33

Project: Research project

Long-term Follow-up of Subjects With Sickle Cell Disease Treated With ExVivo Gene Therapy Using Autologous Hematopoietic Stem Cells TransducedWith a Lentiviral Vector

Gupta, A. O. (PI)

BLUEBIRD BIO, INC.

8/8/23 → 8/31/33

Project: Research project

Engineering Protein Modulators of Notch Activation for CAR T-cell immunotherapy

Muretta, J. M. (PI), Allred, J. R. (CoI) & Gordon, W. R. (CoI)

NIH NATIONAL CANCER INSTITUTE (NCI)

8/1/23 → 7/31/26

Project: Research project

Transplant and Cellular Therapy

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