Toward Pharmacogenomics-Enabled Healthcare at Statewide Scale: Implementing Precision Medicine

Organization profile

Organization profile

Precision medicine is transforming the diagnosis and treatment of many diseases. The leading edge of precision medicine is pharmacogenomics (PGx)—a powerful tool using an individual’s genetic makeup to prescribe the correct medication, at the appropriate dose, at the right time. PGx reduces the risk of adverse drug reactions and maximizes the effectiveness of treatment for every patient. Yet despite its proven scientific basis, immense promise, and successful deployment by a small group of pioneering provider organizations, incorporating PGx into clinical practice across the nation has proved slow and challenging—even at advanced academic medical centers. This Grand Challenge project will take a statewide approach to deploying PGx, in order to bring the benefits of this major healthcare innovation to all Minnesotans and to launch the research and innovation needed to make Minnesota a national leader in PGx. As a strong, interdisciplinary team across multiple institutions in our state, we will systematically identify the barriers to PGx implementation and create evidence-based solutions. We will build on the work of our state’s early adopters of pharmacogenomics—Mayo Clinic and Children’s Minnesota—and forge a collaboration including urban and rural health care providers, large and small pharmacies, private and public institutions, and researchers at the University of Minnesota. The ultimate goal is to improve patient outcomes, reduce health care costs, and place our healthcare systems and state at the cutting edge of precision medicine research and implementation. Our project creates a framework for statewide PGx that will advance the work of multiple health systems caring for millions of patients. More details can be found at [].

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    Grand Challenges Research Awards: Phase 3


    Project: Grand Challenges

    Research Output

    Leading in dickensian times: Address of the president-elect at the 2019 AACP annual meeting

    Sorensen, T. D., Jan 1 2019, In : American journal of pharmaceutical education. 83, 6, p. 1414-1416 3 p., 7780.

    Research output: Contribution to journalArticle

    Primary care providers believe that comprehensive medication management improves their work-life

    Funk, K. A., Pestka, D. L., Roth, M. T., Carroll, J. K. & Sorensen, T. D., Jan 1 2019, In : Journal of the American Board of Family Medicine. 32, 4, p. 462-473 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations