Organization profile
Organization profile
Scientists at the UMN Stem Cell Institute study the basic biology of how stem cells work. The SCI faculty works in collaboration with many other areas in the University to lay the foundation for safe and effective treatments using stem cells. Scientists at the SCI performs research and do not treat patients directly. We bring together talent and expertise from across the University of Minnesota to use stem cell biology to advance regenerative medicine therapies for devastating disorders and to provide education and training for the stem cell scientists of tomorrow.
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
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SDG 2 Zero Hunger -
SDG 3 Good Health and Well-being -
SDG 5 Gender Equality -
SDG 6 Clean Water and Sanitation -
SDG 9 Industry, Innovation, and Infrastructure -
SDG 10 Reduced Inequalities -
SDG 14 Life Below Water -
SDG 15 Life on Land -
SDG 17 Partnerships for the Goals
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Collaborations and top research areas from the last five years
Profiles
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Optimizing non-viral delivery methods to support the manufacture of clinical grade oligodendrocyte progenitor cells
Dutton, J. R. (PI), Osborn, M. J. (CoI), Parr, A. M. (CoI), Renaud, A. C. (Other Role) & Wiesen, L. B. (Other Role)
MINNESOTA OFFICE OF HIGHER EDUCATION
9/1/25 → 6/30/26
Project: Research project
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Understanding SCA1 pathogenesis in human cerebellar organoids
Cvetanovic, M. (PI), Pacak, C. A. (CoI), Vasan, G. (CoI), Dutton, J. R. (Co-Principal Investigator), Walker, K. E. (Graduate Student), McCall, A. (Other Role), Renaud, A. C. (Other Role) & Zhang, Y. (Other Role)
NIH NAT INST OF NEURO DISORDERS & STROKE
7/1/25 → 6/30/27
Project: Research project
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A novel approach to restore functional TDP43 for the treatment of FTD and ALS
Chen, L. (PI), Dutton, J. R. (PI), Sachs, J. N. (PI), Braun, A. R. (CoI) & Nathan Kochen, N. (Graduate Student)
NIH NATIONAL INSTITUTE ON AGING
5/1/25 → 4/30/27
Project: Research project
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DMSO-free cryopreservation of hiPSC-derived cardiomyocytes: low temperature characterization and protocol development
Mallya, A. S., Burrows, T., Hsieh, J., Louwagie, T., Dutton, J. R., Ogle, B. M. & Hubel, A., Dec 2025, In: Stem Cell Research and Therapy. 16, 1, 301.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Dynein-driven regulation of postsynaptic membrane architecture and synaptic function
Neisch, A. L., Pengo, T., Avery, A. W., Li, M. G. & Hays, T. S., Mar 2025, In: Journal of cell science. 138, 5, jcs263844.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Examining the Roles of m6A Sites in mRNA Using the Luciferase Gene Fused With Mutated RRACH Motifs
Katoku-Kikyo, N. & Kikyo, N., Nov 5 2025, In: Bio-protocol. 15, 21, e5492.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Supporting data for "3D Printed Stem-Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds"
Han, G., Joung, D., Truong, V. T., Neitzke, C. C., Guo, S.-Z., Walsh, P., Monat, J. R., Meng, F., Park, S. H., Dutton, J. R., Parr, A. M. & McAlpine, M., Data Repository for the University of Minnesota, 2020
DOI: 10.13020/femp-z102, http://hdl.handle.net/11299/213681
Dataset
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Supporting data for "3D Printed Organ Models with Physical Properties of Tissue and Integrated Sensors"
Qiu, K., Zhao, Z., Haghiashtiani, G., Guo, S.-Z., He, M., Su, R., Zhu, Z., Bhuiyan, D. B., Murugan, P., Meng, F., Park, S. H., Chu, C. C., Ogle, B. M., Saltzman, D. A., Konety, B. R., Sweet, R. M. & McAlpine, M., Data Repository for the University of Minnesota, 2020
DOI: 10.13020/rbvt-5s33, http://hdl.handle.net/11299/213784
Dataset
Press/Media
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In ‘Groundbreaking’ Study, UMN Researchers 3D Print Working Heart Pump With Real Human Cells
7/15/20
1 item of Media coverage
Press/Media: Research