Pharmacy Research and Graduate Education

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Muscarinic Receptors Medicine & Life Sciences
N-Methylscopolamine Medicine & Life Sciences
Carbachol Medicine & Life Sciences
Neuroblastoma Medicine & Life Sciences
Cyclic GMP Medicine & Life Sciences
Muscarinic Antagonists Medicine & Life Sciences
Brain Medicine & Life Sciences
Agmatine Medicine & Life Sciences

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Profiles

No photo of Esam E El-Fakahany

Esam E El-Fakahany

19792023
No photo of Carolyn A Fairbanks

Carolyn A Fairbanks

19822019

Projects 1982 2023

University of Minnesota Clinical and Translational Scien

Blazar, B. R., AbuSalah, A. M., Adam, T. J., Aliferis, MD, PhD, C., Allen, J. R., Beckman, K. B., Billings, J. L., Bloomfield, H. E., Bornsztein, B., Brearley, A. M., Call, K. T., Chi, C., Clancy, T. R., Connett, J. E., Daniels, B. S., Eder, M., El-Fakahany, E. E., Fischer, G., Fulkerson, J., Garwood, M., Georgopoulos, A. P., Guan, W., Henderson, J. N., Hodges, J. S., Ingbar, D. H., Jones-Webb, R. J., Jordan, C. M., Karypis, G., Knights, D., Kumar, V., LeBien, T. W., Lim, K. O., Ma, S., Melton-Meaux, G. B., Myers, C. L., Neuhauser, C., Oakes, M., Okuyemi, K., Pakhomov, S. V., Panoskaltsis-Mortari, A., Pieczkiewicz, D. S., Raymond, N. C., Riggs, S., Rudser, K., Ruggles, S., Schacker, T. W., Schleiss, M. R., Shekhar, S., Shen, S., Simon, G. J., Ugurbil, K., Vock, D. M., Volkov, B. B., Wang, J., Warren, J. R., Weber-Main, A. M., Weisdorf, D. J., Wolf, S. M., Zellmer-Bruhn, M. E. & Zhang, R.

NIH NAT'L CTR FOR ADVANCING TRAN SCIENCE

3/30/18 → 2/28/23

Project: Research project

science

Controlling Neuropathic Pain By Novel Non-Opioid Pharmac

Fairbanks, C. A., Mc Ivor, R. S. & Vulchanova, L.

U.S. DEPARTMENT OF DEFENSE

9/1/15 → 3/1/19

Project: Research project

Neuralgia
Pharmacology
Genes
Therapeutics

Inhibition of Opioid Tolerance

Fairbanks, C. A., Vulchanova, L., Wickman, K. D., Wilcox, G. L. & Mc Ivor, R. S.

NIH NIDA NATL INST ON DRUG AB

6/1/14 → 5/31/19

Project: Research project

Opioid Analgesics

Research Output 1979 2018

Role of membrane cholesterol in differential sensitivity of muscarinic receptor subtypes to persistently bound xanomeline

Randáková, A., Dolejší, E., Rudajev, V., Zimčík, P., Doležal, V., El-Fakahany, E. E. & Jakubík, J., May 1 2018, In : Neuropharmacology. 133, p. 129-144 16 p.

Research output: Contribution to journal › Article

xanomeline
Muscarinic Receptors
Cholesterol
Membranes
Isoleucine
2 Citations

Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors

Jakubík, J., Randáková, A., Zimčík, P., El-Fakahany, E. E. & Doležal, V., Jan 16 2017, In : Scientific reports. 7, 40381.

Research output: Contribution to journal › Article

N-Methylscopolamine
Muscarinic Receptors
Allosteric Site
Binding Sites
Quinuclidinyl Benzilate
2 Citations

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T. L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., Swedien, D. S., Stamschror, J. D., Alvarez, J., Luna, F., Galván, A., Bae, Y. K., Wulfkuhle, J. D., Gallagher, R. I., Petricoin, E. F., Norris, B. & 17 othersFlory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A., Oct 19 2017, In : Cell Chemical Biology. 24, 10, p. 1259-1275.e6

Research output: Contribution to journal › Article

Biguanides
Cytochrome P-450 CYP3A
Mitochondria
Heme
Cytochrome P-450 Enzyme System