Pharmacy Research and Graduate Education

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Muscarinic Receptors Medicine & Life Sciences
N-Methylscopolamine Medicine & Life Sciences
Carbachol Medicine & Life Sciences
Cyclic GMP Medicine & Life Sciences
Neuroblastoma Medicine & Life Sciences
Muscarinic Antagonists Medicine & Life Sciences
Brain Medicine & Life Sciences
Pirenzepine Medicine & Life Sciences

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No photo of Esam E El-Fakahany

Projects 1995 2023

Research Output 1979 2018

Role of membrane cholesterol in differential sensitivity of muscarinic receptor subtypes to persistently bound xanomeline

Randáková, A., Dolejší, E., Rudajev, V., Zimčík, P., Doležal, V., El-Fakahany, E. E. & Jakubík, J. May 1 2018 In : Neuropharmacology. 133, p. 129-144 16 p.

Research output: Contribution to journalArticle

Muscarinic Receptors
1 Citations

Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors

Jakubík, J., Randáková, A., Zimčík, P., El-Fakahany, E. E. & Doležal, V. Jan 16 2017 In : Scientific Reports. 7, 40381

Research output: Contribution to journalArticle

Muscarinic Receptors
Allosteric Site
Binding Sites
Quinuclidinyl Benzilate

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

Guo, Z. , Sevrioukova, I. F. , Denisov, I. G. , Zhang, X. , Chiu, T. L. , Thomas, D. G. , Hanse, E. A. , Cuellar, R. A. D. , Grinkova, Y. V. , Langenfeld, V. W. , Swedien, D. S. , Stamschror, J. D. , Alvarez, J. , Luna, F. , Galván, A. , Bae, Y. K. , Wulfkuhle, J. D. , Gallagher, R. I. , Petricoin, E. F. , Norris, B. & 17 others Flory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A. Oct 19 2017 In : Cell Chemical Biology. 24, 10, p. 1259-1275.e6

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System