Pediatric Infectious Diseases

MN DEPARTMENT OF HEALTH, CENTERS FOR DISEASE CONTROL & PREVENTION

10/16/23 → 8/31/25

Project: Research project

Component A: Longitudinal Surveillance of Congenital CMV Infections Identified by Newborn Screening

Schleiss, M. R. (PI), Baker-James, K. C. (CoI) & Jansen, R. J. (CoI)

CENTERS FOR DISEASE CONTROL & PREVENTION

9/30/23 → 9/29/27

Project: Research project

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)

Blazar, B. R. (PI), Beebe, T. J. (CoI), Bellin, M. D. (CoI), Berge, J. M. (CoI), Billings, J. L. (CoI), Bischof, J. C. (CoI), Brearley, A. M. (CoI), Call, K. T. (CoI), Fu, S. S. (CoI), Fulkerson, J. (CoI), Guan, W. (CoI), Hardeman, R. R. (CoI), Haynes, D. A. (CoI), Henning-Smith, C. E. (CoI), Johnson, S. (CoI), Jones-Webb, R. J. (CoI), Kozhimannil, K. B. (CoI), Langworthy, B. (CoI), Lim, H. H. (CoI), Melton-Meaux, G. B. (CoI), Nunez, A. (CoI), Pakhomov, S. V. (CoI), Pieczkiewicz, D. S. (CoI), Randolph, A. C. (CoI), Riggs, S. (CoI), Rudser, K. (CoI), Schleiss, M. R. (CoI), Shen, S. (CoI), Vaughn, B. P. (CoI) & Vock, D. M. (CoI)

NIH NAT'L CTR FOR ADVANCING TRAN SCIENCE

9/18/23 → 7/31/30

Project: Research project

Microbial-induced maternal factors that influence fetal immune development

Schuldt, N. (PI), Bierle, C. J. (CoI), Hamilton Hart, S. E. (CoI) & Subramanian, S. (CoI)

CHILDREN'S HOSPITALS & CLINICS OF MN

9/14/23 → 8/31/26

Project: Research project

Effect Modification of Racial Disparities in Pediatric COVID-19 Severity

Norton, L. E. (PI)

7/1/23 → 6/30/25

Project: Research project

A Phase 1/2a Open-Label Dose-Ranging and Observer-Blind Placebo-Controlled, Safety and Immunogenicity Study of mRNA-1647 Cytomegalovirus Vaccine in Female and Male Participants 9 to 15 Years of Age and Participants 16 to 25 Years of Age

1/20/23 → 1/17/27

Project: Research project

A Phase 1, Randomized, Observer-blind, Placebo-controlled, Age De-escalation Study of the Safety, Tolerability, and Immunogenicity of mRNA-1345 and mRNA-1365 in Participants Aged 5 months to <24 months

1/20/23 → 1/17/27

Project: Research project

Multi-Center Molecular Diagnosis and Host Response of Respiratory Viral Infections in Pediatric Transplant RecipientsTransplant Recipients

ARKANSAS CHILDREN'S RESEARCH INSTITUTE, NIH Nat'l Inst of Allergy & Infect Dis

10/27/22 → 8/31/26

Project: Research project

Trophoblast development and placental susceptibility to cytomegalovirus infection

Bierle, C. J. (PI) & Gearhart, M. D. (CoI)

IMMUNE DEFICIENCY FOUNDATION

8/9/22 → 4/30/27

Project: Research project

Transcriptomic Approaches to Diagnosis and Management of Inborn Errors of Immunity

Thielen, B. K. (PI), Albert, F. W. (CoI) & Billington, C. (CoI)

7/1/22 → 12/31/24

Project: Research project

Novel Platform for Preclinical Evaluation of Vaccine for Congenital CMV Infection

LIMMATECH BIOLOGICS AG

1/4/22 → 1/4/25

Project: Research project

Viral Vectored COVID-19 Vaccines in a Guinea Pig Perinatal Infection Model

11/1/21 → 10/31/24

Project: Research project

A Phase 3, Randomized, Observer-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety and Immunogenicity of mRNA-1647Cytomegalovirus (CMV) Vaccine in Healthy Participants 16 to 40 Years of Age

7/22/21 → 6/30/26

Project: Research project

The role of the microbiome in the outcome of human respiratory viral infections

MERCK AND CO INC

7/1/21 → 2/20/25

Project: Research project

A Phase 2/3, Two-Part, Open-Label, Dose-Escalation, AgeDe-escalation and Randomized, Observer-Blind, Placebo-Controlled Expansion Study to Evaluate the Safety, Tolerability, Reactogenicity, and Effectiveness of mRNA-1273 SARS-CoV-2 Vaccine in Healthy C

3/22/21 → 4/1/26

Project: Research project

Optimizing Immunity and Maternal Host Defense Against Congenital Cytomegalovirus Infection

Schleiss, M. R. (PI) & Bierle, C. J. (CoI)

9/1/19 → 5/31/25

Project: Research project

Finished

Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections

ARKANSAS CHILDREN'S RESEARCH INSTITUTE, NIH Nat'l Inst of Allergy & Infect Dis

10/24/22 → 5/31/24

Project: Research project

Targeted Clinical Research to Address Select Viral Infection -- Protocol: A Prospective Study of Acute Flaccid Myelitis (AFM) to define natural history, risk factors, and pathogenetic mechanisms, DMID Protocol Number 19-005

Schleiss, M. R. (PI) & Moen, A. M. (CoI)

THE UNIVERSITY OF ALABAMA AT BIRMINGHAM, NATIONAL INSTITUTES OF HEALTH (NIH)

9/1/22 → 5/31/24

Project: Research project

EHR Surveillance of Lower Respiratory Tract (LRTI) and Respiratory Syncytial Virus (RSV) LRTI in Infants

CHILDREN'S HEALTH CARE, MERCK AND CO INC

CLINETIC, INC

6/30/22 → 12/31/23

Project: Research project

Treatment of COVID-19 and Disparities in Outcomes by Race/Ethnicity and Comorbidities among a National Sample of Hospitalized Pediatric Patients in the United States

Norton, L. E. (PI)

11/1/21 → 8/31/23

Project: Research project

Repurposing the Antiviral Drug, Valganciclovir to Treat Cytomegalovirus-Induced Hearing Loss

THE UNIVERSITY OF UTAH, CURES WITHIN REACH

10/1/21 → 6/30/24

Project: Research project

Congenital and Perinatal Infections Rare Diseases Clinical Research Consortium (RDCRC)

Bierle, C. J. (PI)

THE UNIVERSITY OF ALABAMA AT BIRMINGHAM, NIH Nat'l Inst of Allergy & Infect Dis

9/1/21 → 8/31/22

Project: Research project

A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Rilematovir in Infants and Children (?28 Days to ?5 Years of Age) and Subsequently in Neonates (<28 Days of Age), Hospitalized With Acute Respiratory

JANSSEN RESEARCH & DEVELOPMENT, LLC

8/26/21 → 10/26/22

Project: Research project

Cytomegalovirus Surveillance Project

MN DEPARTMENT OF HEALTH, CENTERS FOR DISEASE CONTROL & PREVENTION

4/1/21 → 12/31/22

Project: Research project

FAST-CMV: A Point-of-Care Cytomegalovirus Serodiagnostic and Avidity Assay

LUNA INNOVATIONS INCORPORATED, NIH Nat'l Inst of Allergy & Infect Dis

11/1/19 → 4/30/23

Project: Research project

Coordinating Center for Research to Promote the Health of Children with Birth Defects and People with Developmental and Other Disabilities (Year 3)

Schleiss, M. R. (PI) & Osterholm, E. A. (CoI)

UNIVERSITY OF SOUTH CAROLINA, CENTERS FOR DISEASE CONTROL & PREVENTION

9/30/19 → 9/29/22

Project: Research project

Congenital and Perinatal Infections Rare Diseases Clinical Research Consortium (RDCRC)

Schleiss, M. R. (PI) & Moen, A. M. (CoI)

THE UNIVERSITY OF ALABAMA AT BIRMINGHAM, NIH Nat'l Inst of Allergy & Infect Dis

9/1/19 → 8/31/24

Project: Research project

Congenital cytomegalovirus infection, KIR genotypes, and

Spector, L. G. (PI) & Schleiss, M. R. (CoI)

NIH NATIONAL CANCER INSTITUTE (NCI)

4/1/18 → 4/1/22

Project: Research project

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)

Blazar, B. R. (PI), AbuSalah, A. M. (CoI), Adam, T. J. (CoI), Aliferis, MD, PhD, C. (CoI), Allen, J. (CoI), Beckman, K. B. (CoI), Billings, J. L. (CoI), Bloomfield, H. E. (CoI), Bornsztein, B. (CoI), Brearley, A. M. (CoI), Call, K. T. (CoI), Chi, C.-L. (CoI), Clancy, T. R. (CoI), Connett, J. E. (CoI), Daniels, B. S. (CoI), Eder, M. (CoI), El-Fakahany, E. E. (CoI), Fischer, G. (CoI), Fulkerson, J. (CoI), Garwood, M. (CoI), Georgopoulos, A. P. (CoI), Guan, W. (CoI), Henderson, J. N. (CoI), Hodges, J. S. (CoI), Ingbar, D. H. (CoI), Jones-Webb, R. J. (CoI), Jordan, C. (CoI), Karypis, G. (CoI), Knights, D. (CoI), Kumar, V. (CoI), LeBien, T. W. (CoI), Lim, K. O. (CoI), Ma, S. (CoI), Melton-Meaux, G. B. (CoI), Myers, C. L. (CoI), Neuhauser, C. (CoI), Oakes, M. (CoI), Okuyemi, K. (CoI), Pakhomov, S. V. (CoI), Panoskaltsis-Mortari, A. (CoI), Pieczkiewicz, D. S. (CoI), Raymond, N. C. (CoI), Riggs, S. (CoI), Rudser, K. (CoI), Ruggles, S. (CoI), Schacker, T. W. (CoI), Schleiss, M. R. (CoI), Shekhar, S. (CoI), Shen, S. (CoI), Simon, G. J. (CoI), Ugurbil, K. (CoI), Vock, D. M. (CoI), Volkov, B. B. (CoI), Wang, J. (CoI), Warren, R. (CoI), Weber-Main, A. M. (CoI), Weisdorf, D. J. (CoI), Wolf, S. M. (CoI), Zellmer-Bruhn, M. E. (CoI) & Zhang, R. (CoI)

NIH NAT'L CTR FOR ADVANCING TRAN SCIENCE

3/30/18 → 11/17/23

Project: Research project

FASTTM-CMV: A Point-of-Care Cytomegalovi rus Serodiagnos

LUNA INNOVATIONS INCORPORATED, NIH Nat'l Inst of Allergy & Infect Dis

8/1/17 → 7/31/18

Project: Research project

Randomized Controlled Trial of Valganciclovir for Asympt

THE UNIVERSITY OF UTAH, NATIONAL INSTITUTES OF HEALTH (NIH)

7/6/17 → 6/30/20

Project: Research project

Longitudinal Assessment of Asymptomatic Congenital CMV I

Schleiss, M. R. (PI), Georgieff, M. K. (CoI) & Nestrasil, I. (CoI)

MARCH OF DIMES FOUNDATION

6/1/17 → 7/31/18

Project: Research project

A Randomized, Double-Blind, Placebo-Controlled Clinical

MERCK AND CO INC

5/1/17 → 4/30/22

Project: Research project

Defining the viral determinants of cytomegalovirus trans

Bierle, C. J. (PI) & Schleiss, M. R. (CoI)

1/5/17 → 11/30/18

Project: Research project

Molecular characterization of culture-negative, PCR posi

LIVERPOOL SCHOOL OF TROPICAL MEDICINE, PFIZER, INC.

7/1/16 → 6/30/18

Project: Research project

Cytomegalovirus Surveillance Project

MN DEPARTMENT OF HEALTH, CENTERS FOR DISEASE CONTROL & PREVENTION

4/21/16 → 3/31/21

Project: Research project

Preclinical Evaluation of a Novel rLCMV Single-Cycled Ve

Schleiss, M. R. (PI) & Lokensgard, J. R. (CoI)

8/27/15 → 2/28/18

Project: Research project

Optimized vaccines against congenital infection and mate

8/6/15 → 5/31/22

Project: Research project

Integrated Newborn Screening Approach for Congenital CMV

CHILDREN'S HOSPITALS & CLINICS OF MN

7/1/15 → 2/1/17

Project: Research project

ELISPOT Peptide Mapping Assay to Identify Novel Candidat

3/1/15 → 2/28/18

Project: Research project

A Phase II, Randomized, Double-blind, Placebo-controlled

ANSUN BIOPHARMA, INC

2/1/14 → 12/31/20

Project: Research project

Novel Vectored Glycoprotein Immunization in Guinea Pigs

HOOKIPA BIOTECH GMBH

12/9/13 → 1/21/16

Project: Research project

An Open Label study to examine the effects of DAS181 adm

ANSUN BIOPHARMA, INC

8/13/13 → 12/31/20

Project: Research project

Erythrophagocytosis by endothelial cells infected with K

MN MED FDN

11/1/12 → 10/31/14

Project: Research project

The role of hypoxia in Kaposi sarcoma pathogenesis

MN MED FDN

11/1/12 → 10/31/14

Project: Research project

The immune pathogenesis of prenatal Listeria monocytogen

Way, S. S. (PI)

7/15/12 → 9/5/12

Project: Research project

Placental trophoblast infection and TLR mediated respons

McGregor, A. (PI) & Schleiss, M. R. (CoI)

7/5/12 → 1/1/13

Project: Research project

Development of an effective DISC vaccine strategy agains

McGregor, A. (PI) & Schleiss, M. R. (CoI)

7/1/12 → 1/1/13

Project: Research project

Vaccine against CMV endothelial tropism & congenital infection

McGregor, A. (PI), Choi, Y. (CoI) & Schleiss, M. R. (CoI)