Pediatric Epidemiology & Clinical Research

2022

A Narrative Review of Postoperative Anticoagulation Therapy for Congenital Cardiac Disease

Boucher, A. A., Heneghan, J. A., Jang, S., Spillane, K. A., Abarbanell, A. M., Steiner, M. E. & Meyer, A. D., Jun 14 2022, In: Frontiers in Surgery. 9, 907782.

Research output: Contribution to journal › Review article › peer-review

Open Access

Anti-obesity pharmacotherapy for treatment of pediatric type 2 diabetes: Review of the literature and lessons learned from adults

Bensignor, M. O., Kelly, A. S. & Arslanian, S., Oct 27 2022, In: Frontiers in Endocrinology. 13, 1043650.

Research output: Contribution to journal › Review article › peer-review

Open Access

Developing Bottom-Up Induced Pluripotent Stem Cell Derived Solid Tumor Models Using Precision Genome Editing Technologies

Becklin, K. L., Draper, G. M., Madden, R. A., Kluesner, M. G., Koga, T., Huang, M., Weiss, W. A., Spector, L. G., Largaespada, D. A., Moriarity, B. S. & Webber, B. R., Aug 1 2022, In: CRISPR Journal. 5, 4, p. 517-535 19 p.

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Germline De Novo Mutations as a Cause of Childhood Cancer

Rashed, W. M., Marcotte, E. L. & Spector, L. G., 2022, In: JCO Precision Oncology. 6

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Landscape of germline cancer predisposition mutations testing and management in pediatrics: Implications for research and clinical care

Shahani, S. A. & Marcotte, E. L., Sep 26 2022, In: Frontiers in Pediatrics. 10, 1011873.

Research output: Contribution to journal › Review article › peer-review

Open Access

Maternal Body Mass Index, Diabetes, and Gestational Weight Gain and Risk for Pediatric Cancer in Offspring: A Systematic Review and Meta-Analysis

Marley, A. R., Domingues, A., Ghosh, T., Turcotte, L. M. & Spector, L. G., Apr 1 2022, In: JNCI Cancer Spectrum. 6, 2, pkac020.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Scopus citations

Maternal obesity and acute lymphoblastic leukemia risk in offspring: A summary of trends, epidemiological evidence, and possible biological mechanisms

Marley, A. R., Ryder, J. R., Turcotte, L. M. & Spector, L. G., Oct 2022, In: Leukemia research. 121, 106924.

Research output: Contribution to journal › Review article › peer-review

Nutritional Status at Diagnosis as Predictor of Survival from Childhood Cancer: A Review of the Literature

Karalexi, M. A., Markozannes, G., Tagkas, C. F., Katsimpris, A., Tseretopoulou, X., Tsilidis, K. K., Spector, L. G., Schüz, J., Siahanidou, T., Petridou, E. T. & Ntzani, E. E., Oct 2022, In: Diagnostics. 12, 10, 2357.

Research output: Contribution to journal › Review article › peer-review

Open Access

Obesity in children and adolescents: epidemiology, causes, assessment, and management

Jebeile, H., Kelly, A. S., O'Malley, G. & Baur, L. A., May 2022, In: The Lancet Diabetes and Endocrinology. 10, 5, p. 351-365 15 p.

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

2021

Clinical approaches to minimize iatrogenic weight gain in children and adolescents

Sweeney, B., Kelly, A. S., San Giovanni, C. B., Kelsey, M. M. & Skelton, J. A., Feb 2021, In: Clinical obesity. 11, 1, e12417.

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

The Effects of Anti-obesity Pharmacotherapy Interventions on Psychosocial Factors Among Adolescents with Obesity: a Scoping Review

Dillard, J. R., Newsome, F. A., Kelly, A. S., Gross, A. C., Morgan-Daniel, J., Adkins, L. E., Madem, S. S. & Cardel, M. I., Mar 2021, In: Current Nutrition Reports. 10, 1, p. 58-70 13 p.

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

The Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screening

Marcotte, E. L., Spector, L. G., Mendes-de-Almeida, D. P. & Nelson, H. H., Apr 23 2021, In: Frontiers in Pediatrics. 9, 639479.

Research output: Contribution to journal › Review article › peer-review

Open Access

12 Scopus citations

2020

Development of paediatric non-stage prognosticator guidelines for population-based cancer registries and updates to the 2014 Toronto Paediatric Cancer Stage Guidelines

Gupta, S., Aitken, J., Bartels, U., Bhakta, N., Bucurenci, M., Brierley, J. D., De Camargo, B., Chokunonga, E., Clymer, J., Coza, D., Fraser, C., Fuentes-Alabi, S., Gatta, G., Gross, T., Jakab, Z., Kohler, B., Kutluk, T., Moreno, F., Nakata, K., Nur, S., & 13 othersParkin, D. M., Penberthy, L., Pole, J., Poynter, J. N., Pritchard-Jones, K., Ramirez, O., Renner, L., Steliarova-Foucher, E., Sullivan, M., Swaminathan, R., Van Eycken, L., Vora, T. & Frazier, A. L., Sep 2020, In: The Lancet Oncology. 21, 9, p. e444-e451

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Obesity Treatment among Adolescents: A Review of Current Evidence and Future Directions

Cardel, M. I., Atkinson, M. A., Taveras, E. M., Holm, J. C. & Kelly, A. S., Jun 2020, In: JAMA Pediatrics. 174, 6, p. 609-617 9 p.

Research output: Contribution to journal › Review article › peer-review

78 Scopus citations

Prognostic Factors for Development of Subsequent Metastases in Localized Osteosarcoma: A Systematic Review and Identification of Literature Gaps

Basile, P., Greengard, E., Weigel, B. & Spector, L., 2020, In: Sarcoma. 2020, 7431549.

Research output: Contribution to journal › Review article › peer-review

Open Access

10 Scopus citations

2019

Cardiovascular Risks and Benefits of Medications Used for Weight Loss

Bramante, C. T., Raatz, S., Bomberg, E. M., Oberle, M. M. & Ryder, J. R., 2019, In: Frontiers in Endocrinology. 10, p. 883

Research output: Contribution to journal › Review article › peer-review

Open Access

7 Scopus citations

Clinical Considerations Regarding the Use of Obesity Pharmacotherapy in Adolescents with Obesity

Srivastava, G., Fox, C. K., Kelly, A. S., Jastreboff, A. M., Browne, A. F., Browne, N. T., Pratt, J. S. A., Bolling, C., Michalsky, M. P., Cook, S., Lenders, C. M. & Apovian, C. M., Feb 2019, In: Obesity. 27, 2, p. 190-204 15 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

61 Scopus citations

Is there etiologic heterogeneity between subtypes of childhood acute lymphoblastic leukemia? A review of variation in risk by subtype

Williams, L. A., Yang, J. J., Hirsch, B. A., Marcotte, E. L. & Spector, L. G., May 2019, In: Cancer Epidemiology Biomarkers and Prevention. 28, 5, p. 846-856 11 p.

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Medical conditions and modifiable risk factors for myelodysplastic syndrome: A systematic review

Sweeney, M. R., Applebaum, K. M., Arem, H., Braffett, B. H., Poynter, J. N. & Robien, K., Sep 1 2019, In: Cancer Epidemiology Biomarkers and Prevention. 28, 9, p. 1502-1517 16 p.

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Precision medicine in adult and pediatric obesity: a clinical perspective

Bomberg, E. M., Ryder, J. R., Brundage, R. C., Straka, R. J., Fox, C. K., Gross, A. C., Oberle, M. M., Bramante, C. T., Sibley, S. D. & Kelly, A. S., Jan 1 2019, In: Therapeutic Advances in Endocrinology and Metabolism. 10

Research output: Contribution to journal › Review article › peer-review

Open Access

13 Scopus citations

Risk factors for development of Canine and Human Osteosarcoma: A comparative review

Makielski, K. M., Mills, L. J., Sarver, A. L., Henson, M. S., Spector, L. G., Naik, S. & Modiano, J. F., Jun 1 2019, In: Veterinary Sciences. 6, 2, 48.

Research output: Contribution to journal › Review article › peer-review

Open Access

37 Scopus citations

Severe Obesity in the Pediatric Population: Current Concepts in Clinical Care

Fox, C. K., Gross, A., Bomberg, E. M., Ryder, J. R., Oberle, M. M., Bramante, C. T. & Kelly, A. S., Sep 15 2019, In: Current obesity reports. 8, 3, p. 201-209 9 p.

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

The Benefits and Risks of Iron Supplementation in Pregnancy and Childhood

Georgieff, M. K., Krebs, N. F. & Cusick, S. E., Aug 21 2019, In: Annual review of nutrition. 39, p. 121-146 26 p.

Research output: Contribution to journal › Review article › peer-review

54 Scopus citations

2018

An overview of disparities in childhood cancer: Report on the Inaugural Symposium on Childhood Cancer Health Disparities, Houston, Texas, 2016

Scheurer, M. E., Lupo, P. J., Schüz, J., Spector, L. G., Wiemels, J. L., Aplenc, R., Gramatges, M. M., Schiffman, J. D., Pombo-de-Oliveira, M. S., Yang, J. J., Heck, J. E., Metayer, C., Orjuela-Grimm, M. A., Bona, K., Aristizabal, P., Austin, M. T., Rabin, K. R., Russell, H. V. & Poplack, D. G., Feb 17 2018, In: Pediatric hematology and oncology. 35, 2, p. 95-110 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

17 Scopus citations

Approaches for reducing the risk of early-life iron deficiency-induced brain dysfunction in children

Cusick, S. E., Georgieff, M. K. & Rao, R., Feb 17 2018, In: Nutrients. 10, 2, 227.

Research output: Contribution to journal › Review article › peer-review

Open Access

47 Scopus citations

Germline mutations as potential causes of childhood solid tumours: Comments on the Norwegian childhood cancer cohort study editorial

Ravindranath, Y. & Spector, L. G., Apr 1 2018, In: British Journal of Cancer. 118, 8, p. 1033-1034 2 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Nutritional influences on brain development

Georgieff, M. K., Ramel, S. E. & Cusick, S. E., Aug 2018, In: Acta Paediatrica, International Journal of Paediatrics. 107, 8, p. 1310-1321 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

98 Scopus citations

Treatment Options for Severe Obesity in the Pediatric Population: Current Limitations and Future Opportunities

Ryder, J. R., Fox, C. K. & Kelly, A. S., Jun 2018, In: Obesity. 26, 6, p. 951-960 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

43 Scopus citations

Working toward precision medicine approaches to treat severe obesity in adolescents: report of an NIH workshop

Kelly, A. S., Marcus, M. D., Yanovski, J. A., Yanovski, S. Z. & Osganian, S. K., Nov 1 2018, In: International Journal of Obesity. 42, 11, p. 1834-1844 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

22 Scopus citations

2017

Impact of Health Status and Lifestyle Modifications on Vascular Structure and Function in Children and Adolescents

Dengel, D. R. & Ryder, J. R., Jul 1 2017, In: American Journal of Lifestyle Medicine. 11, 4, p. 330-343 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Maternal fetal loss history and increased acute leukemia subtype risk in subsequent offspring: a systematic review and meta-analysis

Karalexi, M. A., Dessypris, N., Skalkidou, A., Biniaris-Georgallis, S. I., Kalogirou, Thomopoulos, T. P., Herlenius, E., Spector, L. G., Loutradis, D., Chrousos, G. P. & Petridou, E. T., Jun 1 2017, In: Cancer Causes and Control. 28, 6, p. 599-624 26 p.

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Pharmacotherapy in the Management of Pediatric Obesity

Kelly, A. S. & Fox, C. K., Aug 1 2017, In: Current diabetes reports. 17, 8, 55.

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Review of Childhood Obesity: From Epidemiology, Etiology, and Comorbidities to Clinical Assessment and Treatment

Kumar, S. & Kelly, A. S., Feb 1 2017, In: Mayo Clinic Proceedings. 92, 2, p. 251-265 15 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

680 Scopus citations

2016

Cardiovascular effects of bariatric surgery

Beamish, A. J., Olbers, T., Kelly, A. S. & Inge, T. H., Dec 1 2016, In: Nature Reviews Cardiology. 13, 12, p. 730-743 14 p.

Research output: Contribution to journal › Review article › peer-review

57 Scopus citations

Epidemiology of colorectal cancer

Marley, A. R. & Nan, H., 2016, In: International Journal of Molecular Epidemiology and Genetics. 7, 3, p. 105

Research output: Contribution to journal › Review article › peer-review

Imprinting defects in osteosarcoma: DNA- and chromatin-modifying drugs hold promise for osteosarcoma therapy

Sarver, A. E. & Subramanian, S., Jul 2016, In: Epigenomics. 8, 7, p. 885-888 4 p.

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Paediatric extracranial germ-cell tumours

Shaikh, F., Murray, M. J., Amatruda, J. F., Coleman, N., Nicholson, J. C., Hale, J. P., Pashankar, F., Stoneham, S. J., Poynter, J. N., Olson, T. A., Billmire, D. F., Stark, D., Rodriguez-Galindo, C. & Frazier, A. L., Apr 1 2016, In: The Lancet Oncology. 17, 4, p. e149-e162

Research output: Contribution to journal › Review article › peer-review

Open Access

41 Scopus citations

Pediatric obesity pharmacotherapy: Current state of the field, review of the literature and clinical trial considerations

Kelly, A. S., Fox, C. K., Rudser, K. D., Gross, A. C. & Ryder, J. R., Jul 1 2016, In: International Journal of Obesity. 40, 7, p. 1043-1050 8 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

51 Scopus citations

2015

A Catalog of Genetic Syndromes in Childhood Cancer

Zimmerman, R., Schimmenti, L. & Spector, L., Dec 2015, In: Pediatric Blood and Cancer. 62, 12, p. 2071-2075 5 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

12 Scopus citations

Family history of cancer and risk of pediatric and adolescent Hodgkin lymphoma: A Children's Oncology Group study

Linabery, A. M., Erhardt, E. B., Richardson, M. R., Ambinder, R. F., Friedman, D. L., Glaser, S. L., Monnereau, A., Spector, L. G., Ross, J. A. & Grufferman, S., Nov 1 2015, In: International Journal of Cancer. 137, 9, p. 2163-2174 12 p.

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Family history of cancer and risk of pediatric and adolescent Hodgkin lymphoma: A Children's Oncology Group study

Linabery, A. M., Erhardt, E. B., Richardson, M. R., Ambinder, R. F., Friedman, D. L., Glaser, S. L., Monnereau, A., Spector, L. G., Ross, J. A. & Grufferman, S., 2015, In: International Journal of Cancer. 137, 9, p. 2163-2174 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Genetic and nongenetic risk factors for childhood cancer

Spector, L. G., Pankratz, N. & Marcotte, E. L., Feb 1 2015, In: Pediatric clinics of North America. 62, 1, p. 11-25 15 p.

Research output: Contribution to journal › Review article › peer-review

118 Scopus citations

2013

Children's oncology Group's 2013 blueprint for research: Rare tumors

Rodriguez-Galindo, C., Krailo, M., Frazier, L., Chintagumpala, M., Amatruda, J., Katzenstein, H., Malogolowkin, M., Spector, L., Pashankar, F., Meyers, R. & Tomlinson, G., Jun 2013, In: Pediatric Blood and Cancer. 60, 6, p. 1016-1021 6 p.

Research output: Contribution to journal › Review article › peer-review