Obstetrics, Gynecology and Women's Health - Oncology

42 Active
127 Finished

1 - 50 out of 169 results

Active
DESTINY-Endometrial01: An Open-Label, Sponsor-Blinded, Randomized, Controlled, Multicenter, Phase III Study of Trastuzumab Deruxtecan (T-DXd) Plus Rilvegostomig or...
Geller, M. A. (PI)
ASTRAZENECA
5/1/25 → 4/30/36
Project: Research project
A phase 1a/b study to evaluate the safety and efficacy of OPB-101, an autologous mesothelin (MSLN) CAR T cell therapy with antigen-dependent expression of OUTSMART designed IL-2 cytokine in platinum-resistant ovarian cancer
Geller, M. A. (PI)
OUTPACE BIO, INC
3/20/25 → 3/19/35
Project: Research project
A PHASE 3, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND,MULTICENTER TRIAL OF SELINEXOR IN MAINTENANCE THERAPYAFTER SYSTEMIC THERAPY FOR PATIENTS WITH P53WILD-TYPE,ADVANCED OR RECURRENT ENDOMETRIAL CARCINOMA
Erickson, B. K. (PI)
KARYOPHARM THERAPEUTICS
3/3/25 → 5/12/35
Project: Research project
Hybrid Content Confirmation and Cognitive Debriefing Interviews of Patient-Reported Outcomes in Patients with Recurrent or Advanced Endometrial Cancer
Erickson, B. K. (PI)
LUMANITY PATIENT CENTERED OUTCOMES LLC
2/7/25 → 2/6/26
Project: Research project
CATALINA-2: A PHASE 2 STUDY EVALUATING THE EFFICACY AND SAFETY OF TORL-1-23 IN WOMEN WITH ADVANCED PLATINUM-RESISTANT EPITHELIAL OVARIAN CANCER (INCLUDING PRIMARY PERITONEAL AND FALLOPIAN TUBE CANCERS) EXPRESSING CLAUDIN 6
Winterhoff, B. J. (PI)
TORL BIOTHERAPEUTICS, LLC
12/4/24 → 12/3/35
Project: Research project
Characterize the metabolic landscape of ARID1A-mutated ovarian cancer
Bazzaro, M. (PI), Hoshino, A. (Other Role) & Shetty, M. J. (Other Role)
NIH NATIONAL CANCER INSTITUTE (NCI)
12/1/24 → 11/30/26
Project: Research project
UNTOLD: UNderstanding The experience of Ovarian cancer - Life after Diagnosis: A Mixed Methods Approach
Vogel, R. (PI), Blaes, A. H. (CoI), Girard, A. (CoI), Teoh, D. G. (CoI) & Brown, K. (Other Role)
CENTERS FOR DISEASE CONTROL & PREVENTION
9/30/24 → 9/29/26
Project: Research project
Single-Arm Phase II Study of Carboplatin and Mirvetuximab Soravtansine in First-Line Treatment ofPatients receiving Neoadjuvant Chemotherapy with Advanced-Stage Ovarian, Fallopian Tube or PrimaryPeritoneal Cancer who are Folate Receptor positive
Erickson, B. K. (PI)
THE UNIVERSITY OF ALABAMA, IMMUNOGEN, INC
9/1/24 → 8/31/27
Project: Research project
Stigmatizing Language in Cancer Care Electronic Health Records
Dona, A. C. (PI)
NATL INSTITUTE ON MINORITY HEALTH (NIH)
8/28/24 → 8/27/28
Project: Research project
A Randomized, Open-label, Phase 3 Study of Sacituzumab GovitecanVersus Treatment of Physician's Choice in Participants With Endometrial Cancer Who Have Received Prior Platinum-based Chemotherapy and Anti-PD-1/PD-L1 Immunotherapy
Erickson, B. K. (PI)
GILEAD SCIENCES, INC.
8/5/24 → 8/4/35
Project: Research project
GMP manufacturing of cytokine armored CAR-NK cells for the treatment of advanced epithelial ovarian cancer
Moriarity, B. S. (PI) & Geller, M. A. (Co-Principal Investigator)
MN OVARIAN CANCER ALLIANCE
8/1/24 → 7/31/25
Project: Research project
A Phase 2 Pan-tumor, Open-label Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects with Recurrent or Metastatic Solid Tumors (IDeate-5)
Teoh, D. G. (PI)
DAIICHI SANKYO, INC.
7/10/24 → 7/9/35
Project: Research project
Trapping Inhibitory Signals in Synergy with Cytokine Signaling to Maximize NK Cell Immunotherapy in Ovarian Cancer
Geller, M. A. (PI) & Vogel, R. (CoI)
US DEPT OF DEFENSE ARMY
7/1/24 → 6/30/28
Project: Research project
A Two-Arm Randomized, Double-Blind, Placebo-Controlled Phase 2 Selection Trial to Evaluate the Efficacy and Safety of VB10.16 Alone or in Combination with Atezolizumab in Patients with HPV16-Positive, PD-L1-positive...
Teoh, D. G. (PI)
NYKODE THERAPEUTICS ASA
6/10/24 → 6/9/35
Project: Research project
Cancer Center Support Grant
Yee, D. (PI), Antonarakis, E. (CoI), Beckman, K. B. (CoI), Betts, B. (CoI), Blaes, A. H. (CoI), Eaton, A. (CoI), Ellis, K. M. (CoI), Felices, M. (CoI), Geller, M. A. (CoI), Ghebre, R. G. (CoI), Griffin, T. J. (CoI), Hallstrom, T. C. (CoI), Harki, D. A. (CoI), Hatsukami, D. K. (CoI), Hirsch, B. A. (CoI), Huang, R. S. S. (CoI), Johnson, S. (CoI), Juckett, M. B. (CoI), Lange, C. A. (CoI), Le, C. T. (CoI), Luo, X. (CoI), McKenna, D. H. (CoI), Miller, J. S. (CoI), Moriarity, B. S. (CoI), Muretta, J. M. (CoI), Murray, T. (CoI), Nelson, H. H. (CoI), Ondrey, F. G. (CoI), Patel, M. R. (CoI), Pennell, C. A. (CoI), Petersen, A. J. (CoI), Peterson, L. A. (CoI), Poynter, J. (CoI), Pratt, R. J. (CoI), Sarver, A. L. (CoI), Schendzielos, D. L. (CoI), Schilz, A. (CoI), Schwertfeger, K. (CoI), Seelig, D. (CoI), Shimizu, Y. (CoI), Stepanov, I. (CoI), Temiz, N. A. (CoI), Ventz, S. (CoI), Villalta, P. W. (CoI), Vogel, R. (CoI), Wagner, J. E. (CoI), Wang, J. (CoI), Webber, B. R. (CoI), Weigel, B. J. (CoI), Yamamoto, M. (CoI) & Zhang, L. (CoI)
NIH NATIONAL CANCER INSTITUTE (NCI)
2/1/24 → 1/31/29
Project: Research project
Phase 1/2 Study of REGN5668 (MUC16 X CD28, a Costimulatory Bispecific) Administered in Combination with Cemiplimab or REGN4018 (MUC16 X CD3)
Geller, M. A. (PI)
REGENERON PHARMACEUTICALS, INC.
1/17/24 → 1/17/34
Project: Research project
Development and Pilot Testing of a mLearning Intervention to Address Sexual Health Needs of Gynecologic Cancer Survivors
Girard, A. (PI), Geller, M. A. (CoI), Pratt, R. J. (CoI), Rider, G. N. (CoI) & Vogel, R. (CoI)
AMERICAN CANCER SOCIETY, INC
1/1/24 → 12/31/27
Project: Research project
Ovarian Cancer Precision Medicine Initiative (OCPMI)
Winterhoff, B. J. (PI), Henzler, C. (CoI) & Nelson, A. C. (CoI)
ADELSON MEDICAL RESEARCH FOUNDATION
10/1/23 → 9/30/25
Project: Research project
Precision medicine for ARID1A-mutated ovarian cancer
Bazzaro, M. (PI) & Petersen, A. J. (CoI)
MN OVARIAN CANCER ALLIANCE
10/1/23 → 9/30/25
Project: Research project
Increasing access to cancer trials in Minnesota (InACT-MN)
Erickson, B. K. (PI), Geller, M. A. (CoI), Greeno, E. W. (CoI), Kratzke, R. A. (CoI), Ondrey, F. G. (CoI), Teoh, D. G. (CoI) & Yee, D. (CoI)
NIH NATIONAL CANCER INSTITUTE (NCI)
9/18/23 → 8/31/28
Project: Research project
Do Cytomegalovirus and Epstein-Barr virus infections exacerbate symptoms of cognitive decline following chemotherapy for ovarian cancer?
Vogel, R. (PI) & Geller, M. A. (CoI)
U.S. DEPARTMENT OF DEFENSE
7/15/23 → 7/14/25
Project: Research project
Time toxicity of cancer: the time demands of cancer-related activities and their impact on well-being and quality of life
Vogel, R. (PI), Blaes, A. H. (CoI) & Teoh, D. G. (CoI)
NIH NATIONAL CANCER INSTITUTE (NCI)
2/3/23 → 1/31/27
Project: Research project
APOBEC MUTAGENESIS IN BREAST CANCER
Yee, D. (PI), Largaespada, D. A. (CoI), Temiz, N. A. (CoI) & Vogel, R. (CoI)
UT HEALTH SCIENCE CENTER SAN ANTONIO, NATIONAL INSTITUTES OF HEALTH (NIH)
8/1/22 → 7/31/25
Project: Research project
APOBEC Mutagenesis in Breast Cancer
Harki, D. A. (PI), Walters, M. A. (CoI) & Vogel, R. (Other Role)
UT HEALTH SCIENCE CENTER SAN ANTONIO, NATIONAL INSTITUTES OF HEALTH (NIH)
8/1/22 → 7/31/25
Project: Research project
Application of engineered tumor infiltrating lymphocytes (TIL) in pediatric osteosarcoma
Webber, B. R. (PI), Largaespada, D. A. (CoI), Moriarity, B. S. (CoI), Starr, T. (CoI) & Weigel, B. J. (CoI)
V FOUNDATION FOR CANCER RESEARCH
7/15/22 → 7/15/25
Project: Research project
A Randomized Controlled Trial of Robotic versus Open Radical Hysterectomy for Cervical Cancer(ROCC trial)
Rivard, C. (PI)
THE GOG FOUNDATION, INC
6/21/22 → 12/31/26
Project: Research project
A PHASE 1, FIRST IN HUMAN, DOSE-ESCALATION STUDY OF TORL-1-23 IN PARTICIPANTS WITHADVANCED CANCER
Winterhoff, B. J. (PI)
TORL BIOTHERAPEUTICS, LLC
4/1/22 → 1/1/26
Project: Research project
UNC-45A uniquely contributes to AD pathology
Bazzaro, M. (PI)
ALZHEIMER'S ASSOCIATION
2/1/22 → 1/31/26
Project: Research project
A Phase I Study of HCW9218, a Bifunctional TGF-? Antagonist/IL-15 Protein Complex, in Select Advanced Solid Tumors After Failing at Least Two Prior Therapies
Geller, M. A. (PI)
HCW BIOLOGICS, INC
1/21/22 → 1/31/26
Project: Research project
A Phase 3 Randomized, Open-label, Active-comparator Controlled ClinicalStudy of Pembrolizumab versus Platinum Doublet Chemotherapy in Participants WithMismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma in theFirst-line Settin
Geller, M. A. (PI)
THE GOG FOUNDATION, INC, MERCK, SHARP & DOHME LLC
11/2/21 → 11/30/26
Project: Research project
Intra-tumoral activation of antiviral CD8 T cells for tumor immunotherapy
Masopust, D. (PI), Geller, M. A. (CoI) & Vezys, V. (CoI)
V FOUNDATION FOR CANCER RESEARCH
11/1/21 → 11/1/25
Project: Research project
Increasing HPV vaccination coverage among adolescent and young adult (AYA) cancer survivors: A multilevel intervention
Teoh, D. G. (PI), Melton-Meaux, G. B. (CoI), Sadak, K. T. (CoI) & Vogel, R. (CoI)
U.S. DEPARTMENT OF DEFENSE
8/15/21 → 8/14/25
Project: Research project
A paradigm shift for ovarian cancer biomarkers: Utilizing routine Pap tests as liquid biopsies for the development of targeted mass spectrometry-based proteomic assays for early detection
Skubitz, A. P. (PI), Boylan, K. L. (CoI), Geller, M. A. (CoI) & Petersen, A. J. (CoI)
NIH NATIONAL CANCER INSTITUTE (NCI)
8/5/21 → 7/31/26
Project: Research project
A Phase IB/II Multi-Cohort Study of Targeted Agents with Atezolizumab for Patients with Recurrent orPersistent Endometrial Cancer
Erickson, B. K. (PI)
ALLIANCE FOUNDATION TRIALS, LLC
5/19/21 → 5/31/26
Project: Research project
Phase 1 First-in-Human Study of Leukocyte Immunoglobulin-Like Receptor B2 (LILRB2) Inhibitor Monoclonal Antibody (mAb) JTX-8064, as Monotherapy and in Combination with a Programmed Cell Death Receptor-1 (PD-1) Inhibitor, in Adult Subjectswith Advanced
Teoh, D. G. (PI)
JOUNCE THERAPEUTICS, INC
5/1/21 → 4/30/26
Project: Research project
NK cells, their receptors, and cancer therapy
Miller, J. S. (PI), Bachanova, V. (CoI), Basu, S. (CoI), Brunstein, C. G. (CoI), Cichocki, F. M. (CoI), Felices, M. (CoI), Geller, M. A. (CoI), Grzywacz, B. J. (CoI), Le, C. T. (CoI), Luo, X. (CoI), Starr, T. (CoI), Walcheck, B. (CoI), Warlick, E. D. (CoI) & Weisdorf, D. J. (CoI)
NIH NATIONAL CANCER INSTITUTE (NCI)
4/9/21 → 3/31/26
Project: Research project
Expression of recombinant Fc receptors by engineered NK cells to enhance cancer cell killing
Walcheck, B. (PI), Geller, M. A. (CoI), Miller, J. S. (CoI), Moriarity, B. S. (CoI), Rendahl, A. (CoI), Starr, T. (CoI) & Wu, J. (CoI)
NIH NATIONAL CANCER INSTITUTE (NCI)
4/1/21 → 3/31/26
Project: Research project
A NON-RANDOMIZED PROSPECTIVE CLINICAL TRIAL COMPARING THE NON-INFERIORITY OFSALPINGECTOMY TO SALPINGO-OOPHORECTOMY TO REDUCE THE RISK OF OVARIAN CANCERAMONG BRCA1 CARRIERS [SOROCk]
Erickson, B. K. (PI)
NRG ONCOLOGY FOUNDATION, INC., NIH NATIONAL CANCER INSTITUTE (NCI)
3/31/21 → 2/28/26
Project: Research project
A Randomized Phase II Trial of Radiation Therapy and Cisplatin Alone or in Combination with Intravenous Triapine in Women with Newly Diagnosed Bulky Stage IB2, Stage II, IIIB, or IVA Cancer of the Uterine Cervix or Stage II-IVA Vaginal Cancer.
Teoh, D. G. (PI)
NRG ONCOLOGY FOUNDATION, INC., NIH NATIONAL CANCER INSTITUTE (NCI)
3/15/19 → 2/28/26
Project: Research project
Phase II Study of Pembrolizumab in the Immunoreactive Ovarian Cancer Subtype
Winterhoff, B. J. (PI)
UNIVERSITY OF CALIFORNIA, LOS ANGELES, MERCK
3/6/19 → 3/30/26
Project: Research project
NRG Oncology Fixed Price Subaward Master Agreement
Geller, M. A. (PI)
NRG ONCOLOGY FOUNDATION, INC., NIH NATIONAL CANCER INSTITUTE (NCI)
3/1/19 → 2/28/26
Project: Research project
A Randomized, Double-Blind, Phase 3 Comparison of Platinum-Based Therapy With TSR-042 and Niraparib Versus Standard of Care Platinum-Based Therapy as First-Line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer
Teoh, D. G. (PI)
TESARO, INC.
9/1/18 → 6/26/26
Project: Research project
Finished
A Randomized Phase II Study of Letrozole Versus Observation in Patients with Newly Diagnosed Uterine Leiomyosarcoma
Mattson, J. N. (PI)
GYNECOLOGIC ONCOLOGY GROUP
6/10/24 → 12/7/24
Project: Research project
UW Support Services Agreement (UWMSN-2024-2662-ASSA3)
Argenta, P. A. (PI)
UNIVERSITY OF WISCONSIN-MADISON, CENTERS FOR DISEASE CONTROL & PREVENTION
4/1/24 → 9/29/24
Project: Research project
Northwestern Cancer Prevention Consortium -- Surgical Window of Opportunity Study of Megestrol Acetate Compared with Megestrol Acetate and Metformin for Endometrial Intraepithelial Neoplasia - Fixed Price
Erickson, B. K. (PI)
NORTHWESTERN UNIVERSITY, NIH NATIONAL CANCER INSTITUTE (NCI)
8/1/23 → 6/20/25
Project: Research project
Northwestern Cancer Prevention Consortium -- Surgical Window of Opportunity Study of Megestrol Acetate Compared with Megestrol Acetate and Metformin for Endometrial Intraepithelial Neoplasia
Erickson, B. K. (PI)
NORTHWESTERN UNIVERSITY, NIH NATIONAL CANCER INSTITUTE (NCI)
8/1/23 → 6/20/25
Project: Research project
Examining the associations between cytomegalovirus (CMV), inflammation and 'chemo brain'
Vogel, R. (PI)
MN OVARIAN CANCER ALLIANCE
6/1/23 → 8/31/24
Project: Research project
Single cell analyses of pre- and post-treatment HGSOC to identify therapy resistance mechanisms of persister cells
Winterhoff, B. J. (PI)
HARVARD UNIVERSITY, ADELSON MEDICAL RESEARCH FOUNDATION
4/1/23 → 9/30/23
Project: Research project
Mayo Clinic Ovarian Cancer SPORE - Project 4 - Treatment of Advanced Ovarian Cancer Using Gene-Edited CAR NK Cells (Development of a dual CAR Natural Killer cells for ovarian cancer therapy)
Moriarity, B. S. (PI) & Starr, T. (CoI)
MAYO CLINIC ROCHESTER
3/6/23 → 8/31/23
Project: Research project
Ovarian Cancer Genome Analysis Platform
Winterhoff, B. J. (PI)
JOHNS HOPKINS UNIVERSITY, ADELSON MEDICAL RESEARCH FOUNDATION
10/1/22 → 9/30/23
Project: Research project