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2019

Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation

Hughey, C. C., James, F. D., Wang, Z., Goelzer, M. & Wasserman, D. H., May 2019, In : Molecular Metabolism. 23, p. 1-13 13 p.

Research output: Contribution to journalArticle

Open Access

Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and postabsorptive responses of mice in an age-dependent manner

Trefts, E., Hughey, C. C., Lantier, L., Lark, D. S., Boyd, K. L., Pozzi, A., Zent, R. & Wasserman, D. H., Jan 1 2019, In : American Journal of Physiology - Endocrinology and Metabolism. 316, 6, p. E1118-E1135

Research output: Contribution to journalArticle

Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis

Puchalska, P., Martin, S. E., Huang, X., Lengfeld, J. E., Daniel, B., Graham, M. J., Han, X., Nagy, L., Patti, G. J. & Crawford, P. A., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 383-398.e7

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Iatrogenic hyperinsulinemia, not hyperglycemia, drives insulin resistance in type 1 diabetes as revealed by comparison with GCK-MODY (MODY2)

Gregory, J. M., Smith, T. J., Slaughter, J. C., Mason, H. R., Hughey, C. C., Smith, M. S., Kandasamy, B., Greeley, S. A. W., Philipson, L. H., Naylor, R. N., Letourneau, L. R., Abumrad, N. N., Cherrington, A. D. & Moore, D. J., Aug 1 2019, In : Diabetes. 68, 8, p. 1565-1576 12 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense

Horton, J. L., Davidson, M. T., Kurishima, C., Vega, R. B., Powers, J. C., Matsuura, T. R., Petucci, C., Lewandowski, E. D., Crawford, P. A., Muoio, D. M., Recchia, F. A. & Kelly, D. P., Feb 21 2019, In : JCI Insight. 4, 4

Research output: Contribution to journalArticle

Open Access
15 Scopus citations
2018

Glycine N-methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates

Hughey, C. C., Trefts, E., Bracy, D. P., James, F. D., Patrick Donahue, E. & Wasserman, D. H., Jan 1 2018, In : Journal of Biological Chemistry. 293, 30, p. 11944-11954 11 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome

d'Avignon, D. A., Puchalska, P., Ercal, B., Chang, Y. J., Martin, S. E., Graham, M. J., Patti, G. J., Han, X. & Crawford, P. A., Jun 21 2018, In : JCI Insight. 3, 12

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Intra- and inter-subject variability for increases in serum ketone bodies in patients with type 2 diabetes treated with the sodium glucose co-transporter 2 inhibitor canagliflozin

Polidori, D., Iijima, H., Goda, M., Maruyama, N., Inagaki, N. & Crawford, P. A., May 2018, In : Diabetes, Obesity and Metabolism. 20, 5, p. 1321-1326 6 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

In vivo NMR investigations of glyphosate influences on plant metabolism

d'Avignon, D. A. & Ge, X., Jul 2018, In : Journal of Magnetic Resonance. 292, p. 59-72 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Isotope Tracing Untargeted Metabolomics Reveals Macrophage Polarization-State-Specific Metabolic Coordination across Intracellular Compartments

Puchalska, P., Huang, X., Martin, S. E., Han, X., Patti, G. J. & Crawford, P. A., Nov 30 2018, In : iScience. 9, p. 298-313 16 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Lipidomics reveals a systemic energy deficient state that precedes neurotoxicity in neonatal monkeys after sevoflurane exposure

Wang, C., Liu, F., Frisch-Daiello, J. L., Martin, S., Patterson, T. A., Gu, Q., Liu, S., Paule, M. G., Hanig, J. P., Slikker, W., Crawford, P. A., Wang, C. & Han, X., Dec 11 2018, In : Analytica Chimica Acta. 1037, p. 87-96 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

Hunter, R. W., Hughey, C. C., Lantier, L., Sundelin, E. I., Peggie, M., Zeqiraj, E., Sicheri, F., Jessen, N., Wasserman, D. H. & Sakamoto, K., Sep 1 2018, In : Nature Medicine. 24, 9, p. 1395-1406 12 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

SIRT2 knockout exacerbates insulin resistance in high fat-fed mice

Lantier, L., Williams, A. S., Hughey, C. C., Bracy, D. P., James, F. D., Ansari, M. A., Gius, D. & Wasserman, D. H., Dec 2018, In : PloS one. 13, 12, e0208634.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2017

Allergenome characterization of the mosquito Aedes aegypti

Cantillo, J. F., Puerta, L., Puchalska, P., Lafosse-Marin, S., Subiza, J. L. & Fernández-Caldas, E., Oct 2017, In : Allergy: European Journal of Allergy and Clinical Immunology. 72, 10, p. 1499-1509 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Circulating acylcarnitine profile in human heart failure: A surrogate of fatty acid metabolic dysregulation in mitochondria and beyond

Ruiz, M., Labarthe, F., Fortier, A., Bouchard, B., Legault, J. T., Bolduc, V., Rigal, O., Chen, J., Ducharme, A., Crawford, P. A., Tardif, J. C. & Des Rosiers, C., Oct 11 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 313, 4, p. 768-781 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Enterobacteria secrete an inhibitor of Pseudomonas virulence during clinical bacteriuria

Ohlemacher, S. I., Giblin, D. E., D'Avignon, D. A., Stapleton, A. E., Trautner, B. W. & Henderson, J. P., Nov 1 2017, In : Journal of Clinical Investigation. 127, 11, p. 4018-4030 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Liver AMP-activated protein kinase is unnecessary for gluconeogenesis but protects energy state during nutrient deprivation

Hasenour, C. M., Ridley, D. E., James, F. D., Hughey, C. C., Donahue, E. P., Viollet, B., Foretz, M., Young, J. D. & Wasserman, D. H., Jan 2017, In : PloS one. 12, 1, e0170382.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice

Hughey, C. C., James, F. D., Bracy, D. P., Patrick Donahue, E., Young, J. D., Viollet, B., Foretz, M. & Wasserman, D. H., Jan 1 2017, In : Journal of Biological Chemistry. 292, 49, p. 20125-20140 16 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2016

Comprehensive and quantitative analysis of polyphosphoinositide species by shotgun lipidomics revealed their alterations in db/db mouse brain

Wang, C., Palavicini, J. P., Wang, M., Chen, L., Yang, K., Crawford, P. A. & Han, X., Jan 1 2016, In : Analytical chemistry. 88, 24, p. 12137-12144 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide

Ippolito, J. E., Brandenburg, M. W., Ge, X., Crowley, J. R., Kirmess, K. M., Som, A., D'Avignon, D. A., Arbeit, J. M., Achilefu, S., Yarasheski, K. E. & Milbrandt, J., Jul 2016, In : PloS one. 11, 7, e0159675.

Research output: Contribution to journalArticle

15 Scopus citations

Lactate metabolism is associated with mammalian mitochondria

Chen, Y. J., Mahieu, N. G., Huang, X., Singh, M., Crawford, P. A., Johnson, S. L., Gross, R. W., Schaefer, J. & Patti, G. J., Nov 1 2016, In : Nature Chemical Biology. 12, 11, p. 937-943 7 p.

Research output: Contribution to journalArticle

62 Scopus citations

The Failing Heart Relies on Ketone Bodies as a Fuel

Aubert, G., Martin, O. J., Horton, J. L., Lai, L., Vega, R. B., Leone, T. C., Koves, T., Gardell, S. J., Krüger, M., Hoppel, C. L., Lewandowski, E. D., Crawford, P. A., Muoio, D. M. & Kelly, D. P., Feb 23 2016, In : Circulation. 133, 8, p. 698-705 8 p.

Research output: Contribution to journalArticle

181 Scopus citations

The Rho Guanine Nucleotide Exchange Factor DRhoGEF2 Is a Genetic Modifier of the PI3K Pathway in Drosophila

Chang, Y. J., Zhou, L., Binari, R., Manoukian, A., Mak, T., McNeill, H. & Stambolic, V., Jan 1 2016, In : PloS one. 11, 3, p. e0152259

Research output: Contribution to journalArticle

3 Scopus citations
2015

The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes

Chang, Y. J., Pownall, S., Jensen, T. E., Mouaaz, S., Foltz, W., Zhou, L., Liadis, N., Woo, M., Hao, Z., Dutt, P., Bilan, P. J., Klip, A., Mak, T. & Stambolic, V., Oct 29 2015, In : eLife. 4, OCTOBER2015, e06011.

Research output: Contribution to journalArticle

14 Scopus citations
2014

5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) effect on glucose production, but not energy metabolism, is independent of hepatic AMPK in vivo

Hasenour, C. M., Ridley, D. E., Hughey, C. C., James, F. D., Donahue, E. P., Shearer, J., Viollet, B., Foretz, M. & Wasserman, D. H., Feb 28 2014, In : Journal of Biological Chemistry. 289, 9, p. 5950-5959 10 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling

Schugar, R. C., Moll, A. R., André d'Avignon, D., Weinheimer, C. J., Kovacs, A. & Crawford, P. A., Oct 1 2014, In : Molecular Metabolism. 3, 7, p. 754-769 16 p.

Research output: Contribution to journalArticle

49 Scopus citations

Diminishing impairments in glucose uptake, mitochondrial content, and ADP-stimulated oxygen flux by mesenchymal stem cell therapy in the infarcted heart

Hughey, C. C., James, F. D., Ma, L., Bracy, D. P., Wang, Z., Wasserman, D. H., Rottman, J. N. & Shearer, J., Jan 1 2014, In : American Journal of Physiology - Cell Physiology. 306, 1, p. C19-C27

Research output: Contribution to journalArticle

4 Scopus citations

Identification of native angiotensin-I converting enzyme inhibitory peptides in commercial soybean based infant formulas using HPLC-Q-ToF-MS

Puchalska, P., Concepción García, M. & Luisa Marina, M., Aug 15 2014, In : Food Chemistry. 157, p. 62-69 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Impairments of hepatic gluconeogenesis and ketogenesis in PPARα-deficient neonatal mice

Cotter, D. G., Ercal, B., André D'Avignon, D., Dietzen, D. J. & Crawford, P. A., Jul 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 2, p. E176-E185

Research output: Contribution to journalArticle

10 Scopus citations

Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia

Cotter, D. G., Ercal, B., Huang, X., Leid, J. M., D'Avignon, D. A., Graham, M. J., Dietzen, D. J., Brunt, E. M., Patti, G. J. & Crawford, P. A., Dec 1 2014, In : Journal of Clinical Investigation. 124, 12, p. 5175-5190 16 p.

Research output: Contribution to journalArticle

57 Scopus citations

Myostatin inhibits proliferation and insulin-stimulated glucose uptake in mouse liver cells

Watts, R., Ghozlan, M., Hughey, C. C., Johnsen, V. L., Shearer, J. & Hittel, D. S., Jun 2014, In : Biochemistry and Cell Biology. 92, 3, p. 226-234 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

X13CMS: Global tracking of isotopic labels in untargeted metabolomics

Huang, X., Chen, Y. J., Cho, K., Nikolskiy, I., Crawford, P. A. & Patti, G. J., Feb 4 2014, In : Analytical Chemistry. 86, 3, p. 1632-1639 8 p.

Research output: Contribution to journalArticle

81 Scopus citations
2013
12 Scopus citations

Enhanced cardiac protein glycosylation (O-GlcNAc) of selected mitochondrial proteins in rats artificially selected for low running capacity

Johnsen, V. L., Belke, D. D., Hughey, C. C., Hittel, D. S., Hepple, R. T., Koch, L. G., Britton, S. L. & Shearer, J., Jan 7 2013, In : Physiological genomics. 45, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth

Cotter, D. G., Ercal, B., D'Avignon, D. A., Dietzen, D. J. & Crawford, P. A., Jul 5 2013, In : Journal of Biological Chemistry. 288, 27, p. 19739-19749 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Mesenchymal stem cell transplantation for the infarcted heart: Therapeutic potential for insulin resistance beyond the heart

Hughey, C. C., Ma, L., James, F. D., Bracy, D. P., Wang, Z., Wasserman, D. H., Rottman, J. N., Hittel, D. S. & Shearer, J., Sep 4 2013, In : Cardiovascular Diabetology. 12, 1, 128.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner

Chambers, K. T., Chen, Z., Lai, L., Leone, T. C., Towle, H. C., Kralli, A., Crawford, P. A. & Finck, B. N., Aug 1 2013, In : Molecular Metabolism. 2, 3, p. 194-204 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Role of Choline Deficiency in the Fatty Liver Phenotype of Mice Fed a Low Protein, Very Low Carbohydrate Ketogenic Diet

Schugar, R. C., Huang, X., Moll, A. R., Brunt, E. M. & Crawford, P. A., Aug 29 2013, In : PloS one. 8, 8, e74806.

Research output: Contribution to journalArticle

22 Scopus citations

Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation

Cotter, D. G., Schugar, R. C., Wentz, A. E., André d'Avignon, D. & Crawford, P. A., Feb 15 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 304, 4, p. E363-E374

Research output: Contribution to journalArticle

22 Scopus citations
2012

Increased oxygen consumption and OXPHOS potential in superhealer mesenchymal stem cells

Hughey, C. C., Alfaro, M. P., Belke, D. D., Rottman, J. N., Young, P. P., Wasserman, D. H. & Shearer, J., Jun 28 2012, In : Cell Regeneration. 1, 1, p. 1:3 3.

Research output: Contribution to journalArticle

Open Access

Liver-Specific PGC-1beta Deficiency Leads to Impaired Mitochondrial Function and Lipogenic Response to Fasting-Refeeding

Chambers, K. T., Chen, Z., Crawford, P. A., Fu, X., Burgess, S. C., Lai, L., Leone, T. C., Kelly, D. P. & Finck, B. N., Dec 28 2012, In : PloS one. 7, 12, e52645.

Research output: Contribution to journalArticle

17 Scopus citations
2011

Altered systemic ketone body metabolism in advanced heart failure

Janardhan, A., Chen, J. & Crawford, P. A., Dec 19 2011, In : Texas Heart Institute Journal. 38, 5, p. 533-538 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet

Garbow, J. R., Doherty, J. M., Schugar, R. C., Travers, S., Weber, M. L., Wentz, A. E., Ezenwajiaku, N., Cotter, D. G., Brunt, E. M. & Crawford, P. A., Jun 1 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 6, p. G956-G967

Research output: Contribution to journalArticle

69 Scopus citations

Hyperinsulinemic-euglycemic clamp in the conscious rat

Hughey, C. C., Hittel, D. S., Johnsen, V. L. & Shearer, J., Feb 2011, In : Journal of Visualized Experiments. 48, e2432.

Research output: Contribution to journalArticle

14 Scopus citations

Obligate role for ketone body oxidation in neonatal metabolic homeostasis

Cotter, D. G., D'Avignon, D. A., Wentz, A. E., Weber, M. L. & Crawford, P. A., Mar 4 2011, In : Journal of Biological Chemistry. 286, 9, p. 6902-6910 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Respirometric oxidative phosphorylation assessment in saponin-permeabilized cardiac fibers

Hughey, C. C., Hittel, D. S., Johnsen, V. L. & Shearer, J., Feb 2011, In : Journal of Visualized Experiments. 48, e2431.

Research output: Contribution to journalArticle

15 Scopus citations

The novel function of advanced glycation end products in regulation of MMP-9 production

Zhang, F., Banker, G., Liu, X., Suwanabol, P. A., Lengfeld, J., Yamanouchi, D., Kent, K. C. & Liu, B., Dec 1 2011, In : Journal of Surgical Research. 171, 2, p. 871-876 6 p.

Research output: Contribution to journalArticle

45 Scopus citations
2010

Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity

Etzion, S., Etzion, Y., Debosch, B., Crawford, P. A. & Muslin, A. J., Dec 1 2010, In : Journal of Molecular and Cellular Cardiology. 49, 6, p. 931-940 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF

Gasmi-Seabrook, G. M. C., Marshall, C. B., Cheung, M., Kim, B., Wang, F., Jang, Y. J., Mak, T. W., Stambolic, V. & Ikura, M., Feb 19 2010, In : Journal of Biological Chemistry. 285, 8, p. 5137-5145 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2009

Balance of beneficial and deleterious health effects of quinones: A case study of the chemical properties of genistein and estrone quinones

Zhang, Q., Tu, T., D'Avignon, D. A. & Gross, M. L., Jan 28 2009, In : Journal of the American Chemical Society. 131, 3, p. 1067-1076 10 p.

Research output: Contribution to journalArticle

17 Scopus citations