Research Output

2020

Nonalcoholic Steatohepatitis: A Review

Sheka, A. C., Adeyi, O., Thompson, J., Hameed, B., Crawford, P. A. & Ikramuddin, S., Mar 24 2020, In : JAMA. 323, 12, p. 1175

Research output: Contribution to journalArticle

3 Scopus citations

Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation

Al Batran, R., Gopal, K., Capozzi, M. E., Chahade, J. J., Saleme, B., Tabatabaei-Dakhili, S. A., Greenwell, A. A., Niu, J., Almutairi, M., Byrne, N. J., Masson, G., Kim, R., Eaton, F., Mulvihill, E. E., Garneau, L., Masters, A. R., Desta, Z., Velázquez-Martínez, C. A., Aguer, C., Crawford, P. A. & 4 others, Sutendra, G., Campbell, J. E., Dyck, J. R. B. & Ussher, J. R., May 5 2020, In : Cell Metabolism. 31, 5, p. 909-919.e8

Research output: Contribution to journalArticle

1 Scopus citations
2019

Application of stable isotope labels for metabolomics in studies in fatty liver disease

Puchalska, P. & Crawford, P. A., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 259-272 14 p. (Methods in Molecular Biology; vol. 1996).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis

Puchalska, P., Martin, S. E., Huang, X., Lengfeld, J. E., Daniel, B., Graham, M. J., Han, X., Nagy, L., Patti, G. J. & Crawford, P. A., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 383-398.e7

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Ketogenic therapies for lymphedema?

Puchalska, P. & Crawford, P. A., Jul 1 2019, In : Nature Metabolism. 1, 7, p. 656-657 2 p.

Research output: Contribution to journalComment/debate

Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword

Hughey, C. C. & Crawford, P. A., Jun 4 2019, In : Cell Metabolism. 29, 6, p. 1236-1238 3 p.

Research output: Contribution to journalShort survey

The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense

Horton, J. L., Davidson, M. T., Kurishima, C., Vega, R. B., Powers, J. C., Matsuura, T. R., Petucci, C., Lewandowski, E. D., Crawford, P. A., Muoio, D. M., Recchia, F. A. & Kelly, D. P., Feb 21 2019, In : JCI Insight. 4, 4

Research output: Contribution to journalArticle

Open Access
20 Scopus citations
2018

Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome

d'Avignon, D. A., Puchalska, P., Ercal, B., Chang, Y. J., Martin, S. E., Graham, M. J., Patti, G. J., Han, X. & Crawford, P. A., Jun 21 2018, In : JCI Insight. 3, 12

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Intra- and inter-subject variability for increases in serum ketone bodies in patients with type 2 diabetes treated with the sodium glucose co-transporter 2 inhibitor canagliflozin

Polidori, D., Iijima, H., Goda, M., Maruyama, N., Inagaki, N. & Crawford, P. A., May 2018, In : Diabetes, Obesity and Metabolism. 20, 5, p. 1321-1326 6 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

In vivo NMR investigations of glyphosate influences on plant metabolism

d'Avignon, D. A. & Ge, X., Jul 2018, In : Journal of Magnetic Resonance. 292, p. 59-72 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Isotope Tracing Untargeted Metabolomics Reveals Macrophage Polarization-State-Specific Metabolic Coordination across Intracellular Compartments

Puchalska, P., Huang, X., Martin, S. E., Han, X., Patti, G. J. & Crawford, P. A., Nov 30 2018, In : iScience. 9, p. 298-313 16 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Ketone bodies as epigenetic modifiers

Ruan, H. B. & Crawford, P. A., Jul 1 2018, In : Current opinion in clinical nutrition and metabolic care. 21, 4, p. 260-266 7 p.

Research output: Contribution to journalReview article

7 Scopus citations
2 Scopus citations
2017

Circulating acylcarnitine profile in human heart failure: A surrogate of fatty acid metabolic dysregulation in mitochondria and beyond

Ruiz, M., Labarthe, F., Fortier, A., Bouchard, B., Legault, J. T., Bolduc, V., Rigal, O., Chen, J., Ducharme, A., Crawford, P. A., Tardif, J. C. & Des Rosiers, C., Oct 11 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 313, 4, p. 768-781 14 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics

Puchalska, P. & Crawford, P. A., Feb 7 2017, In : Cell Metabolism. 25, 2, p. 262-284 23 p.

Research output: Contribution to journalReview article

Open Access
212 Scopus citations
2016

Comprehensive and quantitative analysis of polyphosphoinositide species by shotgun lipidomics revealed their alterations in db/db mouse brain

Wang, C., Palavicini, J. P., Wang, M., Chen, L., Yang, K., Crawford, P. A. & Han, X., Jan 1 2016, In : Analytical chemistry. 88, 24, p. 12137-12144 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Lactate metabolism is associated with mammalian mitochondria

Chen, Y. J., Mahieu, N. G., Huang, X., Singh, M., Crawford, P. A., Johnson, S. L., Gross, R. W., Schaefer, J. & Patti, G. J., Nov 1 2016, In : Nature Chemical Biology. 12, 11, p. 937-943 7 p.

Research output: Contribution to journalArticle

70 Scopus citations

The Failing Heart Relies on Ketone Bodies as a Fuel

Aubert, G., Martin, O. J., Horton, J. L., Lai, L., Vega, R. B., Leone, T. C., Koves, T., Gardell, S. J., Krüger, M., Hoppel, C. L., Lewandowski, E. D., Crawford, P. A., Muoio, D. M. & Kelly, D. P., Feb 23 2016, In : Circulation. 133, 8, p. 698-705 8 p.

Research output: Contribution to journalArticle

194 Scopus citations

The Rho Guanine Nucleotide Exchange Factor DRhoGEF2 Is a Genetic Modifier of the PI3K Pathway in Drosophila

Chang, Y. J., Zhou, L., Binari, R., Manoukian, A., Mak, T., McNeill, H. & Stambolic, V., Jan 1 2016, In : PloS one. 11, 3, p. e0152259

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2015

The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes

Chang, Y. J., Pownall, S., Jensen, T. E., Mouaaz, S., Foltz, W., Zhou, L., Liadis, N., Woo, M., Hao, Z., Dutt, P., Bilan, P. J., Klip, A., Mak, T. & Stambolic, V., Oct 29 2015, In : eLife. 4, OCTOBER2015, e06011.

Research output: Contribution to journalArticle

15 Scopus citations
2014

Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling

Schugar, R. C., Moll, A. R., André d'Avignon, D., Weinheimer, C. J., Kovacs, A. & Crawford, P. A., Oct 1 2014, In : Molecular Metabolism. 3, 7, p. 754-769 16 p.

Research output: Contribution to journalArticle

54 Scopus citations

Impairments of hepatic gluconeogenesis and ketogenesis in PPARα-deficient neonatal mice

Cotter, D. G., Ercal, B., André D'Avignon, D., Dietzen, D. J. & Crawford, P. A., Jul 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 2, p. E176-E185

Research output: Contribution to journalArticle

11 Scopus citations

Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia

Cotter, D. G., Ercal, B., Huang, X., Leid, J. M., D'Avignon, D. A., Graham, M. J., Dietzen, D. J., Brunt, E. M., Patti, G. J. & Crawford, P. A., Dec 1 2014, In : Journal of Clinical Investigation. 124, 12, p. 5175-5190 16 p.

Research output: Contribution to journalArticle

66 Scopus citations

Stem cell-based therapies for multiple sclerosis: Recent advances in animal models and human clinical trials

Lutz, S. E., Lengfeld, J. & Agalliu, D., Mar 2014, In : Regenerative Medicine. 9, 2, p. 129-132 4 p.

Research output: Contribution to journalReview article

4 Scopus citations

X13CMS: Global tracking of isotopic labels in untargeted metabolomics

Huang, X., Chen, Y. J., Cho, K., Nikolskiy, I., Crawford, P. A. & Patti, G. J., Feb 4 2014, In : Analytical Chemistry. 86, 3, p. 1632-1639 8 p.

Research output: Contribution to journalArticle

83 Scopus citations
2013

Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth

Cotter, D. G., Ercal, B., D'Avignon, D. A., Dietzen, D. J. & Crawford, P. A., Jul 5 2013, In : Journal of Biological Chemistry. 288, 27, p. 19739-19749 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Ketone body metabolism and cardiovascular disease

Cotter, D. G., Schugar, R. C. & Crawford, P. A., Jun 10 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 304, 8, p. H1060-H1076

Research output: Contribution to journalReview article

163 Scopus citations

Metabolic stress in the myocardium: Adaptations of gene expression

Crawford, P. A. & Schaffer, J. E., Feb 1 2013, In : Journal of Molecular and Cellular Cardiology. 55, 1, p. 130-138 9 p.

Research output: Contribution to journalReview article

9 Scopus citations

PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner

Chambers, K. T., Chen, Z., Lai, L., Leone, T. C., Towle, H. C., Kralli, A., Crawford, P. A. & Finck, B. N., Aug 1 2013, In : Molecular Metabolism. 2, 3, p. 194-204 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Role of Choline Deficiency in the Fatty Liver Phenotype of Mice Fed a Low Protein, Very Low Carbohydrate Ketogenic Diet

Schugar, R. C., Huang, X., Moll, A. R., Brunt, E. M. & Crawford, P. A., Aug 29 2013, In : PloS one. 8, 8, e74806.

Research output: Contribution to journalArticle

23 Scopus citations

Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation

Cotter, D. G., Schugar, R. C., Wentz, A. E., André d'Avignon, D. & Crawford, P. A., Feb 15 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 304, 4, p. E363-E374

Research output: Contribution to journalArticle

23 Scopus citations
2012

Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease

Schugar, R. C. & Crawford, P. A., Jul 1 2012, In : Current opinion in clinical nutrition and metabolic care. 15, 4, p. 374-380 7 p.

Research output: Contribution to journalReview article

49 Scopus citations
2011

Altered systemic ketone body metabolism in advanced heart failure

Janardhan, A., Chen, J. & Crawford, P. A., Dec 19 2011, In : Texas Heart Institute Journal. 38, 5, p. 533-538 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet

Garbow, J. R., Doherty, J. M., Schugar, R. C., Travers, S., Weber, M. L., Wentz, A. E., Ezenwajiaku, N., Cotter, D. G., Brunt, E. M. & Crawford, P. A., Jun 1 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 6, p. G956-G967

Research output: Contribution to journalArticle

72 Scopus citations

Obligate role for ketone body oxidation in neonatal metabolic homeostasis

Cotter, D. G., D'Avignon, D. A., Wentz, A. E., Weber, M. L. & Crawford, P. A., Mar 4 2011, In : Journal of Biological Chemistry. 286, 9, p. 6902-6910 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

The novel function of advanced glycation end products in regulation of MMP-9 production

Zhang, F., Banker, G., Liu, X., Suwanabol, P. A., Lengfeld, J., Yamanouchi, D., Kent, K. C. & Liu, B., Dec 1 2011, In : Journal of Surgical Research. 171, 2, p. 871-876 6 p.

Research output: Contribution to journalArticle

47 Scopus citations
2010

Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity

Etzion, S., Etzion, Y., Debosch, B., Crawford, P. A. & Muslin, A. J., Dec 1 2010, In : Journal of Molecular and Cellular Cardiology. 49, 6, p. 931-940 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Coordinated regulation of the metabolome and lipidome at the host-microbial interface

Bäckhed, F. & Crawford, P. A., Mar 1 2010, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1801, 3, p. 240-245 6 p.

Research output: Contribution to journalReview article

52 Scopus citations

Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF

Gasmi-Seabrook, G. M. C., Marshall, C. B., Cheung, M., Kim, B., Wang, F., Jang, Y. J., Mak, T. W., Stambolic, V. & Ikura, M., Feb 19 2010, In : Journal of Biological Chemistry. 285, 8, p. 5137-5145 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2009

Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation

Crawford, P. A., Crowley, J. R., Sambandam, N., Muegge, B. D., Costello, E. K., Hamady, M., Knight, R. & Gordon, J. I., Jul 7 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 27, p. 11276-11281 6 p.

Research output: Contribution to journalArticle

165 Scopus citations
2008

DEAD-box protein-103 (DP103, Ddx20) is essential for early embryonic development and modulates ovarian morphology and function

Mouillet, J. F., Yan, X., Ou, Q., Jin, L., Muglia, L. J., Crawford, P. A. & Sadovsky, Y., May 1 2008, In : Endocrinology. 149, 5, p. 2168-2175 8 p.

Research output: Contribution to journalArticle

31 Scopus citations
2007
77 Scopus citations
2005

DJ-1, a novel regulator of the tumor suppressor PTEN

Kim, R. H., Peters, M., Jang, Y., Shi, W., Pintilie, M., Fletcher, G. C., DeLuca, C., Liepa, J., Zhou, L., Snow, B., Binari, R. C., Manoukian, A. S., Bray, M. R., Liu, F. F., Tsao, M. S. & Mak, T. W., Mar 2005, In : Cancer Cell. 7, 3, p. 263-273 11 p.

Research output: Contribution to journalArticle

420 Scopus citations

Microbial regulation of intestinal radiosensitivity

Crawford, P. A. & Gordon, J. I., Sep 13 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 37, p. 13254-13259 6 p.

Research output: Contribution to journalArticle

114 Scopus citations

Specific ablation of the apoptotic functions of cytochrome c reveals a differential requirement for cytochrome c and Apaf-1 in apoptosis

Hao, Z., Duncan, G. S., Chang, C. C., Elia, A., Fang, M., Wakeham, A., Okada, H., Calzascia, T., Jang, Y., You-Ten, A., Yeh, W. C., Ohashi, P., Wang, X. & Mak, T. W., May 20 2005, In : Cell. 121, 4, p. 579-591 13 p.

Research output: Contribution to journalArticle

209 Scopus citations
2004

p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1

You, H., Jang, Y. J., You-Ten, A. I., Okada, H., Liepa, J., Wakeham, A., Zaugg, K. & Mak, T. W., Sep 28 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 39, p. 14057-14062 6 p.

Research output: Contribution to journalArticle

99 Scopus citations
2001

Regulation of PTEN transcription by p53

Stambolic, V., MacPherson, D., Sas, D., Lin, Y., Snow, B., Jang, Y., Benchimol, S. & Mak, T. W., Jan 1 2001, In : Molecular Cell. 8, 2, p. 317-325 9 p.

Research output: Contribution to journalArticle

671 Scopus citations

RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons

Enomoto, H., Crawford, P. A., Gorodinsky, A., Heuckeroth, R. O., Johnson, E. M. & Milbrandt, J., Nov 20 2001, In : Development. 128, 20, p. 3963-3974 12 p.

Research output: Contribution to journalArticle

218 Scopus citations

The DEAD box protein DP103 is a regulator of steroidogenic factor-1

Ou, Q., Mouillet, J. F., Yan, X., Dorn, C., Crawford, P. A. & Sadovsky, Y., Jan 1 2001, In : Molecular Endocrinology. 15, 1, p. 69-79 11 p.

Research output: Contribution to journalArticle

72 Scopus citations
2000

Steroidogenic factor 1 is a monomeric orphan, but does not work alone

Ou, Q., Mouillet, J. F., Yan, X., Dorn, C., Crawford, P. A. & Sadovsky, Y., Jan 1 2000, In : Endocrine Research. 26, 4, p. 1003-1004 2 p.

Research output: Contribution to journalArticle