Research Output

1988

The potency of fluorinated ether anesthetics correlates with their 19F spin-spin relaxation times in brain tissue

Evers, A. S., Haycock, J. C. & Andre d'Avignon, D., Mar 30 1988, In : Biochemical and Biophysical Research Communications. 151, 3, p. 1039-1045 7 p.

Research output: Contribution to journalArticle

1994

NMR studies of fluororetinol analogs complexed to two homologous rat cellular retinol-binding proteins

Rong, D., Lovey, A. J., Rosenberger, M., Andréd'Avignon, D. & Li, E., Sep 21 1994, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1208, 1, p. 136-144 9 p.

Research output: Contribution to journalArticle

1995

Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice

Crawford, P. A., Sadovsky, Y., Woodson, K., Lee, S. L. & Milbrandt, J., Aug 1995, In : Molecular and cellular biology. 15, 8, p. 4331-4336 6 p.

Research output: Contribution to journalArticle

Open Access
130 Scopus citations

Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids

Sadovsky, Y., Crawford, P. A., Woodson, K. G., Polish, J. A., Clements, M. A., Tourtellotte, L. M., Simburger, K. & Milbrandt, J., Dec 6 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 24, p. 10939-10943 5 p.

Research output: Contribution to journalArticle

353 Scopus citations

Stability-indicating proton nuclear magnetic resonance spectroscopic method for determination of S-adenosyl-L-methionine in tablets.

Revelle, L. K., d'Avignon, D. A., Reepmeyer, J. C. & Zerfing, R. C., Jan 1 1995, In : Journal of AOAC International. 78, 2, p. 353-358 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
1996
1997

Characterization of the promoter of SF-1, an orphan nuclear receptor required for adrenal and gonadal development

Woodson, K. G., Crawford, P. A., Sadovsky, Y. & Milbrandt, J., Jan 1 1997, In : Molecular Endocrinology. 11, 2, p. 117-126 10 p.

Research output: Contribution to journalArticle

61 Scopus citations

Nuclear receptor steroidogenic factor 1 directs embryonic stem cells toward the steroidogenic lineage

Crawford, P. A., Sadovsky, Y. & Milbrandt, J., Jul 1997, In : Molecular and cellular biology. 17, 7, p. 3997-4006 10 p.

Research output: Contribution to journalArticle

94 Scopus citations

Role of steroidogenic-factor 1 in basal and 3',5'-cyclic adenosine monophosphate-mediated regulation of cytochrome P450 side-chain cleavage enzyme in the mouse

Chau, Y. M., Crawford, P. A., Woodson, K. G., Polish, J. A., Olson, L. M. & Sadovsky, Y., Oct 1 1997, In : Biology of reproduction. 57, 4, p. 765-771 7 p.

Research output: Contribution to journalArticle

58 Scopus citations

The activation function-2 hexamer of steroidogenic factor-1 is required, but not sufficient for potentiation by SRC-1

Crawford, P. A., Polish, J. A., Ganpule, G. & Sadovsky, Y., Jan 1 1997, In : Molecular Endocrinology. 11, 11, p. 1626-1635 10 p.

Research output: Contribution to journalArticle

91 Scopus citations
1998

Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1

Crawford, P. A., Dorn, C., Sadovsky, Y. & Milbrandt, J., May 1998, In : Molecular and cellular biology. 18, 5, p. 2949-2956 8 p.

Research output: Contribution to journalArticle

275 Scopus citations
1999

Activation of luteinizing hormone β gene by gonadotropin-releasing hormone requires the synergy of early growth response-1 and steroidogenic factor-1

Dorn, C., Ou, Q., Svaren, J., Crawford, P. A. & Sadovsky, Y., May 14 1999, In : Journal of Biological Chemistry. 274, 20, p. 13870-13876 7 p.

Research output: Contribution to journalArticle

145 Scopus citations

Thermodynamics and kinetics of a folded-folded' transition at valine-9 of a GCN4-like leucine zipper

D'Avignon, D. A., Bretthorst, G. L., Holtzer, M. E. & Holtzer, A., Jan 1 1999, In : Biophysical journal. 76, 5, p. 2752-2759 8 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations
2000

2,6-Dimethoxyphenylphosphirane oxide and sulfide and their thermolysis to phosphinidene chalcogenides - Kinetic and mechanistic studies

Gaspar, P. P., Qian, H., Beatty, A. M., André D'Avignon, D., Kao, J. L. F., Watt, J. C. & Rath, N. P., Jan 1 2000, In : Tetrahedron. 56, 1, p. 105-119 15 p.

Research output: Contribution to journalArticle

Steroidogenic factor 1 is a monomeric orphan, but does not work alone

Ou, Q., Mouillet, J. F., Yan, X., Dorn, C., Crawford, P. A. & Sadovsky, Y., Jan 1 2000, In : Endocrine Research. 26, 4, p. 1003-1004 2 p.

Research output: Contribution to journalArticle

2001

Anodic Cyclization Reactions: Reversing the Polarity of Ketene Dithioacetal Groups

Sun, Y., Liu, B., Kao, J., Andre' D'Avignon, D. & Moeller, K. D., May 31 2001, In : Organic Letters. 3, 11, p. 1729-1732 4 p.

Research output: Contribution to journalArticle

Regulation of PTEN transcription by p53

Stambolic, V., MacPherson, D., Sas, D., Lin, Y., Snow, B., Jang, Y., Benchimol, S. & Mak, T. W., Jan 1 2001, In : Molecular Cell. 8, 2, p. 317-325 9 p.

Research output: Contribution to journalArticle

671 Scopus citations

RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons

Enomoto, H., Crawford, P. A., Gorodinsky, A., Heuckeroth, R. O., Johnson, E. M. & Milbrandt, J., Nov 20 2001, In : Development. 128, 20, p. 3963-3974 12 p.

Research output: Contribution to journalArticle

216 Scopus citations

The DEAD box protein DP103 is a regulator of steroidogenic factor-1

Ou, Q., Mouillet, J. F., Yan, X., Dorn, C., Crawford, P. A. & Sadovsky, Y., Jan 1 2001, In : Molecular Endocrinology. 15, 1, p. 69-79 11 p.

Research output: Contribution to journalArticle

72 Scopus citations
2004

p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1

You, H., Jang, Y. J., You-Ten, A. I., Okada, H., Liepa, J., Wakeham, A., Zaugg, K. & Mak, T. W., Sep 28 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 39, p. 14057-14062 6 p.

Research output: Contribution to journalArticle

99 Scopus citations
2005

DJ-1, a novel regulator of the tumor suppressor PTEN

Kim, R. H., Peters, M., Jang, Y., Shi, W., Pintilie, M., Fletcher, G. C., DeLuca, C., Liepa, J., Zhou, L., Snow, B., Binari, R. C., Manoukian, A. S., Bray, M. R., Liu, F. F., Tsao, M. S. & Mak, T. W., Mar 2005, In : Cancer Cell. 7, 3, p. 263-273 11 p.

Research output: Contribution to journalArticle

417 Scopus citations

Microbial regulation of intestinal radiosensitivity

Crawford, P. A. & Gordon, J. I., Sep 13 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 37, p. 13254-13259 6 p.

Research output: Contribution to journalArticle

113 Scopus citations

Specific ablation of the apoptotic functions of cytochrome c reveals a differential requirement for cytochrome c and Apaf-1 in apoptosis

Hao, Z., Duncan, G. S., Chang, C. C., Elia, A., Fang, M., Wakeham, A., Okada, H., Calzascia, T., Jang, Y., You-Ten, A., Yeh, W. C., Ohashi, P., Wang, X. & Mak, T. W., May 20 2005, In : Cell. 121, 4, p. 579-591 13 p.

Research output: Contribution to journalArticle

208 Scopus citations
2007
77 Scopus citations
2008

DEAD-box protein-103 (DP103, Ddx20) is essential for early embryonic development and modulates ovarian morphology and function

Mouillet, J. F., Yan, X., Ou, Q., Jin, L., Muglia, L. J., Crawford, P. A. & Sadovsky, Y., May 1 2008, In : Endocrinology. 149, 5, p. 2168-2175 8 p.

Research output: Contribution to journalArticle

31 Scopus citations
2009

Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation

Crawford, P. A., Crowley, J. R., Sambandam, N., Muegge, B. D., Costello, E. K., Hamady, M., Knight, R. & Gordon, J. I., Jul 7 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 27, p. 11276-11281 6 p.

Research output: Contribution to journalArticle

165 Scopus citations
2010

Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity

Etzion, S., Etzion, Y., Debosch, B., Crawford, P. A. & Muslin, A. J., Dec 1 2010, In : Journal of Molecular and Cellular Cardiology. 49, 6, p. 931-940 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Coordinated regulation of the metabolome and lipidome at the host-microbial interface

Bäckhed, F. & Crawford, P. A., Mar 1 2010, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1801, 3, p. 240-245 6 p.

Research output: Contribution to journalReview article

52 Scopus citations

Rapid vacuolar sequestration: The horseweed glyphosate resistance mechanism

Ge, X., André d'Avignon, D., Ackerman, J. J. H. & Douglas Sammons, R., Apr 1 2010, In : Pest management science. 66, 4, p. 345-348 4 p.

Research output: Contribution to journalArticle

Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF

Gasmi-Seabrook, G. M. C., Marshall, C. B., Cheung, M., Kim, B., Wang, F., Jang, Y. J., Mak, T. W., Stambolic, V. & Ikura, M., Feb 19 2010, In : Journal of Biological Chemistry. 285, 8, p. 5137-5145 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2011

Altered systemic ketone body metabolism in advanced heart failure

Janardhan, A., Chen, J. & Crawford, P. A., Dec 19 2011, In : Texas Heart Institute Journal. 38, 5, p. 533-538 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet

Garbow, J. R., Doherty, J. M., Schugar, R. C., Travers, S., Weber, M. L., Wentz, A. E., Ezenwajiaku, N., Cotter, D. G., Brunt, E. M. & Crawford, P. A., Jun 1 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 6, p. G956-G967

Research output: Contribution to journalArticle

72 Scopus citations

Obligate role for ketone body oxidation in neonatal metabolic homeostasis

Cotter, D. G., D'Avignon, D. A., Wentz, A. E., Weber, M. L. & Crawford, P. A., Mar 4 2011, In : Journal of Biological Chemistry. 286, 9, p. 6902-6910 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

The novel function of advanced glycation end products in regulation of MMP-9 production

Zhang, F., Banker, G., Liu, X., Suwanabol, P. A., Lengfeld, J., Yamanouchi, D., Kent, K. C. & Liu, B., Dec 1 2011, In : Journal of Surgical Research. 171, 2, p. 871-876 6 p.

Research output: Contribution to journalArticle

46 Scopus citations
2012

Increased oxygen consumption and OXPHOS potential in superhealer mesenchymal stem cells

Hughey, C. C., Alfaro, M. P., Belke, D. D., Rottman, J. N., Young, P. P., Wasserman, D. H. & Shearer, J., Jun 28 2012, In : Cell Regeneration. 1, 1, p. 1:3 3.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease

Schugar, R. C. & Crawford, P. A., Jul 1 2012, In : Current opinion in clinical nutrition and metabolic care. 15, 4, p. 374-380 7 p.

Research output: Contribution to journalReview article

49 Scopus citations
2013

Application of 31P-NMR spectroscopy to glyphosate studies in plants: Insights into cellular uptake and vacuole sequestration correlated to herbicide resistance

Ge, X., Andre'd'Avignon, D., Ackerman, J. J. H., Ostrander, E. & Sammons, R. D., Jan 1 2013, Handbook on Herbicides: Biological Activity, Classification and Health and Environmental Implications. Nova Science Publishers, Inc., p. 55-83 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth

Cotter, D. G., Ercal, B., D'Avignon, D. A., Dietzen, D. J. & Crawford, P. A., Jul 5 2013, In : Journal of Biological Chemistry. 288, 27, p. 19739-19749 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Ketone body metabolism and cardiovascular disease

Cotter, D. G., Schugar, R. C. & Crawford, P. A., Jun 10 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 304, 8, p. H1060-H1076

Research output: Contribution to journalReview article

158 Scopus citations

Metabolic stress in the myocardium: Adaptations of gene expression

Crawford, P. A. & Schaffer, J. E., Feb 1 2013, In : Journal of Molecular and Cellular Cardiology. 55, 1, p. 130-138 9 p.

Research output: Contribution to journalReview article

9 Scopus citations

PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner

Chambers, K. T., Chen, Z., Lai, L., Leone, T. C., Towle, H. C., Kralli, A., Crawford, P. A. & Finck, B. N., Aug 1 2013, In : Molecular Metabolism. 2, 3, p. 194-204 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Role of Choline Deficiency in the Fatty Liver Phenotype of Mice Fed a Low Protein, Very Low Carbohydrate Ketogenic Diet

Schugar, R. C., Huang, X., Moll, A. R., Brunt, E. M. & Crawford, P. A., Aug 29 2013, In : PloS one. 8, 8, e74806.

Research output: Contribution to journalArticle

23 Scopus citations

Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation

Cotter, D. G., Schugar, R. C., Wentz, A. E., André d'Avignon, D. & Crawford, P. A., Feb 15 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 304, 4, p. E363-E374

Research output: Contribution to journalArticle

23 Scopus citations
2014

Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling

Schugar, R. C., Moll, A. R., André d'Avignon, D., Weinheimer, C. J., Kovacs, A. & Crawford, P. A., Oct 1 2014, In : Molecular Metabolism. 3, 7, p. 754-769 16 p.

Research output: Contribution to journalArticle

52 Scopus citations

Impairments of hepatic gluconeogenesis and ketogenesis in PPARα-deficient neonatal mice

Cotter, D. G., Ercal, B., André D'Avignon, D., Dietzen, D. J. & Crawford, P. A., Jul 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 2, p. E176-E185

Research output: Contribution to journalArticle

11 Scopus citations

Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia

Cotter, D. G., Ercal, B., Huang, X., Leid, J. M., D'Avignon, D. A., Graham, M. J., Dietzen, D. J., Brunt, E. M., Patti, G. J. & Crawford, P. A., Dec 1 2014, In : Journal of Clinical Investigation. 124, 12, p. 5175-5190 16 p.

Research output: Contribution to journalArticle

66 Scopus citations

Stem cell-based therapies for multiple sclerosis: Recent advances in animal models and human clinical trials

Lutz, S. E., Lengfeld, J. & Agalliu, D., Mar 2014, In : Regenerative Medicine. 9, 2, p. 129-132 4 p.

Research output: Contribution to journalReview article

4 Scopus citations

X13CMS: Global tracking of isotopic labels in untargeted metabolomics

Huang, X., Chen, Y. J., Cho, K., Nikolskiy, I., Crawford, P. A. & Patti, G. J., Feb 4 2014, In : Analytical Chemistry. 86, 3, p. 1632-1639 8 p.

Research output: Contribution to journalArticle

82 Scopus citations
2015

The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes

Chang, Y. J., Pownall, S., Jensen, T. E., Mouaaz, S., Foltz, W., Zhou, L., Liadis, N., Woo, M., Hao, Z., Dutt, P., Bilan, P. J., Klip, A., Mak, T. & Stambolic, V., Oct 29 2015, In : eLife. 4, OCTOBER2015, e06011.

Research output: Contribution to journalArticle

15 Scopus citations
2016

Comprehensive and quantitative analysis of polyphosphoinositide species by shotgun lipidomics revealed their alterations in db/db mouse brain

Wang, C., Palavicini, J. P., Wang, M., Chen, L., Yang, K., Crawford, P. A. & Han, X., Jan 1 2016, In : Analytical chemistry. 88, 24, p. 12137-12144 8 p.

Research output: Contribution to journalArticle

16 Scopus citations