Molecular Medicine

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Steroidogenic Factor 1 Medicine & Life Sciences
Ketone Bodies Medicine & Life Sciences
Liver Medicine & Life Sciences
Glucose Medicine & Life Sciences
Gluconeogenesis Medicine & Life Sciences
Carbohydrate-Restricted Diet Medicine & Life Sciences
glyphosate Medicine & Life Sciences
Ketogenic Diet Medicine & Life Sciences

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Profiles

No photo of Peter Crawford

Peter Crawford

Person: Faculty

19952020
No photo of Dana d'Avignon

Dana d'Avignon

Person: Researcher

19812018
No photo of Curtis Hughey

Curtis Hughey

Person: Faculty

20102019

Projects 2017 2020

Ketone Body Metabolism and Integrated Metabolic Homeosta

Crawford, P.

NIH Natl Inst of Diabetes/Dig/Kidney Dis

9/1/17 → 3/31/20

Project: Research project

Ketone Bodies
Homeostasis

Probing the Role of Mitochondrial Short-chain Carbon

Crawford, P.

University of Pennsylvania

9/15/17 → 3/31/19

Project: Research project

Homeostasis
Carbon

Research Output 1981 2019

Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis

Puchalska, P., Martin, S. E., Huang, X., Lengfeld, J. E., Daniel, B., Graham, M. J., Han, X., Nagy, L., Patti, G. J. & Crawford, P., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 383-398.e7

Research output: Contribution to journal › Article

Hepatocytes
Fibrosis
Macrophages
Coenzyme A-Transferases
Keto Acids

The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense

Horton, J. L., Davidson, M. T., Kurishima, C., Vega, R. B., Powers, J. C., Matsuura, T. R., Petucci, C., Lewandowski, E. D., Crawford, P., Muoio, D. M., Recchia, F. A. & Kelly, D. P., Feb 21 2019, In : JCI insight. 4, 4

Research output: Contribution to journal › Article

Open Access
Physiological Stress
3-Hydroxybutyric Acid
Ketone Bodies
Heart Failure
Ketones
1 Citation (Scopus)

Glycine N-methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates

Hughey, C., Trefts, E., Bracy, D. P., James, F. D., Patrick Donahue, E. & Wasserman, D. H., Jan 1 2018, In : Journal of Biological Chemistry. 293, 30, p. 11944-11954 11 p.

Research output: Contribution to journal › Article

Glycine N-Methyltransferase
Carbon Cycle
Gluconeogenesis
S-Adenosylmethionine
Methionine