Research Output 1974 2019

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2019

Both the classical and alternative non-homologous end joining pathways contribute to the fusion of drastically shortened telomeres induced by TRF2 overexpression

Nera, B., Huang, H. S., Hendrickson, E. A. & Xu, L., Apr 18 2019, In : Cell Cycle. 18, 8, p. 880-888 9 p.

Research output: Contribution to journalArticle

Telomere Shortening
Ligases
DNA Ligases
Telomere-Binding Proteins
Chromosomes
3 Citations (Scopus)

Chromothripsis during telomere crisis is independent of NHEJ, and consistent with a replicative origin

Cleal, K., Jones, R. E., Grimstead, J. W., Hendrickson, E. A. & Baird, D. M., May 1 2019, In : Genome Research. 29, 5, p. 737-749 13 p.

Research output: Contribution to journalArticle

Open Access
Telomere
Genome
Genomic Instability
Sequence Analysis
Chromothripsis
2 Citations (Scopus)

DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase

Liddiard, K., Ruis, B. L., Kan, Y., Cleal, K., Ashelford, K. E., Hendrickson, E. A. & Baird, D. M., Jan 1 2019, In : Nucleic acids research. 47, 5, p. 2402-2424 23 p.

Research output: Contribution to journalArticle

Open Access
DNA Ligases
Chromatids
Telomere
Cell Cycle
Ligases

Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors

Kearse, M. G., Goldman, D. H., Choi, J., Nwaezeapu, C., Liang, D., Green, K. M., Goldstrohm, A., Todd, P. K., Green, R. & Wilusz, J. E., Jul 1 2019, In : Genes and Development. 33, 13-14, p. 871-885 15 p.

Research output: Contribution to journalArticle

Open Access
Protein Synthesis Inhibitors
Initiator Codon
Ribosomes
Cycloheximide
Messenger RNA

The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10

Paulson, C. N., John, K., Baxley, R. M., Kurniawan, F., Orellana, K., Francis, R., Sobeck, A., Eichman, B. F., Chazin, W. J., Aihara, H., Georg, G., Hawkinson, J. E. & Bielinsky, A. K., Aug 1 2019, In : Open biology. 9, 8, 190117.

Research output: Contribution to journalArticle

Open Access
Minichromosome Maintenance Proteins
Suramin
DNA-Binding Proteins
Fluorescence Polarization
Surface Plasmon Resonance
2018
1 Citation (Scopus)

A role for monomethylation of histone H3-K27 in gene activity in Drosophila

Wang, L., Joshi, P., Miller, E. L., Higgins, L., Slattery, M. G. & Simon, J. A., Mar 1 2018, In : Genetics. 208, 3, p. 1023-1036 14 p.

Research output: Contribution to journalArticle

Open Access
Polycomb Repressive Complex 2
Histones
Drosophila
Genes
Diptera
2 Citations (Scopus)

CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length

Gu, P., Jia, S., Takasugi, T., Smith, E., Nandakumar, J., Hendrickson, E. A. & Chang, S., Aug 1 2018, In : Aging cell. 17, 4, e12783.

Research output: Contribution to journalArticle

Telomerase
Telomere
Mutation
DNA
Clustered Regularly Interspaced Short Palindromic Repeats
4 Citations (Scopus)

Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner

Becker, J., Gallo, D., Leung, W., Croissant, T., Thu, Y-M., Nguyen, H. D., Starr, T., Brown, G. W. & Bielinsky, A. K., Jan 1 2018, In : Nucleic acids research. 46, 11, p. 5634-5650 17 p.

Research output: Contribution to journalArticle

Open Access
Flap Endonucleases
Genomic Instability
Proliferating Cell Nuclear Antigen
DNA Damage
Hypersensitivity
1 Citation (Scopus)

High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction

Li, G., Martínez-Bonet, M., Wu, D., Yang, Y., Cui, J., Nguyen, H. N., Cunin, P., Levescot, A., Bai, M., Westra, H. J., Okada, Y., Brenner, M. B., Raychaudhuri, S., Hendrickson, E. A., Maas, R. L. & Nigrovic, P. A., Aug 1 2018, In : Nature Genetics. 50, 8, p. 1180-1188 9 p.

Research output: Contribution to journalArticle

Open Access
Single Nucleotide Polymorphism
Enzymes
Genome-Wide Association Study
Juvenile Arthritis
Carrier Proteins
9 Citations (Scopus)

Identification of diverse target RNAs that are functionally regulated by human pumilio proteins

Bohn, J. A., Van Etten, J. L., Schagat, T. L., Bowman, B. M., McEachin, R. C., Freddolino, P. L. & Goldstrohm, A., Jan 1 2018, In : Nucleic acids research. 46, 1, p. 362-386 25 p.

Research output: Contribution to journalArticle

Open Access
RNA
Response Elements
Untranslated RNA
Messenger RNA
RNA-Binding Proteins
2 Citations (Scopus)

PARP1 is required for preserving telomeric integrity but is dispensable for A-NHEJ

Harvey, A., Mielke, N., Grimstead, J. W., Jones, R. E., Nguyen, T., Mueller, M., Baird, D. M. & Hendrickson, E. A., Oct 1 2018, In : Oncotarget. 9, 78, p. 34821-34837 17 p.

Research output: Contribution to journalArticle

Telomere
Breast Neoplasms
Genetic Markers
Ovarian Neoplasms
DNA Damage

PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation

Ngo, G., Hyatt, S., Grimstead, J., Jones, R., Hendrickson, E. A., Pepper, C. & Baird, D., Dec 1 2018, In : Oncotarget. 9, 101, p. 37549-37563 15 p.

Research output: Contribution to journalArticle

Telomere
Plasma Cell Leukemia
Cell Line
Genomic Instability
Telomerase
5 Citations (Scopus)

The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells

Abshire, E. T., Chasseur, J., Bohn, J. A., Del Rizzo, P. A., Freddolino, P. L., Goldstrohm, A. & Trievel, R. C., Jul 6 2018, In : Nucleic acids research. 46, 12, p. 6257-6270 14 p.

Research output: Contribution to journalArticle

Open Access
Ribonucleases
Exoribonucleases
Catalytic Domain
Messenger RNA
nocturnin
2017
6 Citations (Scopus)

FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response

Thompson, E. L., Yeo, J. E., Lee, E. A., Kan, Y., Raghunandan, M., Wiek, C., Hanenberg, H., Schärer, O. D., Hendrickson, E. A. & Sobeck, A., Jan 1 2017, In : Nucleic acids research. 45, 20, p. 11837-11857 21 p.

Research output: Contribution to journalArticle

Open Access
Fanconi Anemia
Fanconi Anemia Complementation Group D2 Protein
Chromatin
Fanconi Anemia Complementation Group Proteins
Null Lymphocytes
1 Citation (Scopus)

Human somatic cells deficient for RAD52 are impaired for viral integration and compromised for most aspects of homology-directed repair

Kan, Y., Batada, N. N. & Hendrickson, E. A., Jul 1 2017, In : DNA Repair. 55, p. 64-75 12 p.

Research output: Contribution to journalArticle

Open Access
Virus Integration
Repair
Radiation
Genes
Annealing
20 Citations (Scopus)

Mechanisms of precise genome editing using oligonucleotide donors

Kan, Y., Ruis, B. L., Takasugi, T. & Hendrickson, E. A., Jul 1 2017, In : Genome Research. 27, 7, p. 1099-1111 13 p.

Research output: Contribution to journalArticle

Open Access
Oligonucleotides
Oligodeoxyribonucleotides
Clustered Regularly Interspaced Short Palindromic Repeats
Gene Conversion
Deoxyribonuclease I
11 Citations (Scopus)

Rapid DNA replication origin licensing protects stem cell pluripotency

Matson, J. P., Dumitru, R., Coryell, P., Baxley, R. M., Chen, W., Twaroski, K., Webber, B. R., Tolar, J., Bielinsky, A. K., Purvis, J. E. & Cook, J. G., Nov 17 2017, In : eLife. 6, e30473.

Research output: Contribution to journalArticle

Replication Origin
Licensure
Stem cells
DNA Replication
Stem Cells
2016
48 Citations (Scopus)

CGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic Proteins

Kearse, M. G., Green, K. M., Krans, A., Rodriguez, C. M., Linsalata, A. E., Goldstrohm, A. & Todd, P. K., Apr 21 2016, In : Molecular Cell. 62, 2, p. 314-322 9 p.

Research output: Contribution to journalArticle

Initiator Codon
Poisons
Reading Frames
Proteins
Nucleotides
1 Citation (Scopus)

Mapping ubiquitination sites of S. cerevisiae Mcm10

Zhang, T., Fultz, B. L., Das-Bradoo, S. & Bielinsky, A. K., Dec 1 2016, In : Biochemistry and Biophysics Reports. 8, p. 212-218 7 p.

Research output: Contribution to journalArticle

Ubiquitination
Lysine
Saccharomyces cerevisiae
Proliferating Cell Nuclear Antigen
Machinery
21 Citations (Scopus)

Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells

Alotaibi, M., Sharma, K., Saleh, T., Povirk, L. F., Hendrickson, E. A. & Gewirtz, D. A., Mar 1 2016, In : Radiation research. 185, 3, p. 229-245 17 p.

Research output: Contribution to journalArticle

DNA Repair-Deficiency Disorders
Autophagy
tumors
deoxyribonucleic acid
recovery
7 Citations (Scopus)

Restoration of ATM expression in DNA-PKcs-deficient cells inhibits signal end joining

Neal, J. A., Xu, Y., Abe, M., Hendrickson, E. A. & Meek, K., Apr 1 2016, In : Journal of Immunology. 196, 7, p. 3032-3042 11 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Catalytic Domain
V(D)J Recombination
Cell Line
Cultured Cells
8 Citations (Scopus)

Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic Progression

Thu, Y-M., Van Riper, S. K., Higgins, L., Zhang, T., Becker, J., Markowski, T. W., Nguyen, H. D., Griffin, T. J. & Bielinsky, A. K., May 10 2016, In : Cell Reports. 15, 6, p. 1254-1265 12 p.

Research output: Contribution to journalArticle

Minichromosome Maintenance Proteins
M Phase Cell Cycle Checkpoints
Ligases
Methyl Methanesulfonate
Protein Deficiency
2015
1 Citation (Scopus)

Alternative end joining, clonal evolution, and escape from a telomere-driven crisis

Hendrickson, E. A. & Baird, D. M., Jan 2 2015, In : Molecular and Cellular Oncology. 2, 1, e975623.

Research output: Contribution to journalArticle

Clonal Evolution
Telomere
Genomic Instability
Neoplasms
53 Citations (Scopus)

ATRX represses alternative lengthening of telomeres

Napier, C. E., Huschtscha, L. I., Harvey, A., Bower, K., Noble, J. R., Hendrickson, E. A. & Reddel, R. R., Jan 1 2015, In : Oncotarget. 6, 18, p. 16543-16558 16 p.

Research output: Contribution to journalArticle

Telomere Homeostasis
Telomerase
Telomere Shortening
Chromatin Assembly and Disassembly
Homologous Recombination
27 Citations (Scopus)

A versatile reporter system for CRISPR-mediated chromosomal rearrangements

Li, Y., Park, A. I., Mou, H., Colpan, C., Bizhanova, A., Akama-Garren, E., Joshi, N., Hendrickson, E. A., Feldser, D., Yin, H., Anderson, D. G., Jacks, T., Weng, Z. & Xue, W., May 28 2015, In : Genome biology. 16, 1, 111.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
DNA Breaks
Gene Rearrangement
Nucleotides
Liver
20 Citations (Scopus)

Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation

Batenburg, N. L., Thompson, E. L., Hendrickson, E. A. & Zhu, X. D., May 12 2015, In : EMBO Journal. 34, 10, p. 1399-1416 18 p.

Research output: Contribution to journalArticle

Cockayne Syndrome
Double-Stranded DNA Breaks
Chromatin
Repair
Chemical activation
122 Citations (Scopus)

DNA2 drives processing and restart of reversed replication forks in human cells

Thangavel, S., Berti, M., Levikova, M., Pinto, C., Gomathinayagam, S., Vujanovic, M., Zellweger, R., Moore, H., Lee, E. H., Hendrickson, E. A., Cejka, P., Stewart, S., Lopes, M. & Vindigni, A., Jan 1 2015, In : Journal of Cell Biology. 208, 5, p. 545-562 18 p.

Research output: Contribution to journalArticle

DNA Replication
Homologous Recombination
DNA Damage
Adenosine Triphosphatases
Genome
9 Citations (Scopus)

EIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells

Avdulov, S. V., Herrera, J., Smith, K., Peterson, M., Gomez-Garcia, J., Beadnell, T. C., Schwertfeger, K., Benyumov, A., Manivel, J. C., Li, S., Bielinsky, A. K., Yee, D., Bitterman, P. B. & Polunovsky, V. A., Feb 15 2015, In : Cancer Research. 75, 4, p. 687-697 11 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4E
Breast
Stem Cells
DNA Replication
Lactation
34 Citations (Scopus)

FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2

Castella, M., Jacquemont, C., Thompson, E. L., Yeo, J. E., Cheung, R. S., Huang, J. W., Sobeck, A., Hendrickson, E. A. & Taniguchi, T., Jan 1 2015, In : PLoS Genetics. 11, 10, e1005563.

Research output: Contribution to journalArticle

Fanconi Anemia
anemia
DNA damage
DNA Damage
DNA
27 Citations (Scopus)

XRCC4/XLF Interaction is variably required for DNA repair and is not required for ligase IV stimulation

Roy, S., de Melo, A. J., Xu, Y., Tadi, S. K., Négrel, A., Hendrickson, E. A., Modesti, M. & Meek, K., Jan 1 2015, In : Molecular and cellular biology. 35, 17, p. 3017-3028 12 p.

Research output: Contribution to journalArticle

Ligases
DNA Repair
Ligation
DNA
In Vitro Techniques
2014
144 Citations (Scopus)

Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining

Ghezraoui, H., Piganeau, M., Renouf, B., Renaud, J. B., Sallmyr, A., Ruis, B. L., Oh, S., Tomkinson, A. E., Hendrickson, E. A., Giovannangeli, C., Jasin, M. & Brunet, E., Sep 18 2014, In : Molecular Cell. 55, 6, p. 829-842 14 p.

Research output: Contribution to journalArticle

Genetic Translocation
Clustered Regularly Interspaced Short Palindromic Repeats
Neoplasms
Carcinogenesis
Chromosomes
45 Citations (Scopus)

CtIP mediates replication fork recovery in a FANCD2-regulated manner

Yeo, J. E., Lee, E. H., Hendrickson, E. A. & Sobeck, A., Jan 1 2014, In : Human Molecular Genetics. 23, 14, p. 3695-3705 11 p., ddu078.

Research output: Contribution to journalArticle

Fanconi Anemia
Proteins
Recombinational DNA Repair
Fanconi Anemia Complementation Group D2 Protein
DNA Repair-Deficiency Disorders
12 Citations (Scopus)

Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity

Smith, S., Fox, J., Mejia, M., Ruangpradit, W., Saberi, A., Kim, S., Choi, Y., Oh, S., Wang, Y., Choi, K., Li, L., Hendrickson, E. A., Takeda, S., Muller, M. & Myung, K., Jan 23 2014, In : PloS one. 9, 1, e87203.

Research output: Contribution to journalArticle

histone deacetylase
Histone Deacetylase Inhibitors
DNA repair
DNA Repair
Repair
17 Citations (Scopus)

Mcm10 deficiency causes defective-replisome-induced mutagenesis and a dependency on error-free postreplicative repair

Becker, J., Nguyen, H. D., Wang, X. & Bielinsky, A. K., Jun 1 2014, In : Cell Cycle. 13, 11, p. 1737-1748 12 p.

Research output: Contribution to journalArticle

Mutagenesis
Ubiquitination
DNA
Proliferating Cell Nuclear Antigen
Alleles
37 Citations (Scopus)

Preventing over-resection by DNA2 helicase/nuclease suppresses repair defects in Fanconi anemia cells

Karanja, K., Lee, E. H., Hendrickson, E. A. & Campbell, J. L., May 15 2014, In : Cell Cycle. 13, 10, p. 1540-1550 11 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Formaldehyde
Cisplatin
DNA
Ficusin
30 Citations (Scopus)

The fidelity of the ligation step determines how ends are resolved during nonhomologous end joining

Waters, C. A., Strande, N. T., Pryor, J. M., Strom, C. N., Mieczkowski, P., Burkhalter, M. D., Oh, S., Qaqish, B. F., Moore, D. T., Hendrickson, E. A. & Ramsden, D. A., Jul 3 2014, In : Nature communications. 5, 4286.

Research output: Contribution to journalArticle

Joining
Ligation
bypasses
Chromosome Breakage
Processing
27 Citations (Scopus)

The Mechanism of Gene Targeting in Human Somatic Cells

Kan, Y., Ruis, B. L., Lin, S. & Hendrickson, E. A., Jan 1 2014, In : PLoS Genetics. 10, 4, e1004251.

Research output: Contribution to journalArticle

Gene Targeting
gene targeting
somatic cells
targeting
homologous recombination
19 Citations (Scopus)

The N-terminus of Mcm10 is important for interaction with the 9-1-1 clamp and in resistance to DNA damage

Alver, R. C., Zhang, T., Josephrajan, A., Fultz, B. L., Hendrix, C. J., Das-Bradoo, S. & Bielinsky, A. K., Jan 1 2014, In : Nucleic acids research. 42, 13, p. 8389-8404 16 p.

Research output: Contribution to journalArticle

Ultraviolet Rays
DNA Replication
DNA Damage
Minichromosome Maintenance Proteins
Chromosome Breakage
2013
16 Citations (Scopus)

Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage

Yang, Y., Durando, M., Smith-Roe, S. L., Sproul, C., Greenwalt, A. M., Kaufmann, W., Oh, S., Hendrickson, E. A. & Vaziri, C., Feb 1 2013, In : Nucleic Acids Research. 41, 4, p. 2296-2312 17 p.

Research output: Contribution to journalArticle

S Phase
DNA Damage
Cell Cycle
DNA
Ubiquitin-Protein Ligases
35 Citations (Scopus)
Telomere
Ligases
Genetic Recombination
Chromosomes
Cell Line
12 Citations (Scopus)

Mcm10 Self-Association Is Mediated by an N-Terminal Coiled-Coil Domain

Du, W., Josephrajan, A., Adhikary, S., Bowles, T., Bielinsky, A. K. & Eichman, B. F., Jul 23 2013, In : PloS one. 8, 7, e70518.

Research output: Contribution to journalArticle

Minichromosome Maintenance Proteins
DNA Replication
proteins
Two-Hybrid System Techniques
Mutation
52 Citations (Scopus)

Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence

Liu, Y., Hawkins, O. E., Su, Y., Vilgelm, A. E., Sobolik, T., Thu, Y-M., Kantrow, S., Splittgerber, R. C., Short, S., Amiri, K. I., Ecsedy, J. A., Sosman, J. A., Kelley, M. C. & Richmond, A., Jan 1 2013, In : EMBO Molecular Medicine. 5, 1, p. 149-166 18 p.

Research output: Contribution to journalArticle

Aurora Kinases
DNA Damage
Growth
Pharmaceutical Preparations
Neoplasms
2012
25 Citations (Scopus)

NF-κB inducing kinase (NIK) modulates melanoma tumorigenesis by regulating expression of pro-survival factors through the Β-catenin pathway

Thu, Y-M., Su, Y., Yang, J., Splittgerber, R., Na, S., Boyd, A., Mosse, C., Simons, C. & Richmond, A., May 17 2012, In : Oncogene. 31, 20, p. 2580-2592 13 p.

Research output: Contribution to journalArticle

Catenins
Melanoma
Carcinogenesis
Phosphotransferases
Growth
34 Citations (Scopus)

Specificity of the dRP/AP lyase of ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends

Strande, N., Roberts, S. A., Oh, S., Hendrickson, E. A. & Ramsden, D. A., Apr 20 2012, In : Journal of Biological Chemistry. 287, 17, p. 13686-13693 8 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Joining
Ligation
Chromosome Breakage
DNA
45 Citations (Scopus)

The HSV-1 Exonuclease, UL12, Stimulates Recombination by a Single Strand Annealing Mechanism

Schumacher, A. J., Mohni, K. N., Kan, Y., Hendrickson, E. A., Stark, J. M. & Weller, S. K., Aug 1 2012, In : PLoS pathogens. 8, 8, e1002862.

Research output: Contribution to journalArticle

Exonucleases
Human Herpesvirus 1
Genetic Recombination
DNA Replication
Bacteriophage T4
2011
13 Citations (Scopus)

Androgen receptor regulates transcription of the zeb1 transcription factor

Anose, B. M. & Sanders, M. M., Dec 1 2011, In : International Journal of Endocrinology. 2011, 903918.

Research output: Contribution to journalArticle

Zinc Fingers
Androgen Receptors
Carrier Proteins
Androgens
Prostatic Neoplasms
2010
14 Citations (Scopus)

DNA clasping by mycobacterial HU: The c-terminal region of HupB mediates increased specificity of DNA binding

Kumar, S., Sardesai, A. A., Basu, D., Muniyappa, K. & Hasnain, S. E., Nov 1 2010, In : PloS one. 5, 9, p. 1-10 10 p., e12551.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
DNA
Proteins
proteins
Open Reading Frames
155 Citations (Scopus)

Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells

Fattaha, F., Lee, E. H., Weisenselb, N., Wang, Y., Lichter, N. & Hendrickson, E. A., Feb 1 2010, In : PLoS Genetics. 6, 2, e1000855.

Research output: Contribution to journalArticle

Double-Stranded DNA Breaks
somatic cells
repair
DNA
Null Lymphocytes
30 Citations (Scopus)

Mechanistic issues of the interaction of the hairpin-forming domain of tBid with mitochondrial cardiolipin

Gonzalvez, F., Pariselli, F., Jalmar, O., Dupaigne, P., Sureau, F., Dellinger, M., Hendrickson, E. A., Bernard, S. & Petit, P. X., Feb 22 2010, In : PloS one. 5, 2, e9342.

Research output: Contribution to journalArticle

Mitochondria
Cardiolipins
cardiolipins
mitochondria
cytochrome c
65 Citations (Scopus)

NF-κB inducing kinase: A key regulator in the immune system and in cancer

Thu, Y-M. & Richmond, A., Aug 1 2010, In : Cytokine and Growth Factor Reviews. 21, 4, p. 213-226 14 p.

Research output: Contribution to journalArticle

Immune system
Immune System
Phosphotransferases
Neoplasms
Genetic Models