Organization profile

Organization profile

Microorganisms – bacteria, viruses, fungi – reside in diverse and heavily populated communities on the skin and mucous membranes of animals, including humans. Wherever they are located on or in the body, these microbes maintain intimate and often mutually beneficial relationships between themselves and their animal hosts. The vast community of bacteria residing in the digestive tract can undergo significant changes over the lifespan of food animals and people, and these shifts in population can affect the host’s overall health and development. Drugs, particularly antimicrobial agents, can contribute to these bacterial community shifts. Antimicrobial drugs can promote the growth of food animals, but their widespread use is contributing to increased microbial drug resistance.  Similarly, excessive antibiotic use by people can fight disease, but can also lead to the emergence of drug-resistant microorganisms.   Through genomic analyses and mathematical modeling, faculty in the Microbiome/Antibiotic Resistance research cluster are characterizing the intestinal bacteria, viruses and the small DNA molecules that transfer antibiotic resistance among bacteria in food animals.  They seek to discover how changes in the gut microbial community affect animal growth and well-being.  Their research will contribute to the development of antibiotic alternatives, such as new probiotics, to enhance animal growth and reduce the incidence of antimicrobial drug resistance.

Fingerprint Dive into the research topics where Microbiome and Antibiotic Resistance is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.

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  • Research Output

    A Cell Proliferation and Inflammatory Signature Is Induced by Lawsonia intracellularis Infection in Swine

    Leite, F. L., Abrahante, J. E., Vasquez, E., Vannucci, F., Gebhart, C. J., Winkelman, N., Mueller, A., Torrison, J., Rambo, Z. & Isaacson, R. E., Jan 29 2019, In : mBio. 10, 1

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Chronic obstructive pulmonary disease upper airway microbiome is associated with select clinical characteristics

    Pragman, A. A., Knutson, K. A., Gould, T. J., Hodgson, S. W., Isaacson, R. E., Reilly, C. S. & Wendt, C. H., Jan 1 2019, In : PloS one. 14, 7, e0219962.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Piglet gut microbial shifts early in life: Causes and effects

    Guevarra, R. B., Lee, J. H., Lee, S. H., Seok, M. J., Kim, D. W., Kang, B. N., Johnson, T. J., Isaacson, R. E. & Kim, H. B., Jan 14 2019, In : Journal of Animal Science and Biotechnology. 10, 1, 1.

    Research output: Contribution to journalReview article

  • 15 Scopus citations