Research Output

2018

Disseminating metaproteomic informatics capabilities and knowledge using the galaxy-P framework

Blank, C., Easterly, C., Gruening, B., Johnson, J., Kolmeder, C. A., Kumar, P., May, D., Mehta, S., Mesuere, B., Brown, Z., Elias, J. E., Hervey, W. J., McGowan, T., Muth, T., Nunn, B. L., Rudney, J., Tanca, A., Griffin, T. J. & Jagtap, P. D., Mar 1 2018, In : Proteomes. 6, 1, 7.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Dystrophin As a Molecular Shock Absorber

Le, S., Yu, M., Hovan, L., Zhao, Z., Ervasti, J. & Yan, J., Dec 26 2018, In : ACS nano. 12, 12, p. 12140-12148 9 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
Open Access
1 Scopus citations

Essential nucleotide- and protein-dependent functions of Actb/β-actin

Patrinostro, X., Roy, P., Lindsay, A., Chamberlain, C. M., Sundby, L. J., Starker, C., Voytas, D. F., Ervasti, J. M. & Perrin, B. J., Jul 31 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. 7973-7978 6 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
Open Access
1 Scopus citations

Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms

O'Rourke, A. R., Lindsay, A., Tarpey, M. D., Yuen, S., McCourt, P., Nelson, D. M., Perrin, B. J., Thomas, D. D., Spangenburg, E. E., Lowe, D. A. & Ervasti, J. M., Feb 2018, In : FEBS Journal. 285, 3, p. 481-500 20 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
Open Access

Integrative effects of dystrophin loss on metabolic function of the mdx mouse

Strakova, J., Kamdar, F., Kulhanek, D., Razzoli, M., Garry, D. J., Ervasti, J. M., Bartolomucci, A. & Townsend, D. W., Dec 1 2018, In : Scientific reports. 8, 1, 13624.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle

Olthoff, J. T., Lindsay, A., Abo-Zahrah, R., Baltgalvis, K. A., Patrinostro, X., Belanto, J. J., Yu, D. Y., Perrin, B. J., Garry, D. J., Rodney, G. G., Lowe, D. A. & Ervasti, J. M., Dec 1 2018, In : Nature communications. 9, 1, 5104.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Mouse models of two missense mutations in actin-binding domain 1 of dystrophin associated with duchenne or becker muscular dystrophy

McCourt, J. L., Talsness, D. M., Lindsay, A., Arpke, R. W., Chatterton, P. D., Nelson, D. M., Chamberlain, C. M., Olthoff, J. T., Belanto, J. J., McCourt, P. M., Kyba, M., Lowe, D. A. & Ervasti, J. M., Feb 1 2018, In : Human molecular genetics. 27, 3, p. 451-462 12 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Multi-omic molecular profiling of lung cancer in COPD

Sandri, B. J., Kaplan, A., Hodgson, S. W., Peterson, M., Avdulov, S. V., Higgins, L., Markowski, T., Yang, P., Limper, A. H., Griffin, T. J., Bitterman, P. B., Lock, E. & Wendt, C. H., Jul 1 2018, In : European Respiratory Journal. 52, 1, 1702665.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Neopterin/7,8-dihydroneopterin is elevated in Duchenne muscular dystrophy patients and protects mdx skeletal muscle function

Lindsay, A., Schmiechen, A., Chamberlain, C. M., Ervasti, J. M. & Lowe, D. A., Jul 1 2018, In : Experimental Physiology. 103, 7, p. 995-1009 15 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Plasma lipoproteome in Alzheimer's disease: A proof-of-concept study

Li, D., Huang, F., Zhao, Y., Villata, P. W., Griffin, T. J., Zhang, L., Li, L. & Yu, F., Sep 20 2018, In : Clinical Proteomics. 15, 1, 31.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Regulation of the natriuretic peptide receptor 2 (Npr2) by phosphorylation of juxtamembrane serine and threonine residues is essential for bifurcation of sensory axons

Schmidt, H., Dickey, D. M., Dumoulin, A., Octave, M., Robinson, J. W., Kühn, R., Feil, R., Potter, L. R. & Rathjen, F. G., Nov 7 2018, In : Journal of Neuroscience. 38, 45, p. 9768-9780 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Salivary proteomics of healthy dogs: An in depth catalog

Torres, S. M. F., Furrow, E., Souza, C. P., Granick, J. L., De Jong, E. P., Griffin, T. J. & Wang, X., Jan 2018, In : PloS one. 13, 1, e0191307.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Sizing lipid droplets from adult and geriatric mouse liver tissue via nanoparticle tracking analysis

Muratore, K. A., Najt, C. P., Livezey, N. M., Marti, J., Mashek, D. G. & Arriaga, E. A., Jun 1 2018, In : Analytical and Bioanalytical Chemistry. 410, 16, p. 3629-3638 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction

Park, J. M., Seo, M., Jung, C. H., Grunwald, D., Stone, M., Otto, N. M., Toso, E., Ahn, Y., Kyba, M., Griffin, T. J., Higgins, L. A. & Kim, D. H., Apr 3 2018, In : Autophagy. 14, 4, p. 584-597 14 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

Variable rescue of microtubule and physiological phenotypes in mdx muscle expressing different miniaturized dystrophins

Nelson, D. M., Lindsay, A., Judge, L. M., Duan, D., Chamberlain, J. S., Lowe, D. A. & Ervasti, J. M., Jun 15 2018, In : Human molecular genetics. 27, 12, p. 2090-2100 11 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Xanthine oxidase is hyper-active in Duchenne muscular dystrophy

Lindsay, A., McCourt, P. M., Karachunski, P., Lowe, D. A. & Ervasti, J. M., Dec 2018, In : Free Radical Biology and Medicine. 129, p. 364-371 8 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2017

A coupled approach utilizing immunohistochemistry and immunocytochemistry to visualize cellular lipophagy

Sathyanarayan, A., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 185-191 7 p. (Methods in Molecular Biology; vol. 1554).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Acyl-CoA thioesterase 1 (ACOT1) regulates PPARα to couple fatty acid flux with oxidative capacity during fasting

Franklin, M. P., Sathyanarayan, A. & Mashek, D. G., Aug 2017, In : Diabetes. 66, 8, p. 2112-2123 12 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

A glutamate-substituted mutant mimics the phosphorylated and active form of guanylyl cyclase-A

Otto, N. M., McDowell, W. G., Dickey, D. M. & Potter, L. R., Jul 2017, In : Molecular Pharmacology. 92, 1, p. 67-74 8 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Breaking fat: The regulation and mechanisms of lipophagy

Schulze, R. J., Sathyanarayan, A. & Mashek, D. G., Oct 2017, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1862, 10, p. 1178-1187 10 p.

Research output: Contribution to journalReview article

Open Access
52 Scopus citations
Open Access
6 Scopus citations
Open Access
21 Scopus citations

Caloric restriction prevents carcinogen-initiated liver tumorigenesis in mice

Ploeger, J. M., Manivel, J. C., Boatner, L. N. & Mashek, D. G., Nov 2017, In : Cancer Prevention Research. 10, 11, p. 660-670 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Carbonylated Proteins and Their Metabolic Regulation: Overview of Mechanisms, Target Proteins, and Characterization Using Proteomic Methods

Afiuni-Zadeh, S. & Griffin, T. J., Apr 20 2017, Protein Carbonylation: Principles, Analysis, and Biological Implications. Wiley, p. 110-130 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Chapter 13: Using Galaxy for Proteomics

Guerrero, C. R., Jagtap, P. D., Johnson, J. E. & Griffin, T. J., Jan 1 2017, Proteome Informatics. Bessant, C. & Gaskell, S. J. (eds.). 5 ed. Royal Society of Chemistry, p. 289-320 32 p. (New Developments in Mass Spectrometry; vol. 2017-January, no. 5).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor

Shuhaibar, L. C., Robinson, J. W., Vigone, G., Shuhaibar, N. P., Egbert, J. R., Baena, V., Uliasz, T. F., Kaback, D., Yee, S. P., Feil, R., Fisher, M. C., Dealy, C. N., Potter, L. R. & Jaffe, L. A., Dec 4 2017, In : eLife. 6, e31343.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
3 Scopus citations

Effect of acute physiological free fatty acid elevation in the context of hyperinsulinemia on fiber type-specific IMCL accumulation

Chow, L. S., Mashek, D. G., Wang, Q., Shepherd, S. O., Goodpaster, B. H. & Dubé, J. J., Jul 2017, In : Journal of applied physiology. 123, 1, p. 71-78 8 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

N-(1-Benzyl-3,5-dimethyl‑1H‑pyrazol-4-yl)benzamides: Antiproliferative activity and effects on mTORC1 and autophagy

Ai, T., Willett, R., Williams, J., Ding, R., Wilson, D. J., Xie, J., Kim, D. H., Puertollano, R. & Chen, L., Jan 1 2017, In : ACS Medicinal Chemistry Letters. 8, 1, p. 90-95 6 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
Open Access
6 Scopus citations

Relative importance of βcyto-and γcyto-actin in primary mouse embryonic fibroblasts

Patrinostro, X., O'Rourke, A. R., Chamberlain, C. M., Moriarity, B. S., Perrin, B. J. & Ervasti, J. M., Mar 15 2017, In : Molecular biology of the cell. 28, 6, p. 771-782 12 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
Open Access
3 Scopus citations

Training alters the distribution of perilipin proteins in muscle following acute free fatty acid exposure

Shepherd, S. O., Strauss, J. A., Wang, Q., Dube, J. J., Goodpaster, B., Mashek, D. G. & Chow, L. S., Aug 15 2017, In : Journal of Physiology. 595, 16, p. 5587-5601 15 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
2016

Actin Is Crucial for All Kinetically Distinguishable Forms of Endocytosis at Synapses

Wu, X. S., Lee, S. H., Sheng, J., Zhang, Z., Zhao, W. D., Wang, D., Jin, Y., Charnay, P., Ervasti, J. M. & Wu, L. G., Dec 7 2016, In : Neuron. 92, 5, p. 1020-1035 16 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

An expanded role for mTORC1 in autophagy

Kim, Y. M., Park, J. M., Grunwald, D. & Kim, D. H., Jan 2 2016, In : Molecular and Cellular Oncology. 3, 1, e1010958.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Catalytically active guanylyl cyclase B requires endoplasmic reticulum-mediated glycosylation, and mutations that inhibit this process cause dwarfism

Dickey, D. M., Edmund, A. B., Otto, N. M., Chaffee, T. S., Robinson, J. W. & Potter, L. R., May 20 2016, In : Journal of Biological Chemistry. 291, 21, p. 11385-11393 9 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone

Shuhaibar, L. C., Egbert, J. R., Edmund, A. B., Uliasz, T. F., Dickey, D. M., Yee, S. P., Potter, L. R. & Jaffe, L. A., Jan 1 2016, In : Developmental Biology. 409, 1, p. 194-201 8 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

High frequency hearing loss and hyperactivity in DUX4 transgenic mice

Dandapat, A., Perrin, B. J., Cabelka, C., Razzoli, M., Ervasti, J. M., Bartolomucci, A., Lowe, D. A. & Kyba, M., Mar 2016, In : PloS one. 11, 3, e0151467.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Independent variability of microtubule perturbations associated with dystrophinopathy

Belanto, J. J., Olthoff, J. T., Mader, T. L., Chamberlain, C. M., Nelson, D. M., McCourt, P. M., Talsness, D. M., Gundersen, G. G., Lowe, D. A. & Ervasti, J. M., Nov 15 2016, In : Human molecular genetics. 25, 22, p. 4951-4961 11 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins

Zhang, W., Bu, S. Y., Mashek, M. T., O-Sullivan, I. S., Sibai, Z., Khan, S. A., Ilkayeva, O., Newgard, C. B., Mashek, D. G. & Unterman, T. G., Apr 12 2016, In : Cell reports. 15, 2, p. 349-359 11 p.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations
Open Access
5 Scopus citations

RIPPER: A framework for MS1 only metabolomics and proteomics label-free relative quantification

Van Riper, S. K., Higgins, L., Carlis, J. V. & Griffin, T. J., Jul 1 2016, In : Bioinformatics. 32, 13, p. 2035-2037 3 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic Progression

Thu, Y. M., Van Riper, S. K., Higgins, L. A., Zhang, T., Becker, J. R., Markowski, T. W., Nguyen, H. D., Griffin, T. J. & Bielinsky, A. K., May 10 2016, In : Cell reports. 15, 6, p. 1254-1265 12 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

The role of the proteasome in AML

Csizmar, C. M., Kim, D. H. & Sachs, Z., Dec 2 2016, In : Blood cancer journal. 6, 12, p. e503

Research output: Contribution to journalReview article

Open Access
18 Scopus citations

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

Park, J. M., Jung, C. H., Seo, M., Otto, N. M., Grunwald, D., Kim, K. H., Moriarity, B., Kim, Y. M., Starker, C., Nho, R. S., Voytas, D. & Kim, D. H., Apr 5 2016, In : Autophagy. 12, 3, p. 547-564 18 p.

Research output: Contribution to journalArticle

Open Access
98 Scopus citations

Tryptophan catabolism in acute exacerbations of chronic obstructive pulmonary disease

Gulcev, M., Reilly, C., Griffin, T. J., Broeckling, C. D., Sandri, B. J., Witthuhn, B. A., Hodgson, S. W., Woodruff, P. G. & Wendt, C. H., Sep 29 2016, In : International Journal of COPD. 11, 1, p. 2435-2446 12 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2015

ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1α/PPAR-α signaling

Khan, S. A., Sathyanarayan, A., Mashek, M. T., Ong, K. T., Wollaston-Hayden, E. E. & Mashek, D. G., Feb 1 2015, In : Diabetes. 64, 2, p. 418-426 9 p.

Research output: Contribution to journalArticle

61 Scopus citations