Research Output 1973 2019

2017
33 Citations (Scopus)

Breaking fat: The regulation and mechanisms of lipophagy

Schulze, R. J., Sathyanarayan, A. & Mashek, D., Oct 1 2017, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1862, 10, p. 1178-1187 10 p.

Research output: Contribution to journalReview article

Fats
Research
Metabolic Diseases
Liver
Lipid Droplets
4 Citations (Scopus)
Open Access
Adult Respiratory Distress Syndrome
Bronchoalveolar Lavage Fluid
Survivors
Proteins
Oxidative Stress
16 Citations (Scopus)
Open Access
Idiopathic Pulmonary Fibrosis
Calcium-Binding Proteins
Mesenchymal Stromal Cells
Fibrosis
Myofibroblasts
1 Citation (Scopus)

Caloric restriction prevents carcinogen-initiated liver tumorigenesis in mice

Ploeger, J. M., Manivel, J. C., Boatner, L. N. & Mashek, D., Nov 1 2017, In : Cancer Prevention Research. 10, 11, p. 660-670 11 p.

Research output: Contribution to journalArticle

Caloric Restriction
Carcinogens
Carcinogenesis
Liver
Diet

Carbonylated Proteins and Their Metabolic Regulation: Overview of Mechanisms, Target Proteins, and Characterization Using Proteomic Methods

Afiuni-Zadeh, S. & Griffin, T. J., Apr 20 2017, Protein Carbonylation: Principles, Analysis, and Biological Implications. wiley, p. 110-130 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Carbonylation
Proteins
Oxidative stress
Avidin
Biomarkers
1 Citation (Scopus)

Chapter 13: Using Galaxy for Proteomics

Guerrero, C. R., Jagtap, P. D., Johnson, J. E. & Griffin, T. J., Jan 1 2017, Proteome Informatics. Bessant, C. & Gaskell, S. J. (eds.). 5 ed. Royal Society of Chemistry, p. 289-320 32 p. (New Developments in Mass Spectrometry; vol. 2017-January, no. 5).

Research output: Chapter in Book/Report/Conference proceedingChapter

Galaxies
Mass spectrometry
Bioinformatics
Proteomics
Scalability

Comparative Metaproteomics to Study Environmental Changes

Matallana-Surget, S., Jagtap, P. D., Griffin, T. J., Beraud, M. & Wattiez, R., Oct 29 2017, Metagenomics: Perspectives, Methods, and Applications. Elsevier Inc., p. 327-363 37 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Aquatic ecosystems
Microorganisms
Ecosystems
Ecosystem
Workflow
4 Citations (Scopus)

Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor

Shuhaibar, L. C., Robinson, J. W., Vigone, G., Shuhaibar, N. P., Egbert, J. R., Baena, V., Uliasz, T. F., Kaback, D., Yee, S. P., Feil, R., Fisher, M. C., Dealy, C. N., Potter, L. R. & Jaffe, L. A., Dec 4 2017, In : eLife. 6, e31343.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Guanylate Cyclase
Bone Development
Cyclic GMP
Bone
2 Citations (Scopus)
Peroxiredoxin III
Adipocytes
Down-Regulation
Insulin
Oxidation
3 Citations (Scopus)

Effect of acute physiological free fatty acid elevation in the context of hyperinsulinemia on fiber type-specific IMCL accumulation

Chow, L. S., Mashek, D., Wang, Q., Shepherd, S. O., Goodpaster, B. H. & Dubé, J. J., Jul 1 2017, In : Journal of applied physiology. 123, 1, p. 71-78 8 p.

Research output: Contribution to journalArticle

Open Access
Hyperinsulinism
Nonesterified Fatty Acids
Lipids
Glucose Clamp Technique
Insulin Resistance
4 Citations (Scopus)

N-(1-Benzyl-3,5-dimethyl‑1H‑pyrazol-4-yl)benzamides: Antiproliferative activity and effects on mTORC1 and autophagy

Ai, T., Willett, R., Williams, J., Ding, R., Wilson, D., Xie, J., Kim, D-H., Puertollano, R. & Chen, L., Jan 1 2017, In : ACS Medicinal Chemistry Letters. 8, 1, p. 90-95 6 p.

Research output: Contribution to journalArticle

Open Access
Benzamides
Autophagy
Starvation
Modulators
Fluxes
4 Citations (Scopus)
Open Access
Sphingolipids
Chronic Obstructive Pulmonary Disease
HIV
Tryptophan
Kynurenine
9 Citations (Scopus)

Relative importance of βcyto-and γcyto-actin in primary mouse embryonic fibroblasts

Patrinostro, X., O'Rourke, A. R., Chamberlain, C. M., Moriarity, B. S., Perrin, B. J. & Ervasti, J. M., Mar 15 2017, In : Molecular Biology of the Cell. 28, 6, p. 771-782 12 p.

Research output: Contribution to journalArticle

Actins
Fibroblasts
Gene Targeting
Protein Isoforms
Serum Response Factor
3 Citations (Scopus)
Open Access
C-Type Natriuretic Peptide
Guanylate Cyclase
Conformations
Adenosine Triphosphate
Mutation
9 Citations (Scopus)

Training alters the distribution of perilipin proteins in muscle following acute free fatty acid exposure

Shepherd, S. O., Strauss, J. A., Wang, Q., Dube, J. J., Goodpaster, B., Mashek, D. G. & Chow, L. S., Aug 15 2017, In : Journal of Physiology. 595, 16, p. 5587-5601 15 p.

Research output: Contribution to journalArticle

Nonesterified Fatty Acids
Lipids
Muscles
Triglycerides
Fatty Acids
2016
24 Citations (Scopus)

Actin Is Crucial for All Kinetically Distinguishable Forms of Endocytosis at Synapses

Wu, X. S., Lee, S. H., Sheng, J., Zhang, Z., Zhao, W. D., Wang, D., Jin, Y., Charnay, P., Ervasti, J. M. & Wu, L. G., Dec 7 2016, In : Neuron. 92, 5, p. 1020-1035 16 p.

Research output: Contribution to journalArticle

Endocytosis
Synapses
Actins
Electron Microscopy
Protein Isoforms
2 Citations (Scopus)

An expanded role for mTORC1 in autophagy

Kim, Y-M., Park, J-M., Grunwald, D. S. & Kim, D-H., Jan 2 2016, In : Molecular and Cellular Oncology. 3, 1, e1010958.

Research output: Contribution to journalArticle

Autophagy
Phosphotransferases
Radiation
Membranes
mechanistic target of rapamycin complex 1
8 Citations (Scopus)

Catalytically active guanylyl cyclase B requires endoplasmic reticulum-mediated glycosylation, and mutations that inhibit this process cause dwarfism

Dickey, D. M., Edmund, A. B., Otto, N. M., Chaffee, T. S., Robinson, J. W. & Potter, L. R., May 20 2016, In : Journal of Biological Chemistry. 291, 21, p. 11385-11393 9 p.

Research output: Contribution to journalArticle

Glycosylation
Dwarfism
Guanylate Cyclase
Endoplasmic Reticulum
C-Type Natriuretic Peptide
24 Citations (Scopus)

Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone

Shuhaibar, L. C., Egbert, J. R., Edmund, A. B., Uliasz, T. F., Dickey, D. M., Yee, S. P., Potter, L. R. & Jaffe, L. A., Jan 1 2016, In : Developmental Biology. 409, 1, p. 194-201 8 p.

Research output: Contribution to journalArticle

Natriuretic Peptides
Peptide Receptors
Guanylate Cyclase
Meiosis
Threonine
6 Citations (Scopus)

High frequency hearing loss and hyperactivity in DUX4 transgenic mice

Dandapat, A., Perrin, B. J., Cabelka, C., Razzoli, M., Ervasti, J. M., Bartolomucci, A., Lowe, D. A. & Kyba, M., Mar 1 2016, In : PloS one. 11, 3, e0151467.

Research output: Contribution to journalArticle

High-Frequency Hearing Loss
Audition
hearing
Transgenic Mice
Doxycycline
17 Citations (Scopus)

Independent variability of microtubule perturbations associated with dystrophinopathy

Belanto, J. J., Olthoff, J. T., Mader, T. L., Chamberlain, C. M., Nelson, D. M., McCourt, P. M., Talsness, D. M., Gundersen, G. G., Lowe, D. A. & Ervasti, J. M., Nov 15 2016, In : Human molecular genetics. 25, 22, p. 4951-4961 11 p.

Research output: Contribution to journalArticle

Dystrophin
Microtubules
Inbred mdx Mouse
Utrophin
Tubulin
19 Citations (Scopus)

Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins

Zhang, W., Bu, S. Y., Mashek, M. T., O-Sullivan, I. S., Sibai, Z., Khan, S. A., Ilkayeva, O., Newgard, C. B., Mashek, D. G. & Unterman, T. G., Apr 12 2016, In : Cell reports. 15, 2, p. 349-359 11 p.

Research output: Contribution to journalArticle

Lipase
Lipid Metabolism
Metabolism
Lipolysis
Lipids
5 Citations (Scopus)
Hematopoietic Stem Cell Transplantation
Lung Injury
Proteome
Pneumonia
Hematopoietic Stem Cells
7 Citations (Scopus)

RIPPER: A framework for MS1 only metabolomics and proteomics label-free relative quantification

Van Riper, S. K., Higgins, L., Carlis, J. V. & Griffin, T. J., Jul 1 2016, In : Bioinformatics. 32, 13, p. 2035-2037 3 p.

Research output: Contribution to journalArticle

Metabolomics
Proteomics
Mass Spectrometry
Quantification
Mass spectrometry
9 Citations (Scopus)

Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic Progression

Thu, Y-M., Van Riper, S. K., Higgins, L., Zhang, T., Becker, J., Markowski, T. W., Nguyen, H. D., Griffin, T. J. & Bielinsky, A. K., May 10 2016, In : Cell Reports. 15, 6, p. 1254-1265 12 p.

Research output: Contribution to journalArticle

Minichromosome Maintenance Proteins
M Phase Cell Cycle Checkpoints
Ligases
Methyl Methanesulfonate
Protein Deficiency
16 Citations (Scopus)

The role of the proteasome in AML

Csizmar, C. M., Kim, D-H. & Sachs, Z., Dec 2 2016, In : Blood cancer journal. 6, 12, p. e503

Research output: Contribution to journalReview article

Proteasome Endopeptidase Complex
Acute Myeloid Leukemia
Hematologic Neoplasms
Molecular Targeted Therapy
Mantle-Cell Lymphoma
72 Citations (Scopus)

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

Park, J-M., Jung, C. H., Seo, M., Otto, N. M., Grunwald, D. S., KIM, KWAN. HYUN., Moriarity, B. S., Kim, Y-M., Starker, C., Nho, R. S., Voytas, D. F. & Kim, D-H., Apr 5 2016, In : Autophagy. 12, 3, p. 547-564 18 p.

Research output: Contribution to journalArticle

Autophagy
Starvation
Phosphorylation
Food
Class III Phosphatidylinositol 3-Kinases
7 Citations (Scopus)

Tryptophan catabolism in acute exacerbations of chronic obstructive pulmonary disease

Gulcev, M., Reilly, C. S., Griffin, T. J., Broeckling, C. D., Sandri, B. J., Witthuhn, B. A., Hodgson, S. W., Woodruff, P. G. & Wendt, C. H., Sep 29 2016, In : International Journal of COPD. 11, 1, p. 2435-2446 12 p.

Research output: Contribution to journalArticle

Tryptophan
Chronic Obstructive Pulmonary Disease
Indoleamine-Pyrrole 2,3,-Dioxygenase
Metabolomics
Mass Spectrometry
2015
46 Citations (Scopus)

ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1α/PPAR-α signaling

Khan, S. A., Sathyanarayan, A., Mashek, M. T., Ong, K. T., Wollaston-Hayden, E. E. & Mashek, D., Feb 1 2015, In : Diabetes. 64, 2, p. 418-426 9 p.

Research output: Contribution to journalArticle

Sirtuin 1
Peroxisome Proliferator-Activated Receptors
Lipolysis
Lipase
Fatty Acids
18 Citations (Scopus)

Characterizing cardiac molecular mechanisms of mammalian hibernation via quantitative proteogenomics

Vermillion, K. L., Jagtap, P. D., Johnson, J. E., Griffin, T. J. & Andrews, M. T., Jan 1 2015, In : Journal of Proteome Research. 14, 11, p. 4792-4804 13 p.

Research output: Contribution to journalArticle

Hibernation
Galaxies
Sciuridae
Proteomics
Proteins
5 Citations (Scopus)

Creatine kinase B is necessary to limit myoblast fusion during myogenesis

Simionescu-Bankston, A., Pichavant, C., Canner, J. P., Apponi, L. H., Wang, Y., Steeds, C., Olthoff, J. T., Belanto, J. J., Ervasti, J. M. & Pavlath, G. K., Jun 1 2015, In : American Journal of Physiology - Cell Physiology. 308, 11, p. C919-C931

Research output: Contribution to journalArticle

Muscle Development
Myoblasts
Creatine Kinase
Skeletal Muscle Fibers
Actins
4 Citations (Scopus)

Disease-proportional proteasomal degradation of missense dystrophins

Talsness, D. M., Belanto, J. J. & Ervasti, J. M., Oct 6 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 40, p. 12414-12419 6 p.

Research output: Contribution to journalArticle

Dystrophin
Mutation
Frameshift Mutation
Missense Mutation
Phenotype
41 Citations (Scopus)

Hepatic lipid droplet biology: Getting to the root of fatty liver

Mashek, D. G., Khan, S. A., Sathyanarayan, A., Ploeger, J. M. & Franklin, M. P., Sep 1 2015, In : Hepatology. 62, 3, p. 964-967 4 p.

Research output: Contribution to journalArticle

Fatty Liver
Liver
Lipids
Organelles
Liver Diseases
34 Citations (Scopus)

Heterozygous mutations in natriuretic peptide receptor-B (NPR2) gene as a cause of short stature

Wang, S. R., Jacobsen, C. M., Carmichael, H., Edmund, A. B., Robinson, J. W., Olney, R. C., Miller, T. C., Moon, J. E., Mericq, V., Potter, L. R., Warman, M. L., Hirschhorn, J. N. & Dauber, A., Apr 1 2015, In : Human mutation. 36, 4, p. 474-481 8 p.

Research output: Contribution to journalArticle

Mutation
Haploinsufficiency
Genes
Observation
atrial natriuretic factor receptor B
32 Citations (Scopus)

Metaproteomic analysis using the Galaxy framework

Jagtap, P. D., Blakely, A., Murray, K., Stewart, S., Kooren, J., Johnson, J. E., Rhodus, N. L., Rudney, J. D. & Griffin, T. J., Oct 1 2015, In : Proteomics. 15, 20, p. 3553-3565 13 p.

Research output: Contribution to journalArticle

Galaxies
Workflow
Proteins
Blueprints
Protein Databases
81 Citations (Scopus)

MTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation

Kim, Y. M., Jung, C. H., Seo, M., Kim, E. K., Park, J. M., Bae, S. S. & Kim, D. H., Jan 22 2015, In : Molecular Cell. 57, 2, p. 207-218 12 p.

Research output: Contribution to journalArticle

Endosomes
Autophagy
Epidermal Growth Factor Receptor
Lysosomes
Autophagosomes
50 Citations (Scopus)

Multi-omic data analysis using Galaxy

Boekel, J., Chilton, J. M., Cooke, I. R., Horvatovich, P. L., Jagtap, P. D., Käll, L., Lehtiö, J., Lukasse, P., Moerland, P. D. & Griffin, T. J., Jan 1 2015, In : Nature biotechnology. 33, 2, p. 137-139 3 p.

Research output: Contribution to journalLetter

Galaxies
Proteomics
14 Citations (Scopus)

T Cell-Expressed CD40L potentiates the bone anabolic activity of intermittent PTH treatment

Robinson, J. W., Li, J. Y., Walker, L. D., Tyagi, A. M., Reott, M. A., Yu, M., Adams, J., Weitzmann, M. N. & Pacifici, R., Apr 1 2015, In : Journal of Bone and Mineral Research. 30, 4, p. 695-705 11 p.

Research output: Contribution to journalArticle

CD40 Ligand
Stromal Cells
T-Lymphocytes
Bone and Bones
Parathyroid Hormone

The human saliva proteome: Overview and emerging methods for characterization

Griffin, T. J., Jan 1 2015, Advances in Global Health Through Sensing Technologies 2015. Southern, S. O., Gartner, C., Stallings, J. D. & Rodriguez-Chavez, I. R. (eds.). SPIE, Vol. 9490. 949003

Research output: Chapter in Book/Report/Conference proceedingConference contribution

proteome
saliva
Proteome
emerging
proteins
12 Citations (Scopus)

Using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to detect monoclonal immunoglobulin light chains in serum and urine

Barnidge, D. R., Krick, T. P., Griffin, T. J. & Murray, D. L., Nov 15 2015, In : Rapid Communications in Mass Spectrometry. 29, 21, p. 2057-2060 4 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Ionization
Mass spectrometry
Desorption
Electrophoresis
2014
47 Citations (Scopus)

Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes

Egbert, J. R., Shuhaibar, L. C., Edmund, A. B., Van Helden, D. A., Robinson, J. W., Uliasz, T. F., Baena, V., Geerts, A., Wunder, F., Potter, L. R. & Jaffe, L. A., Jan 1 2014, In : Development (Cambridge). 141, 18, p. 3594-3604 11 p.

Research output: Contribution to journalArticle

Natriuretic Peptides
Peptide Receptors
Granulosa Cells
Guanylate Cyclase
Meiosis
22 Citations (Scopus)

Hepatic ATGL mediates PPAR-α signaling and fatty acid channeling through an L-FABP independent mechanism

Ong, K. T., Mashek, M. T., Davidson, N. O. & Mashek, D., Jan 1 2014, In : Journal of Lipid Research. 55, 5, p. 808-815 8 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Lipase
Liver
Carrier Proteins
Fatty Acids

Human saliva proteome: An overview

Griffin, T. J., Jan 1 2014, Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV. SPIE, Vol. 9112. 91120B

Research output: Chapter in Book/Report/Conference proceedingConference contribution

proteome
saliva
Proteome
proteins
Proteins
4 Citations (Scopus)

Improved intensity-based label-free quantification via proximity-based intensity normalization (PIN)

Van Riper, S. K., de Jong, E., Higgins, L., Carlis, J. V. & Griffin, T. J., Mar 7 2014, In : Journal of Proteome Research. 13, 3, p. 1281-1292 12 p.

Research output: Contribution to journalArticle

Labels
Workflow
High Pressure Liquid Chromatography
Molecules
Proteins
15 Citations (Scopus)

Quantitative proteomic analysis of oral brush biopsies identifies secretory leukocyte protease inhibitor as a promising, mechanism-based oral cancer biomarker

Yang, Y., Rhodus, N. L., Ondrey, F. G., Wuertz, B. R. K., Chen, X., Zhu, Y. & Griffin, T. J., Apr 18 2014, In : PloS one. 9, 4, e95389.

Research output: Contribution to journalArticle

Secretory Leukocyte Peptidase Inhibitor
Biopsy
Mouth Neoplasms
Brushes
Tumor Biomarkers
21 Citations (Scopus)

Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma

Buys, E. S., Potter, L. R., Pasquale, L. R. & Ksander, B. R., May 19 2014, In : Frontiers in Molecular Neuroscience. 7, MAY, 38.

Research output: Contribution to journalReview article

Intraocular Pressure
Glaucoma
Membranes
Optic Nerve Diseases
Natriuretic Peptides
5 Citations (Scopus)

Serum TAG analysis differentiates between genetic and obesity-associated NAFLD

Mashek, D. & Greenberg, A. S., Jan 1 2014, In : Diabetes. 63, 1, p. 42-44 3 p.

Research output: Contribution to journalComment/debate

Obesity
Serum
Non-alcoholic Fatty Liver Disease
11 Citations (Scopus)

The ZZ domain of dystrophin in DMD: Making sense of missense mutations

Vulin, A., Wein, N., Strandjord, D. M., Johnson, E. K., Findlay, A. R., Maiti, B., Howard, M. T., Kaminoh, Y. J., Taylor, L. E., Simmons, T. R., Ray, W. C., Montanaro, F., Ervasti, J. M. & Flanigan, K. M., Feb 1 2014, In : Human mutation. 35, 2, p. 257-264 8 p.

Research output: Contribution to journalArticle

Dystroglycans
Dystrophin
Duchenne Muscular Dystrophy
Missense Mutation
Mutation
19 Citations (Scopus)
Diglycerides
Nonesterified Fatty Acids
Insulin Resistance
Lipids
Ceramides